DK0446315T3 - Fremgangsmåde til fremstilling af PAI-2 - Google Patents

Fremgangsmåde til fremstilling af PAI-2

Info

Publication number: DK0446315T3
Authority: DK; Denmark
Prior art keywords: pct; pai; date; sec; compositions
Prior art date: 1989-09-05

Application number

DK90912919.9T

Other languages

English (en)

Inventor

Peter Lawrence Whitfeld

Michael Andrew Richardson

Clive Leighton Bunn

Original Assignee

Biotech Australia Pty Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-09-05

Filing date

1990-09-04

Publication date

1998-01-05

1990-09-04 Application filed by Biotech Australia Pty Ltd filed Critical Biotech Australia Pty Ltd

1998-01-05 Application granted granted Critical

1998-01-05 Publication of DK0446315T3 publication Critical patent/DK0446315T3/da

Links

102000004179 Plasminogen Activator Inhibitor 2 Human genes 0.000 title abstract 4
108090000614 Plasminogen Activator Inhibitor 2 Proteins 0.000 title abstract 4
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
108010076504 Protein Sorting Signals Proteins 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
210000003527 eukaryotic cell Anatomy 0.000 abstract 1
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
238000011321 prophylaxis Methods 0.000 abstract 1
238000011282 treatment Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
- C07K14/8132—Plasminogen activator inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/91—Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biochemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Oncology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Food Preservation Except Freezing, Refrigeration, And Drying (AREA)

DK90912919.9T 1989-09-05 1990-09-04 Fremgangsmåde til fremstilling af PAI-2 DK0446315T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AUPJ617989		1989-09-05

Publications (1)

Publication Number	Publication Date
DK0446315T3 true DK0446315T3 (da)	1998-01-05

Family

ID=3774166

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90912919.9T DK0446315T3 (da)	1989-09-05	1990-09-04	Fremgangsmåde til fremstilling af PAI-2

Country Status (11)

Country	Link
US (1)	US5298400A (da)
EP (1)	EP0446315B1 (da)
JP (1)	JPH04502108A (da)
KR (1)	KR920701436A (da)
AT (1)	ATE154362T1 (da)
CA (1)	CA2041638C (da)
DE (1)	DE69030920T2 (da)
DK (1)	DK0446315T3 (da)
ES (1)	ES2104610T3 (da)
NZ (1)	NZ235182A (da)
WO (1)	WO1991003556A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1991009124A1 (en) *	1989-12-20	1991-06-27	Biotech Australia Pty. Limited	Variants of pai-2
GB9026737D0 (en) *	1990-12-08	1991-01-30	Delta Biotechnology Ltd	Cancer treatment
AU2299592A (en) *	1991-07-02	1993-02-11	Children's Medical Center Corporation	Treatment of periodontal disease with protease inhibitors
JPH09511220A (ja) *	1993-11-10	1997-11-11	ブリストル‐マイヤーズスクイブカンパニー	バクテリアによって誘発される炎症性疾患の治療
US6458574B1 (en) *	1996-09-12	2002-10-01	Transkaryotic Therapies, Inc.	Treatment of a α-galactosidase a deficiency
US6083725A (en) *	1996-09-13	2000-07-04	Transkaryotic Therapies, Inc.	Tranfected human cells expressing human α-galactosidase A protein
JP2002526382A (ja) *	1998-04-01	2002-08-20	バイオテック・オーストラリア・ピーティーワイ・リミテッド	皮膚創傷の治療へのプロテアーゼ阻害剤の使用
AUPP508798A0 (en)	1998-08-05	1998-08-27	Biotech Australia Pty Limited	Method of treating psoriasis
AUPQ380699A0 (en) *	1999-11-02	1999-11-25	Biotech Australia Pty Limited	Protease inhibitors as modulators of periodontal wound healing
US7325244B2 (en) *	2001-09-20	2008-01-29	Keen Personal Media, Inc.	Displaying a program guide responsive to electronic program guide data and program recording indicators
ES2367257T3 (es)	2002-04-25	2011-10-31	Shire Human Genetic Therapies, Inc.	Tratamiento de deficit de alfa-galactosidasa a.
EP1587923B1 (en)	2003-01-22	2011-08-24	Duke University	Improved constructs for expressing lysosomal polypeptides
TW201629215A (zh) *	2014-09-30	2016-08-16	拜耳保健有限責任公司	使用凝血酶之組成物及治療方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4546082A (en) *	1982-06-17	1985-10-08	Regents Of The Univ. Of California	E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
GB2142078B (en) *	1983-06-23	1986-10-01	Wilmot Breeden Ltd	Electrically-operated vehicle door latch
US4923807A (en) *	1984-05-18	1990-05-08	New England Medical Center Hospitals Inc.	Arg-Serpin human plasminogen activator inhibitor designated PAI-2
GB8517386D0 (en) *	1985-07-09	1985-08-14	Thompson J	Karate protection mit
IL81879A (en) *	1986-03-13	1994-07-31	Biotech Australia Pty Ltd	Purification of minactivin for homogeneity, production of minactivin as recombinant techniques, and uses of homogeneous or recombinant minactivin
AU608752B2 (en) *	1986-03-13	1991-04-18	Australian National University, The	Minactivin produced by recombinant dna technology
CA1331355C (en) *	1986-04-21	1994-08-09	Bioenterprises Pty. Ltd	Immunopotentation
FR2611723B1 (fr) *	1987-02-27	1989-09-08	Transgene Sa	Vecteur d'expression d'adn recombinant codant pour l'hirudine, cultures de cellules de mammiferes infectees ou transformees, procede de preparation de l'hirudine et proteine obtenue
JP2564536B2 (ja) *	1987-03-23	1996-12-18	株式会社蛋白工学研究所	改良されたタンパク質分泌促進能を有するシグナルペプチドをコ−ドしているｄｎａ配列
DE3713272A1 (de) *	1987-04-18	1988-11-03	Behringwerke Ag	Plasminogenaktivator-inhibitor, typ 2 (pai-2)
DE3722673A1 (de) *	1987-04-18	1989-01-19	Behringwerke Ag	Fuer plasminogenaktivator-inhibitor, typ 2 (pai-2) codierende dna

1990
- 1990-09-04 WO PCT/AU1990/000396 patent/WO1991003556A1/en not_active Ceased
- 1990-09-04 ES ES90912919T patent/ES2104610T3/es not_active Expired - Lifetime
- 1990-09-04 EP EP90912919A patent/EP0446315B1/en not_active Expired - Lifetime
- 1990-09-04 DK DK90912919.9T patent/DK0446315T3/da not_active Application Discontinuation
- 1990-09-04 DE DE69030920T patent/DE69030920T2/de not_active Expired - Fee Related
- 1990-09-04 JP JP2511956A patent/JPH04502108A/ja active Pending
- 1990-09-04 KR KR1019910700435A patent/KR920701436A/ko not_active Ceased
- 1990-09-04 AT AT90912919T patent/ATE154362T1/de not_active IP Right Cessation
- 1990-09-04 CA CA002041638A patent/CA2041638C/en not_active Expired - Fee Related
- 1990-09-04 US US07/679,052 patent/US5298400A/en not_active Expired - Lifetime
- 1990-09-05 NZ NZ235182A patent/NZ235182A/xx unknown

Also Published As

Publication number	Publication date
ES2104610T3 (es)	1997-10-16
EP0446315A1 (en)	1991-09-18
WO1991003556A1 (en)	1991-03-21
DE69030920T2 (de)	1998-02-19
EP0446315B1 (en)	1997-06-11
AU629980B2 (en)	1992-10-15
DE69030920D1 (de)	1997-07-17
ATE154362T1 (de)	1997-06-15
KR920701436A (ko)	1992-08-11
NZ235182A (en)	1993-01-27
US5298400A (en)	1994-03-29
CA2041638A1 (en)	1991-03-06
CA2041638C (en)	2001-05-15
JPH04502108A (ja)	1992-04-16
EP0446315A4 (en)	1992-08-05
AU6283190A (en)	1991-04-08

Legal Events

Date	Code	Title	Description
1996-08-19	AHB	Application shelved due to non-payment

Publication	Publication Date	Title
Balian et al.	1979	Isolation of a collagen-binding fragment from fibronectin and cold-insoluble globulin.
ATE146219T1 (de)	1996-12-15	Polypeptid
DE69027989D1 (de)	1996-09-05	Il-3 MIT ZUSÄTZLICHEN CYSTEINRESTEN UND CHEMISCHE MODIFIKATIONEN DAVON
DK0446315T3 (da)	1998-01-05	Fremgangsmåde til fremstilling af PAI-2
ATE80660T1 (de)	1992-10-15	Verfahren zur herstellung eines polypeptides.
ES2054365T3 (es)	1994-08-01	Inhibicion de la via de la regla del n final en celulas vivas.
KR960704934A (ko)	1996-10-09	항혈전활성을 갖는 펩티드 및 이의 제조방법(Peptide having antithrombotic activity and process for producing the same)
Dixit	1979	Isolation and characterization of two α chain size collagenous polypeptide chains c and d from glomerular basement membrane
YU218690A (sh)	1993-05-28	Postupak za pripremanje protein kompleksa u kojima deluje faktor viii:c
EP0458937A4 (en)	1992-04-01	Variants of pai-2
DE69233245D1 (de)	2003-12-11	Verfahren zur Herstellung von Peptiden
Elstow et al.	1983	Extraction, isolation and characterization of neutral salt soluble type V collagen from fetal calf skin
EP0330700A4 (en)	1990-01-08	Human prourokinase-like polypeptide.
BR9303903A (pt)	1994-06-14	Fator-4 de plaqueta modificado ou clivado e processo para sua preparaçao, formulaçao farmacêutica, composto e vetor de dna recombinante e célula hospedeira
ES2033212A6 (es)	1994-05-01	Procedimiento para la obtencion de peptidos puramente glicosilados, parcialmente glicosilados o no glicosilados.