DK0432249T3 - Monoklonale antistoffer over for beta-kæden i leukocytadhæsionsreceptoren, fremgangsmåder til fremstilling af disse antistoffer og anvendelse heraf - Google Patents

Monoklonale antistoffer over for beta-kæden i leukocytadhæsionsreceptoren, fremgangsmåder til fremstilling af disse antistoffer og anvendelse heraf

Info

Publication number
DK0432249T3
DK0432249T3 DK90909864.2T DK90909864T DK0432249T3 DK 0432249 T3 DK0432249 T3 DK 0432249T3 DK 90909864 T DK90909864 T DK 90909864T DK 0432249 T3 DK0432249 T3 DK 0432249T3
Authority
DK
Denmark
Prior art keywords
antibodies
monoclonal antibodies
producing
methods
leukocyte adhesion
Prior art date
Application number
DK90909864.2T
Other languages
Danish (da)
English (en)
Inventor
James E Hildreth
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Application granted granted Critical
Publication of DK0432249T3 publication Critical patent/DK0432249T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK90909864.2T 1989-06-02 1990-05-30 Monoklonale antistoffer over for beta-kæden i leukocytadhæsionsreceptoren, fremgangsmåder til fremstilling af disse antistoffer og anvendelse heraf DK0432249T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36127189A 1989-06-02 1989-06-02

Publications (1)

Publication Number Publication Date
DK0432249T3 true DK0432249T3 (da) 1997-02-17

Family

ID=23421348

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90909864.2T DK0432249T3 (da) 1989-06-02 1990-05-30 Monoklonale antistoffer over for beta-kæden i leukocytadhæsionsreceptoren, fremgangsmåder til fremstilling af disse antistoffer og anvendelse heraf

Country Status (10)

Country Link
US (4) US5888508A (ja)
EP (1) EP0432249B1 (ja)
JP (2) JP3048632B2 (ja)
AT (1) ATE143376T1 (ja)
AU (2) AU645016B2 (ja)
CA (1) CA2033347C (ja)
DE (1) DE69028684T2 (ja)
DK (1) DK0432249T3 (ja)
ES (1) ES2095876T3 (ja)
WO (1) WO1990015076A2 (ja)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5456924A (en) * 1988-12-23 1995-10-10 Immunotec Research Corporation Ltd. Method of treatment of HIV-seropositive individuals with dietary whey proteins
ES2095876T3 (es) * 1989-06-02 1997-03-01 Univ Johns Hopkins Med Anticuerpos monoclonales contra la cadena beta de receptores de adhesion de leucocitos; procedimiento de produccion de estos anticuerpos y utilizacion
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
WO1994004679A1 (en) * 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
GB9115364D0 (en) * 1991-07-16 1991-08-28 Wellcome Found Antibody
AU687755B2 (en) * 1992-08-21 1998-03-05 Genentech Inc. Method for treating an LFA-1-mediated disorder
US5821332A (en) 1993-11-03 1998-10-13 The Board Of Trustees Of The Leland Stanford Junior University Receptor on the surface of activated CD4+ T-cells: ACT-4
US5646251A (en) * 1993-11-05 1997-07-08 The Board Of Trustees Of Leeland Stanford Jr. Univ. Alloreaction-associated antigen (ARAG): a novel member of the immunoglobulin gene superfamily
US6242566B1 (en) 1994-02-10 2001-06-05 Board Of Trustees Of The Leland Stanford Junior University Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
US6867203B2 (en) 1998-12-29 2005-03-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory and immune-suppressive compounds
US6582698B1 (en) 1999-03-19 2003-06-24 Genentech, Inc. Treatment method
JP2002540078A (ja) 1999-03-19 2002-11-26 ジェネンテック・インコーポレーテッド Ｌｆａ−１アンタゴニスト投与量の増加によるｌｆａ−１関連疾患の治療
WO2001051084A1 (en) * 2000-01-14 2001-07-19 Genentech, Inc. Diagnosis and treatment of hepatic inflammatory disorders by inhibiting the binding of lfa-1 to icam-1
JP2003527439A (ja) 2000-03-17 2003-09-16 ミレニアム・ファーマシューティカルズ・インコーポレイテッド 抗ｃｄ１８抗体と抗ｃｃｒ２抗体の混合物を用いる狭窄および再狭窄を抑制する方法
US8658773B2 (en) 2011-05-02 2014-02-25 Immunomedics, Inc. Ultrafiltration concentration of allotype selected antibodies for small-volume administration
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
RU2006146939A (ru) 2004-06-09 2008-07-20 Дженентек Способ лечения кольцевидной гранулемы или саркоида
US8440264B2 (en) * 2006-12-15 2013-05-14 Ford Global Technologies, Llc Method for preparing a brazed surface for receiving a coating
ES3000111T3 (en) 2009-02-13 2025-02-27 Immunomedics Inc Intermediates for preparing conjugates with an intracellularly-cleavable linkage
US20160095939A1 (en) 2014-10-07 2016-04-07 Immunomedics, Inc. Neoadjuvant use of antibody-drug conjugates
EP2478110B1 (en) 2009-09-16 2016-01-06 Immunomedics, Inc. Class i anti-cea antibodies and uses thereof
ES2978177T3 (es) 2009-12-02 2024-09-06 Immunomedics Inc Combinación de radio inmunoterapia y conjugados anticuerpo-fármaco para mejorar la terapia contra el cáncer
CN104379169A (zh) 2012-08-14 2015-02-25 Ibc药品公司 用于治疗疾病的t-细胞重定向双特异性抗体
CN107753954A (zh) 2012-12-13 2018-03-06 免疫医疗公司 功效改进且毒性降低的抗体与sn‑38的免疫缀合物的剂量
WO2017004144A1 (en) 2015-07-01 2017-01-05 Immunomedics, Inc. Antibody-sn-38 immunoconjugates with a cl2a linker
JP6447933B2 (ja) 2014-02-21 2019-01-09 アイビーシー ファーマスーティカルズ，インコーポレイテッド Ｔｒｏｐ−２発現細胞に対する免疫応答を誘発することによる疾患治療
CA2935748A1 (en) 2014-02-25 2015-09-03 Immunomedics, Inc. Humanized rfb4 anti-cd22 antibody
EP3160504B1 (en) 2014-06-24 2020-09-16 Immunomedics, Inc. Anti-histone therapy for vascular necrosis in severe glomerulonephritis
EP3029067A1 (en) 2014-12-01 2016-06-08 Deutsches Krebsforschungszentrum Use of blocking-reagents for reducing unspecific T cell-activation
AU2016252771B2 (en) 2015-04-22 2021-12-16 Immunomedics, Inc. Isolation, detection, diagnosis and/or characterization of circulating Trop-2-positive cancer cells
JP6980980B2 (ja) 2015-06-25 2021-12-15 イミューノメディクス、インコーポレイテッドImmunomedics, Inc. 抗ｈｌａ‐ｄｒまたは抗ｔｒｏｐ‐２抗体と微小管阻害剤、ｐａｒｐ阻害剤、ブルトンキナーゼ阻害剤またはホスホイノシチド３‐キナーゼ阻害剤との併用は癌の治療効果を有意に改善する
WO2022239720A1 (ja) 2021-05-10 2022-11-17 公益財団法人川崎市産業振興財団 抗原への結合親和性を低減させた抗体
USD1005917S1 (en) * 2021-11-04 2023-11-28 Thor Tech, Inc. Wheel

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4506009A (en) * 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
EP0303692A4 (en) * 1987-02-26 1990-12-05 Dana Farber Cancer Institute Cloning of lfa-1
US5091513A (en) * 1987-05-21 1992-02-25 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US4797277A (en) * 1987-09-22 1989-01-10 Pharmacia Ab Method for reperfusion therapy
US5002869A (en) * 1987-11-02 1991-03-26 Dana-Farber Cancer Institute Monoclonal antibody specific to a novel epitope of the LFA-1 antigen of human T lymphocytes
DE3852374T2 (de) * 1987-11-02 1995-05-04 Baylor College Medicine Verwendung von ICAM-1 oder ihre funktionelle Derivate zur Behandlung unspezifischer Entzündungen.
GB8726230D0 (en) * 1987-11-10 1987-12-16 Rosen H Antibodies
US5449760A (en) * 1987-12-31 1995-09-12 Tanox Biosystems, Inc. Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils
US5147637A (en) * 1988-06-07 1992-09-15 The Rockefeller University Method of inhibiting the influx of leukocytes into organs during sepsis or other trauma
ES2201052T3 (es) * 1988-09-28 2004-03-16 Dana Farber Cancer Institute Moleculas de adhesion intercelular y sus ligandos de union.
CA2000048A1 (en) * 1988-10-03 1990-04-03 Edward F. Plow Peptides and antibodies that inhibit integrin-ligand bindin g
US6307025B1 (en) * 1989-04-28 2001-10-23 Biogen, Inc. VCAM fusion proteins and DNA coding therefor
ES2095876T3 (es) * 1989-06-02 1997-03-01 Univ Johns Hopkins Med Anticuerpos monoclonales contra la cadena beta de receptores de adhesion de leucocitos; procedimiento de produccion de estos anticuerpos y utilizacion
JPH05503288A (ja) * 1989-08-18 1993-06-03 ラ　ホヤ　キャンサー　リサーチ　ファウンデーション フィビュリン
US6720141B1 (en) * 1999-11-01 2004-04-13 Interleukin Genetics, Inc. Diagnostics and therapeutics for restenosis

Also Published As

Publication number Publication date
US20010014325A1 (en) 2001-08-16
JP3048632B2 (ja) 2000-06-05
JP3288996B2 (ja) 2002-06-04
JPH04501365A (ja) 1992-03-12
WO1990015076A2 (en) 1990-12-13
AU5847190A (en) 1991-01-07
CA2033347A1 (en) 1990-12-03
WO1990015076A3 (en) 1991-04-18
EP0432249A4 (en) 1992-01-02
EP0432249B1 (en) 1996-09-25
JP2000136200A (ja) 2000-05-16
ES2095876T3 (es) 1997-03-01
US20050158315A1 (en) 2005-07-21
DE69028684D1 (de) 1996-10-31
US6921533B2 (en) 2005-07-26
US7368109B2 (en) 2008-05-06
AU666977B2 (en) 1996-02-29
AU5035393A (en) 1994-02-17
ATE143376T1 (de) 1996-10-15
CA2033347C (en) 2000-02-29
US5888508A (en) 1999-03-30
EP0432249A1 (en) 1991-06-19
US6187308B1 (en) 2001-02-13
AU645016B2 (en) 1994-01-06
DE69028684T2 (de) 1997-05-22

Similar Documents

Publication Publication Date Title
DK0432249T3 (da) Monoklonale antistoffer over for beta-kæden i leukocytadhæsionsreceptoren, fremgangsmåder til fremstilling af disse antistoffer og anvendelse heraf
DK473887A (da) Hybridomacellelinie, monoklonalt antistof, fremgangsmaade til fremstilling af og anvendelse af det monoklonale antistof
DE69221147D1 (de) Nicht glycosylierter Anti-CD3-IgG-Antikörper
DE3167698D1 (en) Method for the determination of antigens with the aid of two or more monoclonal antibodies
ES8706964A1 (es) Un procedimiento para fraccionar anticuerpos de suero.
DK99682A (da) Immunoanalysemetoder under anvendelse af monoklonale antistoffer
NO162179C (no) Monoklonale antistoffer for anvendelse in vitro.
FI853283A7 (fi) Uudet monoklonaaliset glykokonjugaattien vasta-aineet, menetelmät niiden tuottamiseksi, ja niiden käytöt.
DE3485733D1 (de) Spezifische antigene der cea(karzyno-embryonales-antigen)familie, spezifische antikoerper und verfahren zu ihrer verwendung.
DK319685A (da) Monoklonale antistoffer, fremgangsmaade til frembringelse af antistofferne, hybridomaceller, der producerer antistofferne, og anvendelse af antistofferne
DK651787A (da) A-associerede h-antigener, monoklonale antistoffer, der er specifikke heroverfor, og fremgangsmaader til anvendelse af disse til blodtypebestemmelse
DK414386D0 (da) Monoklonalt antistof, cellelinje til fremstilling deraf og antistoffets anvendelse
NO861554L (no) Anti-urokinasemonoklonalt antistoff, matrise inneholdende dette, testmetode og biokjemisk testutstyr som anvender det.
DK134487A (da) Monoklonalt antistof med affinitet for humant interleukin-2
DK494084A (da) Hybridoma, monokloniske antistoffer frembragt hermed og diagnosemetode under anvendelse af disse
IL92312A0 (en) Monoclonal antibody specifically recognizing n-glycolyl type gm2,hybridoma producing the antibody and method for preparing the hybridoma
FI925081A7 (fi) Menetelmä antigeenispesifisen, korkea affiniteetti monokloonisen vasta -aineen valmistamiseksi
FI893427A7 (fi) Monoklonaalinen vasta-aine, joka pystyy tunnistamaan gangliosideja GQ1b ja GT1a, sitä tuottava hybridooma sekä menetelmä hybridooman valmistamiseksi
DK557287D0 (da) Murin hybridoma lym-2, dermed fremstillet monoklonalt antistof og fremangsmaade til fremstilling af antistoffet
DK557187D0 (da) Murin hybridoma lym-1, dermed fremstillet monoklonalt antistof og fremgangsmaade til fremstilling af antistoffet
DK355589A (da) Monoklonalt antistof mod endotelcellers rgd-rettede adhaesionsreceptor, hybridom til produktion af antistofferne, samt analyse for tilstedevaerelsen af ovennaevnte receptor
ATE76510T1 (de) Spezifische antigene der cea(karzyno-embryonales- antigen)familie, spezifische antikoerper und verfahren zu ihrer verwendung.