DK0447324T3 - 2,4-pyrimidindionderivater og lægemidler indeholdende disse - Google Patents

2,4-pyrimidindionderivater og lægemidler indeholdende disse

Info

Publication number: DK0447324T3
Authority: DK; Denmark
Prior art keywords: drugs containing; denotes; pyrimidinedione derivatives; alkyl group; derivatives
Prior art date: 1990-03-15

Application number

DK91400699.4T

Other languages

Danish (da)

English (en)

Inventor

Fur Gerard Le

Laurent Fraisse

Jean-Baptiste Verlhac

Original Assignee

Elf Aquitaine

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-15

Filing date

1991-03-14

Publication date

1996-04-29

1991-03-14 Application filed by Elf Aquitaine, Sanofi Sa filed Critical Elf Aquitaine

1996-04-29 Application granted granted Critical

1996-04-29 Publication of DK0447324T3 publication Critical patent/DK0447324T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Biochemistry (AREA)
Ophthalmology & Optometry (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK91400699.4T 1990-03-15 1991-03-14 2,4-pyrimidindionderivater og lægemidler indeholdende disse DK0447324T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR909003342A FR2659656B1 (fr)	1990-03-15	1990-03-15	Derives de pyrimidinedione-2,4 et medicaments les contenant.

Publications (1)

Publication Number	Publication Date
DK0447324T3 true DK0447324T3 (da)	1996-04-29

Family

ID=9394780

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91400699.4T DK0447324T3 (da)	1990-03-15	1991-03-14	2,4-pyrimidindionderivater og lægemidler indeholdende disse

Country Status (11)

Country	Link
EP (1)	EP0447324B1 (de)
JP (1)	JP2983669B2 (de)
AT (1)	ATE131817T1 (de)
CA (1)	CA2038198A1 (de)
DE (1)	DE69115526T2 (de)
DK (1)	DK0447324T3 (de)
ES (1)	ES2081446T3 (de)
FR (1)	FR2659656B1 (de)
GR (1)	GR3019123T3 (de)
IE (1)	IE71192B1 (de)
PT (1)	PT97035B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU214331B (hu) *	1992-06-17	1998-03-02	Gyógyszerkutató Intézet Kft.	Eljárás piperazin- és homopiperazinszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
EP0748316B1 (de) *	1994-02-28	2002-05-08	Sunkyong Industries Co., Ltd.	Pyrimidin-acyclonukleosid-derivate
JP3497554B2 (ja) *	1994-03-25	2004-02-16	日本臓器製薬株式会社	新規プリン誘導体及びその薬学的に許容される塩
DE19702785A1 (de) *	1997-01-27	1998-07-30	Bayer Ag	Neue cyclische Harnstoffderivate
US6417180B1 (en) *	1998-10-07	2002-07-09	University Of Massachusetts	Zinc finger-reactive antimicrobial compounds
SE9903544D0 (sv)	1999-10-01	1999-10-01	Astra Pharma Prod	Novel compounds
GB2359078A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
GB2359081A (en)	2000-02-11	2001-08-15	Astrazeneca Uk Ltd	Pharmaceutically active thiazolopyrimidines
GB2359551A (en) *	2000-02-23	2001-08-29	Astrazeneca Uk Ltd	Pharmaceutically active pyrimidine derivatives
SE0003828D0 (sv)	2000-10-20	2000-10-20	Astrazeneca Ab	Novel compounds
SE0101322D0 (sv)	2001-04-12	2001-04-12	Astrazeneca Ab	Novel compounds
GB0221828D0 (en)	2002-09-20	2002-10-30	Astrazeneca Ab	Novel compound
GB0328243D0 (en)	2003-12-05	2004-01-07	Astrazeneca Ab	Methods
WO2008024893A2 (en) *	2006-08-23	2008-02-28	Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services	Derivatives of uric and thiouric acid for oxidative stress-related diseases
US9199945B2 (en) *	2013-06-21	2015-12-01	MyoKardia, Inc.	Cycloalkyl-substituted pyrimidinedione compounds
SMT202000071T1 (it)	2013-06-21	2020-03-13	Myokardia Inc	Composti di pirimidinadione contro le condizioni cardiache
CN108912121A (zh) *	2018-08-08	2018-11-30	南京纽邦生物科技有限公司	三种甲基尿酸类化合物的制备方法、中间体及中间体的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2781344A (en) *	1953-05-04	1957-02-12	Monsanto Chemicals	Formylation of amino-pyrimidines
DE2329399A1 (de) *	1973-06-08	1975-01-02	Wuelfing J A Fa	4-alkyl-aminouracile, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
US4452788A (en) *	1982-04-21	1984-06-05	Warner-Lambert Company	Substituted 8-phenylxanthines
FR2531085A1 (fr) *	1982-07-28	1984-02-03	Adir	Nouveaux derives de la xanthine, leur procede de preparation et les compositions pharmaceutiques les renfermant

1990
- 1990-03-15 FR FR909003342A patent/FR2659656B1/fr not_active Expired - Fee Related
1991
- 1991-03-13 CA CA002038198A patent/CA2038198A1/en not_active Abandoned
- 1991-03-14 JP JP3049912A patent/JP2983669B2/ja not_active Expired - Lifetime
- 1991-03-14 EP EP91400699A patent/EP0447324B1/de not_active Expired - Lifetime
- 1991-03-14 DK DK91400699.4T patent/DK0447324T3/da active
- 1991-03-14 AT AT91400699T patent/ATE131817T1/de not_active IP Right Cessation
- 1991-03-14 IE IE85391A patent/IE71192B1/en not_active IP Right Cessation
- 1991-03-14 DE DE69115526T patent/DE69115526T2/de not_active Expired - Fee Related
- 1991-03-14 PT PT97035A patent/PT97035B/pt not_active IP Right Cessation
- 1991-03-14 ES ES91400699T patent/ES2081446T3/es not_active Expired - Lifetime
1996
- 1996-02-28 GR GR960400547T patent/GR3019123T3/el unknown

Also Published As

Publication number	Publication date
PT97035A (pt)	1991-10-31
ATE131817T1 (de)	1996-01-15
JPH04217672A (ja)	1992-08-07
CA2038198A1 (en)	1991-09-16
FR2659656B1 (fr)	1994-09-09
DE69115526D1 (de)	1996-02-01
EP0447324B1 (de)	1995-12-20
IE910853A1 (en)	1991-09-25
FR2659656A1 (fr)	1991-09-20
PT97035B (pt)	1998-07-31
JP2983669B2 (ja)	1999-11-29
EP0447324A1 (de)	1991-09-18
GR3019123T3 (en)	1996-05-31
DE69115526T2 (de)	1996-06-05
ES2081446T3 (es)	1996-03-16
IE71192B1 (en)	1997-02-12

Publication	Publication Date	Title
GR3019123T3 (en)	1996-05-31	2,4-Pyrimidinedione derivatives and medicines containing them
DK0593639T3 (da)	1995-07-03	Pyrrolidin- og thiazolidinderivater, fremstilling af disse forbindelser og lægemidler indeholdende disse
FI96204C (fi)	1996-05-27	Menetelmä terapeuttisesti käyttökelpoisten heterosyklisten yhdisteiden valmistamiseksi
NO2004004I2 (no)	2007-09-10	Bortezomib eller en farmasøytisk akseptabel ester derav, eventuelt i form av et farmasøytisk akseptabelt salt derav
LU90856I2 (fr)	2002-01-24	Uprima - apomorphine hydrochloride et ses d-riv-s pharmaceutiquement acceptables
DK0580502T3 (da)	1999-05-31	3-(hydroxybenzylidenyl)-indolin-2-oner og farmaceutiske sammensætninger indeholdende disse
FI911910L (fi)	1991-10-21	5,5-bis(perfluorialkyyliheterometyyli)-2-hydroksi-2-okso-1,3,2-dioksafosforinaanit, niiden asykliset fosforihapokejohdannaiset sekä suolat tai esterit
IT1224416B (it)	1990-10-04	Chelanti macrociclici e loro chelati
DE69321875D1 (de)	1998-12-10	Benzimidezolderivate mit antidiabetischer und Anti-Plättchenklumpungswirkung
NZ240575A (en)	1993-07-27	N-benzoylproline derivatives and pharmaceutical compositions
ATE166875T1 (de)	1998-06-15	Ellipticinderivate mit antitumorwirkung
FI881609A0 (fi)	1988-04-07	Dihydropyridinamider, foerfarande foer deras framstaellning och deras anvaendning i laekemedel.
DK0571243T3 (da)	1995-12-04	Thiochromanderivater, fremgangsmåder til fremstilling heraf samt farmaceutiske midler indeholdende d isse
PT100891A (pt)	1993-10-29	Per-hidro-1h-pirido {1,2-a} pirazinas 2-substituidas neurolepticas
DE59108565D1 (de)	1997-04-03	Halogenalkyl-azolyl-Derivate
ES2095714T3 (es)	1997-02-16	Nuevas amino-alquil-cromonas, sus procedimientos de preparacion y las composiciones farmaceuticas que las contienen.
FI913548L (fi)	1992-01-26	Uppblaosbar och toembar dyna och med en saodan dyna foersett lyftdon.
WO1987004435A3 (en)	1988-03-24	Xanthine compounds
ES2093051T3 (es)	1996-12-16	Purinil- y pirimidil-tetrahidrofuranos.
ATE15201T1 (de)	1985-09-15	Organophosphat-derivate.
ATE117682T1 (de)	1995-02-15	Substituierte benzothiazolinone, ihre herstellung und sie enthaltende pharmazeutische zusammenstellungen.
DK0631777T3 (da)	2001-03-05	Anvendelse af beta-naphtoquinonderivater til hæmning af blodpladesammenklumpning
DK0481288T3 (da)	1995-09-11	N-phenylpiperidyl-4-aminer og lægemidler indeholdende disse forbindelser
TW279783B (de)	1996-07-01
DE3865362D1 (de)	1991-11-14	Derivat von benzo(b)thiophen-7-carboxylsaeure, verfahren zu dessen herstellung und dieses enthaltende arzneimittel.