DK0443996T3 - Estere af (R)(-)-carnitin og acyl (R)(-)-carnitiner med beta-hydroxysmørsyre og farmaceutiske præparater indeholdende disse til inhibering af neurondegeneration og leverproteolyse samt til behandling af coma - Google Patents

Estere af (R)(-)-carnitin og acyl (R)(-)-carnitiner med beta-hydroxysmørsyre og farmaceutiske præparater indeholdende disse til inhibering af neurondegeneration og leverproteolyse samt til behandling af coma

Info

Publication number: DK0443996T3
Authority: DK; Denmark
Prior art keywords: acid; carnitines; carnitine; coma; beta
Prior art date: 1990-02-23

Application number

DK91830062.5T

Other languages

Danish (da)

English (en)

Inventor

Domenico Misiti

Maria Ornella Tinti

Nazareno Scafetta

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-23

Filing date

1991-02-21

Publication date

1994-07-25

1991-02-21 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1994-07-25 Application granted granted Critical

1994-07-25 Publication of DK0443996T3 publication Critical patent/DK0443996T3/da

Links

-1 acyl (R) (-) - carnitines Chemical class 0.000 title abstract 5
PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 2
206010010071 Coma Diseases 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
210000004185 liver Anatomy 0.000 title abstract 2
230000004770 neurodegeneration Effects 0.000 title abstract 2
230000017854 proteolysis Effects 0.000 title abstract 2
WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 title 2
230000005764 inhibitory process Effects 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
239000002253 acid Substances 0.000 abstract 8
150000003839 salts Chemical class 0.000 abstract 3
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 1
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 abstract 1
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
206010039966 Senile dementia Diseases 0.000 abstract 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
229940009098 aspartate Drugs 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK91830062.5T 1990-02-23 1991-02-21 Estere af (R)(-)-carnitin og acyl (R)(-)-carnitiner med beta-hydroxysmørsyre og farmaceutiske præparater indeholdende disse til inhibering af neurondegeneration og leverproteolyse samt til behandling af coma DK0443996T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT47669A IT1240775B (it)	1990-02-23	1990-02-23	Esteri della l-carnitina e di acil-l-carnitine con l'acido beta-idrossibutirrico e composizioni farmaceutiche che li contengono per la inibizione della degenerazione neuronale, della proteolisi epatica e nel trattamento del coma.

Publications (1)

Publication Number	Publication Date
DK0443996T3 true DK0443996T3 (da)	1994-07-25

Family

ID=11261785

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91830062.5T DK0443996T3 (da)	1990-02-23	1991-02-21	Estere af (R)(-)-carnitin og acyl (R)(-)-carnitiner med beta-hydroxysmørsyre og farmaceutiske præparater indeholdende disse til inhibering af neurondegeneration og leverproteolyse samt til behandling af coma

Country Status (8)

Country	Link
EP (1)	EP0443996B1 (fr)
JP (1)	JP2930755B2 (fr)
AT (1)	ATE107624T1 (fr)
DE (1)	DE69102560T2 (fr)
DK (1)	DK0443996T3 (fr)
ES (1)	ES2056620T3 (fr)
HK (1)	HK1005868A1 (fr)
IT (1)	IT1240775B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1248321B (it) *	1991-05-15	1995-01-05	Sigma Tau Ind Farmaceuti	Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
IT1254136B (it) *	1992-01-16	1995-09-08	Sigma Tau Ind Farmaceuti	Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.
IT1254135B (it) *	1992-01-16	1995-09-08	Sigma Tau Ind Farmaceuti	Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antibatterica.
IT1263013B (it) *	1992-10-20	1996-07-23	Avantgarde Spa	Esteri della l-carnitina e di alcanoil l-carnitine con l'acido glicolico o suoi esteri e composizioni farmaceutiche contenenti tali per il trattamento di affezioni cutanee.
IT1261984B (it) *	1993-06-22	1996-06-11	Avantgarde Spa	Uso di esteri della l-carnitina o di acil l- carnitine con idrossiacidi per produrre composizioni farmaceutiche per il trattamento di affezioni cutanee.
US6323237B1 (en)	1997-03-17	2001-11-27	Btg International Limited	Therapeutic compositions
CN1315473C (zh) *	1997-03-17	2007-05-16	英国技术集团国际有限公司	治疗组合物
US6835750B1 (en)	2000-05-01	2004-12-28	Accera, Inc.	Use of medium chain triglycerides for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism II
US8124589B2 (en)	2000-05-01	2012-02-28	Accera, Inc.	Use of ketogenic compounds for treatment of age-associated memory impairment
ES2752800T3 (es) *	2000-05-01	2020-04-06	Cerecin Inc	Uso de triglicéridos de cadena media para el tratamiento y la prevención de la enfermedad del Parkinson resultante de un metabolismo neuronal reducido
CN1995010B (zh) *	2006-12-29	2012-12-12	辽宁科硕营养科技有限公司	一种合成丙酰左旋肉碱盐酸盐的方法
EP2179284B1 (fr)	2007-07-31	2016-09-28	Accera, Inc.	Utilisation d'essais génomiques et de composés cétogéniques pour le traitement d'une fonction cognitive réduite
US9125881B2 (en)	2008-07-03	2015-09-08	Accera, Inc.	Monoglyceride of acetoacetate and derivatives for the treatment of neurological disorders
CN112341331B (zh) *	2019-08-07	2023-04-07	辽宁科硕营养科技股份有限公司	一种3-羟基丁酸盐及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1116037B (it) *	1979-04-23	1986-02-10	Sigma Tau Ind Farmaceuti	Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1145362B (it) *	1980-03-06	1986-11-05	Sigma Tau Ind Farmaceuti	Classe di acil-derivati della carnitina procedimento per la loro preparazione e loro uso terapeutico
IT1209564B (it) *	1984-06-29	1989-08-30	Magis Farmaceutici	Derivati della l-carnitina o di l-acil carnitina.

1990
- 1990-02-23 IT IT47669A patent/IT1240775B/it active IP Right Grant
1991
- 1991-02-21 AT AT91830062T patent/ATE107624T1/de not_active IP Right Cessation
- 1991-02-21 DK DK91830062.5T patent/DK0443996T3/da active
- 1991-02-21 ES ES91830062T patent/ES2056620T3/es not_active Expired - Lifetime
- 1991-02-21 EP EP91830062A patent/EP0443996B1/fr not_active Expired - Lifetime
- 1991-02-21 DE DE69102560T patent/DE69102560T2/de not_active Expired - Fee Related
- 1991-02-22 JP JP3050644A patent/JP2930755B2/ja not_active Expired - Fee Related
1998
- 1998-06-05 HK HK98104950A patent/HK1005868A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
IT1240775B (it)	1993-12-17
DE69102560T2 (de)	1994-10-13
ATE107624T1 (de)	1994-07-15
EP0443996B1 (fr)	1994-06-22
IT9047669A1 (it)	1991-08-24
JPH0597785A (ja)	1993-04-20
JP2930755B2 (ja)	1999-08-03
HK1005868A1 (en)	1999-01-29
IT9047669A0 (it)	1990-02-23
DE69102560D1 (de)	1994-07-28
EP0443996A1 (fr)	1991-08-28
ES2056620T3 (es)	1994-10-01

Publication	Publication Date	Title
DK0442850T3 (da)	1994-09-05	Estere af acyl L-carnitiner med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende disse til hæmning af neurondegeneration og til behandling af coma
ATE107624T1 (de)	1994-07-15	Ester von (r)(-)-carnitin und acyl (r)(-)- carnitin mit beta-hydroxybuttersäure und diese enthaltende pharmazeutische zusammensetzungen zur inhibierung von neuronaler degeneration, leberproteolyse und zur behandlung von koma.
DK0429403T3 (da)	1994-08-01	Ester af L-carnitin med gamma-hydroxysmørsyre samt farmaceutiske præparater indeholdende denne til inhibering af neurondegeneration og til behandling af coma
CA1252098A (fr)	1989-04-04	Sels de l-carnitine et d'alkanoyl l-carnitines et procede de preparation
ES2345100T3 (es)	2010-09-15	Compuestos que tienen actividad inhibidora reversible de carnitina palmitoiltransferasa.
HUT61001A (en)	1992-11-30	Process for producing phenylpyrazolidinone derivatives and pharmaceutical compositions comprising such compounds
JPS6425777A (en)	1989-01-27	Organic salt of physostigmine
DK0514359T3 (da)	1995-11-13	Alkanoyl-L-carnitin-amider med aminosyrer og farmaceutiske præparater indeholdende disse til fremme af regeneration af nervevæv, inhibering af neuronal degeneration, forøgelse af indlærings- og hukommelsesprocesserne og behandling af coma
HK1005848A1 (en)	1999-01-29	Use of esters of acyl l-carnitines with gamma-hydroxybutyric acid for producing pharmaceutical compositions for the treatment of hepatopathies
HU9600621D0 (en)	1996-05-28	Imidazolidinone derivative, acid-addition salt thereof, and remedy for senile dementia
HUT49328A (en)	1989-09-28	Process for producing 1,2,5,6-tetrahydropyridin-3-carboxaldehyd-oxime derivatives and pharmaceutical compositions containing them as active components
KR940006576A (ko)	1994-04-25	에이즈 및 에이즈 관련 증후군 환자 및 무증후성 hiv혈청양성 환자치료를 위한 l-카르니틴 및 아실 l-카르니틴의 용도
HU895648D0 (en)	1990-01-28	Process for the preparation of n,n-disubstituted diaryl-alkancarboxylic acid amide derivatives and pharmaceutical compositions containing such compounds
EP1853556A1 (fr)	2007-11-14	Derives de l acide aminobutanoique inhibant la cpt
DE69410866D1 (de)	1998-07-16	Verwendung von Ester von Acyl-L-Carnitin mit Gammahydroxybuttersäure zur Behandlung von Alkoholismus