DK0412820T3 - 2-Oxo-1-oxa-8-azaspiro(4,5)decanderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater med indhold deraf - Google Patents

2-Oxo-1-oxa-8-azaspiro(4,5)decanderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater med indhold deraf

Info

Publication number: DK0412820T3
Authority: DK; Denmark
Prior art keywords: ylcarbonyl; alkyl; azaspiro; oxa; oxo
Prior art date: 1989-08-10

Application number

DK90308778.1T

Other languages

English (en)

Inventor

Eva Dr Palosi

Laszlo Dr Szporny

Jozsef Toerley

Istvan Dr Laszlovszky

Bela Kiss

Erzsebet Dr Lapis

Ferenc Auth

Laszlo Dr Gaal

Edit Toth

Bela Dr Hegedues

Dora Dr Groo

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-10

Filing date

1990-08-09

Publication date

1994-03-28

1990-08-09 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1994-03-28 Application granted granted Critical

1994-03-28 Publication of DK0412820T3 publication Critical patent/DK0412820T3/da

Links

SEUNTAIZLCAWDW-UHFFFAOYSA-N 1-oxa-8-azaspiro[4.5]decan-2-one Chemical class O1C(=O)CCC11CCNCC1 SEUNTAIZLCAWDW-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
-1 piperidin-1-ylcarbonyl Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
150000002632 lipids Chemical class 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
208000026935 allergic disease Diseases 0.000 abstract 1
230000003266 anti-allergic effect Effects 0.000 abstract 1
230000002082 anti-convulsion Effects 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001037 epileptic effect Effects 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000006678 phenoxycarbonyl group Chemical group 0.000 abstract 1
150000003242 quaternary ammonium salts Chemical class 0.000 abstract 1
125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
125000004953 trihalomethyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

DK90308778.1T 1989-08-10 1990-08-09 2-Oxo-1-oxa-8-azaspiro(4,5)decanderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater med indhold deraf DK0412820T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU894092A HU204054B (en)	1989-08-10	1989-08-10	Process for producing new 1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives and pharmaceutical compositions comprising same

Publications (1)

Publication Number	Publication Date
DK0412820T3 true DK0412820T3 (da)	1994-03-28

Family

ID=10966859

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90308778.1T DK0412820T3 (da)	1989-08-10	1990-08-09	2-Oxo-1-oxa-8-azaspiro(4,5)decanderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater med indhold deraf

Country Status (22)

Country	Link
US (1)	US5157038A (da)
EP (1)	EP0412820B1 (da)
JP (1)	JPH0377886A (da)
KR (1)	KR940002828B1 (da)
CN (2)	CN1029403C (da)
AT (1)	ATE102204T1 (da)
AU (1)	AU621239B2 (da)
DD (1)	DD299430A5 (da)
DE (1)	DE69006973T2 (da)
DK (1)	DK0412820T3 (da)
ES (1)	ES2062386T3 (da)
FI (1)	FI903973A7 (da)
HU (1)	HU204054B (da)
IE (1)	IE62297B1 (da)
IL (1)	IL95322A (da)
IS (1)	IS1578B (da)
MY (1)	MY107125A (da)
NO (1)	NO903510L (da)
NZ (1)	NZ234844A (da)
PL (2)	PL164653B1 (da)
YU (1)	YU47749B (da)
ZA (1)	ZA906298B (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5756743A (en)	1996-04-10	1998-05-26	Hoechst Marion Roussel Inc.	Spiro cyclopent b!indole-piperidines!
RU2006132465A (ru) *	2004-02-10	2008-03-20	Ф.Хоффманн-Ля Рош Аг (Ch)	Модуляторы хемокинового рецептора ccr5
PE20081735A1 (es) *	2007-02-01	2009-01-18	Glaxo Group Ltd	Derivados de 1-oxa-3[4,5]decan-2-ona en el tratamiento de trastornos alimenticios
JP2010517966A (ja) *	2007-02-01	2010-05-27	グラクソグループリミテッド	摂食障害の処置のための１−オキサ−３−アザスピロ（４．５）デカン−２−オンおよび１−オキサ−３，８−ジアザスピロ（４．５）デカン−２−オン誘導体
JP6503008B2 (ja) *	2017-05-30	2019-04-17	高級アルコール工業株式会社	透明油性固形化粧料

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL127065C (da) *	1964-04-22
US3594306A (en) *	1967-04-03	1971-07-20	Great Canadian Oil Sands	Separation cell and scavenger cell froths treatment
FR96352E (fr) *	1967-12-29	1972-06-16	Science Union & Cie	Nouveaux dérives du spiro (4,5) decane et leur procédé de préparation.
FR2036557A5 (da) *	1969-03-25	1970-12-24	Logeais Laboratoires
GB1301254A (da) *	1971-07-08	1972-12-29
US3856797A (en) *	1972-12-29	1974-12-24	Yoshitomi Pharmaceutical	8-aminoalkyl-3-oxo-1-thia-4,8-diazaspiro(4.5)decanes and analogs thereof
US4244961A (en) *	1978-10-26	1981-01-13	Syntex (U.S.A.) Inc.	1-Oxa-3,8-diazaspiro[4.5]decan-2-ones antihypertensive agents
FR2615515B1 (fr) *	1987-05-22	1989-06-30	Adir	Nouveaux derives du spiro 4, 5 decane, leur procede de preparation et les compositions pharmaceutiques les renfermant
HU204529B (en) *	1989-08-10	1992-01-28	Richter Gedeon Vegyeszet	Process for producing new 1-oxa-2-oxo-8-aza-spiro(4,5)decane derivatives and pharmaceutical compositions containing them

1989
- 1989-08-10 HU HU894092A patent/HU204054B/hu not_active IP Right Cessation
1990
- 1990-08-08 KR KR1019900012167A patent/KR940002828B1/ko not_active Expired - Fee Related
- 1990-08-09 JP JP2209360A patent/JPH0377886A/ja active Pending
- 1990-08-09 MY MYPI90001339A patent/MY107125A/en unknown
- 1990-08-09 DK DK90308778.1T patent/DK0412820T3/da active
- 1990-08-09 DD DD90343362A patent/DD299430A5/de not_active IP Right Cessation
- 1990-08-09 IL IL9532290A patent/IL95322A/en not_active IP Right Cessation
- 1990-08-09 NO NO90903510A patent/NO903510L/no unknown
- 1990-08-09 EP EP90308778A patent/EP0412820B1/en not_active Expired - Lifetime
- 1990-08-09 NZ NZ234844A patent/NZ234844A/en unknown
- 1990-08-09 ZA ZA906298A patent/ZA906298B/xx unknown
- 1990-08-09 ES ES90308778T patent/ES2062386T3/es not_active Expired - Lifetime
- 1990-08-09 IS IS3613A patent/IS1578B/is unknown
- 1990-08-09 DE DE69006973T patent/DE69006973T2/de not_active Expired - Fee Related
- 1990-08-09 YU YU153990A patent/YU47749B/sh unknown
- 1990-08-09 AU AU60805/90A patent/AU621239B2/en not_active Ceased
- 1990-08-09 IE IE288390A patent/IE62297B1/en not_active IP Right Cessation
- 1990-08-09 AT AT90308778T patent/ATE102204T1/de not_active IP Right Cessation
- 1990-08-10 CN CN90106982A patent/CN1029403C/zh not_active Expired - Fee Related
- 1990-08-10 PL PL90286441A patent/PL164653B1/pl unknown
- 1990-08-10 CN CN90106920A patent/CN1028531C/zh not_active Expired - Fee Related
- 1990-08-10 FI FI903973A patent/FI903973A7/fi not_active Application Discontinuation
- 1990-08-10 US US07/566,274 patent/US5157038A/en not_active Expired - Fee Related
- 1990-08-10 PL PL90300608A patent/PL164654B1/pl unknown

Also Published As

Publication number	Publication date
YU153990A (sh)	1992-12-21
PL164654B1 (pl)	1994-08-31
KR940002828B1 (ko)	1994-04-04
US5157038A (en)	1992-10-20
PL286441A1 (en)	1991-07-15
ATE102204T1 (de)	1994-03-15
IL95322A0 (en)	1991-06-30
IE62297B1 (en)	1995-01-25
IE902883A1 (en)	1991-02-27
IS3613A7 (is)	1991-02-11
CN1029403C (zh)	1995-08-02
ZA906298B (en)	1991-06-26
KR910004629A (ko)	1991-03-29
CN1049348A (zh)	1991-02-20
AU621239B2 (en)	1992-03-05
HUT55783A (en)	1991-06-28
CN1028531C (zh)	1995-05-24
AU6080590A (en)	1991-02-14
JPH0377886A (ja)	1991-04-03
FI903973A7 (fi)	1991-02-11
NO903510D0 (no)	1990-08-09
DE69006973D1 (de)	1994-04-07
DD299430A5 (de)	1992-04-16
NO903510L (no)	1991-02-11
HU204054B (en)	1991-11-28
EP0412820B1 (en)	1994-03-02
CN1049347A (zh)	1991-02-20
YU47749B (sh)	1996-01-08
EP0412820A3 (en)	1991-11-27
ES2062386T3 (es)	1994-12-16
PL164653B1 (en)	1994-08-31
IS1578B (is)	1995-06-08
NZ234844A (en)	1992-03-26
EP0412820A2 (en)	1991-02-13
DE69006973T2 (de)	1994-06-16
IL95322A (en)	1994-01-25
FI903973A0 (fi)	1990-08-10
MY107125A (en)	1995-09-30

Publication	Publication Date	Title
DK0437030T3 (da)	1994-05-16	Anvendelse af 4-substituerede imidazoler til nedsættelse af det intraoculære tryk
FI942499A0 (fi)	1994-05-27	Indolijohdannainen, menetelmä sen valmistamiseksi ja sen lääkekäyttö
DK0414422T3 (da)	1994-05-16	2-Oxo-1-oxa-8-azaspiro(4,5)decan-derivater, fremgangsmåder til deres fremstilling samt præparater deraf
DK0412820T3 (da)	1994-03-28	2-Oxo-1-oxa-8-azaspiro(4,5)decanderivater, fremgangsmåder til fremstilling deraf og farmaceutiske præparater med indhold deraf
HUT51597A (en)	1990-05-28	Process for production of derivatives of n,n-disubstituated diaryl-alcane-carbonic acid amid and medical compositions containing them as active substances
ATE103920T1 (de)	1994-04-15	1-oxa-2-oxo-8-azaspiro(4,5>decan-derivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen daraus.
ATE79259T1 (de)	1992-08-15	Prophylaktische und heilende zusammensetzung enthaltende eine 8-chlorbenzothiazepin-verbindung und dessen verwendung.
HUT69166A (en)	1995-08-28	Process to preparare pharmaceutical compns. to prevent and to cure ulcus