DK0424670T3 - Nye CNS-aktive hexapeptider med antiamnestisk virkning - Google Patents

Nye CNS-aktive hexapeptider med antiamnestisk virkning

Info

Publication number: DK0424670T3
Authority: DK; Denmark
Prior art keywords: denotes; hexapeptides; active; lys; met
Prior art date: 1989-09-23

Application number

DK90118102.4T

Other languages

English (en)

Inventor

Hermann Josef Dr Gerhards

Georg Dr Jaeger

Franz Dr Hock

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-23

Filing date

1990-09-20

Publication date

1995-07-17

1990-09-20 Application filed by Hoechst Ag filed Critical Hoechst Ag

1995-07-17 Application granted granted Critical

1995-07-17 Publication of DK0424670T3 publication Critical patent/DK0424670T3/da

Links

230000003496 anti-amnesic effect Effects 0.000 title 1
KDXKERNSBIXSRK-RXMQYKEDSA-N D-lysine Chemical compound NCCCC[C@@H](N)C(O)=O KDXKERNSBIXSRK-RXMQYKEDSA-N 0.000 abstract 2
RVLOMLVNNBWRSR-KNIFDHDWSA-N (2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O RVLOMLVNNBWRSR-KNIFDHDWSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-GSVOUGTGSA-N D-glutamic acid Chemical compound OC(=O)[C@H](N)CCC(O)=O WHUUTDBJXJRKMK-GSVOUGTGSA-N 0.000 abstract 1
CZVQSYNVUHAILZ-UWVGGRQHSA-N His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CC1=CN=CN1 CZVQSYNVUHAILZ-UWVGGRQHSA-N 0.000 abstract 1
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 1
QEFRNWWLZKMPFJ-YGVKFDHGSA-N L-methionine S-oxide Chemical compound CS(=O)CC[C@H](N)C(O)=O QEFRNWWLZKMPFJ-YGVKFDHGSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
150000001370 alpha-amino acid derivatives Chemical class 0.000 abstract 1
235000008206 alpha-amino acids Nutrition 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001589 carboacyl group Chemical group 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
230000007935 neutral effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Gastroenterology & Hepatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Toxicology (AREA)
Psychiatry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

DK90118102.4T 1989-09-23 1990-09-20 Nye CNS-aktive hexapeptider med antiamnestisk virkning DK0424670T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE3931788A DE3931788A1 (de)	1989-09-23	1989-09-23	Neue zns-aktive hexapeptide mit antiamnestischer wirkung

Publications (1)

Publication Number	Publication Date
DK0424670T3 true DK0424670T3 (da)	1995-07-17

Family

ID=6390039

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90118102.4T DK0424670T3 (da)	1989-09-23	1990-09-20	Nye CNS-aktive hexapeptider med antiamnestisk virkning

Country Status (11)

Country	Link
EP (1)	EP0424670B1 (da)
JP (1)	JPH03120295A (da)
AT (1)	ATE118786T1 (da)
AU (1)	AU628653B2 (da)
CA (1)	CA2025941A1 (da)
DE (2)	DE3931788A1 (da)
DK (1)	DK0424670T3 (da)
ES (1)	ES2070229T3 (da)
GR (1)	GR3015492T3 (da)
IE (1)	IE66529B1 (da)
PT (1)	PT95381B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN106608901B (zh) *	2015-10-22	2020-10-16	彭莉	二羟基二甲基四氢异喹啉-3-甲酰-Lys(Lys-Ala),其合成,活性及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE758206A (fr) *	1969-10-31	1971-04-29	Hoechst Ag	Peptides a activite adrenocorticotrope et medicaments qui en contiennent
DE1965102A1 (de) *	1969-12-27	1971-07-01	Hoechst Ag	Neue Tridekapeptide mit hoher adrenocorticotroper Wirkung und Verfahren zu ihrer Herstellung
US4623715A (en) *	1984-10-22	1986-11-18	Hoechst Aktiengeselleschaft	Novel peptides which are active on the central nervous system and have an action on the cholinergic system

1989
- 1989-09-23 DE DE3931788A patent/DE3931788A1/de not_active Withdrawn
1990
- 1990-09-20 DE DE59008515T patent/DE59008515D1/de not_active Expired - Fee Related
- 1990-09-20 EP EP90118102A patent/EP0424670B1/de not_active Expired - Lifetime
- 1990-09-20 AT AT90118102T patent/ATE118786T1/de not_active IP Right Cessation
- 1990-09-20 ES ES90118102T patent/ES2070229T3/es not_active Expired - Lifetime
- 1990-09-20 DK DK90118102.4T patent/DK0424670T3/da active
- 1990-09-21 CA CA002025941A patent/CA2025941A1/en not_active Abandoned
- 1990-09-21 IE IE342090A patent/IE66529B1/en not_active IP Right Cessation
- 1990-09-21 JP JP2250423A patent/JPH03120295A/ja active Pending
- 1990-09-21 PT PT95381A patent/PT95381B/pt not_active IP Right Cessation
- 1990-09-21 AU AU63064/90A patent/AU628653B2/en not_active Ceased
1995
- 1995-03-20 GR GR950400623T patent/GR3015492T3/el unknown

Also Published As

Publication number	Publication date
JPH03120295A (ja)	1991-05-22
PT95381B (pt)	1997-07-31
ES2070229T3 (es)	1995-06-01
EP0424670A1 (de)	1991-05-02
EP0424670B1 (de)	1995-02-22
ATE118786T1 (de)	1995-03-15
AU628653B2 (en)	1992-09-17
AU6306490A (en)	1991-03-28
DE59008515D1 (de)	1995-03-30
DE3931788A1 (de)	1991-04-04
PT95381A (pt)	1991-05-22
CA2025941A1 (en)	1991-03-24
IE66529B1 (en)	1996-01-17
GR3015492T3 (en)	1995-06-30
IE903420A1 (en)	1991-04-10

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