ATE120964T1 - Aza-makrozyklen enthaltende konjugate und verfahren zu deren herstellung. - Google Patents

Aza-makrozyklen enthaltende konjugate und verfahren zu deren herstellung.

Info

Publication number: ATE120964T1
Authority: AT; Austria
Prior art keywords: alk; group; hydrogen atom; different; same
Prior art date: 1990-04-18

Application number

AT91303467T

Other languages

English (en)

Inventor

David Parker

Thomas Andrew Millican

Nigel Robert Arnold Beeley

Original Assignee

Celltech Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-04-18

Filing date

1991-04-18

Publication date

1995-04-15

1991-04-18 Application filed by Celltech Ltd filed Critical Celltech Ltd

1995-04-15 Application granted granted Critical

1995-04-15 Publication of ATE120964T1 publication Critical patent/ATE120964T1/de

Links

150000002678 macrocyclic compounds Chemical class 0.000 title 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000005647 linker group Chemical group 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
230000002159 abnormal effect Effects 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001720 carbohydrates Chemical class 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
238000003384 imaging method Methods 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Radiology & Medical Imaging (AREA)
Biochemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)

AT91303467T 1990-04-18 1991-04-18 Aza-makrozyklen enthaltende konjugate und verfahren zu deren herstellung. ATE120964T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB909008724A GB9008724D0 (en)	1990-04-18	1990-04-18	Chemical compounds

Publications (1)

Publication Number	Publication Date
ATE120964T1 true ATE120964T1 (de)	1995-04-15

Family

ID=10674616

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91303467T ATE120964T1 (de)	1990-04-18	1991-04-18	Aza-makrozyklen enthaltende konjugate und verfahren zu deren herstellung.

Country Status (8)

Country	Link
EP (1)	EP0457438B1 (de)
JP (1)	JPH05500970A (de)
AT (1)	ATE120964T1 (de)
AU (1)	AU652749B2 (de)
CA (1)	CA2058985A1 (de)
DE (1)	DE69108771T2 (de)
GB (1)	GB9008724D0 (de)
WO (1)	WO1991016078A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4115789A1 (de) *	1991-05-10	1992-11-12	Schering Ag	Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
EP0846003A1 (de)	1995-08-17	1998-06-10	Monsanto Company	Verfahren zur diagnostischen bildanalyse unter verwendung von biokonjugaten von metallkomplexen von stickstoffhaltigen makrocyclischen liganden

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8719041D0 (en) *	1987-08-12	1987-09-16	Parker D	Conjugate compounds
GB8719042D0 (en) *	1987-08-12	1987-09-16	Parker D	Conjugate compounds
GB8903023D0 (en) *	1989-02-10	1989-03-30	Parker David	Chemical compounds
GB8914543D0 (en) *	1989-06-23	1989-08-09	Parker David	Chemical compounds

1990
- 1990-04-18 GB GB909008724A patent/GB9008724D0/en active Pending
1991
- 1991-04-18 AU AU76728/91A patent/AU652749B2/en not_active Ceased
- 1991-04-18 JP JP3507526A patent/JPH05500970A/ja active Pending
- 1991-04-18 DE DE69108771T patent/DE69108771T2/de not_active Expired - Fee Related
- 1991-04-18 AT AT91303467T patent/ATE120964T1/de not_active IP Right Cessation
- 1991-04-18 CA CA002058985A patent/CA2058985A1/en not_active Abandoned
- 1991-04-18 EP EP91303467A patent/EP0457438B1/de not_active Expired - Lifetime
- 1991-04-18 WO PCT/GB1991/000613 patent/WO1991016078A1/en not_active Ceased

Also Published As

Publication number	Publication date
DE69108771T2 (de)	1995-10-05
CA2058985A1 (en)	1991-10-19
EP0457438A2 (de)	1991-11-21
JPH05500970A (ja)	1993-02-25
AU7672891A (en)	1991-11-11
EP0457438A3 (de)	1991-11-27
EP0457438B1 (de)	1995-04-12
WO1991016078A1 (en)	1991-10-31
AU652749B2 (en)	1994-09-08
GB9008724D0 (en)	1990-06-13
DE69108771D1 (de)	1995-05-18

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Legal Events

Date	Code	Title	Description
1995-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties