DK0413191T3 - 1-(Pyridinylamino)-2-pyrrolidinoner, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler - Google Patents

1-(Pyridinylamino)-2-pyrrolidinoner, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Info

Publication number
DK0413191T3
DK0413191T3 DK90114659.7T DK90114659T DK0413191T3 DK 0413191 T3 DK0413191 T3 DK 0413191T3 DK 90114659 T DK90114659 T DK 90114659T DK 0413191 T3 DK0413191 T3 DK 0413191T3
Authority
DK
Denmark
Prior art keywords
pyridinylamino
pyrrolidinones
loweralkyl
aryl
drugs
Prior art date
Application number
DK90114659.7T
Other languages
English (en)
Inventor
Richard Charles Dr Effland
David Gordon Dr Wettlaufer
Original Assignee
Hoechst Roussel Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma
Application granted granted Critical
Publication of DK0413191T3 publication Critical patent/DK0413191T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
DK90114659.7T 1989-08-02 1990-07-31 1-(Pyridinylamino)-2-pyrrolidinoner, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler DK0413191T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/388,413 US4994472A (en) 1989-08-02 1989-08-02 1-(pyridinylamino)-2-pyrrolidinones as pain relievers

Publications (1)

Publication Number Publication Date
DK0413191T3 true DK0413191T3 (da) 1994-10-24

Family

ID=23534027

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90114659.7T DK0413191T3 (da) 1989-08-02 1990-07-31 1-(Pyridinylamino)-2-pyrrolidinoner, fremgangsmåde til deres fremstilling og deres anvendelse som lægemidler

Country Status (17)

Country Link
US (1) US4994472A (da)
EP (1) EP0413191B1 (da)
JP (1) JPH0674264B2 (da)
KR (1) KR0164437B1 (da)
AT (1) ATE109142T1 (da)
AU (1) AU635051B2 (da)
CA (1) CA2022484C (da)
DE (1) DE69011013T2 (da)
DK (1) DK0413191T3 (da)
ES (1) ES2059929T3 (da)
FI (1) FI903818A7 (da)
IE (1) IE65117B1 (da)
IL (1) IL95250A (da)
NO (1) NO903388L (da)
NZ (1) NZ234724A (da)
PT (1) PT94878B (da)
ZA (1) ZA906049B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5356908A (en) * 1989-04-21 1994-10-18 E. I. Du Pont De Nemours And Company Fungicidal oxazolidinones
NO905555L (no) * 1989-12-27 1991-06-28 Monsanto Co Nye 2,6-substituert-pyridincarboxylsyrederivater, herbicide preparater inneholdende samme som aktiv bestanddel og anvendelse av derivatene for ugressbekjempelse.
AUPM656594A0 (en) * 1994-06-30 1994-07-21 Orbital Engine Company (Australia) Proprietary Limited A method and apparatus relating to control of the operation of an internal combustion engine
WO1997038993A1 (en) * 1996-04-12 1997-10-23 Hoechst Marion Roussel, Inc. Isatin derivatives as acetylcholinesterase inhibitors and analgesics
US6100276A (en) * 1996-04-12 2000-08-08 Aventis Pharmaceuticals Inc. Isatin derivatives as acetylcholinesterase inhibitors and analgesics
US6825229B2 (en) 2002-03-07 2004-11-30 Blanchette Rockefeller Neurosciences Institute Methods for Alzheimer's Disease treatment and cognitive enhancement
US20050065205A1 (en) 2002-03-07 2005-03-24 Daniel Alkon Methods for Alzheimer's disease treatment and cognitive enhance
CA2490494A1 (en) * 2002-07-02 2004-01-15 Blanchette Rockefeller Neurosciences Institute Pkc activation as a means for enhancing sapp.alpha. secretion and improving cognition using bryostatin type compounds
TW201207390A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Method for screening agent for antidepressant activity
GB0412019D0 (en) * 2004-05-28 2004-06-30 Novartis Ag Organic compounds
US20070054890A1 (en) 2005-07-29 2007-03-08 Alkon Daniel L Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
CN101848726A (zh) 2007-02-09 2010-09-29 布朗歇特洛克菲勒神经科学研究所 苔藓抑素、苔藓抑素类似物和其它相关物质对头部创伤引起的记忆缺陷和脑损伤的疗效

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670184A1 (de) * 1967-01-20 1971-01-21 Boehringer Sohn Ingelheim Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2)
US4260767A (en) * 1979-12-26 1981-04-07 American Cyanamid Company 2-Pyridylhydrazides
US4324884A (en) * 1980-09-25 1982-04-13 General Electric Company Organic amine catalyzed method for making polyetherimide
US4792562A (en) * 1985-12-04 1988-12-20 Hoechst-Roussel Pharmaceuticals, Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing activity
US4752610A (en) * 1985-12-04 1988-06-21 Hoechst-Roussel Pharmaceuticals Inc. N-(pyrrol-1-yl)pyridinamines having memory enhancing properties
JPH0699307B2 (ja) * 1987-08-20 1994-12-07 キッセイ薬品工業株式会社 抗痴呆剤
US4868190A (en) * 1988-12-27 1989-09-19 Hoechst-Roussel Pharmaceuticals, Inc. N-pyridinyl-9H-carbazol-9-amines

Also Published As

Publication number Publication date
IE65117B1 (en) 1995-10-04
JPH0368572A (ja) 1991-03-25
NO903388L (no) 1991-02-04
ES2059929T3 (es) 1994-11-16
EP0413191B1 (en) 1994-07-27
FI903818A0 (fi) 1990-07-31
AU635051B2 (en) 1993-03-11
NO903388D0 (no) 1990-08-01
PT94878B (pt) 1997-08-29
PT94878A (pt) 1991-04-18
IL95250A (en) 1994-01-25
CA2022484A1 (en) 1991-02-03
DE69011013D1 (de) 1994-09-01
IE902786A1 (en) 1991-02-27
KR910004597A (ko) 1991-03-29
FI903818A7 (fi) 1991-02-03
ZA906049B (en) 1991-04-24
CA2022484C (en) 2000-10-17
DE69011013T2 (de) 1994-12-22
KR0164437B1 (ko) 1999-01-15
ATE109142T1 (de) 1994-08-15
NZ234724A (en) 1992-01-29
US4994472A (en) 1991-02-19
IL95250A0 (en) 1991-06-10
EP0413191A1 (en) 1991-02-20
AU6000290A (en) 1991-02-07
JPH0674264B2 (ja) 1994-09-21

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