DK0458823T3 - Fremgangsmåde til fremstilling af enantiomerisk rene polysubstituerede 1,4-dihydropridiner - Google Patents
Fremgangsmåde til fremstilling af enantiomerisk rene polysubstituerede 1,4-dihydropridinerInfo
- Publication number
- DK0458823T3 DK0458823T3 DK90903015.7T DK90903015T DK0458823T3 DK 0458823 T3 DK0458823 T3 DK 0458823T3 DK 90903015 T DK90903015 T DK 90903015T DK 0458823 T3 DK0458823 T3 DK 0458823T3
- Authority
- DK
- Denmark
- Prior art keywords
- dihydropyridines
- enantiomerically pure
- dihydropridines
- polysubstituted
- preparation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 238000007796 conventional method Methods 0.000 abstract 1
- 150000002541 isothioureas Chemical class 0.000 abstract 1
- -1 isothioureido groups Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical class NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 238000000844 transformation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8919477A IT1230752B (it) | 1989-02-17 | 1989-02-17 | Processo per la preparazione di 1,4 diidropiridine polisostituite in forma enantiomericamente pura. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0458823T3 true DK0458823T3 (da) | 1994-02-21 |
Family
ID=11158352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK90903015.7T DK0458823T3 (da) | 1989-02-17 | 1990-02-15 | Fremgangsmåde til fremstilling af enantiomerisk rene polysubstituerede 1,4-dihydropridiner |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5245039A (da) |
| EP (2) | EP0458823B1 (da) |
| JP (1) | JPH04505610A (da) |
| KR (1) | KR0155557B1 (da) |
| AT (1) | ATE95813T1 (da) |
| AU (1) | AU630928B2 (da) |
| CA (1) | CA2047741A1 (da) |
| DE (1) | DE69003936T2 (da) |
| DK (1) | DK0458823T3 (da) |
| ES (1) | ES2060144T3 (da) |
| FI (1) | FI95371C (da) |
| HU (1) | HUT62270A (da) |
| IE (1) | IE66498B1 (da) |
| IT (1) | IT1230752B (da) |
| NO (1) | NO177186C (da) |
| RU (1) | RU2069658C1 (da) |
| WO (1) | WO1990009376A1 (da) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571827A (en) * | 1990-03-13 | 1996-11-05 | Sepracor Inc. | Methods and compositions for treating hypertension, angina and other disorders using optically pure s(-) nitrendipine |
| CA2125149A1 (en) * | 1991-12-02 | 1993-06-10 | James W. Young | Methods and compositions for treating hypertension, angina, and other disorders using optically pure s(-) felodipine |
| US5834496A (en) * | 1991-12-02 | 1998-11-10 | Sepracor, Inc. | Methods for treating hypertension using optically pure S(-) felodipine |
| ES2055655B1 (es) * | 1992-09-22 | 1995-03-01 | Elmuquimica Farm Sl | Procedimiento de obtencion de 2,6-dimetil-4-(2-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isobutil-5-metil. |
| ES2055653B1 (es) * | 1992-09-22 | 1995-03-01 | Elmuquimica Farm Sl | Procedimiento de obtencion del 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-isopropil-5-(2-metoxi)etil. |
| ES2055654B1 (es) * | 1992-09-22 | 1995-03-01 | Elmuquimica Farm Sl | Procedimiento de obtencion de 2,6-dimetil-4-(3-nitrofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-etil-5-metil. |
| ES2055652B1 (es) * | 1992-09-22 | 1995-03-01 | Elmuquimica Farm Sl | Procedimiento de obtencion de 2,6-dimetil-4-(2,3-diclorofenil)-1,4-dihidropiridin-3,5-dicarboxilato de 3-etil-5-metil. |
| GB9405833D0 (en) * | 1994-03-24 | 1994-05-11 | Pfizer Ltd | Separation of the enantiomers of amlodipine |
| FR2719585B1 (fr) * | 1994-05-05 | 1996-08-02 | Lafon Labor | Procédé d'obtention de 1,4-dihydropyridines optiquement pures. |
| US5554621A (en) * | 1995-06-07 | 1996-09-10 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives |
| TWI246921B (en) * | 2000-04-11 | 2006-01-11 | Sankyo Co | Stabilized pharmaceutical composition with calcium blocker |
| ITMI20012434A1 (it) | 2001-11-20 | 2003-05-20 | Dompe Spa | Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3447169A1 (de) * | 1984-12-22 | 1986-07-03 | Bayer Ag, 5090 Leverkusen | Optisch aktive nitrodihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln |
| WO1987000836A1 (en) * | 1985-08-06 | 1987-02-12 | Boehringer Biochemia Robin S.P.A. | Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines |
| EP0225175A3 (en) * | 1985-11-28 | 1988-12-28 | FISONS plc | Dihydropyridine derivatives, processes for their preparation and pharmaceutical compositions thereof |
| US4920225A (en) * | 1986-12-22 | 1990-04-24 | Laboratoires Syntex S.A. | Resolution of 1,4-dihydropyridine derivatives |
| WO1988007525A1 (fr) * | 1987-03-27 | 1988-10-06 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Enantiomeres de 1,4-dihydropyridine |
| AU1541188A (en) * | 1987-03-27 | 1988-11-02 | Byk Gulden Lomberg Chemische Fabrik Gmbh | New optically active compounds |
-
1989
- 1989-02-17 IT IT8919477A patent/IT1230752B/it active
-
1990
- 1990-02-15 RU SU905001680A patent/RU2069658C1/ru active
- 1990-02-15 ES ES90903015T patent/ES2060144T3/es not_active Expired - Lifetime
- 1990-02-15 WO PCT/EP1990/000243 patent/WO1990009376A1/en not_active Ceased
- 1990-02-15 CA CA002047741A patent/CA2047741A1/en not_active Abandoned
- 1990-02-15 KR KR1019900702275A patent/KR0155557B1/ko not_active Expired - Fee Related
- 1990-02-15 DK DK90903015.7T patent/DK0458823T3/da active
- 1990-02-15 EP EP90903015A patent/EP0458823B1/en not_active Expired - Lifetime
- 1990-02-15 JP JP2503175A patent/JPH04505610A/ja active Pending
- 1990-02-15 HU HU901962A patent/HUT62270A/hu unknown
- 1990-02-15 AT AT90903015T patent/ATE95813T1/de not_active IP Right Cessation
- 1990-02-15 EP EP90102951A patent/EP0383320A1/en not_active Withdrawn
- 1990-02-15 AU AU50904/90A patent/AU630928B2/en not_active Ceased
- 1990-02-15 US US07/743,415 patent/US5245039A/en not_active Expired - Fee Related
- 1990-02-15 DE DE90903015T patent/DE69003936T2/de not_active Expired - Fee Related
- 1990-02-16 IE IE58490A patent/IE66498B1/en not_active IP Right Cessation
-
1991
- 1991-08-15 FI FI913861A patent/FI95371C/fi not_active IP Right Cessation
- 1991-08-15 NO NO913188A patent/NO177186C/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2047741A1 (en) | 1990-08-18 |
| ATE95813T1 (de) | 1993-10-15 |
| FI913861A0 (fi) | 1991-08-15 |
| EP0458823A1 (en) | 1991-12-04 |
| IT1230752B (it) | 1991-10-29 |
| KR910700234A (ko) | 1991-03-14 |
| NO177186C (no) | 1995-08-02 |
| JPH04505610A (ja) | 1992-10-01 |
| IT8919477A0 (it) | 1989-02-17 |
| AU5090490A (en) | 1990-09-05 |
| WO1990009376A1 (en) | 1990-08-23 |
| EP0458823B1 (en) | 1993-10-13 |
| RU2069658C1 (ru) | 1996-11-27 |
| FI95371C (fi) | 1996-01-25 |
| DE69003936D1 (de) | 1993-11-18 |
| IE900584L (en) | 1990-08-17 |
| EP0383320A1 (en) | 1990-08-22 |
| DE69003936T2 (de) | 1994-03-31 |
| KR0155557B1 (ko) | 1998-11-16 |
| NO177186B (no) | 1995-04-24 |
| US5245039A (en) | 1993-09-14 |
| NO913188D0 (no) | 1991-08-15 |
| ES2060144T3 (es) | 1994-11-16 |
| AU630928B2 (en) | 1992-11-12 |
| HUT62270A (en) | 1993-04-28 |
| FI95371B (fi) | 1995-10-13 |
| NO913188L (no) | 1991-08-15 |
| IE66498B1 (en) | 1996-01-10 |
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