ATE109142T1 - 1-(pyridinylamino)-2-pyrrolidinone, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel. - Google Patents

1-(pyridinylamino)-2-pyrrolidinone, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.

Info

Publication number: ATE109142T1
Authority: AT; Austria
Prior art keywords: pyridinylamino; loweralkyl; pyrrolidinone; production; medicinal product
Prior art date: 1989-08-02

Application number

AT90114659T

Other languages

English (en)

Inventor

Richard Charles Dr Effland

David Gordon Dr Wettlaufer

Original Assignee

Hoechst Roussel Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-02

Filing date

1990-07-31

Publication date

1994-08-15

1990-07-31 Application filed by Hoechst Roussel Pharma filed Critical Hoechst Roussel Pharma

1994-08-15 Application granted granted Critical

1994-08-15 Publication of ATE109142T1 publication Critical patent/ATE109142T1/de

Links

YNJXHBPCTPWFRU-UHFFFAOYSA-N 1-(pyridin-2-ylamino)pyrrolidin-2-one Chemical compound O=C1CCCN1NC1=CC=CC=N1 YNJXHBPCTPWFRU-UHFFFAOYSA-N 0.000 title abstract 2
229940126601 medicinal product Drugs 0.000 title 1
-1 pyridinylethyl Chemical group 0.000 abstract 3
125000003118 aryl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229940035676 analgesics Drugs 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003287 optical effect Effects 0.000 abstract 1
125000006513 pyridinyl methyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000005301 thienylmethyl group Chemical group [H]C1=C([H])C([H])=C(S1)C([H])([H])* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)

AT90114659T 1989-08-02 1990-07-31 1-(pyridinylamino)-2-pyrrolidinone, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel. ATE109142T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/388,413 US4994472A (en)	1989-08-02	1989-08-02	1-(pyridinylamino)-2-pyrrolidinones as pain relievers

Publications (1)

Publication Number	Publication Date
ATE109142T1 true ATE109142T1 (de)	1994-08-15

Family

ID=23534027

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90114659T ATE109142T1 (de)	1989-08-02	1990-07-31	1-(pyridinylamino)-2-pyrrolidinone, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.

Country Status (17)

Country	Link
US (1)	US4994472A (de)
EP (1)	EP0413191B1 (de)
JP (1)	JPH0674264B2 (de)
KR (1)	KR0164437B1 (de)
AT (1)	ATE109142T1 (de)
AU (1)	AU635051B2 (de)
CA (1)	CA2022484C (de)
DE (1)	DE69011013T2 (de)
DK (1)	DK0413191T3 (de)
ES (1)	ES2059929T3 (de)
FI (1)	FI903818A7 (de)
IE (1)	IE65117B1 (de)
IL (1)	IL95250A (de)
NO (1)	NO903388L (de)
NZ (1)	NZ234724A (de)
PT (1)	PT94878B (de)
ZA (1)	ZA906049B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5356908A (en) *	1989-04-21	1994-10-18	E. I. Du Pont De Nemours And Company	Fungicidal oxazolidinones
IL96755A0 (en) *	1989-12-27	1991-09-16	Monsanto Co	Substituted pyridine compounds
AUPM656594A0 (en) *	1994-06-30	1994-07-21	Orbital Engine Company (Australia) Proprietary Limited	A method and apparatus relating to control of the operation of an internal combustion engine
JP4109718B2 (ja) *	1996-04-12	2008-07-02	アベンティス・ファーマスーティカルズ・インコーポレイテッド	アセチルコリンエステラーゼ阻害剤および鎮痛剤としてのイサチン誘導体
US6100276A (en) *	1996-04-12	2000-08-08	Aventis Pharmaceuticals Inc.	Isatin derivatives as acetylcholinesterase inhibitors and analgesics
US6825229B2 (en)	2002-03-07	2004-11-30	Blanchette Rockefeller Neurosciences Institute	Methods for Alzheimer's Disease treatment and cognitive enhancement
US20050065205A1 (en)	2002-03-07	2005-03-24	Daniel Alkon	Methods for Alzheimer's disease treatment and cognitive enhance
CA2490494A1 (en) *	2002-07-02	2004-01-15	Blanchette Rockefeller Neurosciences Institute	Pkc activation as a means for enhancing sapp.alpha. secretion and improving cognition using bryostatin type compounds
TW201206425A (en)	2004-05-18	2012-02-16	Brni Neurosciences Inst	Treatment of depressive disorders
GB0412019D0 (en) *	2004-05-28	2004-06-30	Novartis Ag	Organic compounds
US20070054890A1 (en)	2005-07-29	2007-03-08	Alkon Daniel L	Protein synthesis required for long-term memory is induced by PKC activation on days preceding associative learning
EP3332797A3 (de)	2007-02-09	2018-08-01	Blanchette Rockefeller Neurosciences Institute	Therapeutische wirkungen von bryostatinen, bryologen und anderen damit zusammenhängenden substanzen auf durch kopftraumata herbeigeführte gedächtnisstörungen und hirnverletzungen

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1670184A1 (de) *	1967-01-20	1971-01-21	Boehringer Sohn Ingelheim	Verfahren zur Herstellung heterocyclisch substituierter Hydrazino-imidazoline-(2)
US4260767A (en) *	1979-12-26	1981-04-07	American Cyanamid Company	2-Pyridylhydrazides
US4324884A (en) *	1980-09-25	1982-04-13	General Electric Company	Organic amine catalyzed method for making polyetherimide
US4792562A (en) *	1985-12-04	1988-12-20	Hoechst-Roussel Pharmaceuticals, Inc.	N-(pyrrol-1-yl)pyridinamines having memory enhancing activity
US4752610A (en) *	1985-12-04	1988-06-21	Hoechst-Roussel Pharmaceuticals Inc.	N-(pyrrol-1-yl)pyridinamines having memory enhancing properties
JPH0699307B2 (ja) *	1987-08-20	1994-12-07	キッセイ薬品工業株式会社	抗痴呆剤
US4868190A (en) *	1988-12-27	1989-09-19	Hoechst-Roussel Pharmaceuticals, Inc.	N-pyridinyl-9H-carbazol-9-amines

1989
- 1989-08-02 US US07/388,413 patent/US4994472A/en not_active Expired - Lifetime
1990
- 1990-07-31 AT AT90114659T patent/ATE109142T1/de not_active IP Right Cessation
- 1990-07-31 DK DK90114659.7T patent/DK0413191T3/da active
- 1990-07-31 EP EP90114659A patent/EP0413191B1/de not_active Expired - Lifetime
- 1990-07-31 IL IL9525090A patent/IL95250A/en active IP Right Revival
- 1990-07-31 FI FI903818A patent/FI903818A7/fi not_active Application Discontinuation
- 1990-07-31 DE DE69011013T patent/DE69011013T2/de not_active Expired - Lifetime
- 1990-07-31 NZ NZ234724A patent/NZ234724A/en unknown
- 1990-07-31 ES ES90114659T patent/ES2059929T3/es not_active Expired - Lifetime
- 1990-08-01 PT PT94878A patent/PT94878B/pt not_active IP Right Cessation
- 1990-08-01 IE IE278690A patent/IE65117B1/en not_active IP Right Cessation
- 1990-08-01 CA CA002022484A patent/CA2022484C/en not_active Expired - Fee Related
- 1990-08-01 KR KR1019900011816A patent/KR0164437B1/ko not_active Expired - Fee Related
- 1990-08-01 AU AU60002/90A patent/AU635051B2/en not_active Ceased
- 1990-08-01 ZA ZA906049A patent/ZA906049B/xx unknown
- 1990-08-01 JP JP2202617A patent/JPH0674264B2/ja not_active Expired - Lifetime
- 1990-08-01 NO NO90903388A patent/NO903388L/no unknown

Also Published As

Publication number	Publication date
CA2022484A1 (en)	1991-02-03
NO903388D0 (no)	1990-08-01
KR910004597A (ko)	1991-03-29
DE69011013T2 (de)	1994-12-22
PT94878A (pt)	1991-04-18
IL95250A0 (en)	1991-06-10
DK0413191T3 (da)	1994-10-24
JPH0368572A (ja)	1991-03-25
NZ234724A (en)	1992-01-29
ES2059929T3 (es)	1994-11-16
CA2022484C (en)	2000-10-17
KR0164437B1 (ko)	1999-01-15
IE65117B1 (en)	1995-10-04
EP0413191A1 (de)	1991-02-20
PT94878B (pt)	1997-08-29
FI903818A7 (fi)	1991-02-03
DE69011013D1 (de)	1994-09-01
IE902786A1 (en)	1991-02-27
IL95250A (en)	1994-01-25
ZA906049B (en)	1991-04-24
EP0413191B1 (de)	1994-07-27
JPH0674264B2 (ja)	1994-09-21
AU6000290A (en)	1991-02-07
AU635051B2 (en)	1993-03-11
FI903818A0 (fi)	1990-07-31
NO903388L (no)	1991-02-04
US4994472A (en)	1991-02-19

Legal Events

Date	Code	Title	Description
1995-02-15	UEP	Publication of translation of european patent specification
2010-10-15	EELA	Cancelled due to lapse of time

Publication	Publication Date	Title
ATE163012T1 (de)	1998-02-15	N-substituierte 4-pyrimidinamine und - pyrimidindiamine, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel
DE69016530D1 (de)	1995-03-16	1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-one, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel.
ATE109142T1 (de)	1994-08-15	1-(pyridinylamino)-2-pyrrolidinone, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.
ATE118002T1 (de)	1995-02-15	2,3-dihydro-1-(pyridinylamino)-indole, verfahren zu ihrer herstellung und ihre anwendung als arzneimittel.