DK0432496T3 - Fremstilling af hypericin - Google Patents

Fremstilling af hypericin

Info

Publication number: DK0432496T3
Authority: DK; Denmark
Prior art keywords: hypericin; preparation; protohypericin; irradiation; preparing
Prior art date: 1989-11-15

Application number

DK90121796.8T

Other languages

Danish (da)

English (en)

Inventor

David Lavie

Yehuda Mazur

Harald Bock

Original Assignee

Yeda Res & Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-15

Filing date

1990-11-14

Publication date

1995-06-26

1990-11-14 Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev

1995-06-26 Application granted granted Critical

1995-06-26 Publication of DK0432496T3 publication Critical patent/DK0432496T3/da

Links

BTXNYTINYBABQR-UHFFFAOYSA-N hypericin Chemical compound C12=C(O)C=C(O)C(C(C=3C(O)=CC(C)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 BTXNYTINYBABQR-UHFFFAOYSA-N 0.000 title abstract 3
229940005608 hypericin Drugs 0.000 title abstract 3
PHOKTTKFQUYZPI-UHFFFAOYSA-N hypericin Natural products Cc1cc(O)c2c3C(=O)C(=Cc4c(O)c5c(O)cc(O)c6c7C(=O)C(=Cc8c(C)c1c2c(c78)c(c34)c56)O)O PHOKTTKFQUYZPI-UHFFFAOYSA-N 0.000 title abstract 3
SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 title abstract 3
YLILOANQCQKPOD-UHFFFAOYSA-N protohypericin Chemical compound C12=C(O)C=C(O)C(C(C3=C(O)C=C(C=C33)C)=O)=C2C3=C2C3=C1C(O)=CC(O)=C3C(=O)C1=C(O)C=C(C)C=C12 YLILOANQCQKPOD-UHFFFAOYSA-N 0.000 abstract 2
CBOKHFLBNZMMAA-UHFFFAOYSA-N Emodin anthrone Natural products OC1=CC(O)=CC2=CC3=CC(C)=CC(O)=C3C(O)=C21 CBOKHFLBNZMMAA-UHFFFAOYSA-N 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
LAJSXCAVRQXZIO-UHFFFAOYSA-N emodin anthrone Chemical compound C1=C(O)C=C2CC3=CC(C)=CC(O)=C3C(=O)C2=C1O LAJSXCAVRQXZIO-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000006025 oxidative dimerization reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C50/00—Quinones
- C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
- C07C50/36—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having four or more rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Hydrogenated Pyridines (AREA)

DK90121796.8T 1989-11-15 1990-11-14 Fremstilling af hypericin DK0432496T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IL9231589A IL92315A (en)	1989-11-15	1989-11-15	Preparation of Hypericin from Amodin Enron

Publications (1)

Publication Number	Publication Date
DK0432496T3 true DK0432496T3 (da)	1995-06-26

Family

ID=11060574

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90121796.8T DK0432496T3 (da)	1989-11-15	1990-11-14	Fremstilling af hypericin

Country Status (11)

Country	Link
US (1)	US5120412A (fr)
EP (1)	EP0432496B1 (fr)
JP (1)	JP2896224B2 (fr)
AT (1)	ATE117978T1 (fr)
AU (1)	AU629066B2 (fr)
CA (1)	CA2029993C (fr)
DE (1)	DE69016620T2 (fr)
DK (1)	DK0432496T3 (fr)
ES (1)	ES2070244T3 (fr)
GR (1)	GR3015919T3 (fr)
IL (1)	IL92315A (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL92315A (en) *	1989-11-15	1996-12-05	Yeda Res & Dev	Preparation of Hypericin from Amodin Enron
US6187572B1 (en)	1990-04-16	2001-02-13	Baxter International Inc.	Method of inactivation of viral and bacterial blood contaminants
US5418130A (en) *	1990-04-16	1995-05-23	Cryopharm Corporation	Method of inactivation of viral and bacterial blood contaminants
WO1994014427A2 (fr) *	1992-12-23	1994-07-07	Zymogenetics, Inc.	Antagonistes du glucagon et procedes s'y rapportant
DE19547317A1 (de) *	1995-12-18	1998-12-24	Dreluso Pharm Dr Elten & Sohn	Antivirales Medikament
US6001882A (en) *	1997-07-03	1999-12-14	The Trustees Of The University Of Pennsylvania	Photoactivated hypericin and the use thereof
IL121440A0 (en)	1997-07-31	1998-01-04	Yeda Res & Dev	The use of 1,3,4,6-tetrahydroxy-helianthrone and its derivatives in photodynamic therapy and certain such novel derivatives
US6238671B1 (en) *	1998-04-22	2001-05-29	Bionorica Arzneimittel Gmbh	Process for the gentle recovery of extract fractions from hypericum, pharmaceutical preparations containing the same and their use
EP1094712A4 (fr) *	1998-07-09	2004-09-08	Cv Technologies Inc	Hypericine et extrait d'hypericum: agents bloquant les canaux de calcium de type c et leur utilisation comme agents therapeutiques diriges contre le canal de calcium de type t
DE19838377C2 (de) *	1998-08-24	2000-10-26	Fiegert Seibt Edda	Verfahren und Vorrichtung zur Extraktherstellung aus pflanzlichem Material
US7195783B2 (en) *	1999-07-09	2007-03-27	Fx Life Sciences International Gmbh	Hypericin and hypericum extract: specific T-type calcium channel blocker, and their use as T-type calcium channel targeted therapeutics
CA2485700A1 (fr) *	2002-05-14	2003-11-20	J-Oil Mills, Inc.	Exhausteur de gout contenant un acide gras polyinsature a longue chaine et/ou un ester de cet acide gras, et composition de graisse vegetale renfermant cet exhausteur de gout
US20070009642A1 (en) *	2003-07-09	2007-01-11	J-Oil Mills, Inc.	Full-bodied taste enhancer containing product of decomposition of long-chain highly unsaturated fatty acid or containing extract therefrom
TWI356681B (en) *	2003-11-12	2012-01-21	J Oil Mills Inc	Body taste improver comprising long-chain highly u
TW200526131A (en) *	2003-11-12	2005-08-16	J Oil Mills Inc	Method of application of body taste enhancer comprising long-chain highly unsaturated fatty acid and/or its ester
JP5023322B2 (ja) *	2006-06-08	2012-09-12	国立大学法人高知大学	縮合多環化合物の製造方法
US20100048728A1 (en) *	2006-08-03	2010-02-25	Hy Biopharma Inc.	Polycyclic dianthraquinones as inhibitors of inflammatory cytokines
EP2477957A4 (fr)	2009-09-15	2013-07-03	Hy Biopharma Inc	Procédés de fabrication de l'hypéricine
CN103274920B (zh) *	2013-06-14	2014-12-17	西北农林科技大学	一种单色光引发高效合成金丝桃素的方法
CN104193610B (zh) *	2014-08-05	2015-12-02	中南大学	金丝桃素的合成方法
US10053413B2 (en) *	2016-03-01	2018-08-21	Soligenix, Inc.	Systems and methods for producing synthetic hypericin
RU2719582C1 (ru) *	2016-03-01	2020-04-21	Солидженикс, Инк.	Системы и способы для получения синтетического гиперицина
CN108997104A (zh) *	2018-09-18	2018-12-14	湖北博瑞生物科技股份有限公司	一种原金丝桃素的合成方法
FR3111640B1 (fr)	2020-06-22	2022-07-22	Total Marketing Services	Composition aqueuse pour la lubrification des systèmes mécaniques
FR3111639B1 (fr)	2020-06-22	2022-08-19	Total Marketing Services	Composition aqueuse pour la lubrification des systèmes mécaniques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1935721A (en) *	1928-12-01	1933-11-21	Gen Aniline Works Inc	Manufacture of nitrogenous compounds derived from perylene quinone
US2707704A (en) *	1951-09-29	1955-05-03	Schenley Ind Inc	Process for the preparation of hypericin
IL92315A (en) *	1989-11-15	1996-12-05	Yeda Res & Dev	Preparation of Hypericin from Amodin Enron

1989
- 1989-11-15 IL IL9231589A patent/IL92315A/en not_active IP Right Cessation
1990
- 1990-11-09 US US07/613,604 patent/US5120412A/en not_active Expired - Lifetime
- 1990-11-14 DK DK90121796.8T patent/DK0432496T3/da active
- 1990-11-14 CA CA002029993A patent/CA2029993C/fr not_active Expired - Lifetime
- 1990-11-14 EP EP90121796A patent/EP0432496B1/fr not_active Expired - Lifetime
- 1990-11-14 AT AT90121796T patent/ATE117978T1/de not_active IP Right Cessation
- 1990-11-14 AU AU66652/90A patent/AU629066B2/en not_active Ceased
- 1990-11-14 ES ES90121796T patent/ES2070244T3/es not_active Expired - Lifetime
- 1990-11-14 DE DE69016620T patent/DE69016620T2/de not_active Expired - Fee Related
- 1990-11-15 JP JP2310109A patent/JP2896224B2/ja not_active Expired - Fee Related
1995
- 1995-04-25 GR GR950401040T patent/GR3015919T3/el unknown

Also Published As

Publication number	Publication date
JPH03220155A (ja)	1991-09-27
CA2029993A1 (fr)	1991-05-16
JP2896224B2 (ja)	1999-05-31
ES2070244T3 (es)	1995-06-01
EP0432496B1 (fr)	1995-02-01
CA2029993C (fr)	2001-01-16
DE69016620T2 (de)	1995-05-24
GR3015919T3 (en)	1995-07-31
IL92315A (en)	1996-12-05
IL92315A0 (en)	1990-07-26
ATE117978T1 (de)	1995-02-15
DE69016620D1 (de)	1995-03-16
US5120412A (en)	1992-06-09
AU629066B2 (en)	1992-09-24
AU6665290A (en)	1991-05-23
EP0432496A3 (en)	1991-10-23
EP0432496A2 (fr)	1991-06-19

Publication	Publication Date	Title
DK0432496T3 (da)	1995-06-26	Fremstilling af hypericin
GB2020000A (en)	1979-11-07	Linear light source
IT1111874B (it)	1986-01-13	Pezzo intermedio con un detettore di luce per un collegamento disimpegnabile ad innesto,impiegato per il collegamento di una fibra per la conduzione di luce con una sorgente di luce a semiconduttore
IL94489A0 (en)	1991-03-10	Chemiluminescent solution based on substituted perylene
DE69224776D1 (de)	1998-04-23	Optisch gepumpte Umwandlungs-Lichtquelle
NO902812D0 (no)	1990-06-25	Fremgangsmaate for omdannelse av lette hydrokarboner til hoeyere hydrokarboner.
IT9019147A0 (it)	1990-01-24	Dispositivo per illuminazione mediante raggi solari
JPS56138973A (en)	1981-10-29	Light emitting diode unit
ES2035621T3 (es)	1993-04-16	Procedimiento de preparacion de fenol.
DE3162637D1 (en)	1984-04-19	Fluorescent composition having the ability to change wavelengths of light, shaped article of said composition as a light wavelength converting element, and device for converting optical energy to electrical energy using said element
JPS54155798A (en)	1979-12-08	Light emitting assembly
GB2025134B (en)	1983-03-02	Light emitting diode
IT7803449A0 (it)	1978-05-24	Lampada a flusso luminoso regolabile
DE3750577D1 (de)	1994-10-27	Mit einer äusseren Beleuchtung illuminierte Anzeigevorrichtung mit Farbänderung.
ES251195Y (es)	1981-09-16	Farola de alumbrado perfeccionada
JPS5275285A (en)	1977-06-24	Light emitting diode assembly
DK0452729T3 (da)	1995-08-21	Fremgangsmåde til fremstilling af substituerede cyclobutaner
ES243464Y (es)	1980-03-01	Una combinacion de aplique de iluminacion.
JPS5693382A (en)	1981-07-28	Light emitting diode
GB1540965A (en)	1979-02-21	Fluorescent plastic light source
JPS52100775A (en)	1977-08-24	Fluorescent lamp
AU525222B2 (en)	1982-10-28	Diels-alder adducts
JPS5431783A (en)	1979-03-08	Indicator with light emitting diode
ES2071731T3 (es)	1995-07-01	Procedimiento para la preparacion de 2-acilamino-9-acil-6-halogeno-purinas.
ES2063303T3 (es)	1995-01-01	Procedimiento para la preparacion de eteres aromaticos.