DK0487410T3 - Endothelinantagonister. - Google Patents

Endothelinantagonister.

Info

Publication number: DK0487410T3
Authority: DK; Denmark
Prior art keywords: representing; residue; leucine; valine; image
Prior art date: 1990-11-21

Application number

DK91403118T

Other languages

English (en)

Inventor

Gilles Hamon

Eve Mahe

Dung Le-Nguyen

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-21

Filing date

1991-11-20

Publication date

2000-03-27

1991-11-20 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

2000-03-27 Application granted granted Critical

2000-03-27 Publication of DK0487410T3 publication Critical patent/DK0487410T3/da

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 5
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 5
229960003136 leucine Drugs 0.000 abstract 5
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 3
229960004295 valine Drugs 0.000 abstract 3
239000004474 valine Substances 0.000 abstract 3
125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 3
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 2
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 2
LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 abstract 2
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 2
229960003767 alanine Drugs 0.000 abstract 2
235000004279 alanine Nutrition 0.000 abstract 2
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 2
125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 abstract 2
229960000310 isoleucine Drugs 0.000 abstract 2
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 2
239000004475 Arginine Substances 0.000 abstract 1
239000004471 Glycine Substances 0.000 abstract 1
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 abstract 1
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
229940000635 beta-alanine Drugs 0.000 abstract 1
235000018417 cysteine Nutrition 0.000 abstract 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
229930182817 methionine Natural products 0.000 abstract 1
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 1
229960005190 phenylalanine Drugs 0.000 abstract 1
125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Dental Preparations (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)

DK91403118T 1990-11-21 1991-11-20 Endothelinantagonister. DK0487410T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9014498A FR2669339B1 (fr)	1990-11-21	1990-11-21	Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives.

Publications (1)

Publication Number	Publication Date
DK0487410T3 true DK0487410T3 (da)	2000-03-27

Family

ID=9402414

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91403118T DK0487410T3 (da)	1990-11-21	1991-11-20	Endothelinantagonister.

Country Status (10)

Country	Link
US (1)	US5510331A (da)
EP (1)	EP0487410B1 (da)
JP (1)	JP3373217B2 (da)
AT (1)	ATE183203T1 (da)
CA (1)	CA2055902A1 (da)
DE (1)	DE69131518T2 (da)
DK (1)	DK0487410T3 (da)
ES (1)	ES2135389T3 (da)
FR (1)	FR2669339B1 (da)
GR (1)	GR3031331T3 (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6087324A (en) *	1993-06-24	2000-07-11	Takeda Chemical Industries, Ltd.	Sustained-release preparation
CA2142985A1 (en) *	1993-06-25	1995-01-05	Kenji Shibata	Endothelin-antagonizing peptide
ATE178071T1 (de) *	1994-07-25	1999-04-15	Kyowa Hakko Kogyo Kk	Endothelin-antagonisierendes peptid
AU3246600A (en)	1999-03-01	2000-09-21	Elan Pharmaceuticals, Inc.	Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7 receptor antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE90108T1 (de) *	1987-10-09	1993-06-15	Takeda Chemical Industries Ltd	Vasokonstriktor-peptid.
GB8913089D0 (en) *	1989-06-07	1989-07-26	Ciba Geigy Japan Ltd	Novel endothelin derivative
AU8523191A (en) *	1990-08-08	1992-03-02	Rockefeller University, The	Analogs of endothelin

1990
- 1990-11-21 FR FR9014498A patent/FR2669339B1/fr not_active Expired - Fee Related
1991
- 1991-11-20 JP JP32971791A patent/JP3373217B2/ja not_active Expired - Fee Related
- 1991-11-20 DE DE69131518T patent/DE69131518T2/de not_active Expired - Fee Related
- 1991-11-20 DK DK91403118T patent/DK0487410T3/da active
- 1991-11-20 CA CA002055902A patent/CA2055902A1/fr not_active Abandoned
- 1991-11-20 ES ES91403118T patent/ES2135389T3/es not_active Expired - Lifetime
- 1991-11-20 AT AT91403118T patent/ATE183203T1/de not_active IP Right Cessation
- 1991-11-20 EP EP91403118A patent/EP0487410B1/fr not_active Expired - Lifetime
1994
- 1994-10-13 US US08/322,707 patent/US5510331A/en not_active Expired - Fee Related
1999
- 1999-09-24 GR GR990402433T patent/GR3031331T3/el unknown

Also Published As

Publication number	Publication date
DE69131518T2 (de)	2000-01-13
JP3373217B2 (ja)	2003-02-04
ES2135389T3 (es)	1999-11-01
GR3031331T3 (en)	1999-12-31
CA2055902A1 (fr)	1992-05-22
US5510331A (en)	1996-04-23
ATE183203T1 (de)	1999-08-15
JPH04283600A (ja)	1992-10-08
DE69131518D1 (de)	1999-09-16
EP0487410B1 (fr)	1999-08-11
FR2669339B1 (fr)	1995-03-03
FR2669339A1 (fr)	1992-05-22
EP0487410A3 (en)	1992-09-30
EP0487410A2 (fr)	1992-05-27

Publication	Publication Date	Title
DK0689592T3 (da)	2000-10-16	Stabile produkter af det baktericide/permeabilitetsforøgende protein og farmaceutiske sammensætninger, der indeholder disse
DK0776209T3 (da)	2008-11-24	Polynukleinsyrer og proteiner fra et porcin reproduktiv og respiratorisk syndrom-virus og anvendelser deraf
HU9401423D0 (en)	1994-08-29	Peptidic ketone derivatives of enzyme inhibitor activity and pharmaceutical compositions containing them
NO923142D0 (no)	1992-08-12	Cykliske peptider og anvendelse derav
WO2000012541A3 (en)	2000-06-08	Cytotoxic peptides modified by bulky or lipophilic moieties
ATE78040T1 (de)	1992-07-15	Oligopeptide sowie zwischenprodukte und verfahren zu ihrer herstellung.
ATE141946T1 (de)	1996-09-15	Hiv-2-virusvarianten
KR910700062A (ko)	1991-03-13	마가이닌 펩타이드의 결실 동족체
FR2647677B1 (fr)	1991-09-27	Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
ES2176456T3 (es)	2002-12-01	Procedimiento de preparacion de un compuesto inhibidor del vih proteasa.
NO921715D0 (no)	1992-04-30	Nye polypeptider med affinitet for lipopolysakkarider og anvendelser derav
ATE213499T1 (de)	2002-03-15	Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose
ES2081442T3 (es)	1996-03-16	Proteasa de bacillus licheniformis.
AU2001284419A1 (en)	2002-03-22	Novel polypeptides and anti-hiv drugs containing the same
NO971621D0 (no)	1997-04-09	Keratinocyttvekstfaktoranaloger
DE69131518D1 (de)	1999-09-16	Endothelin-Antagonisten
DK0556124T3 (da)	1996-07-29	Hidtil ukendte peptidderivater deres fremstilling og anvendelse som lægemidler
IL95166A0 (en)	1991-06-10	Renin-inhibiting amino oligohydroxy derivatives
SE9101687L (sv)	1991-12-06	Dikloranilinfoerening
KR920700224A (ko)	1992-02-19	신규의 생리활성 펩티드 및 이를 유효성분으로서 함유한 칼슘대사 조절제
ES2052447A1 (es)	1994-07-01	Peptidos hemorreguladores.
JPS5283738A (en)	1977-07-12	Novel dipeptide derivatives and their salts