DK0414606T3 - Omega-Phenylaminoalkansyrer, som i den aromatiske ring er substitueret med en gruppe afledt af 19-nor-steroider, deres salte, en fremgangsmåde til deres fremstilling og mellemprodukter ved denne fremgangsmåde, deres anvendelse som lægemidler og præparater med indhold deraf - Google Patents

Omega-Phenylaminoalkansyrer, som i den aromatiske ring er substitueret med en gruppe afledt af 19-nor-steroider, deres salte, en fremgangsmåde til deres fremstilling og mellemprodukter ved denne fremgangsmåde, deres anvendelse som lægemidler og præparater med indhold deraf

Info

Publication number: DK0414606T3
Authority: DK; Denmark
Prior art keywords: denotes; salts; preparation; phenylaminoalkanoic; norsteroids
Prior art date: 1989-08-23

Application number

DK90402328.0T

Other languages

English (en)

Inventor

Daniel Philibert

Lucien Nedelec

Martine Moguilewsky

Francois Nique

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-23

Filing date

1990-08-22

Publication date

1995-02-27

1990-08-22 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1995-02-27 Application granted granted Critical

1995-02-27 Publication of DK0414606T3 publication Critical patent/DK0414606T3/da

Links

238000000034 method Methods 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 3
150000003839 salts Chemical class 0.000 title abstract 3
229940079593 drug Drugs 0.000 title abstract 2
239000003814 drug Substances 0.000 title abstract 2
239000002253 acid Substances 0.000 title 1
150000007513 acids Chemical group 0.000 title 1
125000003118 aryl group Chemical group 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical class [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
229910052783 alkali metal Inorganic materials 0.000 abstract 1
150000001340 alkali metals Chemical class 0.000 abstract 1
229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
150000001342 alkaline earth metals Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
-1 amine salt Chemical class 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
238000002483 medication Methods 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK90402328.0T 1989-08-23 1990-08-22 Omega-Phenylaminoalkansyrer, som i den aromatiske ring er substitueret med en gruppe afledt af 19-nor-steroider, deres salte, en fremgangsmåde til deres fremstilling og mellemprodukter ved denne fremgangsmåde, deres anvendelse som lægemidler og præparater med indhold deraf DK0414606T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8911173A FR2651233B1 (fr)	1989-08-23	1989-08-23	Nouveaux acides omega-phenylamino alcanouiques substitues sur le noyau aromatique par un radical derive de 19-norsterouides, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant.

Publications (1)

Publication Number	Publication Date
DK0414606T3 true DK0414606T3 (da)	1995-02-27

Family

ID=9384880

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90402328.0T DK0414606T3 (da)	1989-08-23	1990-08-22	Omega-Phenylaminoalkansyrer, som i den aromatiske ring er substitueret med en gruppe afledt af 19-nor-steroider, deres salte, en fremgangsmåde til deres fremstilling og mellemprodukter ved denne fremgangsmåde, deres anvendelse som lægemidler og præparater med indhold deraf

Country Status (19)

Country	Link
US (1)	US5166146A (da)
EP (1)	EP0414606B1 (da)
JP (1)	JP3026997B2 (da)
KR (1)	KR910004655A (da)
CN (1)	CN1033808C (da)
AT (1)	ATE113605T1 (da)
AU (1)	AU634569B2 (da)
CA (1)	CA2022648A1 (da)
DE (1)	DE69013815T2 (da)
DK (1)	DK0414606T3 (da)
ES (1)	ES2063313T3 (da)
FR (1)	FR2651233B1 (da)
HU (1)	HU208154B (da)
IE (1)	IE65922B1 (da)
IL (1)	IL95451A (da)
MX (1)	MX22020A (da)
PT (1)	PT95066B (da)
RU (1)	RU2041236C1 (da)
ZA (1)	ZA906341B (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639598A (en) *	1994-05-19	1997-06-17	The Trustees Of The University Of Pennsylvania	Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
US5780220A (en) *	1994-05-19	1998-07-14	Trustees Of The University Of Pennsylvania	Methods and compositions for inhibiting HIV replication
RU2200732C2 (ru) *	1997-08-12	2003-03-20	Глэксо Вэллкам Инк.	Производные трифенилэтилена, способы лечения и профилактики остеопороза, рака груди и сердечно-сосудистого заболевания
US6090798A (en) *	1997-12-19	2000-07-18	Alcon Laboratories, Inc.	Treatment of GLC1A glaucoma with glucocorticoid antagonists
WO2011150209A1 (en)	2010-05-26	2011-12-01	Corcept Therapeutics, Inc.	Treatment of muscular dystrophy
AU2016226451B2 (en)	2015-03-02	2019-12-19	Corcept Therapeutics, Inc.	Use of glucocorticoid receptor antagonist and somatostatin analogues to treat ACTH-secreting tumors
US10610534B2 (en)	2015-03-30	2020-04-07	Corcept Therapeutics, Inc.	Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency
KR20180052120A (ko)	2015-08-13	2018-05-17	코어셉트 쎄라퓨틱스, 잉크.	Acth-의존성 쿠싱 증후군을 감별 진단하는 방법
JP6765443B2 (ja)	2016-01-19	2020-10-07	コーセプトセラピューティクス，インコーポレイテッド	異所性クッシング症候群の鑑別診断
WO2018102369A1 (en)	2016-11-30	2018-06-07	Arno Therapeutics, Inc.	Methods for onapristone synthesis dehydration and deprotection
MX2019011543A (es)	2017-03-31	2019-12-16	Corcept Therapeutics Inc	Moduladores del receptor de glucocorticoides para el tratamiento de cancer cervical.
WO2018236749A2 (en)	2017-06-20	2018-12-27	Corcept Therapeutics, Inc.	Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
JP2024500748A (ja)	2020-12-18	2024-01-10	インスティルバイオ（ユーケイ）リミテッド	腫瘍浸潤リンパ球の処理

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2566779B2 (fr) *	1984-06-29	1987-03-06	Roussel Uclaf	Nouveaux derives steroides substitues en 11b, leur procede de preparation et leur application comme medicaments
FR2596395B1 (fr) *	1986-03-26	1989-05-26	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3619413C2 (de) *	1986-06-10	2000-04-06	Schering Ag	9alpha, 10alpha-Methylen-Estrene, deren Herstellung und diese enthaltende pharmazeutische Präparate
FR2620707B1 (fr) *	1987-09-18	1989-12-08	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

1989
- 1989-08-23 FR FR8911173A patent/FR2651233B1/fr not_active Expired - Fee Related
1990
- 1990-08-03 CA CA002022648A patent/CA2022648A1/fr not_active Abandoned
- 1990-08-10 ZA ZA906341A patent/ZA906341B/xx unknown
- 1990-08-16 US US07/568,597 patent/US5166146A/en not_active Expired - Lifetime
- 1990-08-20 MX MX2202090A patent/MX22020A/es unknown
- 1990-08-20 JP JP02217281A patent/JP3026997B2/ja not_active Expired - Lifetime
- 1990-08-21 IL IL9545190A patent/IL95451A/en not_active IP Right Cessation
- 1990-08-22 DE DE69013815T patent/DE69013815T2/de not_active Expired - Lifetime
- 1990-08-22 HU HU905275A patent/HU208154B/hu not_active IP Right Cessation
- 1990-08-22 AU AU61189/90A patent/AU634569B2/en not_active Ceased
- 1990-08-22 KR KR1019900012958A patent/KR910004655A/ko not_active Abandoned
- 1990-08-22 IE IE303190A patent/IE65922B1/en not_active IP Right Cessation
- 1990-08-22 EP EP90402328A patent/EP0414606B1/fr not_active Expired - Lifetime
- 1990-08-22 PT PT95066A patent/PT95066B/pt not_active IP Right Cessation
- 1990-08-22 DK DK90402328.0T patent/DK0414606T3/da active
- 1990-08-22 ES ES90402328T patent/ES2063313T3/es not_active Expired - Lifetime
- 1990-08-22 AT AT90402328T patent/ATE113605T1/de not_active IP Right Cessation
- 1990-08-23 CN CN90107161A patent/CN1033808C/zh not_active Expired - Fee Related
1992
- 1992-05-18 RU SU925011511A patent/RU2041236C1/ru active

Also Published As

Publication number	Publication date
IE65922B1 (en)	1995-11-29
AU6118990A (en)	1991-02-28
HU905275D0 (en)	1991-02-28
JPH0390097A (ja)	1991-04-16
ZA906341B (en)	1991-10-30
EP0414606A2 (fr)	1991-02-27
DE69013815T2 (de)	1995-03-16
CN1033808C (zh)	1997-01-15
PT95066B (pt)	1997-05-28
HU208154B (en)	1993-08-30
ES2063313T3 (es)	1995-01-01
ATE113605T1 (de)	1994-11-15
JP3026997B2 (ja)	2000-03-27
HUT54706A (en)	1991-03-28
US5166146A (en)	1992-11-24
RU2041236C1 (ru)	1995-08-09
DE69013815D1 (de)	1994-12-08
AU634569B2 (en)	1993-02-25
MX22020A (es)	1993-11-01
EP0414606A3 (en)	1991-07-24
EP0414606B1 (fr)	1994-11-02
IE903031A1 (en)	1991-02-27
IL95451A0 (en)	1991-06-30
PT95066A (pt)	1991-04-18
CN1051362A (zh)	1991-05-15
FR2651233B1 (fr)	1991-12-13
IL95451A (en)	1995-07-31
KR910004655A (ko)	1991-03-29
FR2651233A1 (fr)	1991-03-01
CA2022648A1 (fr)	1991-02-24

Publication	Publication Date	Title
DK0414606T3 (da)	1995-02-27	Omega-Phenylaminoalkansyrer, som i den aromatiske ring er substitueret med en gruppe afledt af 19-nor-steroider, deres salte, en fremgangsmåde til deres fremstilling og mellemprodukter ved denne fremgangsmåde, deres anvendelse som lægemidler og præparater med indhold deraf
PT93502A (pt)	1990-11-07	Processo para a preparacao de novos derivados de insulina e de composicoes farmaceuticas que os contem
ES8705038A1 (es)	1987-04-16	Un procedimiento para preparar azatricicloalquenos.
ES2005059B3 (es)	1990-03-16	Nuevo procedimiento de preparacion de fibratos.
DE3260262D1 (en)	1984-07-26	(2-oxo-3-tetrahydrothienylcarbamoyl)-alkylthio acids, their salts and esters, their preparation and pharmaceutical compositions containing them
DE3378580D1 (en)	1989-01-05	Imidazolylphenyl-tetrahydropyridazines, process for their preparation and pharmaceutical compositions containing them
PT84424B (pt)	1989-10-04	Processo para a preparacao de derivados de heteroaril-oxi-beta-carbolina e de composicoes farmaceuticas que os contem
DK629889D0 (da)	1989-12-13	Aminosyrederivater, deres fremstilling og anvendelse som laegemidler
ES8401068A1 (es)	1983-12-01	Procedimiento para la preparacion de derivados de corinanteina, asi como de sus sales de adicion acida fisiologicamente inocuas.
EP0134179A3 (en)	1986-03-26	Derivatives of 4-phenyl-4-oxo-buten-2-oic acid, their preparation, their use as medicines and compositions containing them
ES2066756T3 (es)	1995-03-16	Nuevos derivados de tironina.
ATE104313T1 (de)	1994-04-15	Neue 9-g(a)-hydroxy-3-oxo-4,24(25)-stigmastadien26-s\|urederivate,verfahren zur herstellung und heilmittel daraus.
FI832522A0 (fi)	1983-07-11	Foerfarande foer framstaellning av nya cefalosporinderivat, anvaendbara som antibiotika
FI870057A0 (fi)	1987-01-07	Nya tyroninderivat.
GR3000773T3 (en)	1991-10-10	2,2;6,6-diethylene-3-oxo-17-alpha-pregn-4-ene-21,17-carbolactones, process for their preparation and pharmaceutical compositions containing them
DK222087D0 (da)	1987-04-30	Aeny fremgangsmaade til fremstilling af kemiske for-bindelserae
DK0424248T3 (da)	1996-03-04	20,21-dinoreburnamein med substitution i 15-stillingen, fremgangsmåde til deres fremstilling samt mellemprodukter til brug derved, deres anvendelse som lægemidler og præparater med indhold deraf
DK533583A (da)	1983-11-22	Steroidestere af n-(2-halogenethyl)-n-nitroso-carbamoyl-aminosyrer og deres peptider, samt fremgangsmaade til deres fremstilling
BR9306695A (pt)	1998-12-08	Processo para a preparação de um composto e uso do composto
EP0128437A3 (en)	1985-10-30	Nortropine derivative, process for its preparation and its use
ES2036561T3 (es)	1993-06-01	Un procedimiento para preparar un grupo de compuestos que son acidos 4-hidroxi-4-(alquenil sustituido)ciclohexanocarboxilicos.