ES2095909T3 - Metodo para producir acido eicosapentaenoico o un ester derivado del mismo. - Google Patents

Metodo para producir acido eicosapentaenoico o un ester derivado del mismo.

Info

Publication number
ES2095909T3
ES2095909T3 ES91305044T ES91305044T ES2095909T3 ES 2095909 T3 ES2095909 T3 ES 2095909T3 ES 91305044 T ES91305044 T ES 91305044T ES 91305044 T ES91305044 T ES 91305044T ES 2095909 T3 ES2095909 T3 ES 2095909T3
Authority
ES
Spain
Prior art keywords
eicosapentaenoic acid
ester derived
producing eicosapentaenoic
present
producing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91305044T
Other languages
English (en)
Inventor
Kazuhiko Hata
Hideo Noda
Masahiro Makuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kansai Chemical Engineering Co Ltd
Nissui Corp
Original Assignee
Kansai Chemical Engineering Co Ltd
Nippon Suisan Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2145617A external-priority patent/JP3040136B2/ja
Priority claimed from JP2145618A external-priority patent/JP3005638B2/ja
Application filed by Kansai Chemical Engineering Co Ltd, Nippon Suisan Kaisha Ltd filed Critical Kansai Chemical Engineering Co Ltd
Application granted granted Critical
Publication of ES2095909T3 publication Critical patent/ES2095909T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C07C51/44—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation by distillation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C07C67/54—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation by distillation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LA INVENCION ACTUAL PROPORCIONA UN METODO PARA PRODUCIR ACIDO EICOSAPENTANOICO Y EL ESTER DERIVADO DEL MISMO, CON UNA CONCENTRACION TAN ELEVADA DEL 80% O MAS, UTILIZANDO UN PROCESO UNICO DE DESTILACION CONTINUA BAJO UNA PRESION REDUCIDA. LA INVENCION ACTUAL PROPORCIONA TAMBIEN UN METODO QUE UTILIZA UN PROCESO DE DESTILACION CONTINUA Y DE ADUCCION DE UREA MEDIANTE LA CONSTRUCCION DE UN APARATO ESPECIFICO.
ES91305044T 1990-06-04 1991-06-04 Metodo para producir acido eicosapentaenoico o un ester derivado del mismo. Expired - Lifetime ES2095909T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2145617A JP3040136B2 (ja) 1990-06-04 1990-06-04 エイコサペンタエン酸またはそのエステルの製造方法
JP2145618A JP3005638B2 (ja) 1990-06-04 1990-06-04 高濃度エイコサペンタエン酸またはそのエステルの製造方法

Publications (1)

Publication Number Publication Date
ES2095909T3 true ES2095909T3 (es) 1997-03-01

Family

ID=26476703

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91305044T Expired - Lifetime ES2095909T3 (es) 1990-06-04 1991-06-04 Metodo para producir acido eicosapentaenoico o un ester derivado del mismo.

Country Status (11)

Country Link
EP (1) EP0460917B1 (es)
JP (1) JPH11236591A (es)
KR (1) KR100208701B1 (es)
AT (1) ATE147062T1 (es)
AU (1) AU641016B2 (es)
CA (1) CA2043615C (es)
DE (1) DE69123880T2 (es)
DK (1) DK0460917T3 (es)
ES (1) ES2095909T3 (es)
GR (1) GR3022660T3 (es)
NO (1) NO177699C (es)

Families Citing this family (43)

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JP3400466B2 (ja) * 1991-10-28 2003-04-28 日本水産株式会社 高純度エイコサペンタエン酸またはそのエステルの製造方法
NO322213B1 (no) * 1998-01-30 2006-08-28 Ube Industries Fremgangsmåte for rensing av varmenedbrytbare aromatiske hydroksylforbindelser ved destillasjon hvor de varmenedbrytbare aromatiske hydroksylforbindelsene befinner seg i en flerkomponentholdig væskeblanding.
NZ332331A (en) * 1998-10-15 2000-03-27 Craig Nazzer Continuous process for removing solids from miscible liquid mixture; lower boiling point liquid(s) removed by flashing or boiling
GB9901809D0 (en) 1999-01-27 1999-03-17 Scarista Limited Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes
JP4558870B2 (ja) 1999-11-08 2010-10-06 株式会社日本触媒 塔式処理方法および装置
FR2833006A1 (fr) * 2001-11-30 2003-06-06 Cognis France Sa Procede de preparation d'ester methylique d'acide oleique industriel
EP3187182B1 (en) 2008-09-02 2021-03-03 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and nicotinic acid and methods of using same
RU2505292C2 (ru) 2009-02-10 2014-01-27 Амарин Фармасьютикалз Айрлэнд Лимитед Способы лечения гипертриглицеридемии
CN107233337A (zh) 2009-04-29 2017-10-10 阿马里纳药物爱尔兰有限公司 含有epa和心血管剂的药物组合物以及使用其的方法
MX377553B (es) 2009-04-29 2025-03-10 Amarin Pharma Inc Composicion farmaceutica estable y metodos de uso de la misma.
BRPI1011883A2 (pt) 2009-06-15 2016-09-13 Amarin Pharma Inc uso de composições para redução de triglicerídeos sem elevar os níveis de o ldl-c em um paciente sob o tratamento concomitante com estatina
NZ599061A (en) 2009-09-23 2014-05-30 Amarin Pharmaceuticals Ie Ltd Pharmaceutical composition comprising omega-3 fatty acid and hydroxy-derivative of a statin and methods of using same
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
NZ744990A (en) 2010-11-29 2019-10-25 Amarin Pharmaceuticals Ie Ltd Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
CN102417447B (zh) * 2011-10-31 2014-04-30 广西亿康药业股份有限公司 十一烯酸的生产方法
US11291643B2 (en) 2011-11-07 2022-04-05 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
WO2013070735A1 (en) 2011-11-07 2013-05-16 Amarin Pharmaceuticals Ireland Limited Methods of treating hypertriglyceridemia
EP2800469B1 (en) 2012-01-06 2021-08-25 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering levels of high-sensitivity (hs-crp) in a subject
US9540306B2 (en) 2012-05-14 2017-01-10 Nippon Suisan Kaisha, Ltd. Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and method for producing same
CN102776067A (zh) * 2012-05-31 2012-11-14 源华能源科技（福建）有限公司 一种分子蒸馏提纯粗脂肪酸甲酯工艺
US9603826B2 (en) 2012-06-29 2017-03-28 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
WO2014074552A2 (en) 2012-11-06 2014-05-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising ldl-c levels in a subject on concomitant statin therapy
US20140187633A1 (en) 2012-12-31 2014-07-03 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis
US9814733B2 (en) 2012-12-31 2017-11-14 A,arin Pharmaceuticals Ireland Limited Compositions comprising EPA and obeticholic acid and methods of use thereof
US9452151B2 (en) 2013-02-06 2016-09-27 Amarin Pharmaceuticals Ireland Limited Methods of reducing apolipoprotein C-III
US9624492B2 (en) 2013-02-13 2017-04-18 Amarin Pharmaceuticals Ireland Limited Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
US9662307B2 (en) 2013-02-19 2017-05-30 The Regents Of The University Of Colorado Compositions comprising eicosapentaenoic acid and a hydroxyl compound and methods of use thereof
US9283201B2 (en) 2013-03-14 2016-03-15 Amarin Pharmaceuticals Ireland Limited Compositions and methods for treating or preventing obesity in a subject in need thereof
US20140271841A1 (en) 2013-03-15 2014-09-18 Amarin Pharmaceuticals Ireland Limited Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin
US10966968B2 (en) 2013-06-06 2021-04-06 Amarin Pharmaceuticals Ireland Limited Co-administration of rosiglitazone and eicosapentaenoic acid or a derivative thereof
US20150065572A1 (en) 2013-09-04 2015-03-05 Amarin Pharmaceuticals Ireland Limited Methods of treating or preventing prostate cancer
US9585859B2 (en) 2013-10-10 2017-03-07 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy
CN103570590B (zh) * 2013-10-30 2016-04-06 临沂远博化工有限公司 一种生产硫酸二甲酯的设备
ES2872449T3 (es) 2013-12-04 2021-11-02 Nippon Suisan Kaisha Ltd Aceite microbiano, procedimiento para fabricar aceite microbiano, aceite microbiano concentrado y procedimiento para fabricar aceite microbiano concentrado
US10561631B2 (en) 2014-06-11 2020-02-18 Amarin Pharmaceuticals Ireland Limited Methods of reducing RLP-C
WO2015195662A1 (en) 2014-06-16 2015-12-23 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids
CN120623044A (zh) 2014-09-17 2025-09-12 株式会社日水 含有二十碳五烯酸烷基酯的组合物及其制造方法
US10406130B2 (en) 2016-03-15 2019-09-10 Amarin Pharmaceuticals Ireland Limited Methods of reducing or preventing oxidation of small dense LDL or membrane polyunsaturated fatty acids
US10966951B2 (en) 2017-05-19 2021-04-06 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject having reduced kidney function
US11058661B2 (en) 2018-03-02 2021-07-13 Amarin Pharmaceuticals Ireland Limited Compositions and methods for lowering triglycerides in a subject on concomitant statin therapy and having hsCRP levels of at least about 2 mg/L
MA50490A (fr) 2018-09-24 2020-09-02 Amarin Pharmaceuticals Ie Ltd Procédés de réduction du risque d'événements cardiovasculaires chez un sujet
CA3160676A1 (en) 2019-11-12 2021-05-20 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of cardiovascular events in a subject with atrial fibrillation and/or atrial flutter
US11986452B2 (en) 2021-04-21 2024-05-21 Amarin Pharmaceuticals Ireland Limited Methods of reducing the risk of heart failure

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2055892C3 (de) * 1970-11-13 1979-08-16 Basf Ag, 6700 Ludwigshafen Verfahren zur Reinigung von Butandiol
DE2220922C2 (de) * 1972-04-28 1985-06-20 Feld & Hahn Gmbh, 5413 Bendorf Verfahren und Vorrichtung zur Abtrennung von Fettsäuren durch Destillation
US4377526A (en) * 1981-05-15 1983-03-22 Nippon Suisan Kaisha, Ltd. Method of purifying eicosapentaenoic acid and its esters
DE3226116A1 (de) * 1981-07-16 1983-02-03 VEB Chemieanlagenbaukombinat Leipzig-Grimma, DDR 7240 Grimma Verfahren und vorrichtung zur kontinuierlichen rektifikation von mehr- und vielstoffgemischen
GB2218984B (en) * 1988-05-27 1992-09-23 Renafield Limited Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses

Also Published As

Publication number Publication date
EP0460917A3 (en) 1993-07-07
KR920000690A (ko) 1992-01-29
KR100208701B1 (ko) 1999-07-15
ATE147062T1 (de) 1997-01-15
GR3022660T3 (en) 1997-05-31
CA2043615C (en) 2001-08-14
EP0460917B1 (en) 1997-01-02
DK0460917T3 (da) 1997-01-20
NO912144L (no) 1991-12-05
AU641016B2 (en) 1993-09-09
JPH11236591A (ja) 1999-08-31
NO912144D0 (no) 1991-06-04
NO177699B (no) 1995-07-31
DE69123880D1 (de) 1997-02-13
EP0460917A2 (en) 1991-12-11
AU7818691A (en) 1991-12-05
DE69123880T2 (de) 1997-07-03
CA2043615A1 (en) 1991-12-05
NO177699C (no) 1995-11-08

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