HRP940701B1 - 2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization - Google Patents

2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization

Info

Publication number
HRP940701B1
HRP940701B1 HRP-1133/91A HRP940701A HRP940701B1 HR P940701 B1 HRP940701 B1 HR P940701B1 HR P940701 A HRP940701 A HR P940701A HR P940701 B1 HRP940701 B1 HR P940701B1
Authority
HR
Croatia
Prior art keywords
substituted pyridine
oxydes
utilization
preparation
collagen
Prior art date
Application number
HRP-1133/91A
Other languages
English (en)
Inventor
Volkmar Guenzler-Pukall
Original Assignee
Volkmar Guenzler-Pukall
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Volkmar Guenzler-Pukall filed Critical Volkmar Guenzler-Pukall
Publication of HRP940701A2 publication Critical patent/HRP940701A2/xx
Publication of HRP940701B1 publication Critical patent/HRP940701B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HRP-1133/91A 1990-06-28 1994-10-19 2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization HRP940701B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4020570A DE4020570A1 (de) 1990-06-28 1990-06-28 2,4- und 2,5-substituierte pyridin-n-oxide, verfahren zu deren herstellung sowie deren verwendung
YU113391A YU113391A (sh) 1990-06-28 1991-06-27 2,4 i 2,5 substituirani piridin-n oksidi i postupak za njihovu proizvodnju

Publications (2)

Publication Number Publication Date
HRP940701A2 HRP940701A2 (en) 1997-02-28
HRP940701B1 true HRP940701B1 (en) 1999-08-31

Family

ID=6409247

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP-1133/91A HRP940701B1 (en) 1990-06-28 1994-10-19 2,4- and 2,5-substituted pyridine-n-oxydes, process for their preparation and utilization

Country Status (27)

Country Link
EP (1) EP0463592B1 (fr)
JP (1) JPH0832687B2 (fr)
KR (1) KR920000724A (fr)
CN (1) CN1038585C (fr)
AT (1) ATE110059T1 (fr)
AU (1) AU636990B2 (fr)
BR (1) BR9102699A (fr)
CA (1) CA2045868A1 (fr)
CZ (1) CZ283782B6 (fr)
DE (2) DE4020570A1 (fr)
DK (1) DK0463592T3 (fr)
EG (1) EG19851A (fr)
ES (1) ES2061118T3 (fr)
FI (1) FI101070B (fr)
HR (1) HRP940701B1 (fr)
HU (1) HU214627B (fr)
IE (1) IE65300B1 (fr)
IL (1) IL98629A (fr)
LT (1) LT3918B (fr)
MA (1) MA22191A1 (fr)
MX (1) MX26415A (fr)
MY (1) MY107573A (fr)
NO (1) NO178026C (fr)
NZ (1) NZ238701A (fr)
PT (1) PT98108B (fr)
YU (1) YU113391A (fr)
ZA (1) ZA914958B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU9492A (sh) * 1991-02-05 1995-03-27 Hoechst Ag. 2,4- i 2,5-bis-tetrazolilni piridini i postupak za njihovo dobijanje
CA2085954A1 (fr) * 1991-12-24 1993-06-25 Klaus Weidmann Pyridine-n-oxydes substitues, procedes pour leur obtention, et leur emploi
TW352384B (en) * 1992-03-24 1999-02-11 Hoechst Ag Sulfonamido- or sulfonamidocarbonylpyridine-2-carboxamides, process for their preparation and their use as pharmaceuticals
TW222585B (fr) * 1992-09-11 1994-04-21 Hoechst Ag
DE4233124A1 (de) * 1992-10-02 1994-04-07 Hoechst Ag Acylsulfonamido- und Sulfonamidopyridin-2-carbonsäureester sowie ihre Pyridin-N-oxide, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6451816B1 (en) 1997-06-20 2002-09-17 Klinge Pharma Gmbh Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
DE19624704A1 (de) * 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalkansäureamide
FR2766187B1 (fr) * 1997-07-17 2000-06-02 Rhone Poulenc Rorer Sa Derives de pyrazine, leur preparation et les medicaments les contenant
DE19756212A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
US6903118B1 (en) 1997-12-17 2005-06-07 Klinge Pharma Gmbh Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
DE19756235A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
DE19756261A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
EP1031564A1 (fr) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibiteurs de la formation du nicotinamide mononucléotide et leur utilisation dans le traitement du cancer
DOP2002000332A (es) 2001-02-14 2002-08-30 Warner Lambert Co Inhibidores de piridina de metaloproteinasas de la matriz
DOP2002000333A (es) 2001-02-14 2002-09-30 Warner Lambert Co Derivados de acido isoftalico como inhibidores de metaloproteinasas de la matriz
JP2004518723A (ja) 2001-02-14 2004-06-24 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー ピリミジンマトリックスメタロプロテイナーゼ阻害剤
US6924276B2 (en) 2001-09-10 2005-08-02 Warner-Lambert Company Diacid-substituted heteroaryl derivatives as matrix metalloproteinase inhibitors
MXPA04002537A (es) 2001-10-12 2004-05-31 Warner Lambert Co Alquinos como inhibidores de metaloproteinasa de matriz.
DE10160357A1 (de) * 2001-12-08 2003-06-18 Aventis Pharma Gmbh Verwendung von Pyridin-2,4-dicarbonsäurediamiden und Pyrimidin-4,6-dicarbonsäurediamiden zur selektiven Inhibierung von Kollagenasen
US6933298B2 (en) 2001-12-08 2005-08-23 Aventis Pharma Deutschland Gmbh Pyridine-2,4-dicarboxylic acid diamides and pyrimidine-4,6-dicarboxylic acid diamides and the use thereof for selectively inhibiting collagenases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5623987B2 (fr) * 1972-02-04 1981-06-03
JPS6052702B2 (ja) 1976-08-27 1985-11-20 中外製薬株式会社 ピリジン誘導体およびその製造方法
JPS57109792A (en) * 1980-12-26 1982-07-08 Banyu Pharmaceut Co Ltd Penicillin derivative and salt thereof
DE3432094A1 (de) 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
JP2512924B2 (ja) * 1987-01-21 1996-07-03 萬有製薬株式会社 育毛剤
DE3703959A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeureamide, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703962A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben sowie arzneimittel auf basis dieser verbindungen
DE3703963A1 (de) 1987-02-10 1988-08-18 Hoechst Ag Pyridin-2,4- und 2,,5-dicarbonsaeure-derivate, verfahren zu ihrer herstellung, verwendung derselben, sowie arzneimittel auf basis dieser verbindungen
JP2600786B2 (ja) * 1988-04-12 1997-04-16 萬有製薬株式会社 育毛剤
DE3826471A1 (de) 1988-08-04 1990-02-22 Hoechst Ag Verbessertes verfahren zur herstellung von n,n'-bis(alkoxyalkyl)-pyridin-2,4-dicarbonsaeurediamiden
DE3924093A1 (de) 1989-07-20 1991-02-07 Hoechst Ag N,n'-bis(alkoxy-alkyl)-pyridin-2,4-dicarbonsaeurediamide, verfahren zu deren herstellung sowie deren verwendung
ZA91291B (en) 1990-01-16 1991-09-25 Hoechst Ag Di(nitroxyalkyl)amides of pyridine-2,4-and-2,5-dicarboxylic acids,a process for the preparation thereof,and the use thereof

Also Published As

Publication number Publication date
HU214627B (hu) 1998-04-28
CN1038585C (zh) 1998-06-03
CS195991A3 (en) 1992-02-19
KR920000724A (ko) 1992-01-29
IE65300B1 (en) 1995-10-18
AU7935691A (en) 1992-01-02
CN1057649A (zh) 1992-01-08
EP0463592B1 (fr) 1994-08-17
MA22191A1 (fr) 1991-12-31
IE912253A1 (en) 1992-01-01
LTIP1464A (en) 1995-05-25
LT3918B (en) 1996-04-25
EG19851A (en) 1996-10-31
BR9102699A (pt) 1992-02-04
NO178026B (no) 1995-10-02
IL98629A0 (en) 1992-07-15
FI913118A0 (fi) 1991-06-26
CA2045868A1 (fr) 1991-12-29
ATE110059T1 (de) 1994-09-15
NO178026C (no) 1996-01-10
DE59102547D1 (de) 1994-09-22
JPH0832687B2 (ja) 1996-03-29
DE4020570A1 (de) 1992-01-02
HU912158D0 (en) 1991-12-30
NZ238701A (en) 1994-06-27
PT98108B (pt) 1998-12-31
JPH04230264A (ja) 1992-08-19
NO912541D0 (no) 1991-06-27
YU113391A (sh) 1995-10-03
MY107573A (en) 1996-04-30
DK0463592T3 (da) 1994-12-19
MX26415A (es) 1993-05-01
PT98108A (pt) 1993-06-30
EP0463592A1 (fr) 1992-01-02
ZA914958B (en) 1992-03-25
AU636990B2 (en) 1993-05-13
HRP940701A2 (en) 1997-02-28
HUT59104A (en) 1992-04-28
NO912541L (no) 1991-12-30
ES2061118T3 (es) 1994-12-01
CZ283782B6 (cs) 1998-06-17
IL98629A (en) 1996-05-14
FI101070B (fi) 1998-04-15
FI913118L (fi) 1991-12-29

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Payment date: 20000627

Year of fee payment: 10

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