DK0401508T3 - Proteaseinhibitorer, fremgangsmåde til deres fremstilling samt lægemidler med indhold deraf - Google Patents

Proteaseinhibitorer, fremgangsmåde til deres fremstilling samt lægemidler med indhold deraf

Info

Publication number: DK0401508T3
Authority: DK; Denmark
Prior art keywords: peptide variants; preparation; trypsin inhibitor; processes; protease inhibitors
Prior art date: 1989-05-13

Application number

DK90108284.2T

Other languages

English (en)

Inventor

Hans Prof Dr Fritz

Wolfgang Dr Gebhard

Rathindra Dr Das

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-13

Filing date

1990-05-01

Publication date

1995-05-15

1990-05-01 Application filed by Bayer Ag filed Critical Bayer Ag

1995-05-15 Application granted granted Critical

1995-05-15 Publication of DK0401508T3 publication Critical patent/DK0401508T3/da

Links

238000000034 method Methods 0.000 title abstract 2
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
229940079593 drug Drugs 0.000 title 1
239000003814 drug Substances 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 4
230000002401 inhibitory effect Effects 0.000 abstract 2
LKDMKWNDBAVNQZ-UHFFFAOYSA-N 4-[[1-[[1-[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)CC1=CC=CC=C1 LKDMKWNDBAVNQZ-UHFFFAOYSA-N 0.000 abstract 1
241000894006 Bacteria Species 0.000 abstract 1
102000004173 Cathepsin G Human genes 0.000 abstract 1
108090000617 Cathepsin G Proteins 0.000 abstract 1
241000206602 Eukaryota Species 0.000 abstract 1
102000016387 Pancreatic elastase Human genes 0.000 abstract 1
108010067372 Pancreatic elastase Proteins 0.000 abstract 1
108090000113 Plasma Kallikrein Proteins 0.000 abstract 1
102100034869 Plasma kallikrein Human genes 0.000 abstract 1
102000012479 Serine Proteases Human genes 0.000 abstract 1
108010022999 Serine Proteases Proteins 0.000 abstract 1
229940122618 Trypsin inhibitor Drugs 0.000 abstract 1
101710162629 Trypsin inhibitor Proteins 0.000 abstract 1
238000010353 genetic engineering Methods 0.000 abstract 1
108010093564 inter-alpha-inhibitor Proteins 0.000 abstract 1
244000005700 microbiome Species 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
210000002966 serum Anatomy 0.000 abstract 1
239000002753 trypsin inhibitor Substances 0.000 abstract 1
108010088854 urinastatin Proteins 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8114—Kunitz type inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Zoology (AREA)
Urology & Nephrology (AREA)
General Engineering & Computer Science (AREA)
Physics & Mathematics (AREA)
Plant Pathology (AREA)
Pulmonology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Reproductive Health (AREA)
Microbiology (AREA)

DK90108284.2T 1989-05-13 1990-05-01 Proteaseinhibitorer, fremgangsmåde til deres fremstilling samt lægemidler med indhold deraf DK0401508T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3915689		1989-05-13
DE4001244		1990-01-18

Publications (1)

Publication Number	Publication Date
DK0401508T3 true DK0401508T3 (da)	1995-05-15

Family

ID=25880860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90108284.2T DK0401508T3 (da)	1989-05-13	1990-05-01	Proteaseinhibitorer, fremgangsmåde til deres fremstilling samt lægemidler med indhold deraf

Country Status (17)

Country	Link
US (1)	US5407915A (da)
EP (1)	EP0401508B1 (da)
JP (2)	JP3126975B2 (da)
KR (1)	KR0156246B1 (da)
AT (1)	ATE114332T1 (da)
AU (1)	AU623769B2 (da)
CA (1)	CA2016627C (da)
DE (1)	DE59007737D1 (da)
DK (1)	DK0401508T3 (da)
ES (1)	ES2066033T3 (da)
GR (1)	GR3015124T3 (da)
HU (1)	HU214985B (da)
IE (1)	IE65710B1 (da)
IL (1)	IL94349A (da)
NZ (1)	NZ233635A (da)
PH (1)	PH27530A (da)
PT (1)	PT94016B (da)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20060134087A1 (en) *	1988-09-02	2006-06-22	Dyax Corp.	ITI-D1 Kunitz domain mutants as hNE inhibitors
US5663143A (en) *	1988-09-02	1997-09-02	Dyax Corp.	Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US7078383B2 (en) *	1988-09-02	2006-07-18	Dyax Corp.	ITI-D1 Kunitz domain mutants as HNE inhibitors
AU641568B2 (en) *	1990-11-13	1993-09-23	Mochida Pharmaceutical Co., Ltd.	Polypeptide,DNA fragment encoding the same and process for producing the same, and enzyme inhibition process, drug composition and methods of treating using the same
CA2105304C (en) *	1991-03-01	2005-10-04	Arthur C. Ley	Inhibitors of human neutrophil elastase and human cathepsin g
CA2082226A1 (en) *	1991-11-08	1993-05-09	Hideaki Morishita	Polypeptide, dna fragment encoding the same, drug composition containing the same and process for producing the same
IL104327A0 (en) *	1992-01-07	1993-05-13	Novo Nordisk As	Variant of human kunitz-type protease inhibitor
JP2769083B2 (ja) *	1993-02-22	1998-06-25	日清食品株式会社	エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法
JP3570558B2 (ja) *	1993-05-01	2004-09-29	持田製薬株式会社	Ｄｎａ断片およびそれを含むベクター、該ベクターによって形質転換された形質転換体、該ベクターを用いる蛋白質の産生方法
US5650394A (en) *	1993-11-04	1997-07-22	Adeza Biomedical	Use of urinastatin-like compounds to prevent premature delivery
ES2229236T3 (es)	1994-01-11	2005-04-16	Dyax Corporation	Inhibidores de la plasmina humana derivados de los dominios de kunitz.
US6057287A (en)	1994-01-11	2000-05-02	Dyax Corp.	Kallikrein-binding "Kunitz domain" proteins and analogues thereof
WO1996026273A1 (en) *	1995-02-23	1996-08-29	Adeza Biomedical Corporation	Polypeptides derived from urinastatin having calcium channel blocking activity and their use to delay premature delivery
IL126115A (en) *	1996-03-11	2007-03-08	Aerovance Inc	Significantly purified protein with suppressive activity for sirin protease and its pharmaceutical preparations
DK1140150T3 (da) *	1998-12-22	2004-03-22	Bayer Ag	Fremgangsmåde til accelerering af hastigheden af mucociliær clearance under anvendelse af en serinproteaseinhibitor af Kunitz-type
US20070140979A1 (en) *	1998-12-22	2007-06-21	Bayer Aktiengesellschaft	Method for accelerating the rate of mucociliary clearance
US6660482B1 (en) *	2000-02-28	2003-12-09	Rhode Island Hospital	Inter-alpha-trypsin inhibitor as a marker for sepsis
KR20040004562A (ko) *	2001-03-27	2004-01-13	어웨어, 인크.	수신기 투과성 ｑ-모드
US7153829B2 (en)	2002-06-07	2006-12-26	Dyax Corp.	Kallikrein-inhibitor therapies
WO2003103475A2 (en)	2002-06-07	2003-12-18	Dyax Corp.	Prevention and reduction of blood loss
JP2005537006A (ja)	2002-08-28	2005-12-08	ダイアックス、コープ	臓器及び組織の保存方法
DK1587907T3 (da) *	2003-01-07	2011-04-04	Dyax Corp	Kunitz-domænebibliotek
US6989369B2 (en) *	2003-02-07	2006-01-24	Dyax Corp.	Kunitz domain peptides
US7235530B2 (en)	2004-09-27	2007-06-26	Dyax Corporation	Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
CA2744235A1 (en) *	2009-01-06	2010-07-15	Dyax Corp.	Treatment of mucositis with kallikrein inhibitors
EP3459564B1 (en)	2010-01-06	2021-10-27	Takeda Pharmaceutical Company Limited	Plasma kallikrein binding proteins
CA2823776A1 (en)	2011-01-06	2012-07-12	Dyax Corp.	Plasma kallikrein binding proteins
PL3110434T3 (pl)	2014-02-24	2019-01-31	Takeda Gmbh	Białka fuzyjne uti
IL295414B2 (en)	2014-03-27	2026-02-01	Takeda Pharmaceuticals Co	Compositions and methods for treating macular edema due to diabetes
AU2016366557B2 (en)	2015-12-11	2024-01-25	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US12528880B2 (en)	2020-01-13	2026-01-20	Takeda Pharmaceutical Company Limited	Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack
CA3174478A1 (en)	2020-03-05	2021-09-10	DiaMedica USA Inc.	Ulinastatin polypeptides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU560584B2 (en) *	1983-07-28	1987-04-09	Bayer Aktiengesellschaft	Homologues of aprotinin
US4711848A (en) *	1984-03-14	1987-12-08	Zymogenetics, Inc.	Site specific mutagenesis in alpha-1-antitrypsin
FR2599752B1 (fr) *	1986-06-10	1989-11-03	Transgene Sa	Variants de l'alpha1- antitrypsine utiles notamment comme inhibiteurs de la kallikreine
FR2601033B1 (fr) *	1986-07-02	1990-01-19	Transgene Sa	Variants de l'alpha-antitryspine humaine glycosylee et procede pour la preparation
EP0255011A3 (en) *	1986-07-29	1988-11-23	Miles Inc.	Human inter-alpha-trypsin inhibitor gene

1990
- 1990-05-01 AT AT90108284T patent/ATE114332T1/de not_active IP Right Cessation
- 1990-05-01 ES ES90108284T patent/ES2066033T3/es not_active Expired - Lifetime
- 1990-05-01 EP EP90108284A patent/EP0401508B1/de not_active Expired - Lifetime
- 1990-05-01 DE DE59007737T patent/DE59007737D1/de not_active Expired - Fee Related
- 1990-05-01 DK DK90108284.2T patent/DK0401508T3/da active
- 1990-05-02 PH PH40464A patent/PH27530A/en unknown
- 1990-05-10 NZ NZ233635A patent/NZ233635A/en unknown
- 1990-05-10 IL IL94349A patent/IL94349A/en not_active IP Right Cessation
- 1990-05-11 PT PT94016A patent/PT94016B/pt active IP Right Grant
- 1990-05-11 JP JP02120186A patent/JP3126975B2/ja not_active Expired - Fee Related
- 1990-05-11 HU HU903010A patent/HU214985B/hu not_active IP Right Cessation
- 1990-05-11 CA CA002016627A patent/CA2016627C/en not_active Expired - Fee Related
- 1990-05-11 IE IE171390A patent/IE65710B1/en not_active IP Right Cessation
- 1990-05-11 AU AU54970/90A patent/AU623769B2/en not_active Ceased
- 1990-05-12 KR KR1019900006865A patent/KR0156246B1/ko not_active Expired - Fee Related
1993
- 1993-03-05 US US08/027,602 patent/US5407915A/en not_active Expired - Fee Related
1995
- 1995-02-22 GR GR940403586T patent/GR3015124T3/el unknown
2000
- 2000-09-13 JP JP2000278172A patent/JP2001112492A/ja active Pending

Also Published As

Publication number	Publication date
DE59007737D1 (de)	1995-01-05
KR900017607A (ko)	1990-12-19
JP2001112492A (ja)	2001-04-24
AU623769B2 (en)	1992-05-21
CA2016627C (en)	2000-08-22
GR3015124T3 (en)	1995-05-31
EP0401508A3 (de)	1991-03-27
PH27530A (en)	1993-08-18
ES2066033T3 (es)	1995-03-01
PT94016B (pt)	1997-05-28
PT94016A (pt)	1991-01-08
NZ233635A (en)	1991-12-23
HU214985B (hu)	1998-08-28
HU903010D0 (en)	1990-09-28
US5407915A (en)	1995-04-18
JP3126975B2 (ja)	2001-01-22
EP0401508B1 (de)	1994-11-23
IE901713L (en)	1990-11-13
IE65710B1 (en)	1995-11-15
IL94349A0 (en)	1991-03-10
JPH03255099A (ja)	1991-11-13
ATE114332T1 (de)	1994-12-15
CA2016627A1 (en)	1990-11-13
EP0401508A2 (de)	1990-12-12
AU5497090A (en)	1990-11-15
KR0156246B1 (ko)	1998-11-16
IL94349A (en)	1998-01-04

Publication	Publication Date	Title
DK0401508T3 (da)	1995-05-15	Proteaseinhibitorer, fremgangsmåde til deres fremstilling samt lægemidler med indhold deraf
Johnson et al.	1986	Cathepsin L inactivates alpha 1-proteinase inhibitor by cleavage in the reactive site region.
ATE226636T1 (de)	2002-11-15	Serpin-resistenter t-pa; mutanten; gene
NO930517L (no)	1993-08-16	Benzimidazolylderivater, legemidler inneholdende disse, og fremgangsmaate for deres fremstilling
PL319782A1 (en)	1997-08-18	Inhibitors of serinic proteases and anticoagulative protecins extracted from nematodes
MX9603775A (es)	1997-07-31	Proteinas inhibidoras del dominio de kunitz, derivadas del inhibidor del precursor de la beta-proteina amiloide de alzheimer.
Chen et al.	1996	Solubilization, partial purification, and affinity labeling of the membrane-bound isoprenylated protein endoprotease
WO1996035788A3 (en)	1996-12-12	Kunitz type protease inhibitors
WO2002076939A3 (en)	2003-10-16	Cysteine protease inhibitors
TR200002940T2 (tr)	2001-02-21	Parazitlerin sebep olduğu hastalıkların papain süperfamilyasından sistein proteazların inhibisyonu yoluyla tedavisi
ATE250574T1 (de)	2003-10-15	Neue verbindungen
DK0419099T3 (da)	1996-03-11	Proteiner med antikoagulationsegenskaber
Rowan et al.	1990	Inhibition of cysteine proteinases by a protein inhibitor from potato
NZ319474A (en)	2000-01-28	Guanidino protease inhibitors
ATE92935T1 (de)	1993-08-15	Serinproteaseinhibitoren und isolierungsverfahren dazu.
KR890004724A (ko)	1989-05-09	신규 프로테아제 제제(製劑)
Braud et al.	2002	The stratagem utilized by the plasminogen activator from the snake Trimeresurus stejnegeri to escape serpins
HK1043534A1 (zh)	2002-09-20	蛋白酶抑制剂
Takahara et al.	1982	Mouse plasma trypsin inhibitors: Inhibitory spectrum of contrapsin and alpha-1-antitrypsin
Groutas et al.	1992	Inhibitors of human neutrophil cathepsin G: structural and biochemical studies
Sulikowski et al.	2002	α1‐Proteinase inhibitor mutants with specificity for plasma kallikrein and C1s but not C1
Ascenzi et al.	1990	Binding of the Bovine Basic Pancreatic Trypsin Inhibitor (Kunitz) to the 33,000 M r and 54,000 M r Species of Human Urokinase: Thermodynamic Study
Ecke et al.	1994	Alternative targeting of a serpin-type inhibitor by glycosaminoglycans (GAGs): Heparin binding of protein C inhibitor (pci) prevents its interaction with tissue kallikrein (tk)
Rarabas et al.	1994	Investigations of thrombin inhibitors in fibrinolytic systems
Hayashi et al.	1994	Fibrin (ogen) binding region in urinary protein c inhibitor