DK0460917T3 - Fremgangsmåde til fremstilling af eicosapentaensyre eller et esterderivat deraf - Google Patents

Fremgangsmåde til fremstilling af eicosapentaensyre eller et esterderivat deraf

Info

Publication number: DK0460917T3
Authority: DK; Denmark
Prior art keywords: ester derivative; eicosapentaenoic acid; preparing; present; continuous distillation
Prior art date: 1990-06-04

Application number

DK91305044.9T

Other languages

English (en)

Inventor

Kazuhiko Hata

Hideo Noda

Masahiro Makuta

Original Assignee

Kansai Chem Eng

Nippon Suisan Kaisha Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-04

Filing date

1991-06-04

Publication date

1997-01-20

1990-06-04 Priority claimed from JP2145617A external-priority patent/JP3040136B2/ja

1990-06-04 Priority claimed from JP2145618A external-priority patent/JP3005638B2/ja

1991-06-04 Application filed by Kansai Chem Eng, Nippon Suisan Kaisha Ltd filed Critical Kansai Chem Eng

1997-01-20 Application granted granted Critical

1997-01-20 Publication of DK0460917T3 publication Critical patent/DK0460917T3/da

Links

JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical class CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 title abstract 2
229960005135 eicosapentaenoic acid Drugs 0.000 title abstract 2
JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 title abstract 2
235000020673 eicosapentaenoic acid Nutrition 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 4
238000001944 continuous distillation Methods 0.000 abstract 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 1
239000004202 carbamide Substances 0.000 abstract 1
238000010276 construction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
- C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
- C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Crystallography & Structural Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Fats And Perfumes (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK91305044.9T 1990-06-04 1991-06-04 Fremgangsmåde til fremstilling af eicosapentaensyre eller et esterderivat deraf DK0460917T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2145617A JP3040136B2 (ja)	1990-06-04	1990-06-04	エイコサペンタエン酸またはそのエステルの製造方法
JP2145618A JP3005638B2 (ja)	1990-06-04	1990-06-04	高濃度エイコサペンタエン酸またはそのエステルの製造方法

Publications (1)

Publication Number	Publication Date
DK0460917T3 true DK0460917T3 (da)	1997-01-20

Family

ID=26476703

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91305044.9T DK0460917T3 (da)	1990-06-04	1991-06-04	Fremgangsmåde til fremstilling af eicosapentaensyre eller et esterderivat deraf

Country Status (11)

Country	Link
EP (1)	EP0460917B1 (da)
JP (1)	JPH11236591A (da)
KR (1)	KR100208701B1 (da)
AT (1)	ATE147062T1 (da)
AU (1)	AU641016B2 (da)
CA (1)	CA2043615C (da)
DE (1)	DE69123880T2 (da)
DK (1)	DK0460917T3 (da)
ES (1)	ES2095909T3 (da)
GR (1)	GR3022660T3 (da)
NO (1)	NO177699C (da)

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JP3400466B2 (ja) *	1991-10-28	2003-04-28	日本水産株式会社	高純度エイコサペンタエン酸またはそのエステルの製造方法
NO322213B1 (no) *	1998-01-30	2006-08-28	Ube Industries	Fremgangsmåte for rensing av varmenedbrytbare aromatiske hydroksylforbindelser ved destillasjon hvor de varmenedbrytbare aromatiske hydroksylforbindelsene befinner seg i en flerkomponentholdig væskeblanding.
NZ332331A (en) *	1998-10-15	2000-03-27	Craig Nazzer	Continuous process for removing solids from miscible liquid mixture; lower boiling point liquid(s) removed by flashing or boiling
GB9901809D0 (en)	1999-01-27	1999-03-17	Scarista Limited	Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
JP4558870B2 (ja)	1999-11-08	2010-10-06	株式会社日本触媒	塔式処理方法および装置
FR2833006A1 (fr) *	2001-11-30	2003-06-06	Cognis France Sa	Procede de preparation d'ester methylique d'acide oleique industriel
EP3187182B1 (en)	2008-09-02	2021-03-03	Amarin Pharmaceuticals Ireland Limited	Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same
RU2505292C2 (ru)	2009-02-10	2014-01-27	Амарин Фармасьютикалз Айрлэнд Лимитед	Способы лечения гипертриглицеридемии
CN107233337A (zh)	2009-04-29	2017-10-10	阿马里纳药物爱尔兰有限公司	含有epa和心血管剂的药物组合物以及使用其的方法
MX377553B (es)	2009-04-29	2025-03-10	Amarin Pharma Inc	Composicion farmaceutica estable y metodos de uso de la misma.
BRPI1011883A2 (pt)	2009-06-15	2016-09-13	Amarin Pharma Inc	uso de composições para redução de triglicerídeos sem elevar os níveis de o ldl-c em um paciente sob o tratamento concomitante com estatina
NZ599061A (en)	2009-09-23	2014-05-30	Amarin Pharmaceuticals Ie Ltd	Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
US11712429B2 (en)	2010-11-29	2023-08-01	Amarin Pharmaceuticals Ireland Limited	Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
NZ744990A (en)	2010-11-29	2019-10-25	Amarin Pharmaceuticals Ie Ltd	Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
CN102417447B (zh) *	2011-10-31	2014-04-30	广西亿康药业股份有限公司	十一烯酸的生产方法
US11291643B2 (en)	2011-11-07	2022-04-05	Amarin Pharmaceuticals Ireland Limited	Methods of treating hypertriglyceridemia
WO2013070735A1 (en)	2011-11-07	2013-05-16	Amarin Pharmaceuticals Ireland Limited	Methods of treating hypertriglyceridemia
EP2800469B1 (en)	2012-01-06	2021-08-25	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject
US9540306B2 (en)	2012-05-14	2017-01-10	Nippon Suisan Kaisha, Ltd.	Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and method for producing same
CN102776067A (zh) *	2012-05-31	2012-11-14	源华能源科技（福建）有限公司	一种分子蒸馏提纯粗脂肪酸甲酯工艺
US9603826B2 (en)	2012-06-29	2017-03-28	Amarin Pharmaceuticals Ireland Limited	Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
WO2014074552A2 (en)	2012-11-06	2014-05-15	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US20140187633A1 (en)	2012-12-31	2014-07-03	Amarin Pharmaceuticals Ireland Limited	Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9814733B2 (en)	2012-12-31	2017-11-14	A,arin Pharmaceuticals Ireland Limited	Compositions comprising EPA and obeticholic acid and methods of use thereof
US9452151B2 (en)	2013-02-06	2016-09-27	Amarin Pharmaceuticals Ireland Limited	Methods of reducing apolipoprotein C-III
US9624492B2 (en)	2013-02-13	2017-04-18	Amarin Pharmaceuticals Ireland Limited	Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en)	2013-02-19	2017-05-30	The Regents Of The University Of Colorado	Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en)	2013-03-14	2016-03-15	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en)	2013-03-15	2014-09-18	Amarin Pharmaceuticals Ireland Limited	Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en)	2013-06-06	2021-04-06	Amarin Pharmaceuticals Ireland Limited	Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en)	2013-09-04	2015-03-05	Amarin Pharmaceuticals Ireland Limited	Methods of treating or preventing prostate cancer
US9585859B2 (en)	2013-10-10	2017-03-07	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN103570590B (zh) *	2013-10-30	2016-04-06	临沂远博化工有限公司	一种生产硫酸二甲酯的设备
ES2872449T3 (es)	2013-12-04	2021-11-02	Nippon Suisan Kaisha Ltd	Aceite microbiano, procedimiento para fabricar aceite microbiano, aceite microbiano concentrado y procedimiento para fabricar aceite microbiano concentrado
US10561631B2 (en)	2014-06-11	2020-02-18	Amarin Pharmaceuticals Ireland Limited	Methods of reducing RLP-C
WO2015195662A1 (en)	2014-06-16	2015-12-23	Amarin Pharmaceuticals Ireland Limited	Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
CN120623044A (zh)	2014-09-17	2025-09-12	株式会社日水	含有二十碳五烯酸烷基酯的组合物及其制造方法
US10406130B2 (en)	2016-03-15	2019-09-10	Amarin Pharmaceuticals Ireland Limited	Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
US10966951B2 (en)	2017-05-19	2021-04-06	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering triglycerides in a subject having reduced kidney function
US11058661B2 (en)	2018-03-02	2021-07-13	Amarin Pharmaceuticals Ireland Limited	Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
MA50490A (fr)	2018-09-24	2020-09-02	Amarin Pharmaceuticals Ie Ltd	Procédés de réduction du risque d'événements cardiovasculaires chez un sujet
CA3160676A1 (en)	2019-11-12	2021-05-20	Amarin Pharmaceuticals Ireland Limited	Methods of reducing the risk of cardiovascular events in a subject with atrial fibrillation and/or atrial flutter
US11986452B2 (en)	2021-04-21	2024-05-21	Amarin Pharmaceuticals Ireland Limited	Methods of reducing the risk of heart failure

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2055892C3 (de) *	1970-11-13	1979-08-16	Basf Ag, 6700 Ludwigshafen	Verfahren zur Reinigung von Butandiol
DE2220922C2 (de) *	1972-04-28	1985-06-20	Feld & Hahn Gmbh, 5413 Bendorf	Verfahren und Vorrichtung zur Abtrennung von Fettsäuren durch Destillation
US4377526A (en) *	1981-05-15	1983-03-22	Nippon Suisan Kaisha, Ltd.	Method of purifying eicosapentaenoic acid and its esters
DE3226116A1 (de) *	1981-07-16	1983-02-03	VEB Chemieanlagenbaukombinat Leipzig-Grimma, DDR 7240 Grimma	Verfahren und vorrichtung zur kontinuierlichen rektifikation von mehr- und vielstoffgemischen
GB2218984B (en) *	1988-05-27	1992-09-23	Renafield Limited	Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses

1991
- 1991-06-03 CA CA002043615A patent/CA2043615C/en not_active Expired - Fee Related
- 1991-06-04 ES ES91305044T patent/ES2095909T3/es not_active Expired - Lifetime
- 1991-06-04 AU AU78186/91A patent/AU641016B2/en not_active Ceased
- 1991-06-04 DE DE69123880T patent/DE69123880T2/de not_active Expired - Fee Related
- 1991-06-04 EP EP91305044A patent/EP0460917B1/en not_active Expired - Lifetime
- 1991-06-04 DK DK91305044.9T patent/DK0460917T3/da active
- 1991-06-04 AT AT91305044T patent/ATE147062T1/de not_active IP Right Cessation
- 1991-06-04 KR KR1019910009345A patent/KR100208701B1/ko not_active Expired - Fee Related
- 1991-06-04 NO NO912144A patent/NO177699C/no unknown
1997
- 1997-02-26 GR GR970400347T patent/GR3022660T3/el unknown
1998
- 1998-12-14 JP JP10354409A patent/JPH11236591A/ja active Pending

Also Published As

Publication number	Publication date
EP0460917A3 (en)	1993-07-07
KR920000690A (ko)	1992-01-29
KR100208701B1 (ko)	1999-07-15
ATE147062T1 (de)	1997-01-15
GR3022660T3 (en)	1997-05-31
CA2043615C (en)	2001-08-14
EP0460917B1 (en)	1997-01-02
NO912144L (no)	1991-12-05
AU641016B2 (en)	1993-09-09
JPH11236591A (ja)	1999-08-31
NO912144D0 (no)	1991-06-04
ES2095909T3 (es)	1997-03-01
NO177699B (no)	1995-07-31
DE69123880D1 (de)	1997-02-13
EP0460917A2 (en)	1991-12-11
AU7818691A (en)	1991-12-05
DE69123880T2 (de)	1997-07-03
CA2043615A1 (en)	1991-12-05
NO177699C (no)	1995-11-08

Publication	Publication Date	Title
NO177699C (no)	1995-11-08	Fremgangsmåte og apparat for fremstilling av eicosapentaensyre eller dens esterderivat
NO944644L (no)	1995-06-09	Fremstilling av 3,4,4-trisubstituert-piperidinyl-N-alkylkarboksylater og mellomprodukter
DK542785D0 (da)	1985-11-22	Fremgangsmaade til fremstilling af 7-halogen-7-deoxylincomycin eller dermed analoge forbindelser
ATE123482T1 (de)	1995-06-15	Verfahren zur umwandlung eines einsatzmaterials, das lineare olefine enthält.
DK0535939T3 (da)	1997-08-11	Fremgangsmåde til fremstilling af omega 9-type polyumættet fedtsyre
DK0655454T3 (da)	2001-10-08	Fremgangsmåde til fremstilling af 2,2-difluorketensilylacetaler og alfa,alfa-difluor-beta-silyloxy-1,3-dioxolan-4-propansyreestere
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DE59209181D1 (de)	1998-03-12	Verfahren zur Herstellung von Mikrostrukturkörpern
ATE104268T1 (de)	1994-04-15	Verfahren zur herstellung eines alphaketocarbons\|ureester.
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ATE312193T1 (de)	2005-12-15	Microbiologische herstellung von l-ascorbinsäure
DK211189D0 (da)	1989-05-01	Fremgangsmaade til fremstilling af 5-chlor-3-chlorsulfonyl-2-thiophencarboxylsyreestere
DE69103175D1 (de)	1994-09-08	Verfahren zur Herstellung von Terpenketonen.
DE3869885D1 (de)	1992-05-14	Verfahren zur herstellung des gereinigten naphthalin-2,6-dicarbonsaeure-bis (2-hydroxyethyl)-esters.
FI102083B1 (fi)	1998-10-15	Menetelmä L-karnitiinin valmistamiseksi epäjatkuvasti mikrobiologista tietä
ATE127470T1 (de)	1995-09-15	Verfahren zur herstellung von phosphatidylcholinderivaten.
ATE224901T1 (de)	2002-10-15	Verfahren zur herstellung von 5-brom-2- fluorbenzolboronsäure
CA2064740A1 (en)	1991-03-01	Method for Enrichment of Oxygen 18 with a Laser
ATE167674T1 (de)	1998-07-15	Verfahren zur herstellung von l-ascorbinsäure
ATE130608T1 (de)	1995-12-15	Verfahren zur herstellung von fluoromethyl substituierten pyridin-carbodithioaten.
ATE55769T1 (de)	1990-09-15	Substituierte dioxanone, verfahren zu deren herstellung und deren verwendung.
DE69228761D1 (de)	1999-04-29	Verfahren zur herstellung von neuraminidase
DE69720432D1 (de)	2003-05-08	Verfahren zur herstellung von 2-hydroxynaphtalin-3,6-dicarbonsaure
DE3862402D1 (de)	1991-05-23	Verfahren zur herstellung von 2,3,5,6-tetrafluorbenzoesaeure.
ATE148092T1 (de)	1997-02-15	Verfahren zur herstellung von hochreinen carbonsäure-phenylestern