DK0427963T3 - Fremgangsmåde til fremstilling af rene, asymmetrisk disubstituerede urinstoffer - Google Patents
Fremgangsmåde til fremstilling af rene, asymmetrisk disubstituerede urinstofferInfo
- Publication number
- DK0427963T3 DK0427963T3 DK90119673.3T DK90119673T DK0427963T3 DK 0427963 T3 DK0427963 T3 DK 0427963T3 DK 90119673 T DK90119673 T DK 90119673T DK 0427963 T3 DK0427963 T3 DK 0427963T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- unsubstituted
- pure
- preparation
- dialkylurea
- Prior art date
Links
- 235000013877 carbamide Nutrition 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 150000003672 ureas Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000004982 aromatic amines Chemical class 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 abstract 1
- -1 heterocyclic amine Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000004817 pentamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
- C07C273/1854—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas by reactions not involving the formation of the N-C(O)-N- moiety
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Surgical Instruments (AREA)
- Seasonings (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT257589 | 1989-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0427963T3 true DK0427963T3 (da) | 1994-05-02 |
Family
ID=3536751
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90119673.3T DK0427963T3 (da) | 1989-11-10 | 1990-10-15 | Fremgangsmåde til fremstilling af rene, asymmetrisk disubstituerede urinstoffer |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5099021A (pl) |
| EP (1) | EP0427963B1 (pl) |
| JP (1) | JPH03173860A (pl) |
| CN (1) | CN1025026C (pl) |
| AT (1) | ATE103589T1 (pl) |
| CA (1) | CA2028916A1 (pl) |
| CZ (1) | CZ282545B6 (pl) |
| DE (1) | DE59005183D1 (pl) |
| DK (1) | DK0427963T3 (pl) |
| ES (1) | ES2062248T3 (pl) |
| FI (1) | FI905532A7 (pl) |
| HU (1) | HU209386B (pl) |
| IL (1) | IL96049A (pl) |
| PL (1) | PL164621B1 (pl) |
| SK (1) | SK279982B6 (pl) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT394715B (de) * | 1990-08-14 | 1992-06-10 | Chemie Linz Gmbh | Verfahren zur n-alkylierung von harnstoffen |
| US5241118A (en) * | 1991-04-04 | 1993-08-31 | Arco Chemical Technology, L.P. | Process for the preparation of trisubstituted ureas by reductive carbonylation |
| AT397384B (de) * | 1991-08-16 | 1994-03-25 | Chemie Linz Gmbh | Verfahren zur herstellung reiner n,n'-unsymmetrisch substituierter phenylharnstoffe |
| DE4130514A1 (de) * | 1991-09-13 | 1993-03-18 | Chemie Linz Deutschland | Verfahren zur herstellung reiner n,n'-unsymmetrisch substituierter phenylharnstoffe |
| WO2000056725A1 (en) | 1999-03-19 | 2000-09-28 | Du Pont Pharmaceuticals Company | N-adamant-1-yl-n'-[4-chlorobenzothiazol-2-yl] urea useful in the treatment of inflammation and as an anticancer radiosensitizing agent |
| AU8181701A (en) | 2000-06-21 | 2002-01-02 | Hoffmann La Roche | Benzothiazole derivatives |
| US7087761B2 (en) | 2003-01-07 | 2006-08-08 | Hoffmann-La Roche Inc. | Cyclization process for substituted benzothiazole derivatives |
| CN1956983B (zh) | 2004-05-24 | 2010-05-26 | 弗·哈夫曼-拉罗切有限公司 | 4-羟基-4-甲基-哌啶-1-甲酸(4-甲氧基-7-吗啉-4-基-苯并噻唑-2-基)-酰胺 |
| JP4633123B2 (ja) | 2004-11-05 | 2011-02-16 | エフ.ホフマン−ラ ロシュ アーゲー | イソニコチン酸誘導体の製造方法 |
| DE602006012815D1 (de) | 2005-03-23 | 2010-04-22 | Hoffmann La Roche | Acetylenylpyrazolopyrimidinderivate als mglur2-antagonsten |
| AU2006298829B2 (en) | 2005-09-27 | 2011-03-03 | F. Hoffmann-La Roche Ag | Oxadiazolyl pyrazolo-pyrimidines as mGluR2 antagonists |
| WO2008077809A1 (en) * | 2006-12-22 | 2008-07-03 | F. Hoffmann-La Roche Ag | Process for the manufacture of 7-oxa-bicyclo derivatives |
| HUP1100731A2 (en) | 2011-12-30 | 2013-06-28 | Stratoxer S Kft | Complex forming compounds |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2673877A (en) * | 1951-10-26 | 1954-03-30 | Du Pont | Preparation of chlorphenyldimethyl-ureas |
| DE1064051B (de) * | 1958-04-09 | 1959-08-27 | Basf Ag | Verfahren zur Herstellung von substituierten Harnstoffen |
| NL277506A (pl) * | 1961-04-21 | |||
| NL280954A (pl) * | 1961-07-14 | |||
| NL129423C (pl) * | 1964-03-26 | |||
| CH493195A (de) * | 1968-01-23 | 1970-07-15 | Ciba Geigy | Schädlingsbekämpfungsmittel |
| CH505543A (de) * | 1968-11-01 | 1971-04-15 | Ciba Geigy Ag | Schädlingsbekämpfungsmittel |
| DE2436139C3 (de) * | 1973-07-26 | 1983-12-08 | W.H. Dickinson Engineering Ltd., Southampton | Konditioniervorrichtung für Tabak |
| US4212981A (en) * | 1973-07-27 | 1980-07-15 | Shionogi & Co., Ltd. | Process for preparing 3-isoxazolylurea derivatives |
| JPS5810361B2 (ja) * | 1974-10-04 | 1983-02-25 | 塩野義製薬株式会社 | 3−アルチルイソオキサゾ−ル系除草剤 |
| JPS6033109B2 (ja) * | 1977-04-28 | 1985-08-01 | 塩野義製薬株式会社 | 尿素誘導体の合成法 |
| DE2742158B2 (de) * | 1977-09-19 | 1979-08-02 | Skw Trostberg Ag, 8223 Trostberg | Verfahren zur Herstellung substituierter Harnstoffe |
| EP0002881A1 (en) * | 1977-11-02 | 1979-07-11 | FISONS plc | 5-Isoxazolylurea derivatives, their preparation, their use and compositions containing them |
| DE2844962A1 (de) * | 1978-10-16 | 1980-04-30 | Basf Ag | Verfahren zur herstellung von symmetrischen 1,3-disubstituierten harnstoffen |
| DE2937331A1 (de) * | 1979-09-14 | 1981-04-02 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von alkylharnstoffen |
| CH649078A5 (de) * | 1980-01-25 | 1985-04-30 | Reanal Finomvegyszergyar | Verfahren zur herstellung von n-mono- oder disubstituierten n-aryl-harnstoff-derivaten. |
| HU185294B (en) * | 1980-12-29 | 1984-12-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing substituted urea derivatives |
| US4380641A (en) * | 1981-10-26 | 1983-04-19 | Eli Lilly And Company | Insecticidal oxazolyl ureas |
| JPS5939883A (ja) * | 1982-08-27 | 1984-03-05 | Shionogi & Co Ltd | イソオキサゾ−ル系アシル尿素類 |
| DE3413755A1 (de) * | 1984-04-12 | 1985-10-24 | Basf Ag, 6700 Ludwigshafen | Thiazolylharnstoffe, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses |
| FR2577221B1 (fr) * | 1985-02-11 | 1987-02-20 | Rhone Poulenc Agrochimie | Procede de preparation d'une phenyluree substituee |
| KR960012208B1 (ko) * | 1987-06-25 | 1996-09-16 | 일라이 릴리 앤드 캄파니 | 우레아, 카바메이트 및 카바메이트 유도체의 제조방법 |
-
1990
- 1990-10-15 DK DK90119673.3T patent/DK0427963T3/da active
- 1990-10-15 ES ES90119673T patent/ES2062248T3/es not_active Expired - Lifetime
- 1990-10-15 EP EP90119673A patent/EP0427963B1/de not_active Expired - Lifetime
- 1990-10-15 AT AT90119673T patent/ATE103589T1/de active
- 1990-10-15 DE DE90119673T patent/DE59005183D1/de not_active Expired - Fee Related
- 1990-10-17 IL IL9604990A patent/IL96049A/en not_active IP Right Cessation
- 1990-10-30 CA CA002028916A patent/CA2028916A1/en not_active Abandoned
- 1990-10-30 US US07/606,208 patent/US5099021A/en not_active Expired - Fee Related
- 1990-11-08 FI FI905532A patent/FI905532A7/fi not_active Application Discontinuation
- 1990-11-08 JP JP2301250A patent/JPH03173860A/ja active Pending
- 1990-11-09 HU HU907086A patent/HU209386B/hu not_active IP Right Cessation
- 1990-11-09 CZ CS905535A patent/CZ282545B6/cs not_active IP Right Cessation
- 1990-11-09 SK SK5535-90A patent/SK279982B6/sk unknown
- 1990-11-09 CN CN90109034A patent/CN1025026C/zh not_active Expired - Fee Related
- 1990-11-09 PL PL90287708A patent/PL164621B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI905532A0 (fi) | 1990-11-08 |
| PL287708A1 (en) | 1991-11-04 |
| ES2062248T3 (es) | 1994-12-16 |
| JPH03173860A (ja) | 1991-07-29 |
| IL96049A0 (en) | 1991-07-18 |
| EP0427963B1 (de) | 1994-03-30 |
| CZ282545B6 (cs) | 1997-08-13 |
| SK553590A3 (en) | 1999-06-11 |
| ATE103589T1 (de) | 1994-04-15 |
| HUT55748A (en) | 1991-06-28 |
| PL164621B1 (pl) | 1994-08-31 |
| DE59005183D1 (de) | 1994-05-05 |
| US5099021A (en) | 1992-03-24 |
| HU209386B (en) | 1994-05-30 |
| CA2028916A1 (en) | 1991-05-11 |
| HU907086D0 (en) | 1991-05-28 |
| FI905532A7 (fi) | 1991-05-11 |
| CN1025026C (zh) | 1994-06-15 |
| CZ553590A3 (en) | 1997-06-11 |
| EP0427963A1 (de) | 1991-05-22 |
| CN1051726A (zh) | 1991-05-29 |
| SK279982B6 (sk) | 1999-06-11 |
| IL96049A (en) | 1994-10-21 |
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