PT95584A - Processo de preparacao de antraquinonas, dos seus intermediarios e de composicoes farmaceuticas - Google Patents

Processo de preparacao de antraquinonas, dos seus intermediarios e de composicoes farmaceuticas

Info

Publication number: PT95584A
Authority: PT; Portugal
Prior art keywords: group; pct; hydroxy; antraquinones; intermediaries
Prior art date: 1989-10-13

Application number

PT95584A

Other languages

English (en)

Other versions

PT95584B (pt

Inventor

Laurence Hylton Patterson

Original Assignee

Nat Res Dev

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-13

Filing date

1990-10-12

Publication date

1991-09-13

1990-10-12 Application filed by Nat Res Dev filed Critical Nat Res Dev

1991-09-13 Publication of PT95584A publication Critical patent/PT95584A/pt

1997-08-29 Publication of PT95584B publication Critical patent/PT95584B/pt

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
125000002947 alkylene group Chemical group 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004990 dihydroxyalkyl group Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
- C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
- C07C291/04—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds containing amino-oxide bonds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
- C09B1/00—Dyes with anthracene nucleus not condensed with any other ring
- C09B1/50—Amino-hydroxy-anthraquinones; Ethers and esters thereof
- C09B1/51—N-substituted amino-hydroxy anthraquinone
- C09B1/515—N-alkyl, N-aralkyl or N-cycloalkyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
- C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Plural Heterocyclic Compounds (AREA)

PT95584A 1989-10-13 1990-10-12 Processo de preparacao de antraquinonas, dos seus intermediarios e de composicoes farmaceuticas PT95584B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB898923075A GB8923075D0 (en)	1989-10-13	1989-10-13	Anti-cancer compounds

Publications (2)

Publication Number	Publication Date
PT95584A true PT95584A (pt)	1991-09-13
PT95584B PT95584B (pt)	1997-08-29

Family

ID=10664506

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95584A PT95584B (pt)	1989-10-13	1990-10-12	Processo de preparacao de antraquinonas, dos seus intermediarios e de composicoes farmaceuticas

Country Status (14)

Country	Link
US (1)	US5132327A (pt)
EP (1)	EP0450021B1 (pt)
JP (1)	JP2854971B2 (pt)
AT (1)	ATE101181T1 (pt)
AU (1)	AU634125B2 (pt)
CA (1)	CA2038934C (pt)
DE (1)	DE69006482T2 (pt)
DK (1)	DK0450021T3 (pt)
ES (1)	ES2062558T3 (pt)
GB (2)	GB8923075D0 (pt)
NZ (1)	NZ235658A (pt)
PT (1)	PT95584B (pt)
WO (1)	WO1991005824A1 (pt)
ZA (1)	ZA908178B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5141957A (en) *	1990-11-02	1992-08-25	Sphinx Pharmaceuticals Corporation	1,4-bis-(amino-hydroxyalkylamino)-anthraquinones for inhibiting protein kinase c
US5399363A (en) *	1991-01-25	1995-03-21	Eastman Kodak Company	Surface modified anticancer nanoparticles
GB9107843D0 (en) *	1991-04-12	1991-05-29	Patterson Laurence H	Anti-cancer compounds
GB9107852D0 (en) *	1991-04-12	1991-05-29	Patterson Laurence H	Anti-cancer compounds
GB9813062D0 (en) *	1998-06-18	1998-08-19	Univ Wales Medicine	An anthraquinone and its derivatives
GB9815910D0 (en) *	1998-07-21	1998-09-23	Btg Int Ltd	Synthetic method
FR2786484B1 (fr)	1998-11-30	2001-01-05	Oreal	Aminoanthraquinones cationiques, leur utilisation pour la teinture des fibres keratiniques, compositions tinctoriales les renfermant et procedes de teinture
GB9828670D0 (en) *	1998-12-24	1999-02-17	Univ Montfort	Anthraquinone anticancer drugs
GB0112868D0 (en) *	2001-05-25	2001-07-18	Secr Defence	Detection system
WO2003078387A1 (en) *	2002-03-15	2003-09-25	Btg International Limited	Formulations of anthraquinone derivatives
GB0223563D0 (en) *	2002-10-10	2002-11-20	Secr Defence	Detection system
US6949557B2 (en) *	2003-04-29	2005-09-27	Dabur Research Foundation	Hydroanthracene based compounds as anticancer agents
US20050009924A1 (en) *	2003-07-08	2005-01-13	Hsu-Shan Huang	Synthesis and pharmaceuticals of novel bis-substituted anthraquinone derivatives
MXPA06002936A (es) *	2003-09-17	2006-06-14	Btg Int Ltd	Formulaciones de derivados de antraquinona.
EP1701939B1 (en) *	2003-12-23	2009-02-25	Somanta Limited	Anthraquinone compounds as anti cancer compounds
EP1732881A2 (en) *	2004-02-13	2006-12-20	Kudos Pharmaceuticals Limited	Process for the preparation of aq4n
US20050222190A1 (en) *	2004-03-30	2005-10-06	Curd John G	1,4-bis-N-oxide azaanthracenediones and the use thereof
JP2008531720A (ja) *	2005-03-04	2008-08-14	ノバセアインコーポレイティッド	過剰増殖疾患のアントラキノンによる治療
US20070117784A1 (en) *	2005-03-04	2007-05-24	Novacea, Inc.	Treatment of hyperproliferative diseases with anthraquinones
WO2008103320A1 (en) *	2007-02-16	2008-08-28	Novacea, Inc.	Methods of treating ophthalmic disorders with anthraquinones
EP2362890B1 (en)	2008-10-27	2014-07-16	Life Technologies Corporation	Anthraquinone based near ir emitting compounds and uses thereof
GB201005939D0 (en)	2010-04-09	2010-05-26	Biostatus Ltd	Method of analysing a cell or other biological material containing nucleic acid
GB201214169D0 (en)	2012-08-08	2012-09-19	Biostatus Ltd	New compounds and uses thereof
WO2014062856A1 (en)	2012-10-16	2014-04-24	Halozyme, Inc.	Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
US9272981B1 (en) *	2015-06-23	2016-03-01	Amazon Technologies, Inc.	Method of preparing a compound
US11292803B2 (en)	2018-08-21	2022-04-05	The Board Of Trustees Of The University Of Illinois	Bioreducible N-oxide-based probes for imaging of hypoxia
CN119118908B (zh) *	2024-08-13	2025-09-19	甘肃中医药大学	一种大黄酸氮氧自由基衍生物及其合成方法与应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE194218C (pt) *
US3174994A (en) *	1962-01-30	1965-03-23	Smith Kline French Lab	Hypocholesterolemic n-oxide compositions
SE7708452L (sv) *	1977-07-22	1979-01-23	Allied Chem	Komposition innehallande en antrakinonforening
US4138415A (en) *	1978-05-05	1979-02-06	American Cyanamid Company	1,4-Bis(aminoalkylamino)-anthraquinones and leuco derivatives thereof
US4278689A (en) *	1978-07-11	1981-07-14	American Cyanamid Company	1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4820738A (en) *	1977-08-15	1989-04-11	American Cyanamid Company	1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4430501A (en) *	1979-08-02	1984-02-07	American Cyanamid Company	1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4197249A (en) *	1977-08-15	1980-04-08	American Cyanamid Company	1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4540519A (en) *	1977-08-15	1985-09-10	American Cyanamid Company	1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
US4526989A (en) *	1978-07-11	1985-07-02	American Cyanamid Company	1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
US4614618A (en) *	1979-08-02	1986-09-30	American Cyanamid Company	1,4-bis(substituted-amino)-5,8-dihydroxy anthraquinones and leuco bases thereof
US4275010A (en) *	1979-10-24	1981-06-23	American Cyanamid Company	5,8-Dihydroxy-1,4-bis(guanidinylamino)anthraquinones
US4278605A (en) *	1980-06-30	1981-07-14	American Cyanamid Company	Heteroalkylenebisanthraquinones
US4555572A (en) *	1983-07-19	1985-11-26	Warner-Lambert Company	Pyrazolo[3,4,5-kl]acridine compositions and methods for their production and use
US4626540A (en) *	1983-11-08	1986-12-02	Warner-Lambert Company	Substituted 1-amino-4-nitro-acridinones and methods of treating bacterial infections and leukemia with them
US4686218A (en) *	1985-01-30	1987-08-11	Smithkline Beckman Corporation	Use of 6-chloro-3-methyl-1H-2,3,4,5-tetrahydro-3-benzazepine-n-oxide, as a prodrug
US4963554A (en) *	1990-02-14	1990-10-16	Ortho Pharmaceutical Corporation	6,7-dimethoxy-1,2-dihydro-2-arylquinazoline-3-oxides

1989
- 1989-10-13 GB GB898923075A patent/GB8923075D0/en active Pending
1990
- 1990-10-12 CA CA002038934A patent/CA2038934C/en not_active Expired - Lifetime
- 1990-10-12 GB GB9022217A patent/GB2237283B/en not_active Expired - Lifetime
- 1990-10-12 AT AT90915322T patent/ATE101181T1/de not_active IP Right Cessation
- 1990-10-12 DE DE90915322T patent/DE69006482T2/de not_active Expired - Fee Related
- 1990-10-12 ZA ZA908178A patent/ZA908178B/xx unknown
- 1990-10-12 AU AU65395/90A patent/AU634125B2/en not_active Ceased
- 1990-10-12 DK DK90915322.3T patent/DK0450021T3/da active
- 1990-10-12 WO PCT/GB1990/001574 patent/WO1991005824A1/en not_active Ceased
- 1990-10-12 JP JP2514278A patent/JP2854971B2/ja not_active Expired - Fee Related
- 1990-10-12 NZ NZ235658A patent/NZ235658A/xx unknown
- 1990-10-12 ES ES90915322T patent/ES2062558T3/es not_active Expired - Lifetime
- 1990-10-12 US US07/674,354 patent/US5132327A/en not_active Expired - Lifetime
- 1990-10-12 EP EP90915322A patent/EP0450021B1/en not_active Expired - Lifetime
- 1990-10-12 PT PT95584A patent/PT95584B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
US5132327A (en)	1992-07-21
CA2038934A1 (en)	1991-04-14
JPH04502166A (ja)	1992-04-16
PT95584B (pt)	1997-08-29
EP0450021A1 (en)	1991-10-09
CA2038934C (en)	2002-11-19
DE69006482D1 (de)	1994-03-17
GB2237283B (en)	1993-01-27
DE69006482T2 (de)	1994-05-11
ATE101181T1 (de)	1994-02-15
GB9022217D0 (en)	1990-11-28
ES2062558T3 (es)	1994-12-16
JP2854971B2 (ja)	1999-02-10
GB2237283A (en)	1991-05-01
AU634125B2 (en)	1993-02-11
NZ235658A (en)	1992-12-23
ZA908178B (en)	1992-06-24
WO1991005824A1 (en)	1991-05-02
GB8923075D0 (en)	1989-11-29
AU6539590A (en)	1991-05-16
DK0450021T3 (da)	1994-03-07
EP0450021B1 (en)	1994-02-02

Legal Events

Date

Code

Title

Description

1991-09-13

BB1A

Laying open of patent application

Effective date: 19910321

2004-02-27

NF3A

Restitutio in integrum

Free format text: RESTITUTIO IN INTEGRUM

Effective date: 20031202

2009-12-02

MM4A

Annulment/lapse due to non-payment of fees, searched and examined patent

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20091123

Publication	Publication Date	Title
DK0450021T3 (da)	1994-03-07	Anti-cancerforbindelser
LU90988I2 (fr)	2003-01-13	Ebixa-mémantine e ses dérivés pharmaceutiquement acceptables
DE69604714D1 (de)	1999-11-25	Stilbenderivate und diese enthaltende pharmazeutische Zusammensetzungen
NO308739B1 (no)	2000-10-23	Imidazolderivater samt medisinsk sammensetning og anti-HIV- sammensetning omfattende samme
ES2097174T3 (es)	1997-04-01	Derivados de la 2-ciclohexan-1-il amina.
EA200100983A1 (ru)	2002-10-31	Производные 13-метилэритромицина
IE890359L (en)	1989-08-06	Indolocarbazole derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
OA08825A (fr)	1989-03-31	Nouveaux dérivés de l'amino tétrahydro-5,6,7,8 naphto (2,3b) furanne, leurs procédés de préparation et les compositions pharmaceutiques qui les contiennent.
ES2098023T3 (es)	1997-04-16	Compuestos de estructura guanidinica y composiciones farmaceuticas que los contienen.
YU237990A (sh)	1993-05-28	Morfolinil derivati doksorubicina i postupak za njihovo dobijanje
UA42733C2 (uk)	2001-11-15	Похідні біснафталіміду та їх фармацевтично прийнятні кислотно-адитивні солі, фармацевтична композиція з цитотоксичною активністю, яка їх містить
PT97571A (pt)	1992-01-31	Processo para a prparacao de hidrazonas
ES2071667T3 (es)	1995-07-01	Derivados de anfotericina b.
PH24709A (en)	1990-10-01	Allylmercaptoacetylsydnonimines and pharmaceutical compositions thereof
DK291390A (da)	1990-12-07	Terapeutiske anvendelser af 2',5'-oligoadenylatderivater
FI923458A0 (fi)	1992-07-31	4,5-cykloalkano-3-benzazepin-7-ol- derivat och deras anvaendning.
ATE132136T1 (de)	1996-01-15	Antitumor anthracenderivate
ES466826A1 (es)	1978-10-01	Procedimiento para la obtencion de derivados de acido benzo-hetero-cigliglioxilico.
ATE101119T1 (de)	1994-02-15	Butensaeure-amide, deren salze, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu deren herstellung.