DK0441765T3 - Nye enzymsubstrater på basis af fedtsyreanaloger - Google Patents

Nye enzymsubstrater på basis af fedtsyreanaloger

Info

Publication number
DK0441765T3
DK0441765T3 DK91870022.0T DK91870022T DK0441765T3 DK 0441765 T3 DK0441765 T3 DK 0441765T3 DK 91870022 T DK91870022 T DK 91870022T DK 0441765 T3 DK0441765 T3 DK 0441765T3
Authority
DK
Denmark
Prior art keywords
fatty acid
enzyme substrates
acid analogues
substrates based
new enzyme
Prior art date
Application number
DK91870022.0T
Other languages
English (en)
Inventor
Steven Paul Adams
Robert Otto Heuckeroth
Jeffrey Ivan Gordon
George William Gokel
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Application granted granted Critical
Publication of DK0441765T3 publication Critical patent/DK0441765T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/11Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/12Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/006General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DK91870022.0T 1990-02-09 1991-02-08 Nye enzymsubstrater på basis af fedtsyreanaloger DK0441765T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/478,298 US5082967A (en) 1988-06-16 1990-02-09 Novel fatty acid analog enzyme substrates

Publications (1)

Publication Number Publication Date
DK0441765T3 true DK0441765T3 (da) 1994-06-13

Family

ID=23899339

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91870022.0T DK0441765T3 (da) 1990-02-09 1991-02-08 Nye enzymsubstrater på basis af fedtsyreanaloger

Country Status (8)

Country Link
US (1) US5082967A (da)
EP (1) EP0441765B1 (da)
JP (1) JPH05271181A (da)
AT (1) ATE105544T1 (da)
CA (1) CA2036027A1 (da)
DE (1) DE69101934T2 (da)
DK (1) DK0441765T3 (da)
ES (1) ES2054480T3 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0445097T3 (da) * 1990-02-26 1996-09-16 Univ Washington Fremgangsmåde til N-myristoylering af protein
ES2088480T3 (es) * 1990-10-12 1996-08-16 Univ Washington Sustratos de enzimas analogos de acidos grasos sustituidos con azido.
EP0618927A4 (en) * 1991-12-10 1995-05-24 Tanox Biosystems Inc CYTOKINE WITH AN UNPAIRED CYSTEIN REST AND CONJUGATES OF IT.
US5236955A (en) * 1992-04-10 1993-08-17 Washington University Anti-fungal agent
US6602861B1 (en) * 1992-04-16 2003-08-05 Research Corporation Technologies, Inc. Acylated phospholipid drugs
US5599947A (en) * 1993-01-14 1997-02-04 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
US6410775B1 (en) * 1995-06-07 2002-06-25 La Jolla Pharmaceutical Company APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies
WO2000037464A2 (en) 1998-12-18 2000-06-29 Basilea Pharmaceutica Ag 4-(aminoalkoxy)benzofurans as n-myristoyltransferase inhibitors
US11021430B2 (en) 2016-04-05 2021-06-01 Moresco Corporation Oxa acid compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3654326A (en) * 1970-07-22 1972-04-04 Hoffmann La Roche 5 9-dioxodecanoic acids and methods for their preparation
DE3135946A1 (de) * 1981-09-10 1983-03-24 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von alkoxyessigsaeuren
DE3230677A1 (de) * 1982-08-18 1984-02-23 Chemische Werke Hüls AG, 4370 Marl Verfahren zur herstellung von carboxymethylierten alkoholen, etheralkoholen, thioalkoholen oder alkylphenolen
US4778877A (en) * 1986-08-07 1988-10-18 Washington University Novel inhibitor peptides II
US4740588A (en) * 1986-08-07 1988-04-26 Washington University Novel substrate peptides
US4778878A (en) * 1986-08-07 1988-10-18 Washington University Novel inhibitor peptides I
TR23339A (tr) * 1987-06-15 1989-12-14 Henkel Kgaa Alkoksillendirme icin katalizoer,olarak eter karbonik asitlerinin toprak alkalisi tozlarinin kullanilmasi
DE3728600A1 (de) * 1987-08-27 1989-03-09 Hoechst Ag Verfahren zur markierung von substanzen mit technetium oder rhenium
DE68901781T2 (de) * 1988-02-03 1993-01-07 Univ Washington Enzymsubstrate auf der basis neuer fettsaeureanaloge.

Also Published As

Publication number Publication date
EP0441765B1 (en) 1994-05-11
CA2036027A1 (en) 1991-08-10
EP0441765A1 (en) 1991-08-14
ATE105544T1 (de) 1994-05-15
ES2054480T3 (es) 1994-08-01
DE69101934T2 (de) 1994-12-08
US5082967A (en) 1992-01-21
DE69101934D1 (de) 1994-06-16
JPH05271181A (ja) 1993-10-19

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