DK0463592T3 - 2,4- og 2,5-substituerede pyridin-N-oxider, fremgangsmåder til deres fremstilling samt deres anvendelse - Google Patents

2,4- og 2,5-substituerede pyridin-N-oxider, fremgangsmåder til deres fremstilling samt deres anvendelse

Info

Publication number: DK0463592T3
Authority: DK; Denmark
Prior art keywords: oxides; substituted pyridine; processes; preparation; collagen
Prior art date: 1990-06-28

Application number

DK91110343.0T

Other languages

Danish (da)

English (en)

Inventor

Ekkehard Dr Baader

Martin Dr Bickel

Volkmar Dr Guenzler-Pukall

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-28

Filing date

1991-06-22

Publication date

1994-12-19

1991-06-22 Application filed by Hoechst Ag filed Critical Hoechst Ag

1994-12-19 Application granted granted Critical

1994-12-19 Publication of DK0463592T3 publication Critical patent/DK0463592T3/da

Links

ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 title abstract 2
102000008186 Collagen Human genes 0.000 abstract 1
108010035532 Collagen Proteins 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229920001436 collagen Polymers 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001506 immunosuppresive effect Effects 0.000 abstract 1
230000004060 metabolic process Effects 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Hematology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Obesity (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Medicinal Preparation (AREA)

DK91110343.0T 1990-06-28 1991-06-22 2,4- og 2,5-substituerede pyridin-N-oxider, fremgangsmåder til deres fremstilling samt deres anvendelse DK0463592T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4020570A DE4020570A1 (de)	1990-06-28	1990-06-28	2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung

Publications (1)

Publication Number	Publication Date
DK0463592T3 true DK0463592T3 (da)	1994-12-19

Family

ID=6409247

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91110343.0T DK0463592T3 (da)	1990-06-28	1991-06-22	2,4- og 2,5-substituerede pyridin-N-oxider, fremgangsmåder til deres fremstilling samt deres anvendelse

Country Status (27)

Country	Link
EP (1)	EP0463592B1 (fr)
JP (1)	JPH0832687B2 (fr)
KR (1)	KR920000724A (fr)
CN (1)	CN1038585C (fr)
AT (1)	ATE110059T1 (fr)
AU (1)	AU636990B2 (fr)
BR (1)	BR9102699A (fr)
CA (1)	CA2045868A1 (fr)
CZ (1)	CZ283782B6 (fr)
DE (2)	DE4020570A1 (fr)
DK (1)	DK0463592T3 (fr)
EG (1)	EG19851A (fr)
ES (1)	ES2061118T3 (fr)
FI (1)	FI101070B (fr)
HR (1)	HRP940701B1 (fr)
HU (1)	HU214627B (fr)
IE (1)	IE65300B1 (fr)
IL (1)	IL98629A (fr)
LT (1)	LT3918B (fr)
MA (1)	MA22191A1 (fr)
MX (1)	MX26415A (fr)
MY (1)	MY107573A (fr)
NO (1)	NO178026C (fr)
NZ (1)	NZ238701A (fr)
PT (1)	PT98108B (fr)
YU (1)	YU113391A (fr)
ZA (1)	ZA914958B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU9492A (sh) *	1991-02-05	1995-03-27	Hoechst Ag.	2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
EP0548883A1 (fr) *	1991-12-24	1993-06-30	Hoechst Aktiengesellschaft	Pyridine-N-oxides substituées, procédé pour leur préparation et leur utilisation comme médicaments
TW352384B (en) *	1992-03-24	1999-02-11	Hoechst Ag	Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
TW222585B (fr) *	1992-09-11	1994-04-21	Hoechst Ag
DE4233124A1 (de) *	1992-10-02	1994-04-07	Hoechst Ag	Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19624659A1 (de)	1996-06-20	1998-01-08	Klinge Co Chem Pharm Fab	Neue Pyridylalken- und Pyridylalkinsäureamide
US6451816B1 (en)	1997-06-20	2002-09-17	Klinge Pharma Gmbh	Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624704A1 (de) *	1996-06-20	1998-01-08	Klinge Co Chem Pharm Fab	Neue Pyridylalkansäureamide
FR2766187B1 (fr) *	1997-07-17	2000-06-02	Rhone Poulenc Rorer Sa	Derives de pyrazine, leur preparation et les medicaments les contenant
DE19756235A1 (de)	1997-12-17	1999-07-01	Klinge Co Chem Pharm Fab	Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
DE19756212A1 (de)	1997-12-17	1999-07-01	Klinge Co Chem Pharm Fab	Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
DE19756261A1 (de)	1997-12-17	1999-07-01	Klinge Co Chem Pharm Fab	Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
US6903118B1 (en)	1997-12-17	2005-06-07	Klinge Pharma Gmbh	Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
EP1031564A1 (fr)	1999-02-26	2000-08-30	Klinge Pharma GmbH	Inhibiteurs de la formation du nicotinamide mononucléotide et leur utilisation dans le traitement du cancer
DOP2002000333A (es)	2001-02-14	2002-09-30	Warner Lambert Co	Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
DOP2002000332A (es)	2001-02-14	2002-08-30	Warner Lambert Co	Inhibidores de piridina de metaloproteinasas de la matriz
WO2002064571A1 (fr)	2001-02-14	2002-08-22	Warner-Lambert Company Llc	Pyrimidine comme inhibiteurs de la métalloprotéinase de matrice
US6924276B2 (en)	2001-09-10	2005-08-02	Warner-Lambert Company	Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
BR0213233A (pt)	2001-10-12	2005-01-04	Warner Lambert Co	Alcinos inibidores de metaloproteinase de matriz
DE10160357A1 (de) *	2001-12-08	2003-06-18	Aventis Pharma Gmbh	Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen
US6933298B2 (en)	2001-12-08	2005-08-23	Aventis Pharma Deutschland Gmbh	Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5623987B2 (fr) *	1972-02-04	1981-06-03
JPS6052702B2 (ja)	1976-08-27	1985-11-20	中外製薬株式会社	ピリジン誘導体およびその製造方法
JPS57109792A (en) *	1980-12-26	1982-07-08	Banyu Pharmaceut Co Ltd	Penicillin derivative and salt thereof
DE3432094A1 (de)	1984-08-31	1986-03-06	Hoechst Ag, 6230 Frankfurt	Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
JP2512924B2 (ja) *	1987-01-21	1996-07-03	萬有製薬株式会社	育毛剤
DE3703963A1 (de)	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
DE3703962A1 (de)	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703959A1 (de)	1987-02-10	1988-08-18	Hoechst Ag	Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
JP2600786B2 (ja) *	1988-04-12	1997-04-16	萬有製薬株式会社	育毛剤
DE3826471A1 (de)	1988-08-04	1990-02-22	Hoechst Ag	Verbessertes verfahren zur herstellung von n,n'-bis(alkoxyalkyl)-pyridin-2,4-dicarbonsaeurediamiden
DE3924093A1 (de)	1989-07-20	1991-02-07	Hoechst Ag	N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
ZA91291B (en)	1990-01-16	1991-09-25	Hoechst Ag	Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof

1990
- 1990-06-28 DE DE4020570A patent/DE4020570A1/de not_active Withdrawn
1991
- 1991-06-22 DK DK91110343.0T patent/DK0463592T3/da active
- 1991-06-22 DE DE59102547T patent/DE59102547D1/de not_active Expired - Fee Related
- 1991-06-22 ES ES91110343T patent/ES2061118T3/es not_active Expired - Lifetime
- 1991-06-22 EP EP91110343A patent/EP0463592B1/fr not_active Expired - Lifetime
- 1991-06-22 AT AT91110343T patent/ATE110059T1/de not_active IP Right Cessation
- 1991-06-26 EG EG39291A patent/EG19851A/xx active
- 1991-06-26 IL IL9862991A patent/IL98629A/en not_active IP Right Cessation
- 1991-06-26 CZ CS911959A patent/CZ283782B6/cs not_active IP Right Cessation
- 1991-06-26 NZ NZ238701A patent/NZ238701A/en unknown
- 1991-06-26 FI FI913118A patent/FI101070B/fi active IP Right Grant
- 1991-06-26 MY MYPI91001142A patent/MY107573A/en unknown
- 1991-06-27 CN CN91104308A patent/CN1038585C/zh not_active Expired - Fee Related
- 1991-06-27 ZA ZA914958A patent/ZA914958B/xx unknown
- 1991-06-27 HU HU912158A patent/HU214627B/hu not_active IP Right Cessation
- 1991-06-27 IE IE225391A patent/IE65300B1/en unknown
- 1991-06-27 MA MA22469A patent/MA22191A1/fr unknown
- 1991-06-27 YU YU113391A patent/YU113391A/sh unknown
- 1991-06-27 PT PT98108A patent/PT98108B/pt not_active IP Right Cessation
- 1991-06-27 NO NO912541A patent/NO178026C/no not_active IP Right Cessation
- 1991-06-27 AU AU79356/91A patent/AU636990B2/en not_active Ceased
- 1991-06-27 BR BR919102699A patent/BR9102699A/pt not_active Application Discontinuation
- 1991-06-27 CA CA002045868A patent/CA2045868A1/fr not_active Abandoned
- 1991-06-27 MX MX2641591A patent/MX26415A/es unknown
- 1991-06-27 JP JP3156562A patent/JPH0832687B2/ja not_active Expired - Lifetime
- 1991-06-28 KR KR1019910010858A patent/KR920000724A/ko not_active Withdrawn
1993
- 1993-11-12 LT LTIP1464A patent/LT3918B/lt not_active IP Right Cessation
1994
- 1994-10-19 HR HRP-1133/91A patent/HRP940701B1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE4020570A1 (de)	1992-01-02
YU113391A (sh)	1995-10-03
CS195991A3 (en)	1992-02-19
IE912253A1 (en)	1992-01-01
MX26415A (es)	1993-05-01
CN1038585C (zh)	1998-06-03
ES2061118T3 (es)	1994-12-01
CZ283782B6 (cs)	1998-06-17
EP0463592B1 (fr)	1994-08-17
AU636990B2 (en)	1993-05-13
NO178026B (no)	1995-10-02
HUT59104A (en)	1992-04-28
PT98108A (pt)	1993-06-30
EG19851A (en)	1996-10-31
NO912541L (no)	1991-12-30
IL98629A0 (en)	1992-07-15
ZA914958B (en)	1992-03-25
MA22191A1 (fr)	1991-12-31
NO178026C (no)	1996-01-10
ATE110059T1 (de)	1994-09-15
HRP940701A2 (en)	1997-02-28
BR9102699A (pt)	1992-02-04
LT3918B (en)	1996-04-25
JPH0832687B2 (ja)	1996-03-29
CA2045868A1 (fr)	1991-12-29
LTIP1464A (en)	1995-05-25
EP0463592A1 (fr)	1992-01-02
DE59102547D1 (de)	1994-09-22
PT98108B (pt)	1998-12-31
HU912158D0 (en)	1991-12-30
KR920000724A (ko)	1992-01-29
AU7935691A (en)	1992-01-02
HRP940701B1 (en)	1999-08-31
MY107573A (en)	1996-04-30
HU214627B (hu)	1998-04-28
CN1057649A (zh)	1992-01-08
JPH04230264A (ja)	1992-08-19
NO912541D0 (no)	1991-06-27
IE65300B1 (en)	1995-10-18
IL98629A (en)	1996-05-14
FI101070B (fi)	1998-04-15
FI913118A0 (fi)	1991-06-26
NZ238701A (en)	1994-06-27
FI913118L (fi)	1991-12-29

Publication	Publication Date	Title
DK0463592T3 (da)	1994-12-19	2,4- og 2,5-substituerede pyridin-N-oxider, fremgangsmåder til deres fremstilling samt deres anvendelse
FI902263A7 (fi)	1991-07-15	Temperaturkompensation i en helix-resonator.
DE3789294D1 (de)	1994-04-14	Triazin-Derivate und diese enthaltende Herbizide.
DE3763215D1 (de)	1990-07-19	Aushaengbares verschwindscharnier fuer schaltschraenke.
DE3770661D1 (de)	1991-07-18	1,2,3,4-tetrahydro-6-substituierte-4-aryl(oder heterozyklo)3-((substituierte amino)carbonyl)-2-thioxo(oder oxo)-5-pyrimidinkarbonsaeuren und -ester.
DE3774902D1 (de)	1992-01-16	Automatisch gesteuerte verstaerkungseinrichtung.
NO170887C (no)	1992-12-23	Substituerte 2,6-substituerte pyridinforbindelser, herbicide preparater inneholdende disse som aktiv bestanddel og anvendelse av forbindelsene for ugressbekjempelse
ES2024688B3 (es)	1992-03-01	Portaguillotina perfeccionada para focos cerrados de chimeneas.
DK275087D0 (da)	1987-05-29	Middel til bekaempelse af skadelige organismer paa basis af aminopyrimidin-derivater, dets fremstilling og anvendelse samt hidtil ukendte aminopyrimidin-forbindelser
NO894008D0 (no)	1989-10-06	Trekonserveringsmiddel og fremgangsmaate for behandling avtre med samme.
DE69012298D1 (de)	1994-10-13	Heizen von Lagern und dergleichen.
DE3881270D1 (de)	1993-07-01	Verwendung von pyrrolidon-derivaten als antiamnetikum.
KR900700479A (ko)	1990-08-13	정신병 치료용 감마-카볼린 n-옥사이드
ES2061775T3 (es)	1994-12-16	Derivados de estrobirulina, su obtencion y empleo.
NO910163L (no)	1991-07-17	Fremgangsmaate for fremstilling og anvendelse av pyridin-2,4- og 2,5-dikarboksylsyredi-(nitroksyalkyl)amid.
DE3866591D1 (de)	1992-01-16	Demontierbares scharnier.
NL194948B (nl)	2003-04-01	Werkwijze voor het bereiden van aromatische polycarbonaten.
DK162389A (da)	1990-10-05	Lukkeorgan til laager, doere, floeje, skuffer og lignende samt anvendelse heraf
ATE104945T1 (de)	1994-05-15	Alkyltetramethylcyclohexan-derivate und deren verwendung als duftstoffe.
IT8747886A0 (it)	1987-04-24	Perfezionamento alle cerniere diporte, sportelli e simili
IT8620110A0 (it)	1986-04-16	Sistema per la regolazione dell'atina dei cestelli estraibili dei mobili, mediante angolari filettati.
ES1006376Y (es)	1989-05-16	Dispositivo de fijacion de elementos empotrables para mobiliario, particularmente de cazoletas empotradas de bisagras.
IT213322Z2 (it)	1989-11-13	Controtelaio ripiegabile, per il montaggio di porte e simili
IT8583368A0 (it)	1985-05-17	Pannello o sportello antina curvo per mobili.
IT8784976A0 (it)	1987-10-13	Metodo per l'apertura di porte sportelli o simili utilizzante dispositivi di sicurezza che operano il confronto tra dve combinazioni di riferimenti disposti su supporti amovibili.