DK0485504T3 - Fremgangsmåde til fremstilling af aktiveret protein C ved celledyrkning - Google Patents

Fremgangsmåde til fremstilling af aktiveret protein C ved celledyrkning

Info

Publication number
DK0485504T3
DK0485504T3 DK90912701.1T DK90912701T DK0485504T3 DK 0485504 T3 DK0485504 T3 DK 0485504T3 DK 90912701 T DK90912701 T DK 90912701T DK 0485504 T3 DK0485504 T3 DK 0485504T3
Authority
DK
Denmark
Prior art keywords
activated protein
preparation
cell culture
cells
disclosed
Prior art date
Application number
DK90912701.1T
Other languages
English (en)
Inventor
Donald C Foster
Anur Ashok Kumar
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DK0485504T3 publication Critical patent/DK0485504T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
DK90912701.1T 1989-08-11 1990-08-07 Fremgangsmåde til fremstilling af aktiveret protein C ved celledyrkning DK0485504T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39286189A 1989-08-11 1989-08-11

Publications (1)

Publication Number Publication Date
DK0485504T3 true DK0485504T3 (da) 1994-04-18

Family

ID=23552314

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90912701.1T DK0485504T3 (da) 1989-08-11 1990-08-07 Fremgangsmåde til fremstilling af aktiveret protein C ved celledyrkning

Country Status (10)

Country Link
EP (1) EP0485504B1 (da)
JP (1) JP3045307B2 (da)
AT (1) ATE97958T1 (da)
AU (1) AU6295390A (da)
CA (1) CA2064774C (da)
DE (1) DE69004964T2 (da)
DK (1) DK0485504T3 (da)
ES (1) ES2047946T3 (da)
IE (1) IE66340B1 (da)
WO (1) WO1991002065A1 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7168591A (en) * 1989-12-29 1991-07-24 Zymogenetics Inc. Hybrid protein c
US5618714A (en) * 1993-12-15 1997-04-08 Eli Lilly And Company Methods for producing protein C
DE19710190A1 (de) * 1997-03-12 1998-09-17 Immuno Ag Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung
GB9810999D0 (en) * 1998-05-21 1998-07-22 Goken Joop Materials and methods relating to the expression of genes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3688900T3 (de) * 1985-06-27 1998-06-10 Univ Washington Expression von Protein C.
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C
AU606582B2 (en) * 1985-09-06 1991-02-14 Codon Methods for the recovery of tissue plasminogen activator
DE3769872D1 (de) * 1986-07-11 1991-06-13 Miles Inc Herstellung von rekombinantem protein.
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C

Also Published As

Publication number Publication date
WO1991002065A1 (en) 1991-02-21
EP0485504A1 (en) 1992-05-20
CA2064774A1 (en) 1991-02-12
DE69004964D1 (de) 1994-01-13
JP3045307B2 (ja) 2000-05-29
ATE97958T1 (de) 1993-12-15
ES2047946T3 (es) 1994-03-01
CA2064774C (en) 2000-01-11
IE902912A1 (en) 1991-02-27
EP0485504B1 (en) 1993-12-01
JPH04507347A (ja) 1992-12-24
DE69004964T2 (de) 1994-03-24
AU6295390A (en) 1991-03-11
IE66340B1 (en) 1995-12-27

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