DE69128564D1 - Extrazelluläre form des menschlichen fibroblasten wachstumsfaktorrezeptors - Google Patents

Extrazelluläre form des menschlichen fibroblasten wachstumsfaktorrezeptors

Info

Publication number
DE69128564D1
DE69128564D1 DE69128564T DE69128564T DE69128564D1 DE 69128564 D1 DE69128564 D1 DE 69128564D1 DE 69128564 T DE69128564 T DE 69128564T DE 69128564 T DE69128564 T DE 69128564T DE 69128564 D1 DE69128564 D1 DE 69128564D1
Authority
DE
Germany
Prior art keywords
growth factor
factor receptor
fibroblast growth
human fibroblast
extra cellular
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69128564T
Other languages
English (en)
Other versions
DE69128564T2 (de
Inventor
Laura Bergonzoni
Guy Mazue
Antonella Isacchi
Romeo Roncucci
Paolo Sarmientos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Pharmacia and Upjohn SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn SpA filed Critical Pharmacia and Upjohn SpA
Application granted granted Critical
Publication of DE69128564D1 publication Critical patent/DE69128564D1/de
Publication of DE69128564T2 publication Critical patent/DE69128564T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/642Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69128564T 1990-01-23 1991-01-21 Extrazelluläre form des menschlichen fibroblasten wachstumsfaktorrezeptors Expired - Fee Related DE69128564T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909001466A GB9001466D0 (en) 1990-01-23 1990-01-23 Extracellular form of the human fibroblast growth factor receptor
PCT/EP1991/000103 WO1991011459A1 (en) 1990-01-23 1991-01-21 Extracellular form of the human fibroblast growth factor receptor

Publications (2)

Publication Number Publication Date
DE69128564D1 true DE69128564D1 (de) 1998-02-12
DE69128564T2 DE69128564T2 (de) 1998-05-07

Family

ID=10669720

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69128564T Expired - Fee Related DE69128564T2 (de) 1990-01-23 1991-01-21 Extrazelluläre form des menschlichen fibroblasten wachstumsfaktorrezeptors

Country Status (5)

Country Link
EP (1) EP0464175B1 (de)
JP (1) JPH04504428A (de)
DE (1) DE69128564T2 (de)
GB (1) GB9001466D0 (de)
WO (1) WO1991011459A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1403285A1 (de) * 1990-07-06 2004-03-31 Gencell S.A. Rezeptoren der Wachstumsfaktoren aus Fibroblasten
DE4129533A1 (de) * 1991-09-05 1993-03-11 Max Planck Gesellschaft Mutierter wachstumsfaktorrezeptor als arzneimittel und seine verwendung zur behandlung von krebs
IL100219A0 (en) * 1991-12-02 1992-09-06 Yeda Res & Dev Variable region within fibroblast growth factor receptors that confers ligand specificity
US5916772A (en) * 1992-06-16 1999-06-29 Whittier Institute For Diabetes And Endocrinology Recombinant production of saporin-containing proteins
EP0646182B1 (de) * 1992-06-18 1996-08-28 The Whittier Institute For Diabetes And Endocrinology Verfahren zur detektion neoplastischer erkrankungen
US6656728B1 (en) 1999-02-08 2003-12-02 Chiron Corporation Fibroblast growth factor receptor-immunoglobulin fusion
EP2083081A1 (de) 2005-07-22 2009-07-29 Five Prime Therapeutics, Inc. Zusammensetzungen und Verfahren zur Behandlung von Krankheiten mit FGFR-Fusionsproteinen
BRPI0916904A2 (pt) 2008-08-04 2016-10-11 Fiveprime Therapeutics Inc polipeptídeos, moléculares de fusão ecd fgfr4, composições farmacêuticas, polinucleotídio e métodos de tratamento de desordem angiogênica, câncer em paciente e degeneração macular em paciente e respectivos usos
WO2011034940A1 (en) 2009-09-15 2011-03-24 Five Prime Therapeutics, Inc. Hair growth methods using fgfr4 extracellular domains
LT2498799T (lt) 2009-11-13 2016-11-10 Five Prime Therapeutics, Inc. Fgfr1 ekstraląstelinio domeno baltymų panaudojimas gydymui vėžio su nuo ligando priklausančiomis, aktyvuojančiomis fgfr2 mutacijomis
WO2011084711A2 (en) 2009-12-17 2011-07-14 Five Prime Therapeutics, Inc. Hair growth methods using fgfr3 extracellular domains
US8481038B2 (en) 2010-11-15 2013-07-09 Five Prime Therapeutics, Inc. Treatment of cancer with elevated dosages of soluble FGFR1 fusion proteins
US8951972B2 (en) 2010-12-09 2015-02-10 Five Prime Therapeutics, Inc. FGFR1 extracellular domain combination therapies for lung cancer
HK1202240A1 (en) 2011-11-14 2015-09-25 戊瑞治疗有限公司 Methods of treating cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU215581B (hu) * 1989-07-06 1999-01-28 Regents Of The University Of California Eljárás fibroblaszt növekedési faktor receptorok előállítására és terápiás alkalmazására

Also Published As

Publication number Publication date
GB9001466D0 (en) 1990-03-21
DE69128564T2 (de) 1998-05-07
JPH04504428A (ja) 1992-08-06
EP0464175B1 (de) 1998-01-07
EP0464175A1 (de) 1992-01-08
WO1991011459A1 (en) 1991-08-08

Similar Documents

Publication Publication Date Title
ATA155790A (de) Wirbelprothese
FI934934A7 (fi) Hepatosyyttikasvutekijäreseptorin typistetyt muodot
FI920027A7 (fi) Fibroblastikasvutekijöiden reseptoreita
DE69128411D1 (de) Orthopädisches Implantat
DE59306316D1 (de) Beinprothese
FI934915A7 (fi) Tuki sydänventtiiliproteesia varten
DE69127354D1 (de) Prothese
DK0474015T3 (da) Endoprotese
FI942017L (fi) Ihmisen interferonin stabilointi
DE69029839D1 (de) Implantierbare Penisprothese
DE69226268D1 (de) Kniegelenkprothese
FI954541L (fi) Keratinosyyttikasvutekijän terapeuttisia käyttöjä
BR9103805A (pt) Implante intracular
DE69128564D1 (de) Extrazelluläre form des menschlichen fibroblasten wachstumsfaktorrezeptors
ITUD920103A1 (it) Protesi di ginocchio tricompartimentale con menischi oscillanti
FI933059L (fi) Biokompatibelt formbart polymermaterial
FI902391A7 (fi) Ihmisen/naudan emäksisen fibroblastikasvutekijän uudet johdannaiset
DE59009986D1 (de) Implantierbare Penisprothese
FI916067A7 (fi) Ihmisen interleukiini 5-reseptori
BR9306919A (pt) Implante peniano
DE59303475D1 (de) Stimmprothese
DE69128423D1 (de) Wirbelsäulenstreckbett
DE69121210D1 (de) Therapeutische verwendung des fibroblastenwachstumsfaktors
DE69124833D1 (de) Hüftgelenkprothese
KR920000201U (ko) 목욕 의자

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee