DK0492485T3 - N-Acyl-2,3-benzodiazepinderivater, farmaceutiske præparater indeholdende dem og fremgangsmåde til deres fremstilling - Google Patents

N-Acyl-2,3-benzodiazepinderivater, farmaceutiske præparater indeholdende dem og fremgangsmåde til deres fremstilling

Info

Publication number: DK0492485T3
Authority: DK; Denmark
Prior art keywords: group; atoms; amino; double bond; general formula
Prior art date: 1990-12-21

Application number

DK91121882T

Other languages

English (en)

Inventor

Imre Moravcsik

Ferenc Dr Andrasi

Pal Dr Berzsenyi

Peter Botka

Sandor Dr Farkas

Tamas Dr Hamori

Jeno Dr Korosi

Istvan Dr Tarnawa

Katalin Dr Goldschmidt

Original Assignee

Gyogyszerkutato Intezet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-21

Filing date

1991-12-23

Publication date

1998-07-27

1991-12-23 Application filed by Gyogyszerkutato Intezet filed Critical Gyogyszerkutato Intezet

1998-07-27 Application granted granted Critical

1998-07-27 Publication of DK0492485T3 publication Critical patent/DK0492485T3/da

Links

238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
-1 cyano, carboxyl Chemical group 0.000 abstract 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000002252 acyl group Chemical group 0.000 abstract 3
125000001931 aliphatic group Chemical group 0.000 abstract 3
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 2
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
210000003169 central nervous system Anatomy 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
230000002082 anti-convulsion Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)

DK91121882T 1990-12-21 1991-12-23 N-Acyl-2,3-benzodiazepinderivater, farmaceutiske præparater indeholdende dem og fremgangsmåde til deres fremstilling DK0492485T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU398/90A HU219778B (hu)	1990-12-21	1990-12-21	Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US08/080,604 US5459137A (en)	1990-12-21	1993-06-21	N-acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same

Publications (1)

Publication Number	Publication Date
DK0492485T3 true DK0492485T3 (da)	1998-07-27

Family

ID=26317922

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91121882T DK0492485T3 (da)	1990-12-21	1991-12-23	N-Acyl-2,3-benzodiazepinderivater, farmaceutiske præparater indeholdende dem og fremgangsmåde til deres fremstilling

Country Status (25)

Country	Link
US (3)	US5459137A (da)
EP (1)	EP0492485B1 (da)
JP (1)	JP2756742B2 (da)
KR (1)	KR0169134B1 (da)
CN (2)	CN1041420C (da)
AT (1)	ATE160350T1 (da)
AU (1)	AU641578B2 (da)
BR (1)	BR9105517A (da)
CA (1)	CA2057504C (da)
CZ (1)	CZ280769B6 (da)
DE (1)	DE69128236T2 (da)
DK (1)	DK0492485T3 (da)
ES (1)	ES2112848T3 (da)
FI (1)	FI102611B1 (da)
GR (1)	GR3026127T3 (da)
HR (1)	HRP920677B1 (da)
HU (1)	HU219778B (da)
IE (1)	IE914518A1 (da)
IL (1)	IL100449A (da)
MX (1)	MX9102734A (da)
NO (1)	NO300376B1 (da)
NZ (1)	NZ241110A (da)
RU (1)	RU2102387C1 (da)
SI (1)	SI9111966B (da)
ZA (1)	ZA9110064B (da)

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HU219778B (hu) *	1990-12-21	2001-07-30	Gyógyszerkutató Intézet Közös Vállalat	Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5519019A (en) *	1990-12-21	1996-05-21	Gyogyszerkutato Intezet	N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
US5521174A (en) *	1990-12-21	1996-05-28	Gyogyszerkutato Intezet Kv.	N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
HU219777B (hu) *	1993-07-02	2001-07-30	Gyógyszerkutató Intézet Kft.	Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására
DE4428835A1 (de) *	1994-08-01	1996-02-08	Schering Ag	Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
US5665878A (en)	1994-08-31	1997-09-09	Eli Lilly And Company	Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives
TR199501072A2 (tr)	1994-08-31	1996-06-21	Lilly Co Eli	Dihidro-2,3-benzodiazepin türevinin fiziksel bicimi.
EP1157992B1 (en) *	1994-08-31	2005-08-24	Eli Lilly And Company	Dihydro-2,3-Benzodiazepine derivatives
TR199501070A2 (tr)	1994-08-31	1996-06-21	Lilly Co Eli	Dihidro-2,3-benzodiazepin türevinin kristalli bicimi.
TR199501071A2 (tr) *	1994-08-31	1996-06-21	Lilly Co Eli	Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
US5670640A (en) *	1996-02-02	1997-09-23	Hoffmann-La Roche Inc.	Process for the manufacture of imidazodiazepine derivatives
US5891871A (en) *	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof
ZA972746B (en) *	1996-04-04	1998-10-09	Egyt Gyogyszervegyeszeti Gyar	Novel 2,3-benzodiazepine derivatives
HU9600871D0 (en) *	1996-04-04	1996-05-28	Gyogyszerkutato Intezet	New 2,3-benzodiazepine derivatives
HUP9701325A1 (hu)	1997-07-31	2000-08-28	Gyógyszerkutató Intézet Kft.	Új 2,3-benzodiazepin-származékok
UA67749C2 (uk) *	1997-08-12	2004-07-15	Егіш Дьйодьсердьяр Рт.	Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
KR20010022856A (ko) *	1997-08-12	2001-03-26	사바 키스 ; 아틸라 만디 야노스 템페 ; 기울라 시미그	Ａｍｐａ/카이네이트 수용체 억제제로서의 1,3-디옥솔로/4,5-ｈ//2,3/벤조디아제핀 유도체
EP1100504A2 (en) *	1998-07-02	2001-05-23	Eisai Co., Ltd.	Pharmaceutical compositions and their uses for treatment of demyelinating disorders
HU227128B1 (en) *	1999-07-07	2010-07-28	Egyt Gyogyszervegyeszeti Gyar	New 2,3-benzodiazepine derivatives
US6720081B2 (en)	1999-12-22	2004-04-13	Schott Spezialglas Gmbh	UV-reflective interference layer system
EP1296960A2 (en) *	2000-06-16	2003-04-02	Annovis, Inc.	5h-2,3-benzodiazepine antagonists of excitatory amino acid receptors
HU225100B1 (hu) *	2000-12-21	2006-06-28	Egyt Gyogyszervegyeszeti Gyar	2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6649607B2 (en)	2001-05-18	2003-11-18	Vela Pharmaceuticals, Inc.	Compositions and methods for treating or preventing convulsions or seizures
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
US7090830B2 (en)	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
US7766013B2 (en)	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US7645442B2 (en)	2001-05-24	2010-01-12	Alexza Pharmaceuticals, Inc.	Rapid-heating drug delivery article and method of use
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
US20040105818A1 (en)	2002-11-26	2004-06-03	Alexza Molecular Delivery Corporation	Diuretic aerosols and methods of making and using them
US7913688B2 (en)	2002-11-27	2011-03-29	Alexza Pharmaceuticals, Inc.	Inhalation device for producing a drug aerosol
US6864251B2 (en) *	2002-12-03	2005-03-08	Vela Pharmaceuticals, Inc.	Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en)	2002-12-03	2003-10-28	Vela Pharmaceuticals, Inc.	Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US7745431B2 (en)	2002-12-03	2010-06-29	Vela Acquisition Corporation	Pharmaceutical composition of 1-(3,4-dimethoxyphenyl)-4-methyl-5-ethyl-7-methoxy-8-hydroxy-5H-2,3-benzodiazepine and uses thereof
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US7022700B2 (en) *	2002-12-03	2006-04-04	Vela Pharmaceuticals, Inc.	Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
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US6858605B2 (en) *	2003-02-04	2005-02-22	Ivax Drug Research Institute, Ltd.	Substituted 2,3-benzodiazepine derivatives
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US7540286B2 (en)	2004-06-03	2009-06-02	Alexza Pharmaceuticals, Inc.	Multiple dose condensation aerosol devices and methods of forming condensation aerosols
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Family Cites Families (8)

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DE2353187A1 (de) *	1973-05-02	1974-11-14	Kali Chemie Ag	Neue benzodiazepinderivate
US4164740A (en) *	1976-03-04	1979-08-14	Constant James N	Synthetic aperture using image scanner
HU186760B (en) *	1981-03-12	1985-09-30	Gyogyszerkutato Intezet	Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
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HU195788B (en) *	1986-05-21	1988-07-28	Gyogyszerkutato Intezet	Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them
HU198494B (en) *	1986-08-15	1989-10-30	Gyogyszerkutato Intezet	Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU219778B (hu) *	1990-12-21	2001-07-30	Gyógyszerkutató Intézet Közös Vállalat	Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények

1990
- 1990-12-21 HU HU398/90A patent/HU219778B/hu unknown
1991
- 1991-12-12 CA CA002057504A patent/CA2057504C/en not_active Expired - Lifetime
- 1991-12-18 KR KR1019910023297A patent/KR0169134B1/ko not_active Expired - Fee Related
- 1991-12-19 RU SU5010635A patent/RU2102387C1/ru active
- 1991-12-19 BR BR919105517A patent/BR9105517A/pt not_active Application Discontinuation
- 1991-12-20 NZ NZ241110A patent/NZ241110A/en not_active IP Right Cessation
- 1991-12-20 FI FI916032A patent/FI102611B1/fi not_active IP Right Cessation
- 1991-12-20 SI SI9111966A patent/SI9111966B/sl unknown
- 1991-12-20 CZ CS913985A patent/CZ280769B6/cs not_active IP Right Cessation
- 1991-12-20 AU AU89963/91A patent/AU641578B2/en not_active Ceased
- 1991-12-20 ZA ZA9110064A patent/ZA9110064B/xx unknown
- 1991-12-20 NO NO915060A patent/NO300376B1/no not_active IP Right Cessation
- 1991-12-20 JP JP3354972A patent/JP2756742B2/ja not_active Expired - Fee Related
- 1991-12-20 IL IL10044991A patent/IL100449A/en not_active IP Right Cessation
- 1991-12-20 CN CN91111088A patent/CN1041420C/zh not_active Expired - Fee Related
- 1991-12-20 MX MX9102734A patent/MX9102734A/es unknown
- 1991-12-20 IE IE451891A patent/IE914518A1/en not_active IP Right Cessation
- 1991-12-23 ES ES91121882T patent/ES2112848T3/es not_active Expired - Lifetime
- 1991-12-23 AT AT91121882T patent/ATE160350T1/de not_active IP Right Cessation
- 1991-12-23 EP EP91121882A patent/EP0492485B1/en not_active Expired - Lifetime
- 1991-12-23 DE DE69128236T patent/DE69128236T2/de not_active Expired - Lifetime
- 1991-12-23 DK DK91121882T patent/DK0492485T3/da active
1992
- 1992-09-30 HR HRP-1966/91A patent/HRP920677B1/xx not_active IP Right Cessation
1993
- 1993-06-21 US US08/080,604 patent/US5459137A/en not_active Expired - Lifetime
1995
- 1995-03-21 US US08/423,032 patent/US5604223A/en not_active Expired - Lifetime
- 1995-04-17 US US08/423,153 patent/US5536832A/en not_active Expired - Lifetime
1998
- 1998-01-10 CN CNB981039766A patent/CN1135982C/zh not_active Expired - Fee Related
- 1998-02-12 GR GR980400299T patent/GR3026127T3/el unknown

Also Published As

Publication number	Publication date
NO915060D0 (no)	1991-12-20
HRP920677B1 (en)	2000-02-29
US5459137A (en)	1995-10-17
IL100449A (en)	1995-12-31
CN1062730A (zh)	1992-07-15
JP2756742B2 (ja)	1998-05-25
CZ280769B6 (cs)	1996-04-17
FI102611B (fi)	1999-01-15
US5604223A (en)	1997-02-18
FI916032A0 (fi)	1991-12-20
IL100449A0 (en)	1992-09-06
CA2057504A1 (en)	1992-06-22
RU2102387C1 (ru)	1998-01-20
GR3026127T3 (en)	1998-05-29
IE914518A1 (en)	1992-07-01
DE69128236D1 (de)	1998-01-02
US5536832A (en)	1996-07-16
SI9111966A (sl)	1998-04-30
DE69128236T2 (de)	1998-05-14
HU908398D0 (en)	1991-07-29
ES2112848T3 (es)	1998-04-16
ZA9110064B (en)	1992-10-28
CA2057504C (en)	2002-02-12
EP0492485B1 (en)	1997-11-19
FI102611B1 (fi)	1999-01-15
HU219778B (hu)	2001-07-30
CN1191111A (zh)	1998-08-26
NO915060L (no)	1992-06-22
KR920012086A (ko)	1992-07-25
HUT59684A (en)	1992-06-29
NZ241110A (en)	1994-04-27
SI9111966B (en)	2001-04-30
AU8996391A (en)	1992-06-25
ATE160350T1 (de)	1997-12-15
CN1041420C (zh)	1998-12-30
FI916032A7 (fi)	1992-06-22
AU641578B2 (en)	1993-09-23
JPH0570463A (ja)	1993-03-23
EP0492485A1 (en)	1992-07-01
CN1135982C (zh)	2004-01-28
MX9102734A (es)	1992-06-01
KR0169134B1 (ko)	1999-01-15
CZ398591A3 (en)	1994-01-19
BR9105517A (pt)	1992-09-01
NO300376B1 (no)	1997-05-20
HRP920677A2 (en)	1994-08-31

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AU641578B2 (en)	1993-09-23	Process for preparing new N-acyl-2,3-benzodiazepine derivatives, their acid addition salts and pharmaceutical compositions containing the same
MY117274A (en)	2004-06-30	Polycyclic amine compounds and their enantiomers,their method of preparation and pharmaceutical compositions in which they are present.
ES8603870A1 (es)	1986-01-01	Un procedimiento para la preparacion de derivados de 2,2'-iminobisetanol.
FR2662162B1 (fr)	1995-01-20	Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
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GEP20053619B (en)	2005-09-26	Pyrazole Derivatives for Treating HIV
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DK0892794T3 (da)	2002-04-15	Acylerede N-hydroxymethyl thalidomid-promedikamenter med immunmodulatorisk virkning
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MD1560F2 (en)	2000-11-30	Cyclic compounds, pharmaceutical compositions on base thereof and methods of treatment of infections or diseases provoked by retroviruses.
HU9200172D0 (en)	1992-04-28	Substituted 1,2,3,4-tetrahydro-cyclopenta/b/indole-and 1,2,3,3a,4,8a-hexahydro-cyclopenta/b/indole derivatives, their intermediate products, process for their production and medical preparations containing them
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GR3017348T3 (en)	1995-12-31	Novel isoindolinone derivative, preparation thereof, and pharmaceutical compositions containing same.
MY114119A (en)	2002-08-30	N-acyl-2, 3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same
IL81933A0 (en)	1987-10-20	Asymmetrical ester derivatives of 1,4-dihydropyridine-3,5-dicarboxylic acid,their preparation and pharmaceutical compositions containing them
DE59606725D1 (de)	2001-05-10	Substituierte phenylamidine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2647785B1 (fr)	1991-09-06	Nouveaux derives de la pyrrolidone, leur procede de preparation et les compositions pharmaceutiques les renfermant
PT100191A (pt)	1993-09-30	Derivados n-acil-2,3-benzodiazepinicos, composicoes farmaceuticas que os contem e processos para a preparacao dos derivados e da composicao, metodo de bloqueioe metodo de tratamento
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DE69205886D1 (de)	1995-12-14	Benzopyranderivate und Verfahren zu deren Herstellung.
FR2601364B1 (fr)	1988-10-21	Nouveaux derives de la piperazine dione-2,6, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
IT1273455B (it)	1997-07-08	Derivati tiolici ad attivita' inibitrice delle metallopeptidasi
FR2691967B1 (fr)	1995-06-09	Nouveaux composes pyrrolothienopyraziniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
FR2677647B1 (fr)	1993-08-20	Nouveaux derives de benzoate d'ethanolamine, leur procede de preparation et les compositions pharmaceutiques les renfermant.