ATE251148T1 - Verfahren zur herstellung von (all-rac)-alpha- tocopherol - Google Patents

Verfahren zur herstellung von (all-rac)-alpha- tocopherol

Info

Publication number: ATE251148T1
Authority: AT; Austria
Prior art keywords: acid; rac; tocopherol; alpha; producing
Prior art date: 2000-03-17

Application number

AT01105979T

Other languages

English (en)

Inventor

Werner Bonrath

Alois Haas

Eike Hoppmann

Thomas Netscher

Horst Pauling

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-17

Filing date

2001-03-10

Publication date

2003-10-15

2001-03-10 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2003-10-15 Application granted granted Critical

2003-10-15 Publication of ATE251148T1 publication Critical patent/ATE251148T1/de

Links

GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
230000005494 condensation Effects 0.000 abstract 2
238000009833 condensation Methods 0.000 abstract 2
239000002184 metal Chemical class 0.000 abstract 2
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical class C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000001707 (E,7R,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol Substances 0.000 abstract 1
GVJHHUAWPYXKBD-IEOSBIPESA-N (R)-alpha-Tocopherol Natural products OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 1
AUFZRCJENRSRLY-UHFFFAOYSA-N 2,3,5-trimethylhydroquinone Chemical compound CC1=CC(O)=C(C)C(C)=C1O AUFZRCJENRSRLY-UHFFFAOYSA-N 0.000 abstract 1
239000007848 Bronsted acid Substances 0.000 abstract 1
KEVYVLWNCKMXJX-ZCNNSNEGSA-N Isophytol Natural products CC(C)CCC[C@H](C)CCC[C@@H](C)CCC[C@@](C)(O)C=C KEVYVLWNCKMXJX-ZCNNSNEGSA-N 0.000 abstract 1
BLUHKGOSFDHHGX-UHFFFAOYSA-N Phytol Natural products CC(C)CCCC(C)CCCC(C)CCCC(C)C=CO BLUHKGOSFDHHGX-UHFFFAOYSA-N 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
HNZBNQYXWOLKBA-UHFFFAOYSA-N Tetrahydrofarnesol Natural products CC(C)CCCC(C)CCCC(C)=CCO HNZBNQYXWOLKBA-UHFFFAOYSA-N 0.000 abstract 1
239000007983 Tris buffer Substances 0.000 abstract 1
229930003427 Vitamin E Natural products 0.000 abstract 1
BOTWFXYSPFMFNR-OALUTQOASA-N all-rac-phytol Natural products CC(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)=CCO BOTWFXYSPFMFNR-OALUTQOASA-N 0.000 abstract 1
229940087168 alpha tocopherol Drugs 0.000 abstract 1
229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
239000003426 co-catalyst Substances 0.000 abstract 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
-1 pentafluorobenzenesulphonyl Chemical group 0.000 abstract 1
BOTWFXYSPFMFNR-PYDDKJGSSA-N phytol Chemical compound CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CO BOTWFXYSPFMFNR-PYDDKJGSSA-N 0.000 abstract 1
239000001117 sulphuric acid Substances 0.000 abstract 1
235000011149 sulphuric acid Nutrition 0.000 abstract 1
229960000984 tocofersolan Drugs 0.000 abstract 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
229940046009 vitamin E Drugs 0.000 abstract 1
239000011709 vitamin E Substances 0.000 abstract 1
235000019165 vitamin E Nutrition 0.000 abstract 1
239000002076 α-tocopherol Substances 0.000 abstract 1
235000004835 α-tocopherol Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
- C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyrane Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)

AT01105979T 2000-03-17 2001-03-10 Verfahren zur herstellung von (all-rac)-alpha- tocopherol ATE251148T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP00105672		2000-03-17

Publications (1)

Publication Number	Publication Date
ATE251148T1 true ATE251148T1 (de)	2003-10-15

Family

ID=8168125

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01105979T ATE251148T1 (de)	2000-03-17	2001-03-10	Verfahren zur herstellung von (all-rac)-alpha- tocopherol

Country Status (11)

Country	Link
US (1)	US6369242B2 (de)
EP (1)	EP1134218B1 (de)
JP (1)	JP2001294584A (de)
KR (1)	KR20010092319A (de)
CN (1)	CN1178930C (de)
AT (1)	ATE251148T1 (de)
BR (1)	BR0101075A (de)
CA (1)	CA2340518A1 (de)
DE (1)	DE60100865T2 (de)
DK (1)	DK1134218T3 (de)
ES (1)	ES2208482T3 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7626046B2 (en)	2001-10-31	2009-12-01	Dsm Ip Assets B.V.	Manufacture of α-tocopherol
US7153994B2 (en)	2001-12-14	2006-12-26	Dsm Ip Assets B.V.	Manufacture of trimethylhydroquinone diacylates
AU2003210291A1 (en) *	2002-02-25	2003-09-09	Dsm Ip Assets B.V.	MANUFACTURE OF (ALL-RAC)-Alpha-TOCOPHEROL
AU2003270295A1 (en) *	2002-11-21	2004-06-15	Dsm Ip Assets B.V.	MANUFACTURE OF Alpha-TOCOPHEROL
US7147767B2 (en) *	2002-12-16	2006-12-12	3M Innovative Properties Company	Plating solutions for electrochemical or chemical deposition of copper interconnects and methods therefor
US6858124B2 (en)	2002-12-16	2005-02-22	3M Innovative Properties Company	Methods for polishing and/or cleaning copper interconnects and/or film and compositions therefor
US6884338B2 (en)	2002-12-16	2005-04-26	3M Innovative Properties Company	Methods for polishing and/or cleaning copper interconnects and/or film and compositions therefor
WO2004096790A1 (en) *	2003-04-28	2004-11-11	Dsm Ip Assets B.V.	Process for the manufacture of tocyl and tocopheryl acylates
KR100984972B1 (ko) *	2004-10-21	2010-10-04	주식회사 만도	유압식 동력조향장치의 유체흐름방향 제어용 체크 밸브
CN111646968B (zh) *	2020-05-28	2022-04-22	万华化学集团股份有限公司	一种制备维生素e的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5273840A (en)	1990-08-01	1993-12-28	Covalent Associates Incorporated	Methide salts, formulations, electrolytes and batteries formed therefrom
JP3848380B2 (ja)	1993-12-14	2006-11-22	エーザイ・アール・アンド・ディー・マネジメント株式会社	α−トコフェロール誘導体の製造法
US5554664A (en)	1995-03-06	1996-09-10	Minnesota Mining And Manufacturing Company	Energy-activatable salts with fluorocarbon anions
US5908939A (en)	1996-11-11	1999-06-01	Roche Vitamins Inc.	Method of making D,L-A-tocopherol
EP0949255B1 (de)	1998-04-06	2006-05-24	DSM IP Assets B.V.	Verfahren zur Herstellung von d,l-alpha-Tocopherol in einem Carbonat-Lösungsmittel und in Anwesenheit eines sauren schwefelhaltigen Katalysators
EP1000940A1 (de)	1998-11-11	2000-05-17	F. Hoffmann-La Roche Ag	Verfahren zur Herstellung von d,l-alpha-Tocopherol

2001
- 2001-03-08 US US09/802,272 patent/US6369242B2/en not_active Expired - Lifetime
- 2001-03-10 AT AT01105979T patent/ATE251148T1/de not_active IP Right Cessation
- 2001-03-10 DE DE60100865T patent/DE60100865T2/de not_active Expired - Lifetime
- 2001-03-10 DK DK01105979T patent/DK1134218T3/da active
- 2001-03-10 ES ES01105979T patent/ES2208482T3/es not_active Expired - Lifetime
- 2001-03-10 EP EP01105979A patent/EP1134218B1/de not_active Expired - Lifetime
- 2001-03-13 CA CA002340518A patent/CA2340518A1/en not_active Abandoned
- 2001-03-14 KR KR1020010013114A patent/KR20010092319A/ko not_active Withdrawn
- 2001-03-14 JP JP2001071442A patent/JP2001294584A/ja not_active Withdrawn
- 2001-03-15 BR BR0101075-1A patent/BR0101075A/pt not_active Application Discontinuation
- 2001-03-16 CN CNB011113987A patent/CN1178930C/zh not_active Expired - Lifetime

Also Published As

Publication number	Publication date
KR20010092319A (ko)	2001-10-24
JP2001294584A (ja)	2001-10-23
US6369242B2 (en)	2002-04-09
DE60100865T2 (de)	2004-07-29
CN1314354A (zh)	2001-09-26
EP1134218B1 (de)	2003-10-01
DK1134218T3 (da)	2004-02-09
EP1134218A1 (de)	2001-09-19
US20010027255A1 (en)	2001-10-04
CA2340518A1 (en)	2001-09-17
ES2208482T3 (es)	2004-06-16
CN1178930C (zh)	2004-12-08
BR0101075A (pt)	2001-11-06
DE60100865D1 (de)	2003-11-06

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Legal Events

Date	Code	Title	Description
2004-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties