DK0414262T3 - Fremgangsmåde til fremstilling af antikonvulsive cycliske aminosyreforbindelser - Google Patents
Fremgangsmåde til fremstilling af antikonvulsive cycliske aminosyreforbindelserInfo
- Publication number
- DK0414262T3 DK0414262T3 DK90116264.4T DK90116264T DK0414262T3 DK 0414262 T3 DK0414262 T3 DK 0414262T3 DK 90116264 T DK90116264 T DK 90116264T DK 0414262 T3 DK0414262 T3 DK 0414262T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- cyclic amino
- anticonvulsant
- amino acid
- acid compounds
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- -1 cyclic amino acid compounds Chemical class 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000001773 anti-convulsant effect Effects 0.000 title 1
- 239000001961 anticonvulsive agent Substances 0.000 title 1
- 229960003965 antiepileptics Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/12—Formation of amino and carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Catalysts (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39905689A | 1989-08-25 | 1989-08-25 | |
| US07/564,623 US5132451A (en) | 1989-08-25 | 1990-08-10 | Process for cyclic amino acid anticonvulsant compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0414262T3 true DK0414262T3 (da) | 1995-05-15 |
Family
ID=27016485
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90116264.4T DK0414262T3 (da) | 1989-08-25 | 1990-08-24 | Fremgangsmåde til fremstilling af antikonvulsive cycliske aminosyreforbindelser |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5693845A (da) |
| EP (1) | EP0414262B1 (da) |
| JP (1) | JP2945728B2 (da) |
| AT (1) | ATE114637T1 (da) |
| AU (2) | AU633612B2 (da) |
| CA (1) | CA2023874A1 (da) |
| DE (1) | DE69014480T2 (da) |
| DK (1) | DK0414262T3 (da) |
| ES (1) | ES2065446T3 (da) |
| FI (1) | FI107914B (da) |
| HK (1) | HK1000799A1 (da) |
| IE (1) | IE66824B1 (da) |
| MY (1) | MY106864A (da) |
| NO (1) | NO179407C (da) |
| NZ (1) | NZ235044A (da) |
| PH (2) | PH27359A (da) |
| PT (1) | PT95097B (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4894476A (en) * | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
| FI905584A7 (fi) * | 1989-11-16 | 1991-05-17 | Lonza Ag | Menetelmä 1-(aminometyyli)sykloheksaanietikkahapon valmistamiseksi |
| AU2001266992B8 (en) * | 2000-06-16 | 2005-12-01 | Teva Pharmaceutical Industries Ltd. | Stable gabapentin having pH within a controlled range |
| EP1289364B1 (en) | 2000-06-16 | 2003-12-10 | Teva Pharmaceutical Industries Ltd. | Stable gabapentin containing more than 2o ppm of chlorine ion |
| US20030119908A1 (en) * | 2001-12-21 | 2003-06-26 | Zambon Group S.P.A. | Stable gabapentin compositions |
| CA2528388A1 (en) * | 2003-06-19 | 2004-12-23 | Pfizer Products Inc. | Biocatalytic preparation of 1-cyanocyclohexaneacetic acid |
| GB0416228D0 (en) | 2004-07-20 | 2004-08-25 | Sandoz Ind Products S A | Process for the preparation of gabapentin |
| US8143443B2 (en) * | 2006-06-30 | 2012-03-27 | Zach System S.P.A. | Process for preparing gabapentin |
| JP4872950B2 (ja) | 2008-03-05 | 2012-02-08 | ソニー株式会社 | 非水電解質二次電池 |
| WO2015144825A1 (en) | 2014-03-27 | 2015-10-01 | Sanovel Ilac Sanayi Ve Ticaret A.S. | Oral liquid pharmaceutical solution of gabapentin |
| CN107235850B (zh) * | 2017-05-31 | 2019-07-26 | 浙江工业大学 | 利用1-氰基环己基乙酸直接合成加巴喷丁的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2264354A (en) * | 1937-12-22 | 1941-12-02 | Ig Farbenindustrie Ag | Addition products of dienes and unsaturated esters, ketones, or nitriles |
| US2467927A (en) * | 1947-05-29 | 1949-04-19 | Goodrich Co B F | Preparation of monomeric alkyl alpha-cyano-acrylates |
| US2502412A (en) * | 1948-02-07 | 1950-04-04 | Goodrich Co B F | Preparation of vinylidene cyanide by pyrolysis of novel 4, 4-disubstituted cyclohexenes |
| US2575376A (en) * | 1949-10-21 | 1951-11-20 | Gen Mills Inc | Formyl cyclohexene nitriles and esters |
| DE1445664A1 (de) * | 1963-07-04 | 1969-11-27 | Klinke Desitin Werk | Verfahren zur Herstellung von alpha,alpha-disubstituierten Succinimiden |
| JPS4822692B1 (da) * | 1963-12-24 | 1973-07-07 | ||
| US3515740A (en) * | 1967-02-20 | 1970-06-02 | Orville D Frampton | Cyano cyclohexenyl compounds |
| US4087544A (en) * | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| GB1478224A (en) * | 1975-01-24 | 1977-06-29 | Science Union & Cie | Dispiroalkanes processes for their preparation and pharma ceutical compositions containing them |
| DE2557220A1 (de) * | 1975-12-19 | 1977-06-23 | Goedecke Ag | N-substituierte spirolactame |
| DE2611690A1 (de) * | 1976-03-19 | 1977-09-22 | Goedecke Ag | Cyclische sulfonyloxyimide |
| DE2626467C2 (de) * | 1976-06-12 | 1984-11-22 | Gödecke AG, 1000 Berlin | 1-(N-Isopropylaminomethyl)-cyclohexanessigsäure, Verfahren zu deren Herstellung und diese Verbindung enthaltende Arzneimittel |
| US4226802A (en) * | 1979-10-29 | 1980-10-07 | Zoecon Corporation | 2-(4-Trifluoromethylphenylamino)-3-methylbutanoic acid esters and intermediates therefor |
| GB8606255D0 (en) * | 1986-03-13 | 1986-04-16 | Wyeth John & Brother Ltd | Nitriles |
| US4894476A (en) * | 1988-05-02 | 1990-01-16 | Warner-Lambert Company | Gabapentin monohydrate and a process for producing the same |
| YU162789A (en) * | 1988-09-01 | 1990-12-31 | Lonza Ag | 2-aza-4-(alcoxycarbonyl) spiro/4,5/decan-3-ones |
| DE3928184A1 (de) * | 1989-08-25 | 1991-02-28 | Goedecke Ag | Verfahren zur herstellung von cyclischen aminosaeurederivaten sowie zwischenprodukte |
-
1990
- 1990-08-22 MY MYPI90001406A patent/MY106864A/en unknown
- 1990-08-22 FI FI904164A patent/FI107914B/fi active IP Right Grant
- 1990-08-22 PH PH41066A patent/PH27359A/en unknown
- 1990-08-22 AU AU61247/90A patent/AU633612B2/en not_active Ceased
- 1990-08-23 CA CA002023874A patent/CA2023874A1/en not_active Abandoned
- 1990-08-24 AT AT90116264T patent/ATE114637T1/de not_active IP Right Cessation
- 1990-08-24 DK DK90116264.4T patent/DK0414262T3/da active
- 1990-08-24 NO NO903732A patent/NO179407C/no not_active IP Right Cessation
- 1990-08-24 JP JP2221433A patent/JP2945728B2/ja not_active Expired - Fee Related
- 1990-08-24 DE DE69014480T patent/DE69014480T2/de not_active Expired - Fee Related
- 1990-08-24 EP EP90116264A patent/EP0414262B1/en not_active Expired - Lifetime
- 1990-08-24 PT PT95097A patent/PT95097B/pt not_active IP Right Cessation
- 1990-08-24 ES ES90116264T patent/ES2065446T3/es not_active Expired - Lifetime
- 1990-08-24 IE IE309490A patent/IE66824B1/en not_active IP Right Cessation
- 1990-08-24 NZ NZ235044A patent/NZ235044A/en unknown
-
1992
- 1992-03-06 US US07/846,509 patent/US5693845A/en not_active Expired - Fee Related
- 1992-10-12 PH PH45082A patent/PH30922A/en unknown
-
1993
- 1993-01-29 AU AU32145/93A patent/AU640582B2/en not_active Ceased
-
1997
- 1997-12-10 HK HK97102377A patent/HK1000799A1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2023874A1 (en) | 1991-02-26 |
| JP2945728B2 (ja) | 1999-09-06 |
| AU640582B2 (en) | 1993-08-26 |
| PH30922A (en) | 1997-12-23 |
| NO903732D0 (no) | 1990-08-24 |
| ES2065446T3 (es) | 1995-02-16 |
| NO179407C (no) | 1996-10-02 |
| HK1000799A1 (en) | 1998-05-01 |
| EP0414262A2 (en) | 1991-02-27 |
| PT95097B (pt) | 1997-04-30 |
| EP0414262B1 (en) | 1994-11-30 |
| FI904164A0 (fi) | 1990-08-22 |
| PT95097A (pt) | 1991-04-18 |
| NO903732L (no) | 1991-02-26 |
| AU633612B2 (en) | 1993-02-04 |
| ATE114637T1 (de) | 1994-12-15 |
| IE66824B1 (en) | 1996-02-07 |
| IE903094A1 (en) | 1991-02-27 |
| NZ235044A (en) | 1994-05-26 |
| NO179407B (no) | 1996-06-24 |
| DE69014480T2 (de) | 1995-04-20 |
| EP0414262A3 (en) | 1991-06-05 |
| PH27359A (en) | 1993-06-21 |
| AU3214593A (en) | 1993-03-25 |
| MY106864A (en) | 1995-08-30 |
| US5693845A (en) | 1997-12-02 |
| DE69014480D1 (de) | 1995-01-12 |
| FI107914B (fi) | 2001-10-31 |
| JPH03236359A (ja) | 1991-10-22 |
| AU6124790A (en) | 1991-02-28 |
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