DK0499544T3 - Anvendelse af tetrahydrothienopyridinderivater som inhibitorer af angiogenese - Google Patents

Anvendelse af tetrahydrothienopyridinderivater som inhibitorer af angiogenese

Info

Publication number: DK0499544T3
Authority: DK; Denmark
Prior art keywords: equals; optionally substituted; angiogenesis; inhibitors; substituted alkyl
Prior art date: 1991-02-14

Application number

DK92400389.0T

Other languages

English (en)

Inventor

Jean-Pierre Cazenave

Jean-Marc Herbert

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-14

Filing date

1992-02-13

Publication date

1995-08-28

1992-02-13 Application filed by Sanofi Sa filed Critical Sanofi Sa

1995-08-28 Application granted granted Critical

1995-08-28 Publication of DK0499544T3 publication Critical patent/DK0499544T3/da

Links

WJFYLCXWEXZNHU-UHFFFAOYSA-N 2,3,3a,4-tetrahydrothieno[3,2-b]pyridine Chemical class N1C=CC=C2SCCC21 WJFYLCXWEXZNHU-UHFFFAOYSA-N 0.000 title 1
230000033115 angiogenesis Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
206010029113 Neovascularisation Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001419 dependent effect Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
230000007170 pathology Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Oncology (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Ophthalmology & Optometry (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Heart & Thoracic Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK92400389.0T 1991-02-14 1992-02-13 Anvendelse af tetrahydrothienopyridinderivater som inhibitorer af angiogenese DK0499544T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9101783A FR2672801B1 (fr)	1991-02-14	1991-02-14	Utilisation de derives de tetrahydrothienopyridine comme inhibiteurs de l'angiogenese.

Publications (1)

Publication Number	Publication Date
DK0499544T3 true DK0499544T3 (da)	1995-08-28

Family

ID=9409732

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92400389.0T DK0499544T3 (da)	1991-02-14	1992-02-13	Anvendelse af tetrahydrothienopyridinderivater som inhibitorer af angiogenese

Country Status (8)

Country	Link
US (1)	US5225420A (da)
EP (1)	EP0499544B1 (da)
JP (1)	JPH072668A (da)
AT (1)	ATE121621T1 (da)
CA (1)	CA2061173A1 (da)
DE (1)	DE69202166T2 (da)
DK (1)	DK0499544T3 (da)
FR (1)	FR2672801B1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5629287A (en) *	1991-01-18	1997-05-13	University College London	Depot formulations
US5610148A (en) *	1991-01-18	1997-03-11	University College London	Macroscopically oriented cell adhesion protein for wound treatment
AU3968597A (en) *	1996-08-02	1998-02-25	Children's Medical Center Corporation	Method of regulating the female reproductive system through angiogenesis inhibitors
WO1998014169A1 (en) *	1996-09-30	1998-04-09	Brigham & Women's Hospital	Methods and compounds for treatment of abnormal uterine bleeding
CA2332608C (en)	1998-06-17	2010-03-23	Bristol-Myers Squibb Company	Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination
CA2457459A1 (en) *	2004-02-11	2005-08-11	Brantford Chemicals Inc.	Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
CN101591346B (zh) *	2009-07-03	2014-10-29	北京华禧联合科技发展有限公司	硫酸氢氯吡格雷有关物质b的合成方法
CN101585842B (zh) *	2009-07-13	2011-07-20	北京赛科药业有限责任公司	氯吡格雷中杂质b的研究及控制方法
CN101863901B (zh) *	2010-06-29	2012-12-05	天津药物研究院	2-(取代苯基)-2-(4,5,6,7-四氢噻吩并[3,2-c]吡啶-5(4H)-基)-N-取代-乙酰胺、其制备方法和用途
CN101967154B (zh) *	2010-10-11	2011-12-28	天津药物研究院	肟类化合物、其制备方法和用途
CN101974016A (zh) *	2010-10-14	2011-02-16	天津药物研究院	酰胺类化合物及其制备方法和用途
CN101962388B (zh) *	2010-10-14	2012-12-19	天津药物研究院	乙酰胺衍生物及其制备方法和用途
CN102329327B (zh) *	2011-10-20	2014-04-09	天津药物研究院	呋喃衍生物、其制备方法和用途
CN103694250B (zh) *	2012-09-28	2016-02-10	武汉启瑞药业有限公司	噻吩吡啶类衍生物及其制备方法和医药用途
CN103694252A (zh) *	2014-01-14	2014-04-02	中国药科大学	一种噻吩并吡啶类化合物及其抗血小板聚集活性

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2530247B1 (fr) *	1982-07-13	1986-05-16	Sanofi Sa	Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
FR2623810B2 (fr) *	1987-02-17	1992-01-24	Sanofi Sa	Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant

1991
- 1991-02-14 FR FR9101783A patent/FR2672801B1/fr not_active Expired - Lifetime
1992
- 1992-02-11 US US07/833,765 patent/US5225420A/en not_active Expired - Lifetime
- 1992-02-13 DK DK92400389.0T patent/DK0499544T3/da active
- 1992-02-13 DE DE69202166T patent/DE69202166T2/de not_active Expired - Lifetime
- 1992-02-13 JP JP4026613A patent/JPH072668A/ja active Pending
- 1992-02-13 CA CA002061173A patent/CA2061173A1/en not_active Abandoned
- 1992-02-13 AT AT92400389T patent/ATE121621T1/de active
- 1992-02-13 EP EP92400389A patent/EP0499544B1/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE69202166T2 (de)	1995-11-09
DE69202166D1 (de)	1995-06-01
EP0499544A2 (fr)	1992-08-19
JPH072668A (ja)	1995-01-06
EP0499544B1 (fr)	1995-04-26
EP0499544A3 (en)	1993-03-03
FR2672801B1 (fr)	1995-03-03
US5225420A (en)	1993-07-06
CA2061173A1 (en)	1992-08-15
ATE121621T1 (de)	1995-05-15
FR2672801A1 (fr)	1992-08-21

Publication	Publication Date	Title
DK0499544T3 (da)	1995-08-28	Anvendelse af tetrahydrothienopyridinderivater som inhibitorer af angiogenese
MX9202166A (es)	1992-11-01	Derivados de amidino fenil alanina, procedimiento para su preparacion su empleo y agentes que los con tienen en calidad de anticoagulantes.
DK0574545T3 (da)	1995-01-30	Phenylamidinderivater som blodpladeaggregationsinhibitorer
DE69008366D1 (de)	1994-06-01	2-Aminopyrimidinon-Derivate.
AP9901578A0 (en)	1999-06-30	Sulfonylbenzene compounds as anti-inflammatory/analgesic agents.
HUT59124A (en)	1992-04-28	Process for producing 2-(aminoalkyl)-5-(arylalkyl)-1,3-dioxane derivatives and pharmaceutical compositions comprising such derivatives as active ingredient
FI933719A0 (fi)	1993-08-24	4-((2-bensotiazolyl)metylamino)-a-((3,4-difluorfenoxi)metyl)-1-piperidinetanol
DK0521393T3 (da)	1996-07-22	Dichlofenac-cholinsalt, fremgangsmåde til fremstilling deraf og farmaceutiske præparater der indeholder det
ES2101059T3 (es)	1997-07-01	Derivados biciclicos nitrogenados, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
DK0429370T3 (da)	1995-06-12	Hiditl ukendte thiophenderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
NO910904L (no)	1991-09-09	Fremgangsmaate for fremstilling av en substituert aminforbindelse.
EP0201349A3 (en)	1987-10-21	Tetrazole derivatives
ES2091670T3 (es)	1996-11-01	Nuevos derivados (ciclohexil)-alquenicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ATE134371T1 (de)	1996-03-15	Fungizide furanonderivate
DK0952157T3 (da)	2003-10-13	9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin
ATE96144T1 (de)	1993-11-15	2-aminoacetamid derivate.
DK1065206T3 (da)	2002-10-28	Tetrazolylalkylindol-forbindelser som anti-inflammatoriske og analgetiske midler
ATE154243T1 (de)	1997-06-15	Hemmstoff der blutgefässhypertrophie