DK0383372T3 - Cykliske triketonforbindelser og trimethylsilyloxybutadienforbindelser samt deres anvendelse til fremstilling af daunomycinonafledede - Google Patents

Cykliske triketonforbindelser og trimethylsilyloxybutadienforbindelser samt deres anvendelse til fremstilling af daunomycinonafledede

Info

Publication number: DK0383372T3
Authority: DK; Denmark
Prior art keywords: compounds; group; daunomycinone; preparation; derivatives
Prior art date: 1989-02-10

Application number

DK90200212.0T

Other languages

English (en)

Inventor

Johan Wilhelm Scheeren

Joannes Franciscus M De Bie

Dirk De Vos

Original Assignee

Pharmachemie Bv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-10

Filing date

1990-01-29

Publication date

1993-08-02

1990-01-29 Application filed by Pharmachemie Bv filed Critical Pharmachemie Bv

1993-08-02 Application granted granted Critical

1993-08-02 Publication of DK0383372T3 publication Critical patent/DK0383372T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 5
YOFDHOWPGULAQF-MQJDWESPSA-N (7s,9s)-9-acetyl-6,7,9,11-tetrahydroxy-4-methoxy-8,10-dihydro-7h-tetracene-5,12-dione Chemical class C1[C@@](O)(C(C)=O)C[C@H](O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-MQJDWESPSA-N 0.000 title abstract 4
238000002360 preparation method Methods 0.000 title abstract 3
125000004122 cyclic group Chemical group 0.000 title abstract 2
UQGOYQLRRBTVFM-UHFFFAOYSA-N buta-1,3-dienoxy(trimethyl)silane Chemical class C[Si](C)(C)OC=CC=C UQGOYQLRRBTVFM-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
YOFDHOWPGULAQF-UHFFFAOYSA-N Daunomycin-Aglycone Natural products C1C(O)(C(C)=O)CC(O)C2=C1C(O)=C1C(=O)C(C=CC=C3OC)=C3C(=O)C1=C2O YOFDHOWPGULAQF-UHFFFAOYSA-N 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 abstract 1
238000005698 Diels-Alder reaction Methods 0.000 abstract 1
229940009456 adriamycin Drugs 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
150000001993 dienes Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK90200212.0T 1989-02-10 1990-01-29 Cykliske triketonforbindelser og trimethylsilyloxybutadienforbindelser samt deres anvendelse til fremstilling af daunomycinonafledede DK0383372T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
NL8900329A NL8900329A (nl)	1989-02-10	1989-02-10	Cyclische triketonverbindingen en trimethylsilyloxybutadieenverbindingen en hun toepassing bij het bereiden van daunomycinonderivaten.

Publications (1)

Publication Number	Publication Date
DK0383372T3 true DK0383372T3 (da)	1993-08-02

Family

ID=19854110

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90200212.0T DK0383372T3 (da)	1989-02-10	1990-01-29	Cykliske triketonforbindelser og trimethylsilyloxybutadienforbindelser samt deres anvendelse til fremstilling af daunomycinonafledede

Country Status (9)

Country	Link
US (1)	US5097051A (da)
EP (1)	EP0383372B1 (da)
JP (1)	JPH02235836A (da)
AT (1)	ATE87901T1 (da)
CA (1)	CA2009096A1 (da)
DE (1)	DE69001266T2 (da)
DK (1)	DK0383372T3 (da)
ES (1)	ES2055296T3 (da)
NL (1)	NL8900329A (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL9001834A (nl) *	1990-08-16	1992-03-16	Pharmachemie Bv	Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.
US5416403A (en) *	1993-02-11	1995-05-16	Hewlett-Packard Corporation	Current stabilizing circuit
FR2740772B1 (fr) *	1995-11-02	1998-01-16	Girex	Procede de preparation d'anthraquinones substituees et application a la preparation de rheines
DE102007031461A1 (de)	2007-07-05	2009-01-08	Sappok, Manfred, Dipl.-Phys. Dr.	Verfahren zum Stabilisieren von Heizöl oder Dieselöl, insbesondere aus der Depolimerisation von kohlenwasserstoffhaltigen Rückständen

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4405522A (en) *	1982-01-18	1983-09-20	Adria Laboratories Inc.	Anthracycline synthesis

1989
- 1989-02-10 NL NL8900329A patent/NL8900329A/nl not_active Application Discontinuation
1990
- 1990-01-29 DE DE9090200212T patent/DE69001266T2/de not_active Expired - Fee Related
- 1990-01-29 DK DK90200212.0T patent/DK0383372T3/da active
- 1990-01-29 EP EP90200212A patent/EP0383372B1/en not_active Expired - Lifetime
- 1990-01-29 ES ES90200212T patent/ES2055296T3/es not_active Expired - Lifetime
- 1990-01-29 AT AT90200212T patent/ATE87901T1/de not_active IP Right Cessation
- 1990-02-01 US US07/473,538 patent/US5097051A/en not_active Expired - Fee Related
- 1990-02-01 CA CA002009096A patent/CA2009096A1/en not_active Abandoned
- 1990-02-03 JP JP2024987A patent/JPH02235836A/ja active Pending

Also Published As

Publication number	Publication date
EP0383372A1 (en)	1990-08-22
NL8900329A (nl)	1990-09-03
US5097051A (en)	1992-03-17
ES2055296T3 (es)	1994-08-16
ATE87901T1 (de)	1993-04-15
DE69001266D1 (de)	1993-05-13
JPH02235836A (ja)	1990-09-18
EP0383372B1 (en)	1993-04-07
CA2009096A1 (en)	1990-08-10
DE69001266T2 (de)	1993-09-16

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