DK0405788T3 - Di-tert-butyl(hydroxy)phenylthiosubstituerede hydroxamsyrederivater - Google Patents

Di-tert-butyl(hydroxy)phenylthiosubstituerede hydroxamsyrederivater

Info

Publication number: DK0405788T3
Authority: DK; Denmark
Prior art keywords: tert; butyl; acid derivatives; hydroxamic acid; phenylthiosubstituted
Prior art date: 1989-06-29

Application number

DK90306401.2T

Other languages

English (en)

Inventor

Saichi Matsumoto

Takuji Mizui

Masami Doteuchi

Original Assignee

Shionogi & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-06-29

Filing date

1990-06-12

Publication date

1994-04-11

1990-06-12 Application filed by Shionogi & Co filed Critical Shionogi & Co

1994-04-11 Application granted granted Critical

1994-04-11 Publication of DK0405788T3 publication Critical patent/DK0405788T3/da

Links

NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
239000002253 acid Substances 0.000 title abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 title 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
206010003210 Arteriosclerosis Diseases 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
208000025865 Ulcer Diseases 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000007815 allergy Effects 0.000 abstract 1
208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
-1 n-butyl-methylene Chemical group 0.000 abstract 1
125000001400 nonyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
231100000397 ulcer Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
- C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK90306401.2T 1989-06-29 1990-06-12 Di-tert-butyl(hydroxy)phenylthiosubstituerede hydroxamsyrederivater DK0405788T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP16749789		1989-06-29

Publications (1)

Publication Number	Publication Date
DK0405788T3 true DK0405788T3 (da)	1994-04-11

Family

ID=15850778

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90306401.2T DK0405788T3 (da)	1989-06-29	1990-06-12	Di-tert-butyl(hydroxy)phenylthiosubstituerede hydroxamsyrederivater

Country Status (8)

Country	Link
US (1)	US5091569A (da)
EP (1)	EP0405788B1 (da)
JP (1)	JP3065636B2 (da)
KR (1)	KR910000631A (da)
AT (1)	ATE102607T1 (da)
DE (1)	DE69007183T2 (da)
DK (1)	DK0405788T3 (da)
ES (1)	ES2062367T3 (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992007825A1 (fr) *	1990-11-05	1992-05-14	Taisho Pharmaceutical Co., Ltd.	Derive de phenol
US5442111A (en) *	1991-05-24	1995-08-15	Warner-Lambert Company	3,5-di-tetriary-4-butyl-4-hydroxyphenyloxy- or tioalkylene N-hydroxyamides, N-hydroxythioamides, N-hydroxyureas, and N-hydroxythioureas as 5-lipoxygenase inhibitors
DE4124345A1 (de) *	1991-07-23	1993-01-28	Gruenenthal Gmbh	Substituierte 3,4-dihydronaphthaline, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
ATE292131T1 (de) *	1992-10-05	2005-04-15	Virginia Tech Intell Prop	Zwischenprodukt zur herstellung von d-chiro- inosose und (+)-d-chiro-inositol
EP0640586B1 (en) *	1993-03-10	1999-06-09	Morinaga Milk Industry Co., Ltd.	Stilbene derivative and stilbene analog derivative, and use thereof
GB9501737D0 (en) *	1994-04-25	1995-03-22	Hoffmann La Roche	Hydroxamic acid derivatives
IL164568A0 (en)	1997-05-14	2005-12-18	Atherogenics Inc	Compounds and methods for the inhibition of the expression of vcam-1
AU2006202461B2 (en) *	1997-05-14	2009-12-03	Atherogenics, Inc.	Compositions and methods for the inhibition of the expression of VCAM-1
US6670398B2 (en)	1997-05-14	2003-12-30	Atherogenics, Inc.	Compounds and methods for treating transplant rejection
EP1695959A1 (en) *	1997-05-14	2006-08-30	Atherogenics, Inc.	Compouds and methods for the inhibition of the expression of VCAM-1
US6852878B2 (en)	1998-05-14	2005-02-08	Atherogenics, Inc.	Thioketals and thioethers for inhibiting the expression of VCAM-1
CA2294247C (en)	1997-07-01	2004-10-26	Atherogenics, Inc.	Antioxidant enhancement of therapy for hyperproliferative conditions
US7312247B2 (en)	2001-03-27	2007-12-25	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US8026280B2 (en)	2001-03-27	2011-09-27	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US7842727B2 (en) *	2001-03-27	2010-11-30	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
US6495719B2 (en) *	2001-03-27	2002-12-17	Circagen Pharmaceutical	Histone deacetylase inhibitors
WO2002076941A2 (en) *	2001-03-27	2002-10-03	Circagen Pharmaceutical	Histone deacetylase inhibitors
WO2003099272A1 (en) *	2002-05-22	2003-12-04	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
US6960683B2 (en)	2002-07-12	2005-11-01	Atherogenics, Inc.	Salt forms of poorly soluble probucol esters and ethers
US6727277B1 (en)	2002-11-12	2004-04-27	Kansas State University Research Foundation	Compounds affecting cholesterol absorption
WO2004046104A2 (en) *	2002-11-20	2004-06-03	Errant Gene Therapeutics, Llc	Treatment of lung cells with histone deacetylase inhibitors
WO2005112914A2 (en)	2004-04-20	2005-12-01	Atherogenics, Inc.	Phenolic antioxidants for the treatment of disorders including arthritis, asthma and coronary artery disease
US7294737B2 (en)	2004-04-20	2007-11-13	Atherogenics, Inc.	Process of preparing esters and ethers of probucol and derivatives thereof
CA2587013A1 (en) *	2004-11-08	2006-05-18	Errant Gene Therapeutics, Llc	Histone deacetylase inhibitors
WO2008118948A1 (en)	2007-03-26	2008-10-02	Atherogenics, Inc.	Methods and compositions of derivatives of probucol for the treatment of diabetes
WO2008130718A1 (en)	2007-04-23	2008-10-30	Atherogenics, Inc.	Sulfonamide containing compounds for treatment of inflammatory disorders
JP2016158850A (ja) *	2015-03-01	2016-09-05	幸爾奥田	クッション付枕カバー

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4029812A (en) *	1976-02-18	1977-06-14	The Dow Chemical Company	Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
AU584669B2 (en) *	1985-02-04	1989-06-01	G.D. Searle & Co.	Novel disubstituted 4-hydroxyphenylthio anilides
IE59397B1 (en) *	1985-03-16	1994-02-23	Wellcome Found	New aryl derivatives
PT82200B (pt) *	1985-03-16	1990-02-08	Wellcome Found	Processo para a preparacao de novos derivados do acido hidroxamico e de composicoes farmaceuticas que os contem
US4623661A (en) *	1985-04-26	1986-11-18	Abbott Laboratories	Lipoxygenase inhibiting compounds
US4605669A (en) *	1985-04-26	1986-08-12	Abbott Laboratories	Lipoxygenase inhibiting naphthohydroxamic acids
US4608390A (en) *	1985-04-26	1986-08-26	Abbott Laboratories	Lipoxygenase inhibiting compounds
CA1316932C (en) *	1985-05-20	1993-04-27	Richard A. Mueller	Methods and compositions for inhibiting lipoxygenase
US4861798A (en) *	1986-12-29	1989-08-29	Bristol-Myers Company	Lipoxygenase inhibitory compounds
US4873259A (en) *	1987-06-10	1989-10-10	Abbott Laboratories	Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
DE3882732T2 (de) *	1987-02-10	1993-12-02	Abbott Lab	Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen.
US4897422A (en) *	1987-02-10	1990-01-30	Abbott Laboratories	Lipoxygenase inhibiting compounds
ATE74269T1 (de) *	1987-07-29	1992-04-15	Takeda Chemical Industries Ltd	Zellproliferationsinhibitor.
GB2212153B (en) *	1987-11-16	1992-01-15	Squibb & Sons Inc	Phenyl hydroxamic acids

1990
- 1990-06-01 JP JP02144955A patent/JP3065636B2/ja not_active Expired - Fee Related
- 1990-06-12 ES ES90306401T patent/ES2062367T3/es not_active Expired - Lifetime
- 1990-06-12 DK DK90306401.2T patent/DK0405788T3/da active
- 1990-06-12 AT AT90306401T patent/ATE102607T1/de not_active IP Right Cessation
- 1990-06-12 DE DE69007183T patent/DE69007183T2/de not_active Expired - Fee Related
- 1990-06-12 EP EP90306401A patent/EP0405788B1/en not_active Expired - Lifetime
- 1990-06-19 US US07/540,625 patent/US5091569A/en not_active Expired - Fee Related
- 1990-06-29 KR KR1019900009767A patent/KR910000631A/ko not_active Ceased

Also Published As

Publication number	Publication date
KR910000631A (ko)	1991-01-29
DE69007183T2 (de)	1994-06-16
ES2062367T3 (es)	1994-12-16
ATE102607T1 (de)	1994-03-15
EP0405788A3 (en)	1991-04-17
EP0405788A2 (en)	1991-01-02
DE69007183D1 (de)	1994-04-14
JPH0395154A (ja)	1991-04-19
EP0405788B1 (en)	1994-03-09
US5091569A (en)	1992-02-25
JP3065636B2 (ja)	2000-07-17

Publication	Publication Date	Title
DK0405788T3 (da)	1994-04-11	Di-tert-butyl(hydroxy)phenylthiosubstituerede hydroxamsyrederivater
CA2174127A1 (en)	1995-04-20	Phenylsulfonyl ureas, processes for their preparation, and their use as herbicides and plant growth regulators
DE69132435D1 (de)	2000-11-09	Inhibitoren retroviraler Proteasen
NZ278072A (en)	1998-02-26	Phenylacetic acid oxime derivatives; biocides
NO965515L (no)	1997-02-20	Metalloproteinaseinhibitorer
ATE77086T1 (de)	1992-06-15	Verfahren zur bekaempfung von pilzen ausserhalb des menschlichen oder tierischen koerpers.
NO871990D0 (no)	1987-05-13	Quinolinkarboksylsyre-derivater.
DK319786D0 (da)	1986-07-04	Aminophenoler og anvendelse deraf i oxidationshaarfarvemidler
ES8706692A1 (es)	1987-06-16	Un metodo para preparar nuevos derivados de cefem
ES2053809T3 (es)	1994-08-01	Derivados de ciclopropano.
GB2170204B (en)	1988-10-12	Thio-substituted aromatic alcohols
ATE174028T1 (de)	1998-12-15	Dimercapto-1,3-dithiolo-2-on oder thion- maleimide, sie enthaltende zusammensetzungen und ihre verwendung als antimicrobielle und unterwasseranwuchsverhindernde mittel
FI941659A0 (fi)	1994-04-11	Menetelmä sinappikaasun tekemiseksi myrkyttömäksi, rikkipitoisia kvaternaarisia ammoniumioneenipolymeerejä sekä niiden käyttäminen mikrobisideinä
JPS5772970A (en)	1982-05-07	Azolylalkyl derivatives, manufacture and use as fungicide
ATE119521T1 (de)	1995-03-15	Butenoinsäure-derivate.
GR3032519T3 (en)	2000-05-31	Cyclohexane derivatives, processes for their preparation and their use as glucose-6-phosphatase inhibitors.
ATE92073T1 (de)	1993-08-15	Phosphorsaeurediester und salze davon.
IE902272L (en)	1990-12-23	Compositions of 5-phenyl-2-furan ketones
CA2183320A1 (en)	1995-08-17	Novel Mercaptoacetylamide Disulfide Derivatives Useful as Inhibitors of Enkephalinase and Ace
EA199700188A1 (ru)	1998-04-30	Пестициды
JPS55131180A (en)	1980-10-11	Water-soluble rust preventive agent
JPS6490102A (en)	1989-04-06	Controller against fire blight
ES483627A1 (es)	1980-09-01	Un procedimiento para la preparacion de imidas derivadas de amidas de acido 2-oxo-3-benzotiazolinacetico y acido butiri-co
JPS56122395A (en)	1981-09-25	Glucosamine derivative, its salt and its preparation
JPS6434368A (en)	1989-02-03	Deodorant