DK0655454T3 - Fremgangsmåde til fremstilling af 2,2-difluorketensilylacetaler og alfa,alfa-difluor-beta-silyloxy-1,3-dioxolan-4-propansyreestere - Google Patents

Fremgangsmåde til fremstilling af 2,2-difluorketensilylacetaler og alfa,alfa-difluor-beta-silyloxy-1,3-dioxolan-4-propansyreestere

Info

Publication number: DK0655454T3
Authority: DK; Denmark
Prior art keywords: alpha; acetals; silyloxy; dioxolane; difluoro
Prior art date: 1993-11-30

Application number

DK94308806T

Other languages

English (en)

Inventor

Thomas Charles Britton

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-30

Filing date

1994-11-29

Publication date

2001-10-08

1994-11-29 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2001-10-08 Application granted granted Critical

2001-10-08 Publication of DK0655454T3 publication Critical patent/DK0655454T3/da

Links

YLDGTYXTMNSOOA-UHFFFAOYSA-N 3-(1,3-dioxolan-4-yl)-2,2-difluoro-3-silyloxypropanoic acid Chemical class OC(=O)C(F)(F)C(O[SiH3])C1COCO1 YLDGTYXTMNSOOA-UHFFFAOYSA-N 0.000 title abstract 2
150000001241 acetals Chemical class 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- C07F7/1872—Preparation; Treatments not provided for in C07F7/20
- C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

DK94308806T 1993-11-30 1994-11-29 Fremgangsmåde til fremstilling af 2,2-difluorketensilylacetaler og alfa,alfa-difluor-beta-silyloxy-1,3-dioxolan-4-propansyreestere DK0655454T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US16054993A	1993-11-30	1993-11-30
US30712294A	1994-09-16	1994-09-16

Publications (1)

Publication Number	Publication Date
DK0655454T3 true DK0655454T3 (da)	2001-10-08

Family

ID=26856978

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK94308806T DK0655454T3 (da)	1993-11-30	1994-11-29	Fremgangsmåde til fremstilling af 2,2-difluorketensilylacetaler og alfa,alfa-difluor-beta-silyloxy-1,3-dioxolan-4-propansyreestere

Country Status (14)

Country	Link
US (1)	US5618951A (da)
EP (1)	EP0655454B1 (da)
JP (1)	JP3615253B2 (da)
KR (2)	KR100344363B1 (da)
AT (1)	ATE204283T1 (da)
BR (1)	BR9404776A (da)
CA (1)	CA2136788C (da)
DE (1)	DE69427955T2 (da)
DK (1)	DK0655454T3 (da)
ES (1)	ES2159296T3 (da)
FI (1)	FI115461B (da)
HU (2)	HU224710B1 (da)
IL (1)	IL111793A (da)
PT (1)	PT655454E (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000501738A (ja)	1995-12-13	2000-02-15	イーライ・リリー・アンド・カンパニー	α，α―ジフルオロ―β―ヒドロキシチオールエステル及びその合成
US5756775A (en) *	1995-12-13	1998-05-26	Eli Lilly And Company	Process to make α,α-difluoro-β-hydroxyl thiol esters
US6001994A (en) *	1995-12-13	1999-12-14	Eli Lilly And Company	Process for making gemcitabine hydrochloride
US7067600B2 (en) *	2001-08-16	2006-06-27	The Goodyear Tire & Rubber Company	Modified silane compounds
KR100578616B1 (ko) *	2004-07-23	2006-05-10	한미약품 주식회사	Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
UA97498C2 (ru) *	2006-11-03	2012-02-27	Басф Се	Способ получения дифторметилпиразолилкарбоксилатов
MX2009005863A (es) *	2006-12-21	2009-06-12	Basf Se	Procedimiento para la preparacion de compuestos heterociclicos sustituidos por fluorometilo.
AR072447A1 (es)	2008-02-29	2010-09-01	Basf Se	Proceso para preparar 2- alcoximetilen-4,4-difluoro-3-oxobutiratos de alquilo
BRPI0911898A2 (pt) *	2008-05-02	2015-10-13	Basf Se	processo para preparar compostos, e, composto.
JP5602131B2 (ja) *	2008-05-02	2014-10-08	ビーエーエスエフソシエタス・ヨーロピア	ハロゲン置換２−（アミノメチリデン）−３−オキソ酪酸エステルの製造方法
US8598222B2 (en) *	2008-05-05	2013-12-03	Basf Se	Method for preparing 1,3,4-substituted pyrazol compounds
KR20110004903A (ko)	2008-05-08	2011-01-14	바스프 에스이	아릴카르복스아미드의 제조 방법
EP2307384B1 (en) *	2008-07-21	2012-04-25	Basf Se	Process for preparing 1,3-disubstituted pyrazolecarboxylic esters
JP5540776B2 (ja) *	2010-03-05	2014-07-02	セントラル硝子株式会社	ジフルオロ酢酸エステルの製造方法
CN113603669A (zh) *	2021-08-06	2021-11-05	江苏八巨药业有限公司	一种吉西他滨关键中间体的制备方法
CN117843519B (zh) *	2024-01-02	2026-07-03	南京工业大学	一种二氟烯酮的制备及其转化为二氟乙酸酯及酰胺的方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4508880A (en) *	1981-06-30	1985-04-02	E. I. Du Pont De Nemours And Company	"Living" polymers and process for their preparation
US4417034A (en) *	1981-06-30	1983-11-22	E. I. Du Pont De Nemours & Co.	Living polymers and process for their preparation
US4414372A (en) *	1982-06-17	1983-11-08	E. I. Du Pont De Nemours & Co.	Process for preparing living polymers
US4482729A (en) *	1984-03-04	1984-11-13	Daikin Kogyo Co., Ltd.	Fluoroalkyl silyl ketene acetals and a process for preparing the same
US4780554A (en) *	1984-11-20	1988-10-25	Union Carbide Corporation	O-silylated ketene acetals and enol ethers and method of preparation
US4754046A (en) *	1987-06-25	1988-06-28	Dow Corning Corporation	Stabilized silyl ketene acetals
US4824981A (en) *	1987-07-06	1989-04-25	Dow Corning Corporation	Process to produce silyl ketene acetals
US4746750A (en) *	1987-08-31	1988-05-24	Dow Corning Corporation	Synthesis of silyl ketene acetal from allyl 2-organoacrylates
JP2594605B2 (ja) *	1988-03-12	1997-03-26	鹿島石油株式会社	光学活性なα，α−ジフルオロ−β−ヒドロキシカルボニル化合物
JPH0267250A (ja) *	1988-09-02	1990-03-07	Asahi Glass Co Ltd	２，２‐ジフルオロ‐３‐ヒドロキシカルボン酸誘導体の製造法
US4824980A (en) *	1988-09-02	1989-04-25	Dow Corning Corporation	Process to produce O-silyl O,N-ketene acetals
KR900012940A (ko) *	1989-02-14	1990-09-03	사와무라 하루오	유기규소 화합물의 제조방법
JPH02270841A (ja) *	1989-04-12	1990-11-05	Asahi Glass Co Ltd	２，２―ジフルオロ―３，４，５―トリヒドロキシカルボン酸誘導体の製造法

1994
- 1994-11-28 KR KR1019940031485A patent/KR100344363B1/ko not_active Expired - Fee Related
- 1994-11-28 CA CA002136788A patent/CA2136788C/en not_active Expired - Fee Related
- 1994-11-28 IL IL11179394A patent/IL111793A/en not_active IP Right Cessation
- 1994-11-29 JP JP29448094A patent/JP3615253B2/ja not_active Expired - Fee Related
- 1994-11-29 PT PT94308806T patent/PT655454E/pt unknown
- 1994-11-29 FI FI945626A patent/FI115461B/fi not_active IP Right Cessation
- 1994-11-29 DK DK94308806T patent/DK0655454T3/da active
- 1994-11-29 BR BR9404776A patent/BR9404776A/pt not_active Application Discontinuation
- 1994-11-29 ES ES94308806T patent/ES2159296T3/es not_active Expired - Lifetime
- 1994-11-29 EP EP94308806A patent/EP0655454B1/en not_active Expired - Lifetime
- 1994-11-29 HU HU9904356A patent/HU224710B1/hu not_active IP Right Cessation
- 1994-11-29 HU HU9403423A patent/HU219466B/hu not_active IP Right Cessation
- 1994-11-29 AT AT94308806T patent/ATE204283T1/de active
- 1994-11-29 DE DE69427955T patent/DE69427955T2/de not_active Expired - Lifetime
1995
- 1995-05-26 US US08/451,284 patent/US5618951A/en not_active Expired - Lifetime
2001
- 2001-11-22 KR KR1020010072944A patent/KR100332322B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT655454E (pt)	2001-12-28
CA2136788C (en)	2005-01-25
DE69427955D1 (de)	2001-09-20
US5618951A (en)	1997-04-08
FI945626A0 (fi)	1994-11-29
FI945626L (fi)	1995-05-31
JPH07188260A (ja)	1995-07-25
HU9403423D0 (en)	1995-02-28
HUT70178A (en)	1995-09-28
CA2136788A1 (en)	1995-05-31
KR100332322B1 (ko)	2002-04-13
ES2159296T3 (es)	2001-10-01
IL111793A0 (en)	1995-01-24
EP0655454B1 (en)	2001-08-16
ATE204283T1 (de)	2001-09-15
KR950014125A (ko)	1995-06-15
KR100344363B1 (ko)	2002-11-30
HU9904356D0 (en)	2000-02-28
IL111793A (en)	1998-12-06
JP3615253B2 (ja)	2005-02-02
HU219466B (hu)	2001-04-28
FI115461B (fi)	2005-05-13
EP0655454A1 (en)	1995-05-31
HU224710B1 (en)	2006-01-30
DE69427955T2 (de)	2002-04-18
BR9404776A (pt)	1995-11-21

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