PT95111A - Processo para a preparacao de proteinas de fusao - Google Patents

Processo para a preparacao de proteinas de fusao

Info

Publication number: PT95111A
Authority: PT; Portugal
Prior art keywords: proteins; manner; fuseo; preparation; fusion protein
Prior art date: 1989-08-29

Application number

PT95111A

Other languages

English (en)

Other versions

PT95111B (pt

Inventor

Brian Seed

Siegfried Stengelin

Wolfgang Ulmer

Paul Haberman

Eugen Uhlmann

Original Assignee

Hoechst Ag

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-29

Filing date

1990-08-28

Publication date

1991-05-22

1990-08-28 Application filed by Hoechst Ag, Gen Hospital Corp filed Critical Hoechst Ag

1991-05-22 Publication of PT95111A publication Critical patent/PT95111A/pt

1998-10-30 Publication of PT95111B publication Critical patent/PT95111B/pt

Links

108090000623 proteins and genes Proteins 0.000 title abstract 3
102000004169 proteins and genes Human genes 0.000 title abstract 2
102000037865 fusion proteins Human genes 0.000 abstract 3
108020001507 fusion proteins Proteins 0.000 abstract 3
108091034117 Oligonucleotide Proteins 0.000 abstract 2
239000000470 constituent Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
230000001105 regulatory effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Plant Pathology (AREA)
Endocrinology (AREA)
Microbiology (AREA)
Diabetes (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

PT95111A 1989-08-29 1990-08-28 Processo para a preparacao de proteinas de fusao PT95111B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39987489A	1989-08-29	1989-08-29

Publications (2)

Publication Number	Publication Date
PT95111A true PT95111A (pt)	1991-05-22
PT95111B PT95111B (pt)	1998-10-30

Family

ID=23581315

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95111A PT95111B (pt)	1989-08-29	1990-08-28	Processo para a preparacao de proteinas de fusao

Country Status (19)

Country	Link
EP (1)	EP0489780B1 (pt)
JP (1)	JP3043803B2 (pt)
KR (1)	KR0159786B1 (pt)
AT (1)	ATE173018T1 (pt)
AU (1)	AU638277B2 (pt)
CA (1)	CA2065146C (pt)
CY (1)	CY2168B1 (pt)
DE (1)	DE69032743T2 (pt)
DK (1)	DK0489780T3 (pt)
ES (1)	ES2124216T3 (pt)
FI (1)	FI113183B (pt)
GR (1)	GR1005153B (pt)
HU (1)	HU216069B (pt)
IE (1)	IE903120A1 (pt)
IL (1)	IL95495A (pt)
NO (1)	NO308667B1 (pt)
PT (1)	PT95111B (pt)
WO (1)	WO1991003550A1 (pt)
ZA (1)	ZA906839B (pt)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5426036A (en) *	1987-05-05	1995-06-20	Hoechst Aktiengesellschaft	Processes for the preparation of foreign proteins in streptomycetes
EP0600372B1 (de) *	1992-12-02	1997-02-05	Hoechst Aktiengesellschaft	Verfahren zur Gewinnung von Proinsulin mit korrekt verbundenen Cystinbrücken
ATE203998T1 (de) *	1993-04-27	2001-08-15	Hoechst Ag	Amorphe monosphärische formen von insulinderivaten
WO1995009914A1 (en) *	1993-10-05	1995-04-13	Asahi Glass Company Ltd.	Multicloning vector, expression vector, and production of foreign protein with expression vector
US6001604A (en) *	1993-12-29	1999-12-14	Bio-Technology General Corp.	Refolding of proinsulins without addition of reducing agents
DE4405179A1 (de) *	1994-02-18	1995-08-24	Hoechst Ag	Verfahren zur Gewinnung von Insulin mit korrekt verbundenen Cystinbrücken
US5683987A (en) *	1994-07-12	1997-11-04	The Board Of Regents Of The University Of Nebraska	Therapeutic oligonucleotides targeting the human MDR1 and MRP genes
DK0821006T3 (da)	1996-07-26	2004-08-16	Aventis Pharma Gmbh	Insulinderivater med öget zinkbinding
DE19735711C2 (de) *	1997-08-18	2001-04-26	Aventis Pharma Gmbh	Verfahren zur Herstellung eines Vorläufers von Insulin oder Insulinderivaten mit korrekt verbundenen Cystinbrücken
DE19825447A1 (de)	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
DE19915938A1 (de)	1999-04-09	2000-10-19	Aventis Pharma Gmbh	Herstellung von pankreatischer Procarboxypeptidase B, Isoformen und Muteinen davon und ihre Verwendung
DE19930676B4 (de)	1999-07-02	2006-01-19	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
US7638618B2 (en)	2001-02-20	2009-12-29	Sanofi-Aventis Deutschland Gmbh	Nucleic acids encoding a hirudin and pro-insulin as superscretable peptides and for parallel improvement of the exported forms of one or more polypeptides of interest
US7202059B2 (en)	2001-02-20	2007-04-10	Sanofi-Aventis Deutschland Gmbh	Fusion proteins capable of being secreted into a fermentation medium
DE10235168A1 (de) *	2002-08-01	2004-02-12	Aventis Pharma Deutschland Gmbh	Verfahren zur Reinigung von Preproinsulin
WO2004044206A1 (en) *	2002-11-12	2004-05-27	Ckd Bio Corp.	Plasmids expressing human insulin and the preparation method for human insuling thereby
NZ586589A (en)	2008-01-09	2012-04-27	Sanofi Aventis Deutschland	Novel insulin analogues having an extremely delayed time-action profile
PL2229407T3 (pl)	2008-01-09	2017-06-30	Sanofi-Aventis Deutschland Gmbh	Nowe pochodne insuliny o ekstremalnie spowolnionym profilu czasu działania
DE102008025007A1 (de)	2008-05-24	2009-11-26	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003566A1 (de)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008003568A1 (de)	2008-01-09	2009-07-16	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
DE102008025008A1 (de)	2008-05-24	2009-11-26	Sanofi-Aventis Deutschland Gmbh	Neue Insulinderivate mit extrem verzögertem Zeit-/ Wirkungsprofil
EP3228320B1 (de)	2008-10-17	2019-12-18	Sanofi-Aventis Deutschland GmbH	Kombination von einem insulin und einem glp-1-agonisten
EP3202394A1 (de)	2009-07-06	2017-08-09	Sanofi-Aventis Deutschland GmbH	Wässrige insulinzubereitungen enthaltend methionin
PE20121316A1 (es)	2009-11-13	2012-10-05	Sanofi Aventis Deutschland	Composicion farmaceutica que comprende un agonista de glp-1 y metionina
PT2554183T (pt)	2009-11-13	2018-07-09	Sanofi Aventis Deutschland	Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
US20140148384A1 (en)	2010-08-30	2014-05-29	Sanofi-Aventis Deutschland Gmbh	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
WO2012152439A1 (en)	2011-05-10	2012-11-15	Glucometrix Ag	Comprehensive buffer system for renaturing human proinsulin or proinsulin derivatives
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CN108079281A (zh)	2011-08-29	2018-05-29	赛诺菲-安万特德国有限公司	用于2型糖尿病患者中的血糖控制的药物组合
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
JP5858945B2 (ja)	2012-03-15	2016-02-10	アークレイ株式会社	酵素を用いた測定方法
TWI758239B (zh)	2014-12-12	2022-03-21	德商賽諾菲阿凡提斯德意志有限公司	甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
EP3350204A2 (en) *	2015-09-18	2018-07-25	BioNet Pharma GmbH	Improvement of expression and folding in the manufacturing process of cd-rap by using a cd-rap precursor protein
WO2020172228A1 (en) *	2019-02-19	2020-08-27	The Trustees Of Princeton University	System and method for light-regulated oligomerization and phase separation of folded domains and rna granule-associated protein domains

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4366246A (en) *	1977-11-08	1982-12-28	Genentech, Inc.	Method for microbial polypeptide expression
US4431739A (en) *	1979-11-05	1984-02-14	Genentech, Inc.	Transformant bacterial culture capable of expressing heterologous protein
US4769326A (en) *	1980-02-29	1988-09-06	The Regents Of The University Of California	Expression linkers
US4652639A (en) *	1982-05-06	1987-03-24	Amgen	Manufacture and expression of structural genes
EP0195680A3 (en) *	1985-03-21	1987-06-10	Immunex Corporation	The synthesis of protein with an identification peptide
DE3526995A1 (de) *	1985-07-27	1987-02-05	Hoechst Ag	Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung

1990
- 1990-08-27 GR GR900100635A patent/GR1005153B/el not_active IP Right Cessation
- 1990-08-27 IL IL9549590A patent/IL95495A/en active IP Right Grant
- 1990-08-28 EP EP90912715A patent/EP0489780B1/en not_active Expired - Lifetime
- 1990-08-28 DE DE69032743T patent/DE69032743T2/de not_active Expired - Lifetime
- 1990-08-28 WO PCT/US1990/004840 patent/WO1991003550A1/en not_active Ceased
- 1990-08-28 AU AU62872/90A patent/AU638277B2/en not_active Expired
- 1990-08-28 JP JP2512297A patent/JP3043803B2/ja not_active Expired - Lifetime
- 1990-08-28 DK DK90912715T patent/DK0489780T3/da active
- 1990-08-28 AT AT90912715T patent/ATE173018T1/de not_active IP Right Cessation
- 1990-08-28 HU HUP9200674A patent/HU216069B/hu unknown
- 1990-08-28 CA CA002065146A patent/CA2065146C/en not_active Expired - Lifetime
- 1990-08-28 PT PT95111A patent/PT95111B/pt not_active IP Right Cessation
- 1990-08-28 IE IE312090A patent/IE903120A1/en not_active IP Right Cessation
- 1990-08-28 ES ES90912715T patent/ES2124216T3/es not_active Expired - Lifetime
- 1990-08-28 KR KR1019920700456A patent/KR0159786B1/ko not_active Expired - Lifetime
- 1990-09-28 ZA ZA906839A patent/ZA906839B/xx unknown
1992
- 1992-02-27 NO NO920774A patent/NO308667B1/no not_active IP Right Cessation
- 1992-02-28 FI FI920923A patent/FI113183B/fi active
2000
- 2000-05-03 CY CY0000013A patent/CY2168B1/xx unknown

Also Published As

Publication number	Publication date
IL95495A0 (en)	1991-06-30
CA2065146A1 (en)	1991-03-01
AU638277B2 (en)	1993-06-24
IL95495A (en)	1996-10-16
JP3043803B2 (ja)	2000-05-22
PT95111B (pt)	1998-10-30
ATE173018T1 (de)	1998-11-15
HU9200674D0 (en)	1992-08-28
FI113183B (fi)	2004-03-15
DE69032743T2 (de)	1999-06-17
NO920774D0 (no)	1992-02-27
HK1012026A1 (en)	1999-07-23
GR1005153B (el)	2006-03-13
HU216069B (hu)	1999-04-28
JPH05501799A (ja)	1993-04-08
ES2124216T3 (es)	1999-02-01
WO1991003550A1 (en)	1991-03-21
EP0489780A1 (en)	1992-06-17
AU6287290A (en)	1991-04-08
GR900100635A (el)	1991-12-30
CA2065146C (en)	2002-07-23
ZA906839B (en)	1991-06-26
HUT60327A (en)	1992-08-28
DK0489780T3 (da)	1999-07-19
IE903120A1 (en)	1991-03-13
NO920774L (no)	1992-04-28
KR0159786B1 (ko)	1998-11-16
CY2168B1 (en)	2002-08-23
EP0489780A4 (en)	1992-08-12
NO308667B1 (no)	2000-10-09
DE69032743D1 (de)	1998-12-10
EP0489780B1 (en)	1998-11-04
FI920923A0 (fi)	1992-02-28

Legal Events

Date	Code	Title	Description
1991-05-22	BB1A	Laying open of patent application	Effective date: 19901207
1998-10-30	FG3A	Patent granted, date of granting	Effective date: 19980709
2001-06-29	PC3A	Transfer or assignment	Free format text: 20010322 AVENTIS PHARMA DEUTSCHLAND GMBH DE
2013-07-17	MM4A	Annulment/lapse due to non-payment of fees, searched and examined patent	Free format text: MAXIMUM VALIDITY LIMIT REACHED Effective date: 20130709

Publication	Publication Date	Title
PT95111A (pt)	1991-05-22	Processo para a preparacao de proteinas de fusao
Walz et al.	1977	Amino acid sequence of human prothrombin fragments 1 and 2.
TW200516144A (en)	2005-05-16	Novel bone mineralization proteins, DNA, vectors, expression systems
ES8600780A1 (es)	1985-11-01	Materiales y metodos de exploracion y amplificacion en celulas hospedantes eucarioticas utilizando dihidrofolato-reduc- tasa resistente a metotrexato.
ATE46536T1 (de)	1989-10-15	Verfahren zur herstellung von reifen proteinen in wirtzellen von wirbeltieren.
ES540880A0 (es)	1986-05-16	Procedimiento para producir un fragmento de dna que compren-de un promotor de fosfatasa acida de levadura
DK13788D0 (da)	1988-01-13	Fremgangsmaade til fremstilling af et polypeptid
AU3461797A (en)	1998-02-10	Fas ligand-like protein, its production and use
ES540939A0 (es)	1988-04-01	Un procedimiento de producir un acido desoxirribonucleico (adn)que tiene o contiene una secuencia de base que codificaun polipeptido de factor de necrosis tumoral de humano
IL74972A (en)	1991-11-21	Atrial natriuretic/vasodilator polypeptides and process for the preparation thereof
IL173399A0 (en)	2006-06-11	Circular dna molecule with conditional origin of replication which contains nucleic acid of interest and selection marker but does not encode its replication initiation protein, method for preparing the same and use thereof in gene therapy
RU93045577A (ru)	1996-02-27	Слитные полипептиды
PT955313E (pt)	2006-07-31	Nova proteina e processo para a sua producao
PT96097A (pt)	1991-09-30	Processo para a preparacao de antigene de toxoplasma gondii bem como de meios de diagnostico, vacinas e anticorpos deles derivados
ATE419357T1 (de)	2009-01-15	Dna 19355 polypeptide, ein homolog des tumornekrosefaktors
ES8604309A1 (es)	1986-01-16	Un procedimiento para obtener un adn que codifica un factor de necrosis de tumor de conejo
JPS6420095A (en)	1989-01-24	Polypeptide having anti-blood coagulating action
CY1106110T1 (el)	2011-06-08	ΜΕΘΟΔΟΣ ΠΑΡΑΣΚΕΥΗΣ ΕΝΟΣ ΠΕΠΤΙΔΙΟΥ ΜΕ pI ΠΑΝΩ ΑΠΟ 8 Ή ΚΑΤΩ ΑΠΟ 5
PT97427A (pt)	1992-01-31	Processo para a preparacao de proteinas de fusao de tendamistato em estreptomicetas
ES2061719T3 (es)	1994-12-16	Proceso para la produccion de proteinas.
PT704527E (pt)	2003-09-30	Sequencias de adn que codificam precursores de insulina biossinteticos e processo para a preparacao de insulina
ES2112847T3 (es)	1998-04-16	Somatotropina con alteraciones en la region de la alfa-helice 1 y combinaciones con otras mutaciones.
DE69634757D1 (de)	2005-06-23	Vektor zur expression von n-terminal verlängerten proteinen in hefezellen
ATE162853T1 (de)	1998-02-15	Menschlicher rekombinanter plazentaler ribonuklease-inhibitor und verfahren zur herstellung
ES553374A0 (es)	1987-05-16	Un procedimiento para mejorar la produccion de un polipeptido deseado en un hospedante transformado con una molecula de adn recombinantes.