DK0450021T3 - Anti-cancerforbindelser - Google Patents

Anti-cancerforbindelser

Info

Publication number: DK0450021T3
Authority: DK; Denmark
Prior art keywords: group; pct; hydroxy; nhr; sec
Prior art date: 1989-10-13

Application number

DK90915322.3T

Other languages

English (en)

Inventor

Laurence Hylton Patterson

Original Assignee

British Tech Group

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-13

Filing date

1990-10-12

Publication date

1994-03-07

1990-10-12 Application filed by British Tech Group filed Critical British Tech Group

1994-03-07 Application granted granted Critical

1994-03-07 Publication of DK0450021T3 publication Critical patent/DK0450021T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 2
230000001093 anti-cancer Effects 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000002947 alkylene group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000004990 dihydroxyalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B1/00—Dyes with anthracene nucleus not condensed with any other ring
- C09B1/50—Amino-hydroxy-anthraquinones; Ethers and esters thereof
- C09B1/51—N-substituted amino-hydroxy anthraquinone
- C09B1/515—N-alkyl, N-aralkyl or N-cycloalkyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)

DK90915322.3T 1989-10-13 1990-10-12 Anti-cancerforbindelser DK0450021T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898923075A GB8923075D0 (en)	1989-10-13	1989-10-13	Anti-cancer compounds

Publications (1)

Publication Number	Publication Date
DK0450021T3 true DK0450021T3 (da)	1994-03-07

Family

ID=10664506

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90915322.3T DK0450021T3 (da)	1989-10-13	1990-10-12	Anti-cancerforbindelser

Country Status (14)

Country	Link
US (1)	US5132327A (da)
EP (1)	EP0450021B1 (da)
JP (1)	JP2854971B2 (da)
AT (1)	ATE101181T1 (da)
AU (1)	AU634125B2 (da)
CA (1)	CA2038934C (da)
DE (1)	DE69006482T2 (da)
DK (1)	DK0450021T3 (da)
ES (1)	ES2062558T3 (da)
GB (2)	GB8923075D0 (da)
NZ (1)	NZ235658A (da)
PT (1)	PT95584B (da)
WO (1)	WO1991005824A1 (da)
ZA (1)	ZA908178B (da)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5141957A (en) *	1990-11-02	1992-08-25	Sphinx Pharmaceuticals Corporation	1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c
US5399363A (en) *	1991-01-25	1995-03-21	Eastman Kodak Company	Surface modified anticancer nanoparticles
GB9107843D0 (en) *	1991-04-12	1991-05-29	Patterson Laurence H	Anti-cancer compounds
GB9107852D0 (en) *	1991-04-12	1991-05-29	Patterson Laurence H	Anti-cancer compounds
GB9813062D0 (en) *	1998-06-18	1998-08-19	Univ Wales Medicine	An anthraquinone and its derivatives
GB9815910D0 (en) *	1998-07-21	1998-09-23	Btg Int Ltd	Synthetic method
FR2786484B1 (fr) *	1998-11-30	2001-01-05	Oreal	Aminoanthraquinones cationiques, leur utilisation pour la teinture des fibres keratiniques, compositions tinctoriales les renfermant et procedes de teinture
GB9828670D0 (en) *	1998-12-24	1999-02-17	Univ Montfort	Anthraquinone anticancer drugs
GB0112868D0 (en) *	2001-05-25	2001-07-18	Secr Defence	Detection system
MXPA04008821A (es) *	2002-03-15	2004-11-26	Btg Int Ltd	Formulaciones de derivados de antraquinona.
GB0223563D0 (en) *	2002-10-10	2002-11-20	Secr Defence	Detection system
US6949557B2 (en) *	2003-04-29	2005-09-27	Dabur Research Foundation	Hydroanthracene based compounds as anticancer agents
US20050009924A1 (en) *	2003-07-08	2005-01-13	Hsu-Shan Huang	Synthesis and pharmaceuticals of novel bis-substituted anthraquinone derivatives
MXPA06002936A (es) *	2003-09-17	2006-06-14	Btg Int Ltd	Formulaciones de derivados de antraquinona.
JP2007516270A (ja) *	2003-12-23	2007-06-21	ソマンタリミテッド	抗ガン性化合物としてのアントラキノン化合物
AU2005214124A1 (en) *	2004-02-13	2005-09-01	Novacea Inc.	Process for the preparation of AQ4N
WO2005097128A1 (en) *	2004-03-30	2005-10-20	Novacea, Inc.	1,4-bis-n-oxide azaanthracenediones and the use thereof
JP2008531720A (ja) *	2005-03-04	2008-08-14	ノバセアインコーポレイティッド	過剰増殖疾患のアントラキノンによる治療
US20070117784A1 (en) *	2005-03-04	2007-05-24	Novacea, Inc.	Treatment of hyperproliferative diseases with anthraquinones
WO2008103320A1 (en) *	2007-02-16	2008-08-28	Novacea, Inc.	Methods of treating ophthalmic disorders with anthraquinones
US8999965B2 (en)	2008-10-27	2015-04-07	Life Technologies Corporation	Anthraquinone based near IR emitting compounds and uses thereof
GB201005939D0 (en)	2010-04-09	2010-05-26	Biostatus Ltd	Method of analysing a cell or other biological material containing nucleic acid
GB201214169D0 (en)	2012-08-08	2012-09-19	Biostatus Ltd	New compounds and uses thereof
WO2014062856A1 (en)	2012-10-16	2014-04-24	Halozyme, Inc.	Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
US9272981B1 (en) *	2015-06-23	2016-03-01	Amazon Technologies, Inc.	Method of preparing a compound
US11292803B2 (en)	2018-08-21	2022-04-05	The Board Of Trustees Of The University Of Illinois	Bioreducible N-oxide-based probes for imaging of hypoxia
CN119118908B (zh) *	2024-08-13	2025-09-19	甘肃中医药大学	一种大黄酸氮氧自由基衍生物及其合成方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE194218C (da) *
US3174994A (en) *	1962-01-30	1965-03-23	Smith Kline French Lab	Hypocholesterolemic n-oxide compositions
SE7708452L (sv) *	1977-07-22	1979-01-23	Allied Chem	Komposition innehallande en antrakinonforening
US4430501A (en) *	1979-08-02	1984-02-07	American Cyanamid Company	1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4540519A (en) *	1977-08-15	1985-09-10	American Cyanamid Company	1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4197249A (en) *	1977-08-15	1980-04-08	American Cyanamid Company	1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4138415A (en) *	1978-05-05	1979-02-06	American Cyanamid Company	1,4-Bis(aminoalkylamino)-anthraquinones and leuco derivatives thereof
US4278689A (en) *	1978-07-11	1981-07-14	American Cyanamid Company	1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4820738A (en) *	1977-08-15	1989-04-11	American Cyanamid Company	1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4526989A (en) *	1978-07-11	1985-07-02	American Cyanamid Company	1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4614618A (en) *	1979-08-02	1986-09-30	American Cyanamid Company	1,4-bis(substituted-amino)-5,8-dihydroxy anthraquinones and leuco bases thereof
US4275010A (en) *	1979-10-24	1981-06-23	American Cyanamid Company	5,8-Dihydroxy-1,4-bis(guanidinylamino)anthraquinones
US4278605A (en) *	1980-06-30	1981-07-14	American Cyanamid Company	Heteroalkylenebisanthraquinones
US4555572A (en) *	1983-07-19	1985-11-26	Warner-Lambert Company	Pyrazolo[3,4,5-kl]acridine compositions and methods for their production and use
US4626540A (en) *	1983-11-08	1986-12-02	Warner-Lambert Company	Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
US4686218A (en) *	1985-01-30	1987-08-11	Smithkline Beckman Corporation	Use of 6-chloro-3-methyl-1H-2,3,4,5-tetrahydro-3-benzazepine-n-oxide, as a prodrug
US4963554A (en) *	1990-02-14	1990-10-16	Ortho Pharmaceutical Corporation	6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides

1989
- 1989-10-13 GB GB898923075A patent/GB8923075D0/en active Pending
1990
- 1990-10-12 DE DE90915322T patent/DE69006482T2/de not_active Expired - Fee Related
- 1990-10-12 JP JP2514278A patent/JP2854971B2/ja not_active Expired - Fee Related
- 1990-10-12 NZ NZ235658A patent/NZ235658A/xx unknown
- 1990-10-12 ZA ZA908178A patent/ZA908178B/xx unknown
- 1990-10-12 DK DK90915322.3T patent/DK0450021T3/da active
- 1990-10-12 PT PT95584A patent/PT95584B/pt not_active IP Right Cessation
- 1990-10-12 US US07/674,354 patent/US5132327A/en not_active Expired - Lifetime
- 1990-10-12 EP EP90915322A patent/EP0450021B1/en not_active Expired - Lifetime
- 1990-10-12 CA CA002038934A patent/CA2038934C/en not_active Expired - Lifetime
- 1990-10-12 AU AU65395/90A patent/AU634125B2/en not_active Ceased
- 1990-10-12 ES ES90915322T patent/ES2062558T3/es not_active Expired - Lifetime
- 1990-10-12 AT AT90915322T patent/ATE101181T1/de not_active IP Right Cessation
- 1990-10-12 GB GB9022217A patent/GB2237283B/en not_active Expired - Lifetime
- 1990-10-12 WO PCT/GB1990/001574 patent/WO1991005824A1/en not_active Ceased

Also Published As

Publication number	Publication date
ES2062558T3 (es)	1994-12-16
CA2038934C (en)	2002-11-19
CA2038934A1 (en)	1991-04-14
PT95584A (pt)	1991-09-13
ATE101181T1 (de)	1994-02-15
ZA908178B (en)	1992-06-24
AU634125B2 (en)	1993-02-11
DE69006482D1 (de)	1994-03-17
WO1991005824A1 (en)	1991-05-02
GB2237283A (en)	1991-05-01
GB9022217D0 (en)	1990-11-28
EP0450021A1 (en)	1991-10-09
US5132327A (en)	1992-07-21
GB2237283B (en)	1993-01-27
AU6539590A (en)	1991-05-16
JPH04502166A (ja)	1992-04-16
NZ235658A (en)	1992-12-23
GB8923075D0 (en)	1989-11-29
PT95584B (pt)	1997-08-29
EP0450021B1 (en)	1994-02-02
DE69006482T2 (de)	1994-05-11
JP2854971B2 (ja)	1999-02-10

Publication	Publication Date	Title
DK0450021T3 (da)	1994-03-07	Anti-cancerforbindelser
MY108261A (en)	1996-09-30	Water soluble camptothecin derivatives
LU90988I2 (fr)	2003-01-13	Ebixa-mémantine e ses dérivés pharmaceutiquement acceptables
ATE141910T1 (de)	1996-09-15	Quarternäre panthenolderivate und ihre verwendung
PT1140851E (pt)	2004-12-31	4-oxo-1,4-di-hidro-3-quinolinacarboxamidas como agentes antivirais
PT87147A (pt)	1988-04-01	Procede de preparation des nouveaux derives de l:amino tetrahydro-5,6,7,8 naphto ]2,3b" furanne
DK0572635T3 (da)	1997-06-16	Hidtil ukendte forbindelser med guanidinstruktur og farmaceutisk komposition indeholdende forbindelserne
YU48136B (sh)	1997-05-28	Morfolinil derivati doksorubicina i postupak za njihovo dobijanje
DE69108067D1 (de)	1995-04-20	Thiazolidin-Derivate mit antihypertensiver Aktivität und deren therapeutische Anwendung.
GB2254613B (en)	1995-01-25	Anti-cancer anthracene compounds
DK0456133T3 (da)	1995-05-22	Hydrazoner
DK540684A (da)	1984-11-14	Benzoquinoliziner
DE69112201D1 (de)	1995-09-21	4,5-cycloalkano-3-benzazepin-7-ol-derivate und ihre verwendung.
ATE83776T1 (de)	1993-01-15	1,2-benzisoxazole und 1,2-benzisothiazole.
SE8304545L (sv)	1984-02-25	Bensamidderivat
IT1272881B (it)	1997-07-01	Composti arilalchilenici