DK0416678T3 - Topiske præparater indeholdende Defibrotid - Google Patents

Topiske præparater indeholdende Defibrotid

Info

Publication number: DK0416678T3
Authority: DK; Denmark
Prior art keywords: preparations containing; topical preparations; defibrotide; containing defibrotide; therapy
Prior art date: 1989-09-07

Application number

DK90202172.4T

Other languages

English (en)

Inventor

Giuseppe Prino

Marisa Mantovani

Roberto Porta

Original Assignee

Crinos Industria Farmaco

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-07

Filing date

1990-08-10

Publication date

1993-12-20

1990-08-10 Application filed by Crinos Industria Farmaco filed Critical Crinos Industria Farmaco

1993-12-20 Application granted granted Critical

1993-12-20 Publication of DK0416678T3 publication Critical patent/DK0416678T3/da

Links

JNWFIPVDEINBAI-UHFFFAOYSA-N [5-hydroxy-4-[4-(1-methylindol-5-yl)-5-oxo-1H-1,2,4-triazol-3-yl]-2-propan-2-ylphenyl] dihydrogen phosphate Chemical compound C1=C(OP(O)(O)=O)C(C(C)C)=CC(C=2N(C(=O)NN=2)C=2C=C3C=CN(C)C3=CC=2)=C1O JNWFIPVDEINBAI-UHFFFAOYSA-N 0.000 title abstract 2
229960004120 defibrotide Drugs 0.000 title abstract 2
230000000699 topical effect Effects 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
239000008280 blood Substances 0.000 abstract 1
210000004369 blood Anatomy 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/755—Polymers containing halogen
- A61K31/76—Polymers containing halogen of vinyl chloride
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK90202172.4T 1989-09-07 1990-08-10 Topiske præparater indeholdende Defibrotid DK0416678T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT8921651A IT1231509B (it)	1989-09-07	1989-09-07	Composizione farmceutica ad uso topico per la terapia della fragilita' capillare.

Publications (1)

Publication Number	Publication Date
DK0416678T3 true DK0416678T3 (da)	1993-12-20

Family

ID=11184862

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90202172.4T DK0416678T3 (da)	1989-09-07	1990-08-10	Topiske præparater indeholdende Defibrotid

Country Status (12)

Country	Link
US (1)	US5116617A (da)
EP (1)	EP0416678B1 (da)
JP (1)	JPH0399019A (da)
KR (1)	KR910005876A (da)
AT (1)	ATE97001T1 (da)
AU (1)	AU623028B2 (da)
CA (1)	CA2021874A1 (da)
DE (1)	DE69004532T2 (da)
DK (1)	DK0416678T3 (da)
ES (1)	ES2045768T3 (da)
IT (1)	IT1231509B (da)
PT (1)	PT95212B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1147777A1 (en) *	2000-04-18	2001-10-24	Crinos Industria Farmacobiologica S.p.A.	Combination of defibrotide and G-CSF and its use to activate haematopoietic progenitors
US8771663B2 (en)	2000-04-18	2014-07-08	Gentium Spa	Formulation having mobilising activity
US7029657B2 (en) *	2002-08-02	2006-04-18	Balance Pharmaceuticals, Inc.	Nasal spray steroid formulation and method
EP1872787A1 (en) *	2006-06-27	2008-01-02	Gentium S.p.A.	Use of defibrotide for the inhibition of heparanase
EP2103689A1 (en)	2008-03-19	2009-09-23	Gentium S.p.A.	Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
DK2637672T3 (da)	2010-11-12	2018-10-22	Gentium S R L	Defibrotid til anvendelse i profylakse og/eller behandling af graft versus host sygdom (gvhd)
KR102038357B1 (ko)	2012-06-22	2019-10-31	젠티엄 에스알엘	디파이브로타이드의 생물학적 활성 측정을 위한 유우글로불린에 기초한 방법
EP3026122A1 (en)	2014-11-27	2016-06-01	Gentium S.p.A.	Cellular-based method for determining the potency of defibrotide
CN111132663A (zh)	2017-08-03	2020-05-08	爵士制药爱尔兰有限公司	包含高浓度核酸的制剂
AU2019252790A1 (en)	2018-04-12	2020-10-15	Jazz Pharmaceuticals, Inc.	Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion
US20220023533A1 (en)	2018-12-07	2022-01-27	Jazz Phrmaceticals Ireland Limited	Subcutaneous delivery of high concentration formulations
WO2021174039A1 (en)	2020-02-28	2021-09-02	Jazz Pharmaceuticals Ireland Limited	Delivery of low viscosity formulations
EP4135717A1 (en)	2020-04-17	2023-02-22	Jazz Pharmaceuticals Ireland Limited	Defibrotide treatment for the prevention of organ rejection and injury
TW202308659A (zh)	2021-05-06	2023-03-01	愛爾蘭商爵士製藥愛爾蘭有限責任公司	用於急性呼吸窘迫症候群之治療及預防的去纖維蛋白多核苷酸

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1043823B (it) *	1970-11-03	1980-02-29	Prephar	Procedimento per l estrazione di acidi nucleici da organi animali
DE2154279A1 (de) *	1970-11-03	1972-05-25	Crinos Industria Farmaco	Medikamente für das fibrinolytische System
IT1170215B (it) *	1983-09-12	1987-06-03	Crinos Industria Farmaco	Composizione farmaceutica per il trattamento di stati di insufficienza renale acuta
IT1170214B (it) *	1983-09-12	1987-06-03	Crinos Industria Farmaco	Composizione farmaceutica per la cura delle arteriopatie periferiche
IT1206341B (it) *	1984-02-16	1989-04-14	Crinos Industria Farmaco	Composizione farmaceutica per il trattamento dell'ischemia acuta del miocardio.

1989
- 1989-09-07 IT IT8921651A patent/IT1231509B/it active
1990
- 1990-07-20 AU AU59173/90A patent/AU623028B2/en not_active Ceased
- 1990-07-24 CA CA002021874A patent/CA2021874A1/en not_active Abandoned
- 1990-08-10 AT AT90202172T patent/ATE97001T1/de not_active IP Right Cessation
- 1990-08-10 ES ES90202172T patent/ES2045768T3/es not_active Expired - Lifetime
- 1990-08-10 DE DE90202172T patent/DE69004532T2/de not_active Expired - Fee Related
- 1990-08-10 EP EP90202172A patent/EP0416678B1/en not_active Expired - Lifetime
- 1990-08-10 KR KR1019900012316A patent/KR910005876A/ko not_active Abandoned
- 1990-08-10 DK DK90202172.4T patent/DK0416678T3/da active
- 1990-08-16 US US07/568,126 patent/US5116617A/en not_active Expired - Fee Related
- 1990-09-03 JP JP2230745A patent/JPH0399019A/ja active Pending
- 1990-09-05 PT PT95212A patent/PT95212B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR910005876A (ko)	1991-04-27
JPH0399019A (ja)	1991-04-24
PT95212B (pt)	1997-06-30
EP0416678A1 (en)	1991-03-13
ES2045768T3 (es)	1994-01-16
CA2021874A1 (en)	1991-03-08
EP0416678B1 (en)	1993-11-10
PT95212A (pt)	1991-05-22
AU623028B2 (en)	1992-04-30
DE69004532T2 (de)	1994-02-24
ATE97001T1 (de)	1993-11-15
IT8921651A0 (it)	1989-09-07
IT1231509B (it)	1991-12-07
US5116617A (en)	1992-05-26
AU5917390A (en)	1991-03-14
DE69004532D1 (de)	1993-12-16

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