DK0455380T3 - Tetraaza-makrocykler, fremgangsmåder til fremstilling deraf og deres anvendelse til magnetisk resona ns-visualisering - Google Patents

Tetraaza-makrocykler, fremgangsmåder til fremstilling deraf og deres anvendelse til magnetisk resona ns-visualisering

Info

Publication number
DK0455380T3
DK0455380T3 DK91303468.2T DK91303468T DK0455380T3 DK 0455380 T3 DK0455380 T3 DK 0455380T3 DK 91303468 T DK91303468 T DK 91303468T DK 0455380 T3 DK0455380 T3 DK 0455380T3
Authority
DK
Denmark
Prior art keywords
group
alk
hydrogen atom
different
same
Prior art date
Application number
DK91303468.2T
Other languages
English (en)
Inventor
David Parker
Nigel Robert Arnold Beeley
Original Assignee
Celltech Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909008720A external-priority patent/GB9008720D0/en
Priority claimed from GB909008724A external-priority patent/GB9008724D0/en
Priority claimed from GB909017148A external-priority patent/GB9017148D0/en
Priority claimed from GB919104391A external-priority patent/GB9104391D0/en
Application filed by Celltech Therapeutics Ltd filed Critical Celltech Therapeutics Ltd
Application granted granted Critical
Publication of DK0455380T3 publication Critical patent/DK0455380T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
DK91303468.2T 1990-04-18 1991-04-18 Tetraaza-makrocykler, fremgangsmåder til fremstilling deraf og deres anvendelse til magnetisk resona ns-visualisering DK0455380T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB909008720A GB9008720D0 (en) 1990-04-18 1990-04-18 Diagnostic agents
GB909008724A GB9008724D0 (en) 1990-04-18 1990-04-18 Chemical compounds
GB909017148A GB9017148D0 (en) 1990-08-03 1990-08-03 Diagnostic agents
GB919104391A GB9104391D0 (en) 1991-03-01 1991-03-01 Diagnostic agents

Publications (1)

Publication Number Publication Date
DK0455380T3 true DK0455380T3 (da) 1997-02-03

Family

ID=27450496

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91303468.2T DK0455380T3 (da) 1990-04-18 1991-04-18 Tetraaza-makrocykler, fremgangsmåder til fremstilling deraf og deres anvendelse til magnetisk resona ns-visualisering

Country Status (15)

Country Link
US (1) US5653960A (da)
EP (1) EP0455380B1 (da)
JP (1) JPH05500969A (da)
AT (1) ATE147635T1 (da)
AU (1) AU654951B2 (da)
CA (1) CA2057868A1 (da)
DE (1) DE69124132T2 (da)
DK (1) DK0455380T3 (da)
FI (1) FI915916A0 (da)
GB (1) GB2250198B (da)
IE (1) IE911297A1 (da)
IL (1) IL97902A (da)
NO (1) NO914979L (da)
NZ (1) NZ237868A (da)
WO (1) WO1991016081A1 (da)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
NZ237868A (en) * 1990-04-18 1994-04-27 Celltech Ltd Paramagnetic metal complexes of 1,4,7,10-tetracyclododecane derivatives and their use as nmr imaging agents
US5409689A (en) * 1993-08-13 1995-04-25 Concat, Ltd. MRI image enhancement using complexes of paramagnetic cations and amine ligands containing a mixture of phosphonate and non-phosphonate pendant arms
TW319763B (da) 1995-02-01 1997-11-11 Epix Medical Inc
JP3356289B2 (ja) * 1995-06-26 2002-12-16 コンキャット リミティド 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
WO2000047111A1 (en) * 1999-02-09 2000-08-17 Board Of Regents The University Of Texas System Ph sensitive mri contrast agents
JP2003501488A (ja) 1999-06-11 2003-01-14 ネオルックス コーポレイション 骨髄抑制のための高投与量放射性核種錯体
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
DE60136476D1 (de) * 2000-09-29 2008-12-18 Anormed Inc -stickstoffhaltigen zyklischen polyaminen und deren verbindungen
EP1390081A2 (en) 2001-01-08 2004-02-25 Neorx Corporation Therapeutic and diagnostic compounds, compositions, and methods
US20060210479A1 (en) * 2004-08-10 2006-09-21 Dow Global Technologies Inc. Targeting chelants and chelates
EP1812453A1 (en) * 2004-10-20 2007-08-01 Therapharm GmbH Method of preparing or synthesizing polyazamacrocycle derivatives

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803528C2 (de) * 1977-03-09 1984-10-18 Tabushi, Iwao, Kyoto Schwermetallionen-Adsorbens und dessen Verwendung zum Adsorbieren von Schwermetallionen
JPS53144592A (en) * 1977-05-19 1978-12-15 Tabuse Iwao 122alkyll1*4*7*100tetrazacyclotridecane
US4432907A (en) * 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4671958A (en) * 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4472509A (en) * 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
SU1098937A1 (ru) * 1983-03-25 1984-06-23 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова 1,4,7,10-Тетра/диоксифосфорилметил/-1,4,7,10-тетраазациклододекан в качестве комплексона дл св зывани катионов меди /п/,кобальта /п/,кадми /п/,свинца /п/ и лантана /ш/
CA1260827A (en) * 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US4659839A (en) * 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
US5342606A (en) * 1984-10-18 1994-08-30 Board Of Regents, The University Of Texas System Polyazamacrocyclic compounds for complexation of metal ions
ATE66469T1 (de) * 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
JPS61226751A (ja) * 1985-03-30 1986-10-08 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料用処理液及びその処理方法
US4678667A (en) * 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
EP0232751B1 (en) * 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
FR2596992B1 (fr) * 1986-04-11 1988-12-16 Guerbet Sa Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
GB8719042D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
CA2004798A1 (en) * 1988-12-09 1990-06-09 Jacques Banville 6-aminoalkyl carbapenems
GB8903023D0 (en) * 1989-02-10 1989-03-30 Parker David Chemical compounds
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
NZ237868A (en) * 1990-04-18 1994-04-27 Celltech Ltd Paramagnetic metal complexes of 1,4,7,10-tetracyclododecane derivatives and their use as nmr imaging agents

Also Published As

Publication number Publication date
GB2250198A (en) 1992-06-03
GB2250198B (en) 1994-06-22
FI915916A7 (fi) 1991-12-16
GB9126303D0 (en) 1992-02-12
US5653960A (en) 1997-08-05
ATE147635T1 (de) 1997-02-15
EP0455380A2 (en) 1991-11-06
DE69124132D1 (de) 1997-02-27
AU7673091A (en) 1991-11-11
EP0455380A3 (en) 1991-11-27
AU654951B2 (en) 1994-12-01
IL97902A0 (en) 1992-06-21
IE911297A1 (en) 1991-10-23
NZ237868A (en) 1994-04-27
EP0455380B1 (en) 1997-01-15
FI915916A0 (fi) 1991-12-16
DE69124132T2 (de) 1997-06-05
NO914979D0 (no) 1991-12-17
CA2057868A1 (en) 1991-10-19
IL97902A (en) 1996-03-31
JPH05500969A (ja) 1993-02-25
NO914979L (no) 1991-12-17
WO1991016081A1 (en) 1991-10-31

Similar Documents

Publication Publication Date Title
DK0455380T3 (da) Tetraaza-makrocykler, fremgangsmåder til fremstilling deraf og deres anvendelse til magnetisk resona ns-visualisering
ATE218554T1 (de) Hepatobillianische magnetische resonanz- kontrastmittel
NO954440L (no) 2 pyridylmetylenpolyazamakrocyklo-fosfonsyrer, komplekser og derivater derav, for anvendelse som kontrastmidler
MX9704646A (es) Derivados del acido 3-aril-tetronico, su obtencion y su empleo como agentes pesticidas.
ES525680A0 (es) Procedimiento para la preparacion de derivados de amino acidos, de efecto edulcorante
PT99556A (pt) Processo para a preparacao de novos compostos poliazamacrociclicos para a complexacao de metais
ATE169827T1 (de) Tetraazamakrocyclische metallkomplexe
NO972726D0 (no) Tricykliske forbindelser
ZA904451B (en) N-substituted lauramides,their preparation and compositions in which they are present
DE69415314D1 (de) Neue bisoxadiazolidinderivate
ATE178059T1 (de) 4-phenylcarbamoyl-3-isoxazolecarbonsäure-deriva e mit entzündungshemmender aktivität
GB2233558B (en) Psychotropic use of aromatic amines
DE69326479D1 (de) Methotrexat-derivate
DE58902234D1 (de) Alpha-hydroxy-azolylethyloxirane und diese enthaltende fungizide.
EP0317188A3 (en) Heteroaromatic enamide derivatives and their use as pesticides
GB9008724D0 (en) Chemical compounds
BR9403270A (pt) Processo para a preparação de um composto e composto
TH14815A (th) สารฆ่าวัชพืชชนิดใหม่
DE58900781D1 (de) Azolylalkene und diese enthaltende fungizide.