DK0489780T3 - Fremstilling af fusionsproteiner - Google Patents

Fremstilling af fusionsproteiner

Info

Publication number: DK0489780T3
Authority: DK; Denmark
Prior art keywords: fusion proteins; preparation; manner; fusion protein; oligonucleotide
Prior art date: 1989-08-29

Application number

DK90912715T

Other languages

Danish (da)

English (en)

Inventor

Siegfried Stengelin

Wolfgang Ulmer

Paul Habermann

Eugen Uhlmann

Brian Seed

Original Assignee

Hoechst Ag

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-29

Filing date

1990-08-28

Publication date

1999-07-19

1990-08-28 Application filed by Hoechst Ag, Gen Hospital Corp filed Critical Hoechst Ag

1999-07-19 Application granted granted Critical

1999-07-19 Publication of DK0489780T3 publication Critical patent/DK0489780T3/da

Links

102000037865 fusion proteins Human genes 0.000 title abstract 4
108020001507 fusion proteins Proteins 0.000 title abstract 4
108091034117 Oligonucleotide Proteins 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
239000000470 constituent Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Plant Pathology (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK90912715T 1989-08-29 1990-08-28 Fremstilling af fusionsproteiner DK0489780T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US39987489A	1989-08-29	1989-08-29
PCT/US1990/004840 WO1991003550A1 (en)	1989-08-29	1990-08-28	Fusion proteins, their preparation and use

Publications (1)

Publication Number	Publication Date
DK0489780T3 true DK0489780T3 (da)	1999-07-19

Family

ID=23581315

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK90912715T DK0489780T3 (da)	1989-08-29	1990-08-28	Fremstilling af fusionsproteiner

Country Status (19)

Country	Link
EP (1)	EP0489780B1 (de)
JP (1)	JP3043803B2 (de)
KR (1)	KR0159786B1 (de)
AT (1)	ATE173018T1 (de)
AU (1)	AU638277B2 (de)
CA (1)	CA2065146C (de)
CY (1)	CY2168B1 (de)
DE (1)	DE69032743T2 (de)
DK (1)	DK0489780T3 (de)
ES (1)	ES2124216T3 (de)
FI (1)	FI113183B (de)
GR (1)	GR1005153B (de)
HU (1)	HU216069B (de)
IE (1)	IE903120A1 (de)
IL (1)	IL95495A (de)
NO (1)	NO308667B1 (de)
PT (1)	PT95111B (de)
WO (1)	WO1991003550A1 (de)
ZA (1)	ZA906839B (de)

Families Citing this family (37)

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US5426036A (en) *	1987-05-05	1995-06-20	Hoechst Aktiengesellschaft	Processes for the preparation of foreign proteins in streptomycetes
ES2097426T3 (es)	1992-12-02	1997-04-01	Hoechst Ag	Procedimiento para la obtencion de proinsulina con puentes de cistina correctamente unidos.
EP0622376B1 (de) *	1993-04-27	2001-08-08	Hoechst Aktiengesellschaft	Amorphe monosphärische Formen von Insulinderivaten
DE69435058T2 (de) *	1993-10-05	2008-04-30	Asahi Glass Co., Ltd.	Multicloning-vektor, expressionsvektor und herstellung von fremdproteinen unter verwendung des expressionsvektors
US6001604A (en) *	1993-12-29	1999-12-14	Bio-Technology General Corp.	Refolding of proinsulins without addition of reducing agents
DE4405179A1 (de) *	1994-02-18	1995-08-24	Hoechst Ag	Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
US5683987A (en) *	1994-07-12	1997-11-04	The Board Of Regents Of The University Of Nebraska	Therapeutic oligonucleotides targeting the human MDR1 and MRP genes
DE59711533D1 (de)	1996-07-26	2004-05-27	Aventis Pharma Gmbh	Insulinderivate mit erhöhter Zinkbindung
DE19735711C2 (de)	1997-08-18	2001-04-26	Aventis Pharma Gmbh	Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
DE19825447A1 (de)	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
DE19915938A1 (de)	1999-04-09	2000-10-19	Aventis Pharma Gmbh	Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
DE19930676B4 (de)	1999-07-02	2006-01-19	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
US7638618B2 (en)	2001-02-20	2009-12-29	Sanofi-Aventis Deutschland Gmbh	Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en)	2001-02-20	2007-04-10	Sanofi-Aventis Deutschland Gmbh	Fusion proteins capable of being secreted into a fermentation medium
DE10235168A1 (de) *	2002-08-01	2004-02-12	Aventis Pharma Deutschland Gmbh	Verfahren zur Reinigung von Preproinsulin
AU2003280870A1 (en) *	2002-11-12	2004-06-03	Ckd Bio Corp.	Plasmids expressing human insulin and the preparation method for human insuling thereby
CA2711749A1 (en)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Novel insulin derivatives having an extremely delayed time-action profile
AU2009203810B2 (en)	2008-01-09	2013-07-25	Sanofi-Aventis Deutschland Gmbh	Novel insulin derivatives having an extremely delayed time-action profile
DE102008003566A1 (de)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025007A1 (de)	2008-05-24	2009-11-26	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025008A1 (de)	2008-05-24	2009-11-26	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003568A1 (de)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
RS59913B1 (sr)	2008-10-17	2020-03-31	Sanofi Aventis Deutschland	Kombinacija insulina i glp-1-agonista
SG10201403840VA (en)	2009-07-06	2014-10-30	Sanofi Aventis Deutschland	Aqueous insulin preparations containing methionine
PL2498801T3 (pl)	2009-11-13	2018-08-31	Sanofi Aventis Deutschland	Kompozycja farmaceutyczna zawierająca desPro<sup>36</sup>eksendyno-4(1-39)-Lys6-NH2 i metioninę
SI2498802T1 (sl)	2009-11-13	2015-05-29	Sanofi-Aventis Deutschland Gmbh	Farmacevtski sestavek, ki vsebuje agonist GLP-1, inzulin in metionin
BR112013004756B1 (pt)	2010-08-30	2020-04-28	Sanofi Aventis Deutschland	uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2
DK2739646T3 (en)	2011-05-10	2018-02-26	Stefan Hermann	COMPREHENSIVE BUFFER SYSTEM FOR RENATURING HUMAN PROINSULIN OR PROINSULIN DERIVATIVES
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CA2846413C (en)	2011-08-29	2021-11-02	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
JP5858945B2 (ja)	2012-03-15	2016-02-10	アークレイ株式会社	酵素を用いた測定方法
TWI758239B (zh)	2014-12-12	2022-03-21	德商賽諾菲阿凡提斯德意志有限公司	甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
CN108602866A (zh) *	2015-09-18	2018-09-28	生命制药有限责任公司	通过使用cd-rap前体蛋白改善cd-rap制备过程中的表达和折叠
JP7460182B2 (ja) *	2019-02-19	2024-04-02	ザ、トラスティーズオブプリンストンユニバーシティ	フォールディングされたドメインおよびｒｎａ顆粒会合タンパク質ドメインの光制御オリゴマー化および相分離のためのシステムおよび方法

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US4366246A (en) *	1977-11-08	1982-12-28	Genentech, Inc.	Method for microbial polypeptide expression
US4431739A (en) *	1979-11-05	1984-02-14	Genentech, Inc.	Transformant bacterial culture capable of expressing heterologous protein
US4769326A (en) *	1980-02-29	1988-09-06	The Regents Of The University Of California	Expression linkers
US4652639A (en) *	1982-05-06	1987-03-24	Amgen	Manufacture and expression of structural genes
EP0195680A3 (de) *	1985-03-21	1987-06-10	Immunex Corporation	Proteinsynthese mit einem Identifizierungspeptid
DE3526995A1 (de) *	1985-07-27	1987-02-05	Hoechst Ag	Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung

1990
- 1990-08-27 GR GR900100635A patent/GR1005153B/el not_active IP Right Cessation
- 1990-08-27 IL IL9549590A patent/IL95495A/en active IP Right Grant
- 1990-08-28 AT AT90912715T patent/ATE173018T1/de not_active IP Right Cessation
- 1990-08-28 JP JP2512297A patent/JP3043803B2/ja not_active Expired - Lifetime
- 1990-08-28 KR KR1019920700456A patent/KR0159786B1/ko not_active Expired - Lifetime
- 1990-08-28 WO PCT/US1990/004840 patent/WO1991003550A1/en not_active Ceased
- 1990-08-28 DK DK90912715T patent/DK0489780T3/da active
- 1990-08-28 DE DE69032743T patent/DE69032743T2/de not_active Expired - Lifetime
- 1990-08-28 ES ES90912715T patent/ES2124216T3/es not_active Expired - Lifetime
- 1990-08-28 HU HUP9200674A patent/HU216069B/hu unknown
- 1990-08-28 EP EP90912715A patent/EP0489780B1/de not_active Expired - Lifetime
- 1990-08-28 IE IE312090A patent/IE903120A1/en not_active IP Right Cessation
- 1990-08-28 PT PT95111A patent/PT95111B/pt not_active IP Right Cessation
- 1990-08-28 CA CA002065146A patent/CA2065146C/en not_active Expired - Lifetime
- 1990-08-28 AU AU62872/90A patent/AU638277B2/en not_active Expired
- 1990-09-28 ZA ZA906839A patent/ZA906839B/xx unknown
1992
- 1992-02-27 NO NO920774A patent/NO308667B1/no not_active IP Right Cessation
- 1992-02-28 FI FI920923A patent/FI113183B/fi active
2000
- 2000-05-03 CY CY0000013A patent/CY2168B1/xx unknown

Also Published As

Publication number	Publication date
KR0159786B1 (ko)	1998-11-16
FI920923A0 (fi)	1992-02-28
EP0489780B1 (de)	1998-11-04
EP0489780A1 (de)	1992-06-17
PT95111B (pt)	1998-10-30
WO1991003550A1 (en)	1991-03-21
IL95495A (en)	1996-10-16
AU6287290A (en)	1991-04-08
PT95111A (pt)	1991-05-22
EP0489780A4 (en)	1992-08-12
ATE173018T1 (de)	1998-11-15
IL95495A0 (en)	1991-06-30
CA2065146C (en)	2002-07-23
DE69032743D1 (de)	1998-12-10
HUT60327A (en)	1992-08-28
HU216069B (hu)	1999-04-28
FI113183B (fi)	2004-03-15
HU9200674D0 (en)	1992-08-28
HK1012026A1 (en)	1999-07-23
GR900100635A (el)	1991-12-30
ES2124216T3 (es)	1999-02-01
ZA906839B (en)	1991-06-26
AU638277B2 (en)	1993-06-24
NO308667B1 (no)	2000-10-09
CA2065146A1 (en)	1991-03-01
NO920774D0 (no)	1992-02-27
JPH05501799A (ja)	1993-04-08
IE903120A1 (en)	1991-03-13
DE69032743T2 (de)	1999-06-17
JP3043803B2 (ja)	2000-05-22
CY2168B1 (en)	2002-08-23
GR1005153B (el)	2006-03-13
NO920774L (no)	1992-04-28

Publication	Publication Date	Title
DK0489780T3 (da)	1999-07-19	Fremstilling af fusionsproteiner
ES8600780A1 (es)	1985-11-01	Materiales y metodos de exploracion y amplificacion en celulas hospedantes eucarioticas utilizando dihidrofolato-reduc- tasa resistente a metotrexato.
ATE46536T1 (de)	1989-10-15	Verfahren zur herstellung von reifen proteinen in wirtzellen von wirbeltieren.
DK13788D0 (da)	1988-01-13	Fremgangsmaade til fremstilling af et polypeptid
EP0722461A4 (de)	1997-02-26	Expression eines fusionspolypeptides, das ohne leadersequenz aus dem cytoplasma transportiert wird
RU93045577A (ru)	1996-02-27	Слитные полипептиды
DE3752372D1 (de)	2003-09-25	Verfahren zur regulierung der metabolischen stabilität von proteinen
PT87138A (pt)	1988-04-01	Process for the preparation of adn recombinant molecules codin g polypeptide adn segments and of antibody compositions relate d with human tissue factor
ES2132232T3 (es)	1999-08-16	Produccion de lactoferrina humana recombinante.
BG100771A (bg)	1997-08-29	Хематопоетичен протеин и материали и методи за неговото получаване
ATE43138T1 (de)	1989-06-15	Herstellung von dns-sequenzen und deren verwendung zur mikrobiologischen herstellung von proteinen, insbesondere menschlichen serumalbuminen.
DE59010913D1 (de)	2000-10-12	Toxoplasma gondii-Antigene, ihre Herstellung und ihre Verwendung
DK1032672T3 (da)	2009-04-27	DNA19355-polypeptid, en tumornekrosefaktor-homolog
ES8604309A1 (es)	1986-01-16	Un procedimiento para obtener un adn que codifica un factor de necrosis de tumor de conejo
JPS6420095A (en)	1989-01-24	Polypeptide having anti-blood coagulating action
NO930428L (no)	1993-03-29	Proteinstrukturen til plantetoksingelonin
ES2112847T3 (es)	1998-04-16	Somatotropina con alteraciones en la region de la alfa-helice 1 y combinaciones con otras mutaciones.
ATE295890T1 (de)	2005-06-15	Vektor zur expression von n-terminal verlängerten proteinen in hefezellen
AR006150A1 (es)	1999-08-11	Proteina de via complementaria natural modificada capaz de formar una convertasa c3 resistente a la regulacion descendente, secuencias de adn quecodifican dicha proteina, usos de dicha proteina y composiciones que la contienen
DK569886A (da)	1986-11-26	Fremstilling af human somatomedin c
GR3036312T3 (en)	2001-10-31	Polypeptides and dna encoding same, associated with human malaria parasites.
JPS6474989A (en)	1989-03-20	Dna to code human lysozyme
IT1243286B (it)	1994-05-26	Processo per isolamento ed espressione del fattore neuronotrofico ciliare umano mediante la tecnologia del dna ricombinante.
ATE492640T1 (de)	2011-01-15	Loslösendes protein 5 - ucp5
TH6687A (th)	1989-10-02	ชิ้นส่วนของจีนที่มีรหัสสำหรับกลิโคโปรตีนของไวรัสโรคกลัวน้ำและกรรมวิธีสำหรับเตรียมกลีโคโปรตีนของไวรัสโรคกลัวน้ำที่ใช้จีนนั้น