DK0448254T3 - Fremgangsmåde til og mellemprodukter for 2R-benzylchroman-6-carbaldehyd - Google Patents

Fremgangsmåde til og mellemprodukter for 2R-benzylchroman-6-carbaldehyd

Info

Publication number: DK0448254T3
Authority: DK; Denmark
Prior art keywords: benzylchroman; chroman; carbaldehyde; intermediates; chromancarboxylate
Prior art date: 1990-03-21

Application number

DK91301891.7T

Other languages

English (en)

Inventor

Frank John Urban

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-21

Filing date

1991-03-07

Publication date

1995-03-20

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23973911&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0448254(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1991-03-07 Application filed by Pfizer filed Critical Pfizer

1995-03-20 Application granted granted Critical

1995-03-20 Publication of DK0448254T3 publication Critical patent/DK0448254T3/da

Links

239000000543 intermediate Substances 0.000 title abstract 2
VZWXIQHBIQLMPN-UHFFFAOYSA-N chromane Chemical compound C1=CC=C2CCCOC2=C1 VZWXIQHBIQLMPN-UHFFFAOYSA-N 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
239000003472 antidiabetic agent Substances 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
229940126904 hypoglycaemic agent Drugs 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
108010079522 solysime Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Analytical Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK91301891.7T 1990-03-21 1991-03-07 Fremgangsmåde til og mellemprodukter for 2R-benzylchroman-6-carbaldehyd DK0448254T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/496,737 US5089637A (en)	1990-03-21	1990-03-21	Process and intermediates for 2r-benzyl-chroman-6-carbaldehyde

Publications (1)

Publication Number	Publication Date
DK0448254T3 true DK0448254T3 (da)	1995-03-20

Family

ID=23973911

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91301891.7T DK0448254T3 (da)	1990-03-21	1991-03-07	Fremgangsmåde til og mellemprodukter for 2R-benzylchroman-6-carbaldehyd

Country Status (20)

Country	Link
US (1)	US5089637A (da)
EP (1)	EP0448254B1 (da)
JP (1)	JPH0764838B2 (da)
KR (1)	KR940005601B1 (da)
AT (1)	ATE117299T1 (da)
AU (1)	AU620756B2 (da)
CA (1)	CA2038610C (da)
DE (1)	DE69106753T2 (da)
DK (1)	DK0448254T3 (da)
ES (1)	ES2067148T3 (da)
FI (1)	FI97385C (da)
GR (1)	GR3015390T3 (da)
HU (1)	HUT61603A (da)
IE (1)	IE64066B1 (da)
IL (1)	IL97549A0 (da)
MY (1)	MY106374A (da)
NO (1)	NO179680C (da)
NZ (1)	NZ237466A (da)
PT (1)	PT97070B (da)
ZA (1)	ZA912063B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5658796A (en) *	1995-06-07	1997-08-19	Seprachem, Inc.	Optical resolution of alkyl chroman-2-carboxylates
WO1999055898A1 (en) *	1998-04-28	1999-11-04	Novo Nordisk A/S	Enzymatic resolvation for obtaining a (-)-3,4-trans-diarylchroman
US6184005B1 (en)	1998-04-28	2001-02-06	Novo Nordisk A/S	Enzymatic resolvation for obtaining a (−)-3,4-trans-diarylchroman
EP1445324A4 (en) *	2001-11-09	2005-02-16	Kaneka Corp	PROCESS FOR PRODUCING OPTICALLY ACTIVE CHROMAN DERIVATIVE AND INTERMEDIATE PRODUCT
JPWO2004108944A1 (ja) *	2003-06-04	2006-07-20	三菱瓦斯化学株式会社	光学活性クロマンカルボン酸エステルの製造方法
JP2008538576A (ja) *	2005-04-22	2008-10-30	ワイス	クロマンおよびクロメン誘導体およびその使用
KR100784850B1 (ko) *	2006-10-19	2007-12-14	충북대학교 산학협력단	크로만-2-카복실산 아릴아마이드 유도체, 그 제조방법 및이를 포함하는 ＮＦ-κＢ 저해제
IT1402974B1 (it)	2010-11-30	2013-09-27	Menarini Int Operations Lu Sa	Processo per la preparazione del nebivololo.
FR2986804A1 (fr) *	2012-02-09	2013-08-16	Servier Lab	Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
CN105246535B (zh)	2013-03-15	2018-03-20	通气道控制技术有限公司	医用呼吸装置

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4654362A (en) *	1983-12-05	1987-03-31	Janssen Pharmaceutica, N.V.	Derivatives of 2,2'-iminobisethanol
KR930005004B1 (ko) *	1985-04-15	1993-06-11	쟈안센 파아마슈우티카 엔. 부이.	치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
WO1986007056A1 (en) *	1985-05-21	1986-12-04	Pfizer Inc.	Hypoglycemic thiazolidinediones
US5037747A (en) *	1988-01-26	1991-08-06	Hoffmann-La Roche Inc.	Production of benzopyran-2-carboxylic acids and esters by enzymatic hydrolysis

1990
- 1990-03-21 US US07/496,737 patent/US5089637A/en not_active Expired - Fee Related
1991
- 1991-03-07 DK DK91301891.7T patent/DK0448254T3/da active
- 1991-03-07 EP EP91301891A patent/EP0448254B1/en not_active Revoked
- 1991-03-07 DE DE69106753T patent/DE69106753T2/de not_active Revoked
- 1991-03-07 ES ES91301891T patent/ES2067148T3/es not_active Expired - Lifetime
- 1991-03-07 AT AT91301891T patent/ATE117299T1/de not_active IP Right Cessation
- 1991-03-14 IL IL97549A patent/IL97549A0/xx unknown
- 1991-03-18 NZ NZ237466A patent/NZ237466A/en unknown
- 1991-03-19 MY MYPI91000453A patent/MY106374A/en unknown
- 1991-03-19 CA CA002038610A patent/CA2038610C/en not_active Expired - Fee Related
- 1991-03-19 NO NO911101A patent/NO179680C/no not_active IP Right Cessation
- 1991-03-19 PT PT97070A patent/PT97070B/pt not_active IP Right Cessation
- 1991-03-20 AU AU73696/91A patent/AU620756B2/en not_active Ceased
- 1991-03-20 HU HU91939A patent/HUT61603A/hu unknown
- 1991-03-20 FI FI911356A patent/FI97385C/fi not_active IP Right Cessation
- 1991-03-20 ZA ZA912063A patent/ZA912063B/xx unknown
- 1991-03-20 JP JP3130827A patent/JPH0764838B2/ja not_active Expired - Fee Related
- 1991-03-20 KR KR1019910004388A patent/KR940005601B1/ko not_active Expired - Fee Related
- 1991-03-21 IE IE93891A patent/IE64066B1/en not_active IP Right Cessation
1995
- 1995-03-13 GR GR950400543T patent/GR3015390T3/el unknown

Also Published As

Publication number	Publication date
JPH04234871A (ja)	1992-08-24
KR940005601B1 (ko)	1994-06-21
EP0448254A3 (en)	1991-12-18
PT97070B (pt)	2001-05-31
DE69106753D1 (de)	1995-03-02
DE69106753T2 (de)	1995-05-18
ATE117299T1 (de)	1995-02-15
AU620756B2 (en)	1992-02-20
NO911101L (no)	1991-09-23
IE64066B1 (en)	1995-07-12
ZA912063B (en)	1992-10-28
ES2067148T3 (es)	1995-03-16
CA2038610C (en)	1999-03-09
GR3015390T3 (en)	1995-06-30
AU7369691A (en)	1991-11-14
EP0448254B1 (en)	1995-01-18
NO179680C (no)	1996-11-27
MY106374A (en)	1995-05-30
NZ237466A (en)	1992-04-28
FI97385C (fi)	1996-12-10
PT97070A (pt)	1991-10-31
FI911356L (fi)	1991-09-22
NO911101D0 (no)	1991-03-19
JPH0764838B2 (ja)	1995-07-12
HUT61603A (en)	1993-01-28
FI97385B (fi)	1996-08-30
CA2038610A1 (en)	1991-09-22
EP0448254A2 (en)	1991-09-25
IL97549A0 (en)	1992-06-21
NO179680B (no)	1996-08-19
KR910016939A (ko)	1991-11-05
HU910939D0 (en)	1991-10-28
FI911356A0 (fi)	1991-03-20
IE910938A1 (en)	1991-09-25
US5089637A (en)	1992-02-18

Publication	Publication Date	Title
PT89553A (pt)	1989-10-04	Processo de preparacao de acidos 2-arilpropionicos opticamente activos
IL97549A0 (en)	1992-06-21	Process and intermediates for 2r-benzyl-chroman-6-carbaldehyde
ATE70832T1 (de)	1992-01-15	Verfahren zur herstellung von 2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigs\|ure.
FR2626289B1 (fr)	1990-06-08	Procede de preparation d'acides aryl-2 alkanoiques optiquement actifs
SE8501679D0 (sv)	1985-04-03	Stereocontrolled acetoxyazetidinone process
AU585703B2 (en)	1989-06-22	Process for the enzymatic resolution of racemic 2-amino- 1-alkanols
SE8000740L (sv)	1980-10-04	Sett att spalta d,l-cis- och d,l-trans-2,2-dimetyl-3-(2,2-dihalogenvinyl)-cyklopropan-1-karboxylsyror
FI853183A0 (fi)	1985-08-19	Foerfarande foer produktion av asymmetriska hydantoiner.
ES2051767T3 (es)	1994-07-01	Cetorreduccion estereoespecifica de esteres de acido carboxilico-biciclooctanodiona por microorganismos.
ES2055122T3 (es)	1994-08-16	Procedimiento de preparacion de acidos 2-ariloxi- o 2-ariltio-alcanoicos.
DE69123009D1 (de)	1996-12-12	Verfahren zur Herstellung optisch aktiver 3-Hydroxybutan-Derivate
ATE63538T1 (de)	1991-06-15	Herstellung von 9-alkenylesterverbindungen.
ATE1553T1 (de)	1982-09-15	Verfahren zur herstellung von penizillinderivaten.
DE69123402D1 (de)	1997-01-16	Verfahren zur Herstellung optisch aktiver Alpha-Hydroxyalkenderivate
DK0479431T3 (da)	2000-03-27	Mellemprodukter for 1-carbacephalosporiner og fremgangsmåde til fremstilling heraf
MY105302A (en)	1994-09-30	Process for dehydrating corticosteroid intermediates.