DK0414606T3 - Omega-Phenylaminoalkansyrer, som i den aromatiske ring er substitueret med en gruppe afledt af 19-nor-steroider, deres salte, en fremgangsmåde til deres fremstilling og mellemprodukter ved denne fremgangsmåde, deres anvendelse som lægemidler og præparater med indhold deraf - Google Patents

Omega-Phenylaminoalkansyrer, som i den aromatiske ring er substitueret med en gruppe afledt af 19-nor-steroider, deres salte, en fremgangsmåde til deres fremstilling og mellemprodukter ved denne fremgangsmåde, deres anvendelse som lægemidler og præparater med indhold deraf

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Publication number
DK0414606T3
DK0414606T3 DK90402328.0T DK90402328T DK0414606T3 DK 0414606 T3 DK0414606 T3 DK 0414606T3 DK 90402328 T DK90402328 T DK 90402328T DK 0414606 T3 DK0414606 T3 DK 0414606T3
Authority
DK
Denmark
Prior art keywords
denotes
salts
preparation
phenylaminoalkanoic
norsteroids
Prior art date
Application number
DK90402328.0T
Other languages
English (en)
Inventor
Daniel Philibert
Lucien Nedelec
Martine Moguilewsky
Francois Nique
Original Assignee
Roussel Uclaf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf filed Critical Roussel Uclaf
Application granted granted Critical
Publication of DK0414606T3 publication Critical patent/DK0414606T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
    • C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK90402328.0T 1989-08-23 1990-08-22 Omega-Phenylaminoalkansyrer, som i den aromatiske ring er substitueret med en gruppe afledt af 19-nor-steroider, deres salte, en fremgangsmåde til deres fremstilling og mellemprodukter ved denne fremgangsmåde, deres anvendelse som lægemidler og præparater med indhold deraf DK0414606T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8911173A FR2651233B1 (fr) 1989-08-23 1989-08-23 Nouveaux acides omega-phenylamino alcanouiques substitues sur le noyau aromatique par un radical derive de 19-norsterouides, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant.

Publications (1)

Publication Number Publication Date
DK0414606T3 true DK0414606T3 (da) 1995-02-27

Family

ID=9384880

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90402328.0T DK0414606T3 (da) 1989-08-23 1990-08-22 Omega-Phenylaminoalkansyrer, som i den aromatiske ring er substitueret med en gruppe afledt af 19-nor-steroider, deres salte, en fremgangsmåde til deres fremstilling og mellemprodukter ved denne fremgangsmåde, deres anvendelse som lægemidler og præparater med indhold deraf

Country Status (19)

Country Link
US (1) US5166146A (da)
EP (1) EP0414606B1 (da)
JP (1) JP3026997B2 (da)
KR (1) KR910004655A (da)
CN (1) CN1033808C (da)
AT (1) ATE113605T1 (da)
AU (1) AU634569B2 (da)
CA (1) CA2022648A1 (da)
DE (1) DE69013815T2 (da)
DK (1) DK0414606T3 (da)
ES (1) ES2063313T3 (da)
FR (1) FR2651233B1 (da)
HU (1) HU208154B (da)
IE (1) IE65922B1 (da)
IL (1) IL95451A (da)
MX (1) MX22020A (da)
PT (1) PT95066B (da)
RU (1) RU2041236C1 (da)
ZA (1) ZA906341B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780220A (en) * 1994-05-19 1998-07-14 Trustees Of The University Of Pennsylvania Methods and compositions for inhibiting HIV replication
US5639598A (en) * 1994-05-19 1997-06-17 The Trustees Of The University Of Pennsylvania Method and kit for identification of antiviral agents capable of abrogating HIV Vpr-Rip-1 binding interactions
RU2200732C2 (ru) * 1997-08-12 2003-03-20 Глэксо Вэллкам Инк. Производные трифенилэтилена, способы лечения и профилактики остеопороза, рака груди и сердечно-сосудистого заболевания
US6090798A (en) * 1997-12-19 2000-07-18 Alcon Laboratories, Inc. Treatment of GLC1A glaucoma with glucocorticoid antagonists
WO2011150209A1 (en) 2010-05-26 2011-12-01 Corcept Therapeutics, Inc. Treatment of muscular dystrophy
JP6821582B2 (ja) 2015-03-02 2021-01-27 コーセプト セラピューティクス， インコーポレイテッド Ａｃｔｈ分泌腫瘍を処置するための糖質コルチコイドレセプターアンタゴニストおよびソマトスタチンアナログの使用
JP6754533B2 (ja) 2015-03-30 2020-09-16 コーセプト セラピューティクス， インコーポレイテッド 副腎機能不全を処置するための糖質コルチコイドと組み合わせた糖質コルチコイドレセプターアンタゴニストの使用
MX383318B (es) 2015-08-13 2025-03-13 Corcept Therapeutics Inc Metodo para diagnosticar de manera diferencial el sindrome de cushing dependiente de la corticotropina.
JP6765443B2 (ja) 2016-01-19 2020-10-07 コーセプト セラピューティクス， インコーポレイテッド 異所性クッシング症候群の鑑別診断
US9943505B2 (en) 2016-09-09 2018-04-17 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat pancreatic cancer
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection
AU2018244928B2 (en) 2017-03-31 2023-10-19 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat cervical cancer
WO2018236749A2 (en) 2017-06-20 2018-12-27 Corcept Therapeutics, Inc. Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
EP4263807A2 (en) 2020-12-18 2023-10-25 Instil Bio (Uk) Limited Processing of tumor infiltrating lymphocytes

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2566779B2 (fr) * 1984-06-29 1987-03-06 Roussel Uclaf Nouveaux derives steroides substitues en 11b, leur procede de preparation et leur application comme medicaments
FR2596395B1 (fr) * 1986-03-26 1989-05-26 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3619413C2 (de) * 1986-06-10 2000-04-06 Schering Ag 9alpha, 10alpha-Methylen-Estrene, deren Herstellung und diese enthaltende pharmazeutische Präparate
FR2620707B1 (fr) * 1987-09-18 1989-12-08 Roussel Uclaf Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant

Also Published As

Publication number Publication date
EP0414606B1 (fr) 1994-11-02
ES2063313T3 (es) 1995-01-01
RU2041236C1 (ru) 1995-08-09
JP3026997B2 (ja) 2000-03-27
EP0414606A3 (en) 1991-07-24
AU634569B2 (en) 1993-02-25
JPH0390097A (ja) 1991-04-16
IE65922B1 (en) 1995-11-29
KR910004655A (ko) 1991-03-29
CA2022648A1 (fr) 1991-02-24
HUT54706A (en) 1991-03-28
DE69013815D1 (de) 1994-12-08
FR2651233A1 (fr) 1991-03-01
CN1051362A (zh) 1991-05-15
HU208154B (en) 1993-08-30
ATE113605T1 (de) 1994-11-15
MX22020A (es) 1993-11-01
EP0414606A2 (fr) 1991-02-27
PT95066B (pt) 1997-05-28
US5166146A (en) 1992-11-24
FR2651233B1 (fr) 1991-12-13
PT95066A (pt) 1991-04-18
ZA906341B (en) 1991-10-30
CN1033808C (zh) 1997-01-15
IL95451A0 (en) 1991-06-30
IE903031A1 (en) 1991-02-27
HU905275D0 (en) 1991-02-28
DE69013815T2 (de) 1995-03-16
IL95451A (en) 1995-07-31
AU6118990A (en) 1991-02-28

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