ES2070229T3 - Nuevos hexapeptidos activos sobre el sistema nervioso central (snc) con efecto antiamnesico. - Google Patents

Nuevos hexapeptidos activos sobre el sistema nervioso central (snc) con efecto antiamnesico.

Info

Publication number
ES2070229T3
ES2070229T3 ES90118102T ES90118102T ES2070229T3 ES 2070229 T3 ES2070229 T3 ES 2070229T3 ES 90118102 T ES90118102 T ES 90118102T ES 90118102 T ES90118102 T ES 90118102T ES 2070229 T3 ES2070229 T3 ES 2070229T3
Authority
ES
Spain
Prior art keywords
denotes
hexapeptides
antiamnesical
cns
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90118102T
Other languages
English (en)
Inventor
Georg Dr Jager
Hermann Josef Dr Gerhards
Franz Dr Hock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2070229T3 publication Critical patent/ES2070229T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA INVENCION TRATA DE UN HEXAPEPTIDO DE FORMULA (I), DESCRIBE UN PROCEDIMIENTO PARA LA PRODUCCION DEL COMPUESTO DE FORMULA (I), RESEÑA LA APLICACION DEL COMPUESTO DE FORMULA (I) COMO MEDICAMENTO Y SE REFIERE A UN MEDIO FARMACEUTICO CONTENIENDO EL COMPUESTO DE FORMULA (I). SIENDO A ELEVADO 1, MET (O) O MET (O SUB 2) QUE SE PRESENTA EN FORMA L O D; A (AL CUADRADO) , GLU, D-GLU, ALA O PIROGLUTAMINO; A ELEVADO 3, HIS, ALA, PHE O D-LYS; A ELEVADO 4, EL RESTO DE UN (ALFA)-AMINOACIDO AROMATICO O ALIFATICO; A ELEVADO 5, LYS O D-LYS; A ELEVADO 6, PHE; R ELEVADO 1, Z, FORNILO O ALCANOLILO; Y N UN NUMERO ENTERO DE 4 A 10.
ES90118102T 1989-09-23 1990-09-20 Nuevos hexapeptidos activos sobre el sistema nervioso central (snc) con efecto antiamnesico. Expired - Lifetime ES2070229T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3931788A DE3931788A1 (de) 1989-09-23 1989-09-23 Neue zns-aktive hexapeptide mit antiamnestischer wirkung

Publications (1)

Publication Number Publication Date
ES2070229T3 true ES2070229T3 (es) 1995-06-01

Family

ID=6390039

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90118102T Expired - Lifetime ES2070229T3 (es) 1989-09-23 1990-09-20 Nuevos hexapeptidos activos sobre el sistema nervioso central (snc) con efecto antiamnesico.

Country Status (11)

Country Link
EP (1) EP0424670B1 (es)
JP (1) JPH03120295A (es)
AT (1) ATE118786T1 (es)
AU (1) AU628653B2 (es)
CA (1) CA2025941A1 (es)
DE (2) DE3931788A1 (es)
DK (1) DK0424670T3 (es)
ES (1) ES2070229T3 (es)
GR (1) GR3015492T3 (es)
IE (1) IE66529B1 (es)
PT (1) PT95381B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106608901B (zh) * 2015-10-22 2020-10-16 彭莉 二羟基二甲基四氢异喹啉-3-甲酰-Lys(Lys-Ala),其合成,活性及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758206A (fr) * 1969-10-31 1971-04-29 Hoechst Ag Peptides a activite adrenocorticotrope et medicaments qui en contiennent
DE1965102A1 (de) * 1969-12-27 1971-07-01 Hoechst Ag Neue Tridekapeptide mit hoher adrenocorticotroper Wirkung und Verfahren zu ihrer Herstellung
US4623715A (en) * 1984-10-22 1986-11-18 Hoechst Aktiengeselleschaft Novel peptides which are active on the central nervous system and have an action on the cholinergic system

Also Published As

Publication number Publication date
JPH03120295A (ja) 1991-05-22
PT95381B (pt) 1997-07-31
EP0424670A1 (de) 1991-05-02
EP0424670B1 (de) 1995-02-22
ATE118786T1 (de) 1995-03-15
DK0424670T3 (da) 1995-07-17
AU628653B2 (en) 1992-09-17
AU6306490A (en) 1991-03-28
DE59008515D1 (de) 1995-03-30
DE3931788A1 (de) 1991-04-04
PT95381A (pt) 1991-05-22
CA2025941A1 (en) 1991-03-24
IE66529B1 (en) 1996-01-17
GR3015492T3 (en) 1995-06-30
IE903420A1 (en) 1991-04-10

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