DK0497201T3 - Tricycliske forbindelser og mellemprodukter deraf - Google Patents

Tricycliske forbindelser og mellemprodukter deraf

Info

Publication number: DK0497201T3
Authority: DK; Denmark
Prior art keywords: alkyl; represents hydrogen; alkoxy; independently represents; alkylthio
Prior art date: 1991-01-23

Application number

DK92101012.0T

Other languages

English (en)

Inventor

Kazuhiro Kubo

Koji Yamada

Toshiaki Kumazawa

Masashi Yanase

Hiroyuki Harakawa

Hiroyuki Obase

Shoji Oda

Shiro Shirakura

Original Assignee

Kyowa Hakko Kogyo Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-23

Filing date

1992-01-22

Publication date

1997-06-23

1992-01-22 Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk

1997-06-23 Application granted granted Critical

1997-06-23 Publication of DK0497201T3 publication Critical patent/DK0497201T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 3
239000000543 intermediate Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
229910052739 hydrogen Inorganic materials 0.000 abstract 6
239000001257 hydrogen Substances 0.000 abstract 6
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
206010003210 Arteriosclerosis Diseases 0.000 abstract 1
102100030817 Liver carboxylesterase 1 Human genes 0.000 abstract 1
101710181187 Liver carboxylesterase 1 Proteins 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
208000011775 arteriosclerosis disease Diseases 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
-1 cyano, carboxy Chemical group 0.000 abstract 1
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
201000005577 familial hyperlipidemia Diseases 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
239000011593 sulfur Substances 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
125000000858 thiocyanato group Chemical group *SC#N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
- C07D313/02—Seven-membered rings
- C07D313/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D313/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D313/12—[b,e]-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/12—[b,e]-condensed
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Cardiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pyrane Compounds (AREA)
Luminescent Compositions (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK92101012.0T 1991-01-23 1992-01-22 Tricycliske forbindelser og mellemprodukter deraf DK0497201T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP658991		1991-01-23

Publications (1)

Publication Number	Publication Date
DK0497201T3 true DK0497201T3 (da)	1997-06-23

Family

ID=11642521

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92101012.0T DK0497201T3 (da)	1991-01-23	1992-01-22	Tricycliske forbindelser og mellemprodukter deraf

Country Status (10)

Country	Link
US (2)	US5340807A (da)
EP (1)	EP0497201B1 (da)
JP (1)	JPH0694464B2 (da)
AT (1)	ATE147738T1 (da)
CA (1)	CA2059792C (da)
DE (1)	DE69216645T2 (da)
DK (1)	DK0497201T3 (da)
ES (1)	ES2099174T3 (da)
GR (1)	GR3022304T3 (da)
HU (1)	HU211887A9 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2106103A1 (en) *	1992-09-16	1994-03-17	Masashi Yanase	Tricyclic compounds
US5679703A (en) *	1992-09-16	1997-10-21	Kyowa Hakko Kogyo, Co., Ltd.	Tricyclic compounds having ACAT inhibiting activity
US5534529A (en) *	1993-06-30	1996-07-09	Sankyo Company, Limited	Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses
AU3358397A (en) *	1996-07-08	1998-02-02	Kyowa Hakko Kogyo Co. Ltd.	Solid dispersions or solid dispersion preparations of tricyclic compounds
US6323206B1 (en)	1996-07-12	2001-11-27	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en)	1998-01-21	2003-01-21	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
US6613905B1 (en)	1998-01-21	2003-09-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
AU2331999A (en)	1998-01-21	1999-08-09	Kyowa Hakko Kogyo Co. Ltd.	Chemokine receptor antagonists and methods of use therefor
CA2318088A1 (en)	1998-01-21	1999-07-29	Yoshisuke Nakasato	Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) *	1998-09-04	2007-09-18	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) *	2001-11-21	2009-06-02	Millennium Pharmaceuticals, Inc.	Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) *	2002-11-13	2007-12-21	Millennium Pharm Inc	CCR1 antagonists and methods of use therefor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2629752A1 (de) *	1976-07-02	1978-01-05	Boehringer Mannheim Gmbh	Neue carbonsaeurederivate und verfahren zu ihrer herstellung
US4489090A (en)	1983-05-06	1984-12-18	American Cyanamid Company	Dibenzocycloalkanamido and dibenzothioxanthenyl benzoic acids
US4868210A (en) *	1988-03-30	1989-09-19	Warner-Lambert Company	Antihyperlipidemic and antiatherosclerotic compounds and compositions

1992
- 1992-01-21 JP JP4008406A patent/JPH0694464B2/ja not_active Expired - Fee Related
- 1992-01-22 ES ES92101012T patent/ES2099174T3/es not_active Expired - Lifetime
- 1992-01-22 CA CA002059792A patent/CA2059792C/en not_active Expired - Fee Related
- 1992-01-22 EP EP92101012A patent/EP0497201B1/en not_active Expired - Lifetime
- 1992-01-22 DK DK92101012.0T patent/DK0497201T3/da active
- 1992-01-22 AT AT92101012T patent/ATE147738T1/de not_active IP Right Cessation
- 1992-01-22 DE DE69216645T patent/DE69216645T2/de not_active Expired - Fee Related
- 1992-12-11 US US08/989,906 patent/US5340807A/en not_active Expired - Fee Related
1994
- 1994-05-02 US US08/236,097 patent/US5478835A/en not_active Expired - Fee Related
1995
- 1995-06-21 HU HU95P/P00308P patent/HU211887A9/hu unknown
1997
- 1997-01-16 GR GR970400064T patent/GR3022304T3/el unknown

Also Published As

Publication number	Publication date
EP0497201A1 (en)	1992-08-05
GR3022304T3 (en)	1997-04-30
HK1000601A1 (en)	1998-04-09
DE69216645T2 (de)	1997-06-05
DE69216645D1 (de)	1997-02-27
US5478835A (en)	1995-12-26
US5340807A (en)	1994-08-23
JPH05132477A (ja)	1993-05-28
ES2099174T3 (es)	1997-05-16
ATE147738T1 (de)	1997-02-15
HU211887A9 (en)	1995-12-28
JPH0694464B2 (ja)	1994-11-24
EP0497201B1 (en)	1997-01-15
CA2059792A1 (en)	1992-07-24
CA2059792C (en)	2001-07-10

Publication	Publication Date	Title
DK0497201T3 (da)	1997-06-23	Tricycliske forbindelser og mellemprodukter deraf
AU1282495A (en)	1995-07-17	Anthranilic acid derivative
AU5702996A (en)	1996-11-29	Oxygen-containing heterocyclic compounds
ZA879414B (en)	1989-08-30	Morpholinoethylester of mycophenolic acid and derivatives thereof
DK0562439T3 (da)	1999-11-15	Triazolopyridazinforbindelser, deres fremstilling og anvendelse
DK42589A (da)	1989-08-02	Anvendelse af arylamida(og arylthioamido)-azabicycloalkaner
GR3023308T3 (en)	1997-08-29	Inhibitor for restenosis after percutaneous coronary arterioplasty.
TW256832B (da)	1995-09-11
DK0459505T3 (da)	1996-11-18	Imidazonaphthyridinderivater
AU577772B2 (en)	1988-10-06	Di-acyloxy naphthalenes & di-hydroxy intermediates as anti-psoriatic agents
ATE125540T1 (de)	1995-08-15	Imidazochinolon-derivate.
DK0543997T3 (da)	2000-04-10	Methotrexatderivat med antirheumatisk aktivitet
AU8003594A (en)	1995-05-22	Quinolinecarboxylic acid derivative and salt thereof
EP0393574A3 (en)	1991-08-21	Hexitol derivatives
ATE172200T1 (de)	1998-10-15	Pyrazoloacridonderivate