DK0455423T3 - Ortho-lithieringsproces til syntese af 2-substituerede 1-(tetrazol-5-yl)benzener - Google Patents

Ortho-lithieringsproces til syntese af 2-substituerede 1-(tetrazol-5-yl)benzener

Info

Publication number
DK0455423T3
DK0455423T3 DK91303757.8T DK91303757T DK0455423T3 DK 0455423 T3 DK0455423 T3 DK 0455423T3 DK 91303757 T DK91303757 T DK 91303757T DK 0455423 T3 DK0455423 T3 DK 0455423T3
Authority
DK
Denmark
Prior art keywords
tetrazol
synthesis
substituted
ortho
benzenes
Prior art date
Application number
DK91303757.8T
Other languages
Danish (da)
English (en)
Inventor
Richard F Shuman
Robert K Anderson
Anthony O King
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24061644&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0455423(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0455423T3 publication Critical patent/DK0455423T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK91303757.8T 1990-05-02 1991-04-25 Ortho-lithieringsproces til syntese af 2-substituerede 1-(tetrazol-5-yl)benzener DK0455423T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/517,889 US5039814A (en) 1990-05-02 1990-05-02 Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes

Publications (1)

Publication Number Publication Date
DK0455423T3 true DK0455423T3 (da) 1997-06-09

Family

ID=24061644

Family Applications (1)

Application Number Title Priority Date Filing Date
DK91303757.8T DK0455423T3 (da) 1990-05-02 1991-04-25 Ortho-lithieringsproces til syntese af 2-substituerede 1-(tetrazol-5-yl)benzener

Country Status (15)

Country Link
US (1) US5039814A (de)
EP (1) EP0455423B1 (de)
JP (1) JPH0717619B2 (de)
AT (1) ATE146461T1 (de)
CA (1) CA2041620C (de)
CY (1) CY1998A (de)
DE (1) DE69123632T2 (de)
DK (1) DK0455423T3 (de)
ES (1) ES2095907T3 (de)
GR (1) GR3022107T3 (de)
HK (1) HK59497A (de)
IE (1) IE911455A1 (de)
LV (1) LV11893B (de)
PT (1) PT97528B (de)
RO (1) RO110339B1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5256654A (en) * 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
US5283242A (en) * 1991-10-24 1994-02-01 American Home Products Corporation Substituted benzimidazoles and quinazolines as antihypertensives
US5252753A (en) * 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
JPH08500323A (ja) * 1991-11-18 1996-01-16 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー Ａ▲ｉｉ▼受容体アンタゴニストの合成のためのテトラゾリルフェニルボロン酸中間体
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
EP0550313A1 (de) * 1991-12-30 1993-07-07 Synthelabo 2-(Tetranol-5-yl)-(1,1'-Biphenyl)derivate, ihre Herstellung und Anwendung als Zwischenverbindungen
FR2688503B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle].
FR2696746B1 (fr) * 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
FR2696745B1 (fr) * 1992-10-12 1995-05-12 Synthelabo Procédé de préparation de dérivés de phényltétrazole.
HU219598B (hu) * 1992-12-17 2001-05-28 Sankyo Co. Ltd. Bifenilvegyületek imidazol- és piridinszármazékai, eljárás előállításukra és ezeket a vegyületeket tartalmazó gyógyszerkészítmények
US5567815A (en) * 1994-07-18 1996-10-22 Bridgestone Corporation Teritary amine containing antonic initiators used in preparing polymers and process for the preparation thereof
ATE176784T1 (de) * 1994-09-20 1999-03-15 Wakunaga Seiyaku Kk Verfahren zur herstellung von n- biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
KR100354802B1 (ko) * 1994-10-20 2002-12-26 한국화학연구원 테트라졸유도체의제조방법
EP0846117B1 (de) * 1995-06-07 2003-05-14 Wyeth Verfahren zur herstellung von biphenylderivaten
US5760220A (en) * 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
ES2264641B1 (es) * 2005-06-17 2008-03-01 Quimica Sintetica, S.A. Procedimiento para la obtencion de derivados de bencimidazol y sus intermedios.
CA2668744C (en) 2006-11-17 2015-09-15 Queen's University At Kingston Compounds and methods for treating protein folding disorders
WO2009078965A1 (en) 2007-12-17 2009-06-25 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin
CN103261142B (zh) 2010-06-03 2014-12-10 联合治疗公司 曲前列环素的制备
ES2581762T3 (es) 2011-03-02 2016-09-07 United Therapeutics Corporation Síntesis de producto intermedio para la producción de treprostinil
CN107108427A (zh) 2014-10-20 2017-08-29 联合治疗学有限公司 用于制备前列环素衍生物的中间体的合成

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3534113A (en) * 1968-02-08 1970-10-13 Lithium Corp Preparation of aryllithium compounds by metalation
CH531511A (de) * 1969-03-05 1972-12-15 Sandoz Ag Verfahren zur Herstellung des N,o-Dilithium-Derivats von 2-Phenyl-2-imidazolin
US4620025A (en) * 1984-08-01 1986-10-28 Merck & Co., Inc. Process for the preparation of biphenyl intermediates
US4870186A (en) * 1987-05-22 1989-09-26 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids

Also Published As

Publication number Publication date
HK59497A (en) 1997-05-16
DE69123632T2 (de) 1997-05-15
PT97528A (pt) 1992-01-31
GR3022107T3 (en) 1997-03-31
IE911455A1 (en) 1991-11-06
ES2095907T3 (es) 1997-03-01
LV11893A (en) 1997-12-20
RO110339B1 (ro) 1995-12-29
PT97528B (pt) 1998-08-31
CY1998A (en) 1997-12-05
ATE146461T1 (de) 1997-01-15
DE69123632D1 (de) 1997-01-30
CA2041620A1 (en) 1991-11-03
JPH0717619B2 (ja) 1995-03-01
EP0455423B1 (de) 1996-12-18
US5039814A (en) 1991-08-13
EP0455423A3 (en) 1992-12-09
CA2041620C (en) 2003-03-11
EP0455423A2 (de) 1991-11-06
JPH04225966A (ja) 1992-08-14
LV11893B (en) 1998-03-20

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