ATE160350T1 - N-acyl-2,3-benzodiazepin-derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung - Google Patents

N-acyl-2,3-benzodiazepin-derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung

Info

Publication number: ATE160350T1
Authority: AT; Austria
Prior art keywords: group; atoms; amino; double bond; general formula
Prior art date: 1990-12-21

Application number

AT91121882T

Other languages

English (en)

Inventor

Ferenc Dr Andrasi

Pal Dr Berzsenyi

Peter Botka

Sandor Dr Farkas

Katalin Dr Goldschmidt

Tamas Dr Hamori

Jeno Dr Korosi

Imre Moravcsik

Istvan Dr Tarnawa

Original Assignee

Gyogyszerkutato Intezet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-21

Filing date

1991-12-23

Publication date

1997-12-15

1991-12-23 Application filed by Gyogyszerkutato Intezet filed Critical Gyogyszerkutato Intezet

1997-12-15 Application granted granted Critical

1997-12-15 Publication of ATE160350T1 publication Critical patent/ATE160350T1/de

Links

238000000034 method Methods 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title abstract 2
-1 cyano, carboxyl Chemical group 0.000 abstract 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
125000002252 acyl group Chemical group 0.000 abstract 3
125000001931 aliphatic group Chemical group 0.000 abstract 3
125000003282 alkyl amino group Chemical group 0.000 abstract 2
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 2
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
210000003169 central nervous system Anatomy 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
230000002082 anti-convulsion Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
230000000324 neuroprotective effect Effects 0.000 abstract 1
125000001312 palmitoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)

AT91121882T 1990-12-21 1991-12-23 N-acyl-2,3-benzodiazepin-derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung ATE160350T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU398/90A HU219778B (hu)	1990-12-21	1990-12-21	Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US08/080,604 US5459137A (en)	1990-12-21	1993-06-21	N-acyl-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same

Publications (1)

Publication Number	Publication Date
ATE160350T1 true ATE160350T1 (de)	1997-12-15

Family

ID=26317922

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91121882T ATE160350T1 (de)	1990-12-21	1991-12-23	N-acyl-2,3-benzodiazepin-derivate, diese enthaltende pharmazeutische zusammensetzungen und verfahren zu ihrer herstellung

Country Status (25)

Country	Link
US (3)	US5459137A (de)
EP (1)	EP0492485B1 (de)
JP (1)	JP2756742B2 (de)
KR (1)	KR0169134B1 (de)
CN (2)	CN1041420C (de)
AT (1)	ATE160350T1 (de)
AU (1)	AU641578B2 (de)
BR (1)	BR9105517A (de)
CA (1)	CA2057504C (de)
CZ (1)	CZ280769B6 (de)
DE (1)	DE69128236T2 (de)
DK (1)	DK0492485T3 (de)
ES (1)	ES2112848T3 (de)
FI (1)	FI102611B1 (de)
GR (1)	GR3026127T3 (de)
HR (1)	HRP920677B1 (de)
HU (1)	HU219778B (de)
IE (1)	IE914518A1 (de)
IL (1)	IL100449A (de)
MX (1)	MX9102734A (de)
NO (1)	NO300376B1 (de)
NZ (1)	NZ241110A (de)
RU (1)	RU2102387C1 (de)
SI (1)	SI9111966B (de)
ZA (1)	ZA9110064B (de)

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US5519019A (en) *	1990-12-21	1996-05-21	Gyogyszerkutato Intezet	N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
HU219778B (hu) *	1990-12-21	2001-07-30	Gyógyszerkutató Intézet Közös Vállalat	Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények
US5521174A (en) *	1990-12-21	1996-05-28	Gyogyszerkutato Intezet Kv.	N-acyl-2,3-benzodiazepine derivatives and a method of treating spasms of the skeletal musculature therewith
HU219777B (hu) *	1993-07-02	2001-07-30	Gyógyszerkutató Intézet Kft.	Optikailag aktív 1-(4-nitro-fenil)-4-metil-7,8-metiléndioxi-3,4-dihidro-5H-2,3-benzodiazepin és eljárás előállítására
DE4428835A1 (de) *	1994-08-01	1996-02-08	Schering Ag	Neue 3-substituierte 3H-2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel
TR199501070A2 (tr) *	1994-08-31	1996-06-21	Lilly Co Eli	Dihidro-2,3-benzodiazepin türevinin kristalli bicimi.
TR199501072A2 (tr) *	1994-08-31	1996-06-21	Lilly Co Eli	Dihidro-2,3-benzodiazepin türevinin fiziksel bicimi.
US5665878A (en) *	1994-08-31	1997-09-09	Eli Lilly And Company	Stereoselective process for producing dihydro-2,3-benzodiazepine derivatives
TR199501071A2 (tr) *	1994-08-31	1996-06-21	Lilly Co Eli	Dihidro-2,3-benzodiazepin türevlerinin üretilmesi icin stereoselektif islem.
CA2198751C (en) *	1994-08-31	2006-07-11	Benjamin Alan Anderson	Dihydro-2,3-benzodiazepine derivatives
US5670640A (en) *	1996-02-02	1997-09-23	Hoffmann-La Roche Inc.	Process for the manufacture of imidazodiazepine derivatives
US5891871A (en) *	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof
ZA972746B (en) *	1996-04-04	1998-10-09	Egyt Gyogyszervegyeszeti Gyar	Novel 2,3-benzodiazepine derivatives
HU9600871D0 (en) *	1996-04-04	1996-05-28	Gyogyszerkutato Intezet	New 2,3-benzodiazepine derivatives
HUP9701325A1 (hu)	1997-07-31	2000-08-28	Gyógyszerkutató Intézet Kft.	Új 2,3-benzodiazepin-származékok
EP1015457B1 (de) *	1997-08-12	2003-11-26	Egis Gyogyszergyar Rt.	1-3 dioxolo/4.5-h//2,3-benzodiazepin derivate als ampa/kainate-rezeptor-hemmer
UA67749C2 (uk) *	1997-08-12	2004-07-15	Егіш Дьйодьсердьяр Рт.	Похідна 8-заміщеного-9н-1,3-діоксол/4,5-h//2,3/бензодіазепіну з властивостями амра/каїнатного антагоніста, спосіб одержання похідних, фармацевтична композиція (варіанти), спосіб її одержання та спосіб лікування
WO2000001376A2 (en) *	1998-07-02	2000-01-13	Eisai Co., Ltd	Pharmaceutical compositions and their uses for treatment of demyelinating disorders
HU227128B1 (en) *	1999-07-07	2010-07-28	Egyt Gyogyszervegyeszeti Gyar	New 2,3-benzodiazepine derivatives
WO2001046718A2 (de)	1999-12-22	2001-06-28	Schott Glas	Uv-reflektierendes interferenzschichtsystem
US6887867B2 (en) *	2000-06-16	2005-05-03	Transgenomic, Inc.	5H-2,3-benzodiazepine antagonists of excitatory amino acid receptors
HU225100B1 (hu) *	2000-12-21	2006-06-28	Egyt Gyogyszervegyeszeti Gyar	2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
US6649607B2 (en) *	2001-05-18	2003-11-18	Vela Pharmaceuticals, Inc.	Compositions and methods for treating or preventing convulsions or seizures
US7645442B2 (en)	2001-05-24	2010-01-12	Alexza Pharmaceuticals, Inc.	Rapid-heating drug delivery article and method of use
US7766013B2 (en)	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
US7090830B2 (en)	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
US20040105818A1 (en)	2002-11-26	2004-06-03	Alexza Molecular Delivery Corporation	Diuretic aerosols and methods of making and using them
US7913688B2 (en)	2002-11-27	2011-03-29	Alexza Pharmaceuticals, Inc.	Inhalation device for producing a drug aerosol
US6638928B1 (en)	2002-12-03	2003-10-28	Vela Pharmaceuticals, Inc.	Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
US6864251B2 (en) *	2002-12-03	2005-03-08	Vela Pharmaceuticals, Inc.	Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US20040152695A1 (en) *	2002-12-03	2004-08-05	Vela Pharmaceuticals, Inc.	Pharmaceutical composition of 1-(3-hydroxy-4-methoxyphenyl)-4-methyl-5-ethyl-7,8-dimethoxy-5H-2,3-benzodiazepine and uses thereof
JP2006510634A (ja)	2002-12-03	2006-03-30	ヴェラファーマスーティカルズインコーポレイテッド	１−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US7022700B2 (en) *	2002-12-03	2006-04-04	Vela Pharmaceuticals, Inc.	Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6858605B2 (en) *	2003-02-04	2005-02-22	Ivax Drug Research Institute, Ltd.	Substituted 2,3-benzodiazepine derivatives
US20040152694A1 (en) *	2003-02-04	2004-08-05	Istvan Kurucz	Methods and compositions for treating inflammatory disorders of the airways
US20040224943A1 (en) *	2003-02-19	2004-11-11	Leventer Steven M.	Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) *	2003-02-19	2004-08-19	Harris Herbert W.	Method of lowering body temperature with (S) tofisopam
US20040234699A1 (en)	2003-05-21	2004-11-25	Alexza Molecular Delivery Corporation	Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
US20050101597A1 (en) *	2003-07-10	2005-05-12	Pharmacia Corporation	Compositions of a cyclooxygenase-2 selective inhibitior and a non-NMDA glutamate modulator for the treatment of central nervous system damage
US7540286B2 (en)	2004-06-03	2009-06-02	Alexza Pharmaceuticals, Inc.	Multiple dose condensation aerosol devices and methods of forming condensation aerosols
EP2246086A3 (de)	2004-08-12	2012-11-21	Alexza Pharmaceuticals, Inc.	Aerosolverabreichungsvorrichtung mit Schlag gezündete Heizeinheit
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DE2353187A1 (de) *	1973-05-02	1974-11-14	Kali Chemie Ag	Neue benzodiazepinderivate
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HU186760B (en) *	1981-03-12	1985-09-30	Gyogyszerkutato Intezet	Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
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HU198494B (en) *	1986-08-15	1989-10-30	Gyogyszerkutato Intezet	Process for producing new 3,4-dihydro-5h-2,3-benzodiazepine derivative and acid addition salts thereof, as well as pharmaceutical compositions comprising same
HU219778B (hu) *	1990-12-21	2001-07-30	Gyógyszerkutató Intézet Közös Vállalat	Eljárás N-acil-2,3-benzodiazepin-származékok, savaddíciós sóik és az ezeket tartalmazó gyógyászati készítmények előállítására, valamint a vegyületek egy csoportja, és az ezeket tartalmazó gyógyászati készítmények

1990
- 1990-12-21 HU HU398/90A patent/HU219778B/hu unknown
1991
- 1991-12-12 CA CA002057504A patent/CA2057504C/en not_active Expired - Lifetime
- 1991-12-18 KR KR1019910023297A patent/KR0169134B1/ko not_active Expired - Fee Related
- 1991-12-19 BR BR919105517A patent/BR9105517A/pt not_active Application Discontinuation
- 1991-12-19 RU SU5010635A patent/RU2102387C1/ru active
- 1991-12-20 IE IE451891A patent/IE914518A1/en not_active IP Right Cessation
- 1991-12-20 AU AU89963/91A patent/AU641578B2/en not_active Ceased
- 1991-12-20 ZA ZA9110064A patent/ZA9110064B/xx unknown
- 1991-12-20 CN CN91111088A patent/CN1041420C/zh not_active Expired - Fee Related
- 1991-12-20 SI SI9111966A patent/SI9111966B/sl unknown
- 1991-12-20 MX MX9102734A patent/MX9102734A/es unknown
- 1991-12-20 NO NO915060A patent/NO300376B1/no not_active IP Right Cessation
- 1991-12-20 IL IL10044991A patent/IL100449A/en not_active IP Right Cessation
- 1991-12-20 NZ NZ241110A patent/NZ241110A/en not_active IP Right Cessation
- 1991-12-20 FI FI916032A patent/FI102611B1/fi not_active IP Right Cessation
- 1991-12-20 CZ CS913985A patent/CZ280769B6/cs not_active IP Right Cessation
- 1991-12-20 JP JP3354972A patent/JP2756742B2/ja not_active Expired - Fee Related
- 1991-12-23 DE DE69128236T patent/DE69128236T2/de not_active Expired - Lifetime
- 1991-12-23 EP EP91121882A patent/EP0492485B1/de not_active Expired - Lifetime
- 1991-12-23 ES ES91121882T patent/ES2112848T3/es not_active Expired - Lifetime
- 1991-12-23 DK DK91121882T patent/DK0492485T3/da active
- 1991-12-23 AT AT91121882T patent/ATE160350T1/de not_active IP Right Cessation
1992
- 1992-09-30 HR HRP-1966/91A patent/HRP920677B1/xx not_active IP Right Cessation
1993
- 1993-06-21 US US08/080,604 patent/US5459137A/en not_active Expired - Lifetime
1995
- 1995-03-21 US US08/423,032 patent/US5604223A/en not_active Expired - Lifetime
- 1995-04-17 US US08/423,153 patent/US5536832A/en not_active Expired - Lifetime
1998
- 1998-01-10 CN CNB981039766A patent/CN1135982C/zh not_active Expired - Fee Related
- 1998-02-12 GR GR980400299T patent/GR3026127T3/el unknown

Also Published As

Publication number	Publication date
CN1041420C (zh)	1998-12-30
DE69128236D1 (de)	1998-01-02
FI916032A0 (fi)	1991-12-20
KR0169134B1 (ko)	1999-01-15
CZ280769B6 (cs)	1996-04-17
US5459137A (en)	1995-10-17
HUT59684A (en)	1992-06-29
HRP920677A2 (en)	1994-08-31
DE69128236T2 (de)	1998-05-14
CN1062730A (zh)	1992-07-15
FI102611B (fi)	1999-01-15
US5604223A (en)	1997-02-18
US5536832A (en)	1996-07-16
JPH0570463A (ja)	1993-03-23
IL100449A (en)	1995-12-31
SI9111966B (en)	2001-04-30
HU219778B (hu)	2001-07-30
BR9105517A (pt)	1992-09-01
AU641578B2 (en)	1993-09-23
FI916032A7 (fi)	1992-06-22
NO915060L (no)	1992-06-22
CZ398591A3 (en)	1994-01-19
NO915060D0 (no)	1991-12-20
NZ241110A (en)	1994-04-27
ZA9110064B (en)	1992-10-28
MX9102734A (es)	1992-06-01
CN1135982C (zh)	2004-01-28
FI102611B1 (fi)	1999-01-15
AU8996391A (en)	1992-06-25
HU908398D0 (en)	1991-07-29
HRP920677B1 (en)	2000-02-29
EP0492485B1 (de)	1997-11-19
NO300376B1 (no)	1997-05-20
CA2057504C (en)	2002-02-12
GR3026127T3 (en)	1998-05-29
ES2112848T3 (es)	1998-04-16
EP0492485A1 (de)	1992-07-01
DK0492485T3 (da)	1998-07-27
CN1191111A (zh)	1998-08-26
JP2756742B2 (ja)	1998-05-25
IE914518A1 (en)	1992-07-01
CA2057504A1 (en)	1992-06-22
IL100449A0 (en)	1992-09-06
KR920012086A (ko)	1992-07-25
RU2102387C1 (ru)	1998-01-20
SI9111966A (sl)	1998-04-30

Legal Events

Date	Code	Title
1998-07-15	UEP	Publication of translation of european patent specification
2004-07-15	EEFA	Change of the company name
2011-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69128236D1 (de)	1998-01-02	N-Acyl-2,3-benzodiazepin-Derivate, diese enthaltende pharmazeutische Zusammensetzungen und Verfahren zu ihrer Herstellung
MY117274A (en)	2004-06-30	Polycyclic amine compounds and their enantiomers,their method of preparation and pharmaceutical compositions in which they are present.
ATE167186T1 (de)	1998-06-15	Diphenylmethane derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammenstellungen
ATE128120T1 (de)	1995-10-15	Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung.
ATE186906T1 (de)	1999-12-15	Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
IL102759A0 (en)	1993-01-31	Hydantoin derivatives,their preparation and pharmaceutical compositions containing them
ATE128458T1 (de)	1995-10-15	Naphtylalkylamine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
ATE103893T1 (de)	1994-04-15	24-homo-vitamin-d-derivate, verfahren zu ihrer herstellung; diese derivate enthaltende pharmazeutische praeparate sowie deren verwendung als arzneimittel.
ATE32221T1 (de)	1988-02-15	3 n-substituierte 3,4-dihydropyrimidinderivate, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen.
GR1001068B (el)	1993-04-28	Νέον παράγωγον 5Η-βενζοδιαζεπίνης, φαρμακευτικαί συν?έσεις περιέχουσαι τούτο, και μέ?οδος δια την παρασκευήν αυτών.
ATE145903T1 (de)	1996-12-15	Kondensierte chinolyl-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln zur behandlung von herz- kreislauferkrangen
DE69710909D1 (de)	2002-04-11	Substituierte tetrahydropyridinderivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
ATE127465T1 (de)	1995-09-15	Isoindolinon-derivat, seine herstellung und dieses enthaltende pharmazeutische zusammen setzungen.
PT85869A (en)	1987-11-01	Process for preparing amino acid derivative anti-convulsant
MY114119A (en)	2002-08-30	N-acyl-2, 3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for preparing same
DE59606725D1 (de)	2001-05-10	Substituierte phenylamidine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2703048B1 (fr)	1996-01-05	Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
ATE188205T1 (de)	2000-01-15	Cyclohexanon-derivate, verfahren zu deren herstellung und zwischenprodukte des verfahrens
PT100191A (pt)	1993-09-30	Derivados n-acil-2,3-benzodiazepinicos, composicoes farmaceuticas que os contem e processos para a preparacao dos derivados e da composicao, metodo de bloqueioe metodo de tratamento
DE69205886D1 (de)	1995-12-14	Benzopyranderivate und Verfahren zu deren Herstellung.
FR2677647B1 (fr)	1993-08-20	Nouveaux derives de benzoate d'ethanolamine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE69417907D1 (de)	1999-05-20	Anthracyclin-disaccharide, verfahren zu ihrer herstellung, und diese enthaltende arzneimittel
HUT55033A (en)	1991-04-29	Process for producing aminooligohydroxy derivatives and pharmaceutical compositions comprising same
FR2691967B1 (fr)	1995-06-09	Nouveaux composes pyrrolothienopyraziniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.