ES2088480T3 - Sustratos de enzimas analogos de acidos grasos sustituidos con azido. - Google Patents

Sustratos de enzimas analogos de acidos grasos sustituidos con azido.

Info

Publication number
ES2088480T3
ES2088480T3 ES91870159T ES91870159T ES2088480T3 ES 2088480 T3 ES2088480 T3 ES 2088480T3 ES 91870159 T ES91870159 T ES 91870159T ES 91870159 T ES91870159 T ES 91870159T ES 2088480 T3 ES2088480 T3 ES 2088480T3
Authority
ES
Spain
Prior art keywords
azido
analogs
sub
suzyzes
enzymes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91870159T
Other languages
English (en)
Inventor
Steven Paul Adams
Balekudru Devadas
Jeffrey Ivan Gordon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St. Louis
Original Assignee
University of Washington
Washington University in St. Louis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St. Louis filed Critical University of Washington
Application granted granted Critical
Publication of ES2088480T3 publication Critical patent/ES2088480T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/12—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE DESCRIBEN ANALOGOS DE ACIDO GRASO AZIDO-SUSTITUIDO QUE SON UTILES EN LA ACILACION DE ACIDO GRASO DE PEPTIDOS Y PROTEINAS Y COMO AGENTES ANTIVIRICOS QUE TIENEN LA SIGUIENTE ESTRUCTURA QUIMICA: Z-(CH SUB 2) SUB X COOR DONDE Z= AZIDO, TETRAZOLILO O TRIAZOLILO R= H O ALQUILO C SUB 1-C SUB 8, Y X= 8-12 O ESTRUCTURA (1) COMO SE DEFINE ANTERIORMENTE Y DONDE UN GRUPO METILENO DE LA POSICION DE CARBONO 3 A DENTRO DE 2 CARBONOS DE Z SE REEMPLAZA CON OXIGENO O AZUFRE.
ES91870159T 1990-10-12 1991-10-09 Sustratos de enzimas analogos de acidos grasos sustituidos con azido. Expired - Lifetime ES2088480T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59618390A 1990-10-12 1990-10-12

Publications (1)

Publication Number Publication Date
ES2088480T3 true ES2088480T3 (es) 1996-08-16

Family

ID=24386292

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91870159T Expired - Lifetime ES2088480T3 (es) 1990-10-12 1991-10-09 Sustratos de enzimas analogos de acidos grasos sustituidos con azido.

Country Status (9)

Country Link
US (2) US5338858A (es)
EP (1) EP0480901B1 (es)
JP (1) JPH0517423A (es)
AT (1) ATE139524T1 (es)
CA (1) CA2053366A1 (es)
DE (1) DE69120368T2 (es)
DK (1) DK0480901T3 (es)
ES (1) ES2088480T3 (es)
GR (1) GR3021022T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5859052A (en) * 1993-01-14 1999-01-12 G. D. Searle & Co. Fatty acid analogs and prodrugs
US5599947A (en) * 1993-01-14 1997-02-04 G. D. Searle & Co. Fatty acid analogs and prodrugs
FR2739860B1 (fr) * 1995-10-17 1998-01-02 Coletica Complexes amphiphiles, procede pour leur preparation et compositions en renfermant
EP1220669A4 (en) * 1999-10-13 2004-12-08 Marco A Chacon THERAPEUTIC MEASURE TO IMPROVE THE EFFECT OF A CALORY RESTRICTION
SG175430A1 (en) * 2009-05-04 2011-12-29 Univ Washington Pet radiotracers for imaging fatty acid metablolism and storage
US20120028335A1 (en) * 2010-07-28 2012-02-02 Life Technologies Corporation Anti-viral azide-containing compounds
US20130209550A1 (en) 2010-07-28 2013-08-15 Life Technologies Corporation Anti-Viral Azide Containing Compounds
WO2019222414A1 (en) * 2018-05-16 2019-11-21 Belite Bio, Llc Fatty acid analogues and methods of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3864364A (en) * 1972-11-30 1975-02-04 Zoecon Corp Azides
JPS5536447A (en) * 1978-09-07 1980-03-14 Otsuka Pharmaceut Co Ltd Butyramide derivative
US4340728A (en) * 1979-11-28 1982-07-20 Fuji Kagaku Kogyo Kabushiki Kaisha Nucleoside derivatives and process for preparing same
DE3365945D1 (en) * 1982-03-20 1986-10-16 Dynamit Nobel Ag Process for preparing 5-chloro-1h-tetrazolo-1-carboxylic-acid esters, and a process for preparing the appropriate dichloroisonitrile-carboxylic-acid esters
US4496577A (en) * 1983-10-05 1985-01-29 Syntex (U.S.A.) Inc. Imidazolidinone prostaglandins, compositions and use
EP0275233A1 (de) * 1987-01-14 1988-07-20 Ciba-Geigy Ag 2-Heterocyclylalkyl-2-penem-Verbindungen
DE68901781T2 (de) * 1988-02-03 1993-01-07 Univ Washington Enzymsubstrate auf der basis neuer fettsaeureanaloge.
US5082967A (en) * 1988-06-16 1992-01-21 Washington University Novel fatty acid analog enzyme substrates

Also Published As

Publication number Publication date
DE69120368D1 (de) 1996-07-25
CA2053366A1 (en) 1992-04-13
DK0480901T3 (da) 1996-08-05
GR3021022T3 (en) 1996-12-31
EP0480901A1 (en) 1992-04-15
US5397701A (en) 1995-03-14
US5338858A (en) 1994-08-16
DE69120368T2 (de) 1996-11-28
EP0480901B1 (en) 1996-06-19
JPH0517423A (ja) 1993-01-26
ATE139524T1 (de) 1996-07-15

Similar Documents

Publication Publication Date Title
DK0658097T3 (da) Deodoriserende kosmetiske midler med et indhold af fedtsyrer
DE59508802D1 (de) Duschöl
DE59407475D1 (de) Lipopeptide aus Actinoplanes sp. mit pharmakologischer Wirkung, Verfahren zu ihrer Herstellung und Verwendung derselben
FR2547829B1 (fr) Compositions contenant des composes d'acides gras insatures et procede de stabilisation de tels composes
DE69331721D1 (de) Neue carbamazepin hapten Analoge
ES8706622A1 (es) Procedimiento para preparar alfa-aminoacidos sustituidos
ATE73458T1 (de) Verfahren zum extrahieren von protein mittels organischer saeure.
EA199800280A1 (ru) Новые производные 5-0-дезозаминил-6-0-метилэритронолида а, способ их получения и их использование при получении биологически активных продуктов
ATE139524T1 (de) Azido-substituierte fettsäuren als enzymsubstratanaloge
ES2054480T3 (es) Nuevos sustratos de enzimas, analogos de acidos grasos.
ES449939A1 (es) Procedimiento para preparar sulfuro de difenilo sustituido.
ATE86854T1 (de) Sauerstoff- oder schwefelsubstituierte fettsaeureanaloga zur behandlung retroviraler infektionen.
ATE204252T1 (de) Verfahren zur herstellung von fettsäurepolyethylenglycolestern
DE69207487D1 (de) Zitronensäureester enthaltendes Haarwuchsmittel
DK314289A (da) Kompositioner
BR9203170A (pt) Processo para obter uma seletividade de deslignificacao melhorada da polpa durante uma deslignificacao com oxigenio de elevada consistencia
AU563426B2 (en) 3-alkoxy-2(n-pyrrolidino)-n-pyridyl-n-furyl (or thienyl) methyl propylamines
KR850000468A (ko) 사이클릭 펩타이드의 제조방법
SE8200757L (sv) Biologiskt aktiva peptider
FR2443460A1 (fr) Derives mercaptoacyles d'acides 4,5-dihydro-1h-pyrrole-2-carboxyliques et d'acides 1,4,5,6-tetrahydropyridine-2-carboxyliques, utiles comme agents hypotenseurs
IT1228934B (it) Derivati dell'acido 7-ossabiciclo (2.2.1.) eptan idrossammico utili come inibitori duplici
BR8801522A (pt) Processo para preparar um ester de acido 1 terc-alquil-5-ciano-1h-pirazol-4-carboxilico
ES8407039A1 (es) Un procedimiento para preparacion de una quinalozina.
KR890700673A (ko) 돼지 성장호르몬 아날로그
HU913953D0 (en) Plant protecting compositions containing salicylaldehyde and salicylic acid derivatives as well as their sulphuric analogues and method for producing active substances

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 480901

Country of ref document: ES