DK0401981T3 - Pyridazinonderivater - Google Patents

Pyridazinonderivater

Info

Publication number: DK0401981T3
Authority: DK; Denmark
Prior art keywords: compounds; pyrido; pyridazine; oxo; substituted
Prior art date: 1989-05-11

Application number

DK90305015.1T

Other languages

English (en)

Inventor

Banavara Lakshmana Mylari

William James Zembrowski

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-11

Filing date

1990-05-10

Publication date

1995-09-04

1990-05-10 Application filed by Pfizer filed Critical Pfizer

1995-09-04 Application granted granted Critical

1995-09-04 Publication of DK0401981T3 publication Critical patent/DK0401981T3/da

Links

AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical compound OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
-1 6-substituted-5-oxo-6H-pyrido[2,3-d]pyridazine-8-ylacetic acid Chemical class 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
150000007513 acids Chemical class 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
208000002249 Diabetes Complications Diseases 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
150000001768 cations Chemical class 0.000 abstract 1
230000001684 chronic effect Effects 0.000 abstract 1
125000004475 heteroaralkyl group Chemical group 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Ophthalmology & Optometry (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

DK90305015.1T 1989-05-11 1990-05-10 Pyridazinonderivater DK0401981T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/350,417 US4996204A (en)	1989-05-11	1989-05-11	Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors

Publications (1)

Publication Number	Publication Date
DK0401981T3 true DK0401981T3 (da)	1995-09-04

Family

ID=23376622

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90305015.1T DK0401981T3 (da)	1989-05-11	1990-05-10	Pyridazinonderivater

Country Status (18)

Country	Link
US (1)	US4996204A (da)
EP (1)	EP0401981B1 (da)
JP (1)	JPH0631235B2 (da)
KR (1)	KR920003559B1 (da)
AT (1)	ATE121743T1 (da)
AU (1)	AU611610B2 (da)
CA (1)	CA2016326C (da)
DE (1)	DE69018876T2 (da)
DK (1)	DK0401981T3 (da)
ES (1)	ES2071016T3 (da)
FI (1)	FI93013C (da)
HU (1)	HU206714B (da)
IE (1)	IE66029B1 (da)
IL (1)	IL94302A (da)
NO (1)	NO173938C (da)
NZ (1)	NZ233599A (da)
PT (1)	PT93984B (da)
ZA (1)	ZA903564B (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4954629A (en) *	1989-05-11	1990-09-04	Pfizer Inc.	Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof
US5716954A (en) *	1991-10-09	1998-02-10	Syntex U.S.A. Inc.	Benzopyridazinone and pyridopyridazinone compounds
NZ254550A (en) *	1992-09-28	1997-08-22	Pfizer	Use of nitrogen-substituted pyrimidines to prepare medicaments useful for treatment or prevention of diabetic complications
GB9314412D0 (en) *	1993-07-13	1993-08-25	Rhone Poulenc Agriculture	New compositions of matter
SK7522001A3 (en)	1998-03-31	2002-02-05	Inst For Pharm Discovery Inc	Substituted indolealkanoic acids
TNSN99224A1 (fr)	1998-12-01	2005-11-10	Inst For Pharm Discovery Inc	Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
HRP20030419A2 (en) *	2000-11-30	2004-08-31	Pfizer Prod Inc	Combination of gaba agonists and aldose reductase inhibitors
ES2240657T3 (es)	2001-02-28	2005-10-16	Pfizer Products Inc.	Compuestos de sulfonilpiridazinona utiles como inhibidores de aldosa reductasa.
ATE348100T1 (de) *	2001-03-30	2007-01-15	Pfizer Prod Inc	Zwischenprodukten für die herstellung von pyridazinon aldose reductase inhibitoren.
AU2002236131B2 (en) *	2001-04-30	2005-04-14	Pfizer Products Inc.	Combinations of aldose reductase inhibitors and cyclooxygenase-2 inhibitors
AU761191B2 (en)	2001-05-24	2003-05-29	Pfizer Products Inc.	Therapies for tissue damage resulting from ischemia
US7572910B2 (en) *	2003-02-20	2009-08-11	Pfizer, Inc.	Pyridazinone aldose reductase inhibitors
PL2593456T3 (pl) *	2010-07-16	2017-06-30	The Trustees Of Columbia University In The City Of New York	Inhibitory reduktazy aldozowej i ich zastosowania
US8916563B2 (en)	2010-07-16	2014-12-23	The Trustees Of Columbia University In The City Of New York	Aldose reductase inhibitors and uses thereof
IL283809B2 (en)	2016-06-21	2024-01-01	Univ Columbia	Compounds for use in a method of treating neuropathy, retinopathy, nephropathy, or cardiomyopathy
IL272246B2 (en)	2017-07-28	2026-01-01	Applied Therapeutics Inc	History of 2-(4-oxo/thioketone/azo-3-((substituted)benzo[d]thiazol-2-yl)methyl)- 3,4-dihydrothieno[3,4-d]pyridazin-1-yl)acetic acid for use as an aldose reductase inhibitor for the treatment of galactosemia or prevention of galactosemia-related complications
AU2020254610A1 (en)	2019-04-01	2021-11-18	Applied Therapeutics Inc.	Inhibitors of aldose reductase
CN113966396A (zh)	2019-05-07	2022-01-21	迈阿密大学	遗传性神经病和相关障碍的治疗和检测

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3821383A (en) *	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
DE2708187A1 (de) *	1977-02-25	1978-08-31	Thomae Gmbh Dr K	Neue pyrido-pyridazin-one
IE47592B1 (en) *	1977-12-29	1984-05-02	Ici Ltd	Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture
US4209527A (en) *	1979-05-16	1980-06-24	Pfizer Inc.	Benzimidazolone derivatives
CA1160518A (en) *	1979-07-06	1984-01-17	E. I. Du Pont De Nemours And Company	Coated cookware with fep topcoat
ES2032749T3 (es) *	1985-11-07	1993-03-01	Pfizer Inc.	Acidos oxoftalazinil-aceticos heterociclicos.
US4954629A (en) *	1989-05-11	1990-09-04	Pfizer Inc.	Process and intermediates for the preparation of oxophthalazinyl acetic acids and analogs thereof

1989
- 1989-05-11 US US07/350,417 patent/US4996204A/en not_active Expired - Lifetime
1990
- 1990-05-06 IL IL9430290A patent/IL94302A/en not_active IP Right Cessation
- 1990-05-08 NZ NZ233599A patent/NZ233599A/en unknown
- 1990-05-09 PT PT93984A patent/PT93984B/pt not_active IP Right Cessation
- 1990-05-09 CA CA002016326A patent/CA2016326C/en not_active Expired - Fee Related
- 1990-05-10 FI FI902335A patent/FI93013C/fi not_active IP Right Cessation
- 1990-05-10 DE DE69018876T patent/DE69018876T2/de not_active Expired - Fee Related
- 1990-05-10 AU AU54905/90A patent/AU611610B2/en not_active Ceased
- 1990-05-10 ZA ZA903564A patent/ZA903564B/xx unknown
- 1990-05-10 AT AT90305015T patent/ATE121743T1/de not_active IP Right Cessation
- 1990-05-10 DK DK90305015.1T patent/DK0401981T3/da active
- 1990-05-10 HU HU902996A patent/HU206714B/hu not_active IP Right Cessation
- 1990-05-10 EP EP90305015A patent/EP0401981B1/en not_active Expired - Lifetime
- 1990-05-10 KR KR1019900006808A patent/KR920003559B1/ko not_active Expired
- 1990-05-10 ES ES90305015T patent/ES2071016T3/es not_active Expired - Lifetime
- 1990-05-10 NO NO902070A patent/NO173938C/no unknown
- 1990-05-11 IE IE170190A patent/IE66029B1/en unknown
- 1990-05-11 JP JP2122832A patent/JPH0631235B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2071016T3 (es)	1995-06-16
ATE121743T1 (de)	1995-05-15
EP0401981B1 (en)	1995-04-26
HU902996D0 (en)	1990-09-28
NO902070D0 (no)	1990-05-10
PT93984A (pt)	1991-01-08
KR920003559B1 (ko)	1992-05-04
US4996204A (en)	1991-02-26
FI93013B (fi)	1994-10-31
ZA903564B (en)	1992-08-26
CA2016326A1 (en)	1990-11-11
PT93984B (pt)	1996-11-29
NZ233599A (en)	1991-07-26
AU5490590A (en)	1990-11-15
NO173938B (no)	1993-11-15
EP0401981A1 (en)	1990-12-12
NO902070L (no)	1990-11-12
FI902335A0 (fi)	1990-05-10
IE66029B1 (en)	1995-11-29
DE69018876T2 (de)	1995-08-24
KR900018092A (ko)	1990-12-20
IE901701L (en)	1990-11-11
DE69018876D1 (de)	1995-06-01
HUT54683A (en)	1991-03-28
JPH035481A (ja)	1991-01-11
FI93013C (fi)	1995-02-10
JPH0631235B2 (ja)	1994-04-27
CA2016326C (en)	1995-05-30
AU611610B2 (en)	1991-06-13
IL94302A (en)	1994-01-25
IL94302A0 (en)	1991-03-10
NO173938C (no)	1994-02-23
HU206714B (en)	1992-12-28

Publication	Publication Date	Title
DE69018876D1 (de)	1995-06-01	Pyridazinon-Derivate.
PT85294A (en)	1987-08-01	Indolinone derivatives
IL60751A (en)	1985-04-30	6-(2'-((substituted phenyl)ethyl and-ethenyl)-4-hydroxy-tetrahydro-2h-pyran-2-one derivatives,their preparation and pharmaceutical compositions containing them
IE801005L (en)	1980-11-16	Benzimidazolones.
PT85998A (en)	1987-11-01	Quinoxalinone derivatives
NO178025C (no)	1996-01-10	Analogifremgangsmåte for fremstilling av terapeutisk aktive (benzhydryloksyetylpiperidyl)alifatiske syrederivater
HUT62855A (en)	1993-06-28	Process for producing glycerol derivatives and pharmaceutical compositions comprising same
EG18597A (en)	1993-08-30	Process for the production of phthalazineacetic acid ester derivatives and a novel intermediate
JPS6429363A (en)	1989-01-31	Heterocyclic derivative
AU1317688A (en)	1988-09-22	Benzoxazine derivatives and processes for preparation thereof