DE69735722D1 - D-methionin zur reduzierung der toxizität von platin-enthaltenden antitumor verbindungen - Google Patents

D-methionin zur reduzierung der toxizität von platin-enthaltenden antitumor verbindungen

Info

Publication number: DE69735722D1
Authority: DE; Germany
Prior art keywords: methionine; platin; platinum; reduce toxicity; antitumor compounds
Prior art date: 1996-10-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69735722T

Other languages

English (en)

Other versions

DE69735722T2 (de

Inventor

C Campbell

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Southern Illinois University System

Southern Illinois University Carbondale

Original Assignee

Southern Illinois University System

Southern Illinois University Carbondale

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-03

Filing date

1997-10-02

Publication date

2006-05-24

1997-10-02 Application filed by Southern Illinois University System, Southern Illinois University Carbondale filed Critical Southern Illinois University System

2006-05-24 Publication of DE69735722D1 publication Critical patent/DE69735722D1/de

2007-04-12 Application granted granted Critical

2007-04-12 Publication of DE69735722T2 publication Critical patent/DE69735722T2/de

2017-10-03 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

FFEARJCKVFRZRR-SCSAIBSYSA-N D-methionine Chemical compound CSCC[C@@H](N)C(O)=O FFEARJCKVFRZRR-SCSAIBSYSA-N 0.000 title abstract 2
230000000259 anti-tumor effect Effects 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
230000001988 toxicity Effects 0.000 title 1
231100000419 toxicity Toxicity 0.000 title 1
BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 4
239000002246 antineoplastic agent Substances 0.000 abstract 2
229940127089 cytotoxic agent Drugs 0.000 abstract 2
229910052697 platinum Inorganic materials 0.000 abstract 2
201000004384 Alopecia Diseases 0.000 abstract 1
229930182818 D-methionine Natural products 0.000 abstract 1
206010059024 Gastrointestinal toxicity Diseases 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
206010029350 Neurotoxicity Diseases 0.000 abstract 1
206010044221 Toxic encephalopathy Diseases 0.000 abstract 1
231100000360 alopecia Toxicity 0.000 abstract 1
229960004316 cisplatin Drugs 0.000 abstract 1
DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
231100000414 gastrointestinal toxicity Toxicity 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
231100000228 neurotoxicity Toxicity 0.000 abstract 1
230000007135 neurotoxicity Effects 0.000 abstract 1
239000003223 protective agent Substances 0.000 abstract 1
230000004083 survival effect Effects 0.000 abstract 1
230000004580 weight loss Effects 0.000 abstract 1
208000016261 weight loss Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Inorganic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE69735722T 1996-10-03 1997-10-02 D-methionin zur reduzierung der toxizität von platin-enthaltenden antitumor verbindungen Expired - Lifetime DE69735722T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US2775096P	1996-10-03	1996-10-03
US27750P		1996-10-03
PCT/US1997/018114 WO1998014182A1 (en)	1996-10-03	1997-10-02	Therapeutic use of d-methionine to reduce the toxicity of platinum-containing anti-tumor compounds

Publications (2)

Publication Number	Publication Date
DE69735722D1 true DE69735722D1 (de)	2006-05-24
DE69735722T2 DE69735722T2 (de)	2007-04-12

Family

ID=21839569

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69735722T Expired - Lifetime DE69735722T2 (de)	1996-10-03	1997-10-02	D-methionin zur reduzierung der toxizität von platin-enthaltenden antitumor verbindungen

Country Status (10)

Country	Link
EP (1)	EP0930877B1 (de)
JP (1)	JP4260889B2 (de)
AT (1)	ATE323475T1 (de)
AU (1)	AU726392B2 (de)
CA (1)	CA2265983C (de)
DE (1)	DE69735722T2 (de)
DK (1)	DK0930877T3 (de)
ES (1)	ES2263172T3 (de)
PT (1)	PT930877E (de)
WO (1)	WO1998014182A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7071230B2 (en)	1997-10-02	2006-07-04	Board Of Trustees Of Southern Illinois University	Therapeutic use of D-methionine to reduce the toxicity of noise
SK1472004A3 (en) *	2001-09-24	2004-10-05	Tosk Inc	Reduced toxicity cisplatin formulations and methods for using the same
US20050090551A1 (en) *	2003-10-27	2005-04-28	Board Of Trustees Of Southern Illinois University	Therapeutic use of methionine for the treatment or prevention of mucositis
USRE48077E1 (en)	2013-02-28	2020-07-07	Anida Pharma Inc.	Methods of treating ototoxicity

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994005299A1 (fr) *	1992-09-04	1994-03-17	Fuji Kagaku Kogyo Kabushiki Kaisha	Compositions medicinales

1997
- 1997-10-02 EP EP97911634A patent/EP0930877B1/de not_active Expired - Lifetime
- 1997-10-02 CA CA002265983A patent/CA2265983C/en not_active Expired - Fee Related
- 1997-10-02 WO PCT/US1997/018114 patent/WO1998014182A1/en not_active Ceased
- 1997-10-02 AU AU48957/97A patent/AU726392B2/en not_active Ceased
- 1997-10-02 AT AT97911634T patent/ATE323475T1/de not_active IP Right Cessation
- 1997-10-02 DE DE69735722T patent/DE69735722T2/de not_active Expired - Lifetime
- 1997-10-02 DK DK97911634T patent/DK0930877T3/da active
- 1997-10-02 JP JP51697398A patent/JP4260889B2/ja not_active Expired - Fee Related
- 1997-10-02 ES ES97911634T patent/ES2263172T3/es not_active Expired - Lifetime
- 1997-10-02 PT PT97911634T patent/PT930877E/pt unknown

Also Published As

Publication number	Publication date
AU726392B2 (en)	2000-11-09
PT930877E (pt)	2006-09-29
DE69735722T2 (de)	2007-04-12
CA2265983A1 (en)	1998-04-09
WO1998014182A1 (en)	1998-04-09
JP2001501626A (ja)	2001-02-06
JP4260889B2 (ja)	2009-04-30
CA2265983C (en)	2003-12-23
EP0930877B1 (de)	2006-04-19
ES2263172T3 (es)	2006-12-01
DK0930877T3 (da)	2006-08-21
ATE323475T1 (de)	2006-05-15
AU4895797A (en)	1998-04-24
EP0930877A1 (de)	1999-07-28

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Legal Events

Date

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Title

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2007-06-06

8364

No opposition during term of opposition

2012-04-13

R082

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