DK0424059T3 - Anvendelse af substituerede imidazoler - Google Patents

Anvendelse af substituerede imidazoler

Info

Publication number: DK0424059T3
Authority: DK; Denmark
Prior art keywords: imidazole; dimethylphenyl; ethyl; substituted imidazoles; compounds
Prior art date: 1989-10-17

Application number

DK90311245.6T

Other languages

Danish (da)

English (en)

Inventor

Risto Lammintausta

Eija Kalso

Original Assignee

Orion Yhtymae Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-17

Filing date

1990-10-15

Publication date

1993-04-05

1990-10-15 Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy

1993-04-05 Application granted granted Critical

1993-04-05 Publication of DK0424059T3 publication Critical patent/DK0424059T3/da

Links

150000002460 imidazoles Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
RHDJRPPFURBGLQ-UHFFFAOYSA-N detomidine Chemical compound CC1=CC=CC(CC=2NC=NC=2)=C1C RHDJRPPFURBGLQ-UHFFFAOYSA-N 0.000 abstract 2
CUHVIMMYOGQXCV-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CNC=N1 CUHVIMMYOGQXCV-UHFFFAOYSA-N 0.000 abstract 2
229960001894 detomidine Drugs 0.000 abstract 1
HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 abstract 1
229960004253 dexmedetomidine Drugs 0.000 abstract 1
229960002140 medetomidine Drugs 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Neurology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Dental Preparations (AREA)
Stringed Musical Instruments (AREA)
Golf Clubs (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Cephalosporin Compounds (AREA)

DK90311245.6T 1989-10-17 1990-10-15 Anvendelse af substituerede imidazoler DK0424059T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FI894911A FI894911A0 (fi)	1989-10-17	1989-10-17	En terapeutiskt vaerdefull foerening.

Publications (1)

Publication Number	Publication Date
DK0424059T3 true DK0424059T3 (da)	1993-04-05

Family

ID=8529172

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90311245.6T DK0424059T3 (da)	1989-10-17	1990-10-15	Anvendelse af substituerede imidazoler

Country Status (13)

Country	Link
US (1)	US5091402A (fr)
EP (1)	EP0424059B1 (fr)
JP (1)	JP2950597B2 (fr)
AT (1)	ATE86109T1 (fr)
AU (1)	AU624028B2 (fr)
CA (1)	CA2027876C (fr)
DE (1)	DE69001006T2 (fr)
DK (1)	DK0424059T3 (fr)
FI (1)	FI894911A0 (fr)
HU (1)	HU207796B (fr)
IE (1)	IE64062B1 (fr)
NZ (2)	NZ235716A (fr)
ZA (1)	ZA908301B (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2256135B (en) *	1991-05-31	1995-01-18	Orion Yhtymae Oy	Transdermal administration of 4-substituted imidazoles
US7091181B2 (en)	1994-12-12	2006-08-15	Omeros Corporation	Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
US5750720A (en) *	1996-03-28	1998-05-12	Ortho Pharmaceutical Corporation	4- (thien-3-yl)methyl!-imidazole analgesics
US5621113A (en) *	1996-03-28	1997-04-15	Ortho Pharmaceutical Corporation	4-[(thien-2-yl)methyl]-imidazole analgesics
US6716867B1 (en)	1998-04-01	2004-04-06	Orion Corporation	Use of dexmedetomidine for ICU sedation
AR015744A1 (es) *	1998-04-01	2001-05-16	Orion Corp	Uso de dexmedetomidina para sedacion en terapia intensiva
PL346908A1 (en)	1998-09-28	2002-03-11	Orion Corp	Use of 3-(1h-imidazol-4-ylmethyl)-indan-5-ol in the manufacture of a medicament for intraspinal, intrathecal or epidural administration
EP1563838A3 (fr) *	1998-10-20	2009-11-04	Omeros Corporation	Solution d'irrigation et méthodes pour inhiber la douleur et l'inflammation
US20030087962A1 (en)	1998-10-20	2003-05-08	Omeros Corporation	Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
US7973068B2 (en)	1998-10-20	2011-07-05	Omeros Corporation	Arthroscopic irrigation solution and method for peripheral vasoconstriction and inhibition of pain and inflammation
EP1227807B1 (fr) *	1998-10-20	2005-03-30	Omeros Corporation	Solution d'irrigation et procede d'inhibition de la douleur et de l'inflammation
EP1196168A2 (fr) *	1999-06-25	2002-04-17	Orion Corporation	Procede d'administration d'un derive d'imidazole pour obtenir une analgesie
EP1223931B1 (fr)	1999-10-29	2005-12-14	Orion Corporation	Utilisation d'un derive d'imidazole pour le traitement ou prevention de l'hypotension et de l'etat de choc
RU2008130448A (ru)	2006-01-27	2010-03-10	Ф. Хоффманн-Ля Рош Аг (Ch)	Применение производных 4-имидазола для расстройств цнс
RU2009112496A (ru)	2006-10-19	2010-11-27	Ф. Хоффманн-Ля Рош Аг (Ch)	Аминометил-4-имидазолы
CA2668454A1 (fr)	2006-11-02	2008-05-08	F. Hoffmann-La Roche Ag	2-imidazoles substitues en tant que modulateurs des recepteurs associes aux amines de trace
JP2010510184A (ja) *	2006-11-16	2010-04-02	エフ．ホフマン−ラロシュアーゲー	置換４−イミダゾール類
CA2672617A1 (fr)	2006-12-13	2008-06-19	F. Hoffmann-La Roche Ag	Utilisation de nouveaux 2-imidazoles comme ligands pour recepteurs associes a une amine de trace (taar)
US20080146523A1 (en)	2006-12-18	2008-06-19	Guido Galley	Imidazole derivatives
CN101600700B (zh)	2007-02-02	2013-08-21	弗·哈夫曼-拉罗切有限公司	作为taar1配体用于cns病症的新的2-氨基噁唑啉
KR101222412B1 (ko)	2007-02-15	2013-01-15	에프. 호프만-라 로슈 아게	Ｔａａｒ1 리간드로서의 2-아미노옥사졸린
CN101687812A (zh)	2007-07-02	2010-03-31	弗·哈夫曼-拉罗切有限公司	对痕量胺相关受体(taar)具有良好亲和性的2-咪唑啉化合物
CA2691704A1 (fr)	2007-07-03	2009-01-08	F. Hoffmann-La Roche Ag	4-imidazolines et leur utilisation comme antidepresseurs
CA2694362A1 (fr)	2007-07-27	2009-02-05	F. Hoffmann-La Roche Ag	2-azetidinemethaneamines et 2-pyrrolidinemethaneamines comme ligands de taar
JP5341084B2 (ja)	2007-08-03	2013-11-13	エフ．ホフマン−ラロシュアーゲー	Ｔａａｒ１リガンドとしてのピリジンカルボキシアミド及びベンズアミド誘導体
US8242153B2 (en)	2008-07-24	2012-08-14	Hoffmann-La Roche Inc.	4,5-dihydro-oxazol-2YL derivatives
ES2733905T3 (es) *	2009-02-13	2019-12-03	Allergan Inc	Composiciones farmacéuticas que comprenden (3-(1-(1H-imidazol-4-il)etil)-2-metilfenil)metanol
SG175979A1 (en) *	2009-05-15	2011-12-29	Recro Pharma Inc	Sublingual dexmedetomidine compositions and methods of use thereof
US8354441B2 (en)	2009-11-11	2013-01-15	Hoffmann-La Roche Inc.	Oxazoline derivatives
US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
US20130072532A1 (en) *	2010-01-08	2013-03-21	Recro Pharma, Inc.	Topical transdermal dexmedetomidine compositions and methods of use thereof
US20130096170A1 (en)	2011-10-14	2013-04-18	Hospira, Inc.	Methods of treating pediatric patients using dexmedetomidine
AU2012340806B2 (en)	2011-11-21	2017-10-19	Allergan, Inc.	Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3H-imidazole derivatives for treating retinal diseases
WO2013090278A2 (fr)	2011-12-11	2013-06-20	Recro Pharma, Inc.	Compositions intranasales de dexmédétomidine et leurs procédés d'utilisation
US8242158B1 (en)	2012-01-04	2012-08-14	Hospira, Inc.	Dexmedetomidine premix formulation
CA2924236C (fr)	2013-10-07	2020-01-07	Teikoku Pharma Usa, Inc.	Procedes et compositions pour l'administration transdermique d'une quantite non sedative de dexmedetomidine
KR101948779B1 (ko)	2013-10-07	2019-05-21	테이코쿠 팔마 유에스에이, 인코포레이티드	덱스메데토미딘 경피 전달 장치 및 이의 사용 방법
CA2924233C (fr)	2013-10-07	2018-10-23	Teikoku Pharma Usa, Inc.	Methodes et compositions permettant de traiter le trouble d'hyperactivite avec deficit de l'attention, l'anxiete et l'insomnie a l'aide de compositions transdermiques de dexmedetomidine
CN104814966B (zh) *	2015-04-20	2017-12-29	宋兴荣	一种椎管内麻醉剂及其制备方法和应用
CN108713019B (zh)	2016-03-17	2021-06-15	豪夫迈·罗氏有限公司	具有作为taar的激动剂的活性的5-乙基-4-甲基-吡唑-3-甲酰胺衍生物
US9717796B1 (en)	2016-04-20	2017-08-01	Slypharma, Llc	Heat sterilizeable, premixed, ready to use dexmedetomidine solution packaged in a flexible plastic container
BR112019006955A2 (pt)	2016-10-31	2019-07-02	Teikoku Pharma Usa Inc	métodos de controle da dor usando dispositivos de distribuição transdérmica de dexmedetomidina
US11160791B2 (en)	2018-11-01	2021-11-02	Medefil, Inc.	Dexmedetomidine injection premix formulation in ready to use (RTU) bags

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2215206B (en) *	1988-02-29	1991-07-03	Farmos Oy	4-substituted imidazole derivatives useful in perioperative care

1989
- 1989-10-17 FI FI894911A patent/FI894911A0/fi not_active Application Discontinuation
1990
- 1990-10-11 JP JP2275142A patent/JP2950597B2/ja not_active Expired - Lifetime
- 1990-10-15 DK DK90311245.6T patent/DK0424059T3/da active
- 1990-10-15 DE DE9090311245T patent/DE69001006T2/de not_active Expired - Fee Related
- 1990-10-15 AU AU64642/90A patent/AU624028B2/en not_active Expired
- 1990-10-15 EP EP90311245A patent/EP0424059B1/fr not_active Expired - Lifetime
- 1990-10-15 AT AT90311245T patent/ATE86109T1/de not_active IP Right Cessation
- 1990-10-16 NZ NZ235716A patent/NZ235716A/en unknown
- 1990-10-16 IE IE371090A patent/IE64062B1/en not_active IP Right Cessation
- 1990-10-16 HU HU906460A patent/HU207796B/hu unknown
- 1990-10-16 NZ NZ245002A patent/NZ245002A/en unknown
- 1990-10-17 US US07/599,189 patent/US5091402A/en not_active Expired - Lifetime
- 1990-10-17 CA CA002027876A patent/CA2027876C/fr not_active Expired - Lifetime
- 1990-10-17 ZA ZA908301A patent/ZA908301B/xx unknown

Also Published As

Publication number	Publication date
ATE86109T1 (de)	1993-03-15
ZA908301B (en)	1991-09-25
HU906460D0 (en)	1991-04-29
IE64062B1 (en)	1995-07-12
EP0424059A1 (fr)	1991-04-24
HUT55228A (en)	1991-05-28
NZ235716A (en)	1997-04-24
CA2027876A1 (fr)	1991-04-18
AU624028B2 (en)	1992-05-28
AU6464290A (en)	1991-04-26
CA2027876C (fr)	2002-01-22
IE903710A1 (en)	1991-04-24
DE69001006D1 (de)	1993-04-08
JPH03133921A (ja)	1991-06-07
JP2950597B2 (ja)	1999-09-20
HU207796B (en)	1993-06-28
FI894911A0 (fi)	1989-10-17
NZ245002A (en)	1997-07-27
DE69001006T2 (de)	1993-07-08
US5091402A (en)	1992-02-25
EP0424059B1 (fr)	1993-03-03

Publication	Publication Date	Title
DK0424059T3 (da)	1993-04-05	Anvendelse af substituerede imidazoler
DE69007740D1 (de)	1994-05-05	Substituierte 5-[(Tetrazolyl)alkenyl]-Imidazole.
DK0403159T3 (da)	2000-08-14	Imidazolylalkensyrer
IL142649A0 (en)	2002-03-10	Azole derivatives
DE68907921D1 (de)	1993-09-09	Substituierte pyrrol-, pyrazol- und triazol-angiotensin ii-antagonisten.
AU554125B2 (en)	1986-08-07	4(aryl-alkyl)imidazole derivatives
GB2215206B (en)	1991-07-03	4-substituted imidazole derivatives useful in perioperative care
DE3684431D1 (de)	1992-04-23	Derivate des ((4-(4-(4-phenyl-1-piperazinyl)phenoxymethyl)-1,3-dioxolan-2yl)methyl)-1h-imidazol und 1h-1,2,4-triazol.
HK33189A (en)	1989-04-28	1,2,3,9-tetrahydro-3-(imidazol-1-ylmethyl)-4h-carbazol-4-one derivatives
ATE197951T1 (de)	2000-12-15	Neue imidazol derivate, ihre herstellung und therapeutische verwendung
ES537182A0 (es)	1985-12-16	Procedimiento de obtencion de compuestos de 1-aril-2-(3-(4-trifluormetilestiril)-1,2,4-triazol-1-il)-1-c 1,2,4,-triazol-1-il-metil) etanol de efecto antifugal.
BR9713542A (pt)	2000-01-25	Compostos de 2 - imidazolinilaminoindol úteis como agonistas do alfa - 2 - adrenoceptor
CA2371012A1 (fr)	1993-01-07	Imidazoles 4-(1h-pyrol-1-yl)
AU641952B2 (en)	1993-10-07	Substituted N-(imidazolyl)alkyl alanine derivatives
UA26893C2 (uk)	1999-12-29	Спосіб отримаhhя оhдасетроhу та його фармацевтичhо прийhятhих солей
ES2091489T3 (es)	1996-11-01	Derivados de imidazol y composiciones farmaceuticas que los contienen.
ATE179979T1 (de)	1999-05-15	Triazolopyrimidinderivate als angiotensin-ii rezeptor antagonisten
KR950704297A (ko)	1995-11-17	항헬리코박터 활성을 갖는 4-퀴놀리닐 유도체(4-quinolinyl derivatives with anti helicobacter activity)
DE60144246D1 (de)	2011-04-28	Imidazolderivate, verfahren zu deren herstellung und deren verwendung
FI962322A0 (fi)	1996-06-03	(S,S,S)-N-(1-(2-karboksi-3-(N2-mesyylilysyyliamino)propyyli)1-syklopentyylikarbonyylityrosiinin kiteinen polymorfinen muoto
PE87998A1 (es)	1998-12-30	DERIVADOS DE BENZO [g] QUINOLINA
FI964114A0 (fi)	1996-10-14	Uusia 1-(5-metaanisulfonamidoindolyyli-2-karbonyyli)-4-(3-(1-metyylietyyliamino)-2-pyridinyyli)piperatsiinin kiteisiä muotoja
LV11461A (lv)	1996-08-20	Dihloraizvietotie imidazola atvasinajumi ka pretsenisu lidzekli
KR840008801A (ko)	1984-12-19	아졸 유도체의 제조방법