DE60324331D1 - Millisekunden-aktivationsschalter für 7-transmembran-proteine - Google Patents

Millisekunden-aktivationsschalter für 7-transmembran-proteine

Info

Publication number
DE60324331D1
DE60324331D1 DE60324331T DE60324331T DE60324331D1 DE 60324331 D1 DE60324331 D1 DE 60324331D1 DE 60324331 T DE60324331 T DE 60324331T DE 60324331 T DE60324331 T DE 60324331T DE 60324331 D1 DE60324331 D1 DE 60324331D1
Authority
DE
Germany
Prior art keywords
compounds
recombinant
labels
present
millise
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60324331T
Other languages
English (en)
Inventor
Moritz Buenemann
Jean-Pierre Vilardaga
Carsten Hoffmann
Martin Johannes Lohse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Julius Maximilians Universitaet Wuerzburg
Original Assignee
Julius Maximilians Universitaet Wuerzburg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Julius Maximilians Universitaet Wuerzburg filed Critical Julius Maximilians Universitaet Wuerzburg
Application granted granted Critical
Publication of DE60324331D1 publication Critical patent/DE60324331D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/10—Screening for compounds of potential therapeutic value involving cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Electrotherapy Devices (AREA)
DE60324331T 2002-12-20 2003-12-19 Millisekunden-aktivationsschalter für 7-transmembran-proteine Expired - Lifetime DE60324331D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10259874 2002-12-20
EP03004394 2003-03-03
PCT/EP2003/014679 WO2004057333A1 (en) 2002-12-20 2003-12-19 Millisecond activation switch for seven-transmembrane proteins

Publications (1)

Publication Number Publication Date
DE60324331D1 true DE60324331D1 (de) 2008-12-04

Family

ID=32683463

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60324331T Expired - Lifetime DE60324331D1 (de) 2002-12-20 2003-12-19 Millisekunden-aktivationsschalter für 7-transmembran-proteine

Country Status (6)

Country Link
US (1) US8084575B2 (de)
EP (1) EP1581811B1 (de)
AT (1) ATE412177T1 (de)
AU (1) AU2003293959A1 (de)
DE (1) DE60324331D1 (de)
WO (1) WO2004057333A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288253B2 (en) 2003-08-08 2007-10-30 Amgen Fremont, Inc. Antibodies directed to parathyroid hormone (PTH) and uses thereof
US7318925B2 (en) 2003-08-08 2008-01-15 Amgen Fremont, Inc. Methods of use for antibodies against parathyroid hormone
FR2890446B1 (fr) 2005-09-05 2008-04-18 Cis Bio Internat Sa Methode de detection d'interaction intracellulaire entre bio-molecules
WO2007100618A2 (en) * 2006-02-23 2007-09-07 Atto Bioscience Novel cell-based phosphodiesterase assays
WO2007139080A1 (ja) * 2006-05-26 2007-12-06 Noacell Science Co., Ltd. 受容体及びイオンチャンネルを介したカルシウムの応答と引き続いて起こる遺伝子発現を測定する連続アッセイ法
US10203320B2 (en) 2008-11-11 2019-02-12 Corning Incorporated Label free method for assessing chemical cardiotoxicity
DE102008064164A1 (de) * 2008-12-22 2010-07-01 Leica Microsystems Cms Gmbh Verfahren zur räumlich hochauflösenden stochastischen Untersuchung einer mit einer Substanz markierten Struktur einer Probe
SG172321A1 (en) * 2009-01-29 2011-07-28 Commw Scient Ind Res Org Measuring g protein coupled receptor activation
US8741591B2 (en) 2009-10-09 2014-06-03 The Research Foundation For The State University Of New York pH-insensitive glucose indicator protein
WO2011069124A2 (en) * 2009-12-04 2011-06-09 Sanford-Burnham Medical Research Institute Method, system and composition for optically inducing cardiomyocyte contraction
BR112016012160A2 (pt) 2013-11-28 2017-09-26 Commw Scient Ind Res Org métodos para detecção de infecção de plasmodium
EP3056902B1 (de) * 2015-02-16 2020-04-01 Universite De Bordeaux Neuartige spannungsabhängige Ionenkanalfusionen und Verwendungsverfahren dafür
CN105671118A (zh) * 2016-03-02 2016-06-15 昆明理工大学 一种基于腺苷受体a2a分子探针的药物活性成分筛选方法
CN108586620B (zh) * 2018-05-10 2021-11-23 山东大学 筛选昆虫性信息素受体的配体的传感器分子以及筛选方法
JP2022551820A (ja) * 2019-10-15 2022-12-14 エフ．ホフマン－ラ ロシュ アーゲー 細胞内または小胞内生体分子相互作用を検出するための人工膜貫通タンパク質
CN119241687A (zh) * 2023-06-27 2025-01-03 沃臻生物科技(佛山)有限公司 一种g蛋白偶联受体的改造方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6702398A (en) 1997-03-14 1998-09-29 Regents Of The University Of California, The Fluorescent protein sensors for detection of analytes
US6376257B1 (en) * 1997-04-24 2002-04-23 University Of Rochester Detection by fret changes of ligand binding by GFP fusion proteins
EP1044374B1 (de) 1997-12-31 2008-10-08 Duke University Glukosebiosensor
EP1088233B9 (de) 1998-06-16 2006-05-17 PerkinElmer BioSignal Inc. Biolumineszentes resonanz-energie-transfersystem (bret) und seine anwendung
AU759888B2 (en) 1998-07-17 2003-05-01 University Of Maryland At Baltimore Engineered proteins for analyte sensing
US7018846B1 (en) * 1998-08-10 2006-03-28 Science & Technology Corporation @ Unm Display of receptors and analysis of binding interactions and drug libraries
WO2000034318A1 (en) 1998-12-11 2000-06-15 Clontech Laboratories, Inc. Fluorescent proteins from non-bioluminescent species of class anthozoa, genes encoding such proteins and uses thereof
ES2272309T3 (es) * 1999-08-03 2007-05-01 Millennium Pharmaceuticals, Inc. 15571, una nueva molecula de tipo gpcr de la familia de tipo secretina y sus usos.
US20020048811A1 (en) 2000-10-16 2002-04-25 Devreotes Peter N. Receptor mediated activation of heterotrimeric G-proteins

Also Published As

Publication number Publication date
WO2004057333A1 (en) 2004-07-08
EP1581811A1 (de) 2005-10-05
EP1581811B1 (de) 2008-10-22
US20060272037A1 (en) 2006-11-30
ATE412177T1 (de) 2008-11-15
AU2003293959A1 (en) 2004-07-14
US8084575B2 (en) 2011-12-27

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