DE69007775D1 - 5'-alkylphosphonylnukleoside als antivirale verbindungen. - Google Patents

5'-alkylphosphonylnukleoside als antivirale verbindungen.

Info

Publication number
DE69007775D1
DE69007775D1 DE90914159T DE69007775T DE69007775D1 DE 69007775 D1 DE69007775 D1 DE 69007775D1 DE 90914159 T DE90914159 T DE 90914159T DE 69007775 T DE69007775 T DE 69007775T DE 69007775 D1 DE69007775 D1 DE 69007775D1
Authority
DE
Germany
Prior art keywords
alkylphosphonyl
nucleosides
antiviral compounds
antiviral
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE90914159T
Other languages
English (en)
Other versions
DE69007775T2 (de
Inventor
Carlo Battistini
Giovanni Franceschi
Domenico Ungheri
Maria Verini
Sergio Vioglio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of DE69007775D1 publication Critical patent/DE69007775D1/de
Application granted granted Critical
Publication of DE69007775T2 publication Critical patent/DE69007775T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE69007775T 1989-09-22 1990-09-20 5'-alkylphosphonylnukleoside als antivirale verbindungen. Expired - Fee Related DE69007775T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898921469A GB8921469D0 (en) 1989-09-22 1989-09-22 5'-alkylphosphonylnucleosides as antivirals
PCT/EP1990/001602 WO1991004261A1 (en) 1989-09-22 1990-09-20 5'-alkylphosphonylnucleosides as antivirals

Publications (2)

Publication Number Publication Date
DE69007775D1 true DE69007775D1 (de) 1994-05-05
DE69007775T2 DE69007775T2 (de) 1994-07-07

Family

ID=10663488

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69007775T Expired - Fee Related DE69007775T2 (de) 1989-09-22 1990-09-20 5'-alkylphosphonylnukleoside als antivirale verbindungen.

Country Status (6)

Country Link
EP (1) EP0445258B1 (de)
JP (1) JPH04501867A (de)
AU (1) AU645762B2 (de)
DE (1) DE69007775T2 (de)
GB (1) GB8921469D0 (de)
WO (1) WO1991004261A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0335770B1 (de) * 1988-04-01 1997-01-15 Merrell Pharmaceuticals Inc. Derivate von Fluorphosphonat-Nukleotiden
JPH04261191A (ja) * 1991-02-13 1992-09-17 Tsumura & Co ヌクレオシド−５’−アルキルフォスフォネート類の合成方法
DE19812156A1 (de) * 1998-03-20 1999-09-30 Forschungszentrum Juelich Gmbh Nucleotidaktivierte Di- und Oligosaccharide sowie Verfahren zu deren Herstellung II
DE19812162A1 (de) * 1998-03-20 1999-09-30 Forschungszentrum Juelich Gmbh Nucleotidaktivierte Di- und Oligosaccharide sowie Verfahren zu deren Herstellung I
FR2981650B1 (fr) * 2011-10-24 2013-12-27 Univ Paris Curie Analogues de nucleosides pour le traitement d'une infection virale et methode d'evaluation de la sensibilite audit traitement

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560478A (en) * 1968-06-14 1971-02-02 Terrell C Myers Analogues of nucleoside phosphates
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
DE3490262T1 (de) * 1983-05-24 1985-11-28 Sri International, Menlo Park, Calif. Antivirus-Mittel
US4826823A (en) * 1985-02-05 1989-05-02 Warner-Lambert Company Methods of using 2-chloro-2'-deoxyadenosine-5'-phosphate and its salts

Also Published As

Publication number Publication date
WO1991004261A1 (en) 1991-04-04
GB8921469D0 (en) 1989-11-08
EP0445258B1 (de) 1994-03-30
EP0445258A1 (de) 1991-09-11
AU6424490A (en) 1991-04-18
AU645762B2 (en) 1994-01-27
JPH04501867A (ja) 1992-04-02
DE69007775T2 (de) 1994-07-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee