ATE97958T1 - Zellenzuchtverfahren fuer die produktion von aktiviertem protein-c. - Google Patents

Zellenzuchtverfahren fuer die produktion von aktiviertem protein-c.

Info

Publication number
ATE97958T1
ATE97958T1 AT90912701T AT90912701T ATE97958T1 AT E97958 T1 ATE97958 T1 AT E97958T1 AT 90912701 T AT90912701 T AT 90912701T AT 90912701 T AT90912701 T AT 90912701T AT E97958 T1 ATE97958 T1 AT E97958T1
Authority
AT
Austria
Prior art keywords
activated protein
production
cell cultivation
cultivation methods
methods
Prior art date
Application number
AT90912701T
Other languages
English (en)
Inventor
Anur Ashok Kumar
Donald C Foster
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of ATE97958T1 publication Critical patent/ATE97958T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6464—Protein C (3.4.21.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
AT90912701T 1989-08-11 1990-08-07 Zellenzuchtverfahren fuer die produktion von aktiviertem protein-c. ATE97958T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39286189A 1989-08-11 1989-08-11
PCT/US1990/004419 WO1991002065A1 (en) 1989-08-11 1990-08-07 Cell culture methods for producing activated protein c

Publications (1)

Publication Number Publication Date
ATE97958T1 true ATE97958T1 (de) 1993-12-15

Family

ID=23552314

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90912701T ATE97958T1 (de) 1989-08-11 1990-08-07 Zellenzuchtverfahren fuer die produktion von aktiviertem protein-c.

Country Status (10)

Country Link
EP (1) EP0485504B1 (de)
JP (1) JP3045307B2 (de)
AT (1) ATE97958T1 (de)
AU (1) AU6295390A (de)
CA (1) CA2064774C (de)
DE (1) DE69004964T2 (de)
DK (1) DK0485504T3 (de)
ES (1) ES2047946T3 (de)
IE (1) IE66340B1 (de)
WO (1) WO1991002065A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2113878T3 (es) * 1989-12-29 1998-05-16 Zymogenetics Inc Proteina c hibrida.
US5618714A (en) * 1993-12-15 1997-04-08 Eli Lilly And Company Methods for producing protein C
DE19710190A1 (de) * 1997-03-12 1998-09-17 Immuno Ag Aktivierter Vitamin K-abhängiger Blutfaktor und Verfahren zu dessen Herstellung
GB9810999D0 (en) * 1998-05-21 1998-07-22 Goken Joop Materials and methods relating to the expression of genes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4959318A (en) * 1985-06-27 1990-09-25 Zymogenetics, Inc. Expression of protein C
DE3688900T3 (de) * 1985-06-27 1998-06-10 Univ Washington Expression von Protein C.
EP0238551A4 (de) * 1985-09-06 1988-02-01 Codon Wiedergewinnungsverfahren von gewebeplasminogen-aktivator.
DE3769872D1 (de) * 1986-07-11 1991-06-13 Miles Inc Herstellung von rekombinantem protein.
JPH0387173A (ja) * 1987-09-10 1991-04-11 Teijin Ltd ヒト活性化天然型ファクター８ｃの製造方法及びそれに用いる形質転換体
US4992373A (en) * 1987-12-04 1991-02-12 Eli Lilly And Company Vectors and compounds for direct expression of activated human protein C

Also Published As

Publication number Publication date
DE69004964D1 (de) 1994-01-13
EP0485504B1 (de) 1993-12-01
CA2064774C (en) 2000-01-11
WO1991002065A1 (en) 1991-02-21
CA2064774A1 (en) 1991-02-12
DK0485504T3 (da) 1994-04-18
JPH04507347A (ja) 1992-12-24
IE902912A1 (en) 1991-02-27
IE66340B1 (en) 1995-12-27
AU6295390A (en) 1991-03-11
EP0485504A1 (de) 1992-05-20
DE69004964T2 (de) 1994-03-24
JP3045307B2 (ja) 2000-05-29
ES2047946T3 (es) 1994-03-01

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee