DK0512754T3 - Reduktionsprodukter af rapamycin som immunosuppressive, antiinflammatoriske og antifungale midler - Google Patents

Reduktionsprodukter af rapamycin som immunosuppressive, antiinflammatoriske og antifungale midler

Info

Publication number: DK0512754T3
Authority: DK; Denmark
Prior art keywords: rapamycin; immunosuppressive; inflammatory; antifungal agents; reducing products
Prior art date: 1991-05-07

Application number

DK92303916T

Other languages

English (en)

Inventor

Craig Eugene Caufield

Philip Floyd Hughes

John Henry Musser

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-07

Filing date

1992-04-30

Publication date

2000-09-18

1991-05-07 Priority claimed from US07/696,692 external-priority patent/US5102876A/en

1991-08-07 Priority claimed from US07/741,714 external-priority patent/US5138051A/en

1992-04-30 Application filed by American Home Prod filed Critical American Home Prod

2000-09-18 Application granted granted Critical

2000-09-18 Publication of DK0512754T3 publication Critical patent/DK0512754T3/da

Links

ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
229960002930 sirolimus Drugs 0.000 title abstract 2
229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
230000003110 anti-inflammatory effect Effects 0.000 title 1
229940121375 antifungal agent Drugs 0.000 title 1
239000003429 antifungal agent Substances 0.000 title 1
230000001506 immunosuppresive effect Effects 0.000 title 1
229940125721 immunosuppressive agent Drugs 0.000 title 1
239000003018 immunosuppressive agent Substances 0.000 title 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
206010007134 Candida infections Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
125000000468 ketone group Chemical group 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
-1 sodium triacetoxyborohydride Chemical compound 0.000 abstract 1
239000012321 sodium triacetoxyborohydride Substances 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Diabetes (AREA)
Obesity (AREA)
Biochemistry (AREA)
Transplantation (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hematology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK92303916T 1991-05-07 1992-04-30 Reduktionsprodukter af rapamycin som immunosuppressive, antiinflammatoriske og antifungale midler DK0512754T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/696,692 US5102876A (en)	1991-05-07	1991-05-07	Reduction products of rapamycin
US07/741,714 US5138051A (en)	1991-08-07	1991-08-07	Rapamycin analogs as immunosuppressants and antifungals

Publications (1)

Publication Number	Publication Date
DK0512754T3 true DK0512754T3 (da)	2000-09-18

Family

ID=27105845

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK92303916T DK0512754T3 (da)	1991-05-07	1992-04-30	Reduktionsprodukter af rapamycin som immunosuppressive, antiinflammatoriske og antifungale midler

Country Status (15)

Country	Link
EP (1)	EP0512754B1 (da)
JP (1)	JP3108192B2 (da)
KR (1)	KR100230877B1 (da)
AT (1)	ATE194352T1 (da)
AU (1)	AU647616B2 (da)
DE (1)	DE69231215T2 (da)
DK (1)	DK0512754T3 (da)
ES (1)	ES2147724T3 (da)
FI (1)	FI97472C (da)
GR (1)	GR3034033T3 (da)
HU (1)	HU217868B (da)
MX (1)	MX9202031A (da)
NZ (1)	NZ242616A (da)
PH (1)	PH30228A (da)
PT (1)	PT512754E (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5776943A (en) *	1991-05-14	1998-07-07	American Home Products Corporation	Rapamycin metabolites
US5118677A (en) *	1991-05-20	1992-06-02	American Home Products Corporation	Amide esters of rapamycin
GB9302567D0 (en) *	1993-02-10	1993-03-24	Smithkline Beecham Plc	Novel compound
CH686761A5 (de)	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
JP3133922B2 (ja)	1995-06-09	2001-02-13	シャープ株式会社	強誘電体薄膜被覆基板、その製造方法、及びキャパシタ構造素子
JP3480624B2 (ja)	1995-06-09	2003-12-22	シャープ株式会社	強誘電体薄膜被覆基板、その製造方法、及びキャパシタ構造素子
US6258823B1 (en) *	1996-07-12	2001-07-10	Ariad Pharmaceuticals, Inc.	Materials and method for treating or preventing pathogenic fungal infection
GB9826882D0 (en)	1998-12-07	1999-01-27	Novartis Ag	Organic compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5023262A (en)	1990-08-14	1991-06-11	American Home Products Corporation	Hydrogenated rapamycin derivatives

1992
- 1992-04-28 FI FI921893A patent/FI97472C/fi not_active IP Right Cessation
- 1992-04-28 JP JP04109579A patent/JP3108192B2/ja not_active Expired - Fee Related
- 1992-04-30 DK DK92303916T patent/DK0512754T3/da active
- 1992-04-30 HU HU9201468A patent/HU217868B/hu not_active IP Right Cessation
- 1992-04-30 PH PH44299A patent/PH30228A/en unknown
- 1992-04-30 EP EP92303916A patent/EP0512754B1/en not_active Expired - Lifetime
- 1992-04-30 AT AT92303916T patent/ATE194352T1/de not_active IP Right Cessation
- 1992-04-30 DE DE69231215T patent/DE69231215T2/de not_active Expired - Fee Related
- 1992-04-30 MX MX9202031A patent/MX9202031A/es unknown
- 1992-04-30 ES ES92303916T patent/ES2147724T3/es not_active Expired - Lifetime
- 1992-04-30 PT PT92303916T patent/PT512754E/pt unknown
- 1992-05-01 KR KR1019920007431A patent/KR100230877B1/ko not_active Expired - Fee Related
- 1992-05-05 AU AU16008/92A patent/AU647616B2/en not_active Ceased
- 1992-05-05 NZ NZ24261692A patent/NZ242616A/en unknown
2000
- 2000-07-27 GR GR20000401723T patent/GR3034033T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
EP0512754B1 (en)	2000-07-05
HUT62589A (en)	1993-05-28
AU1600892A (en)	1992-11-12
FI921893L (fi)	1992-11-08
JP3108192B2 (ja)	2000-11-13
NZ242616A (en)	1994-07-26
JPH05117279A (ja)	1993-05-14
HU9201468D0 (en)	1992-07-28
HU217868B (hu)	2000-04-28
FI97472C (fi)	1996-12-27
MX9202031A (es)	1992-11-01
PT512754E (pt)	2000-11-30
AU647616B2 (en)	1994-03-24
ES2147724T3 (es)	2000-10-01
FI921893A0 (fi)	1992-04-28
DE69231215T2 (de)	2000-11-09
PH30228A (en)	1997-02-05
DE69231215D1 (de)	2000-08-10
FI97472B (fi)	1996-09-13
KR100230877B1 (ko)	1999-11-15
EP0512754A1 (en)	1992-11-11
GR3034033T3 (en)	2000-11-30
KR920021553A (ko)	1992-12-18
ATE194352T1 (de)	2000-07-15

Publication	Publication Date	Title
DE69223583D1 (de)	1998-01-29	Imidazolidyl-Makrolide mit immunosuppressiver Wirkung
DK0386997T3 (da)	1997-04-14	Anvendelse af 4-phenyl-1,2,3,4-tetrahydro-1-naphthalenamin-derivater i behandlingen af psykose, inflammation og som immunosuppressive midler
ES2099158T3 (es)	1997-05-16	Tratamiento del rechazo de trasplantes o de enfermedades autoinmunitarias y complejo de la formula general x-pro-y-boropro asociada al mismo.
NO940805D0 (no)	1994-03-08	O-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl og O-alkynylheteroarylmakrolider
NO961345L (no)	1996-06-03	O-aryl, O-alkyl-, O-alkenyl- og O-alkynylmakrolider med immunundertrykkende aktivitet
PT1123295E (pt)	2005-01-31	Heterociclos de azoto biciclicos
FI933357A0 (fi)	1993-07-27	Foerfarande foer framstaellning av benzamider
ATE144536T1 (de)	1996-11-15	Cyclosporin- derivate
ATE136900T1 (de)	1996-05-15	Prolinderivat von rapamycin, seine herstellung und verwendung
NO305992B1 (no)	1999-08-30	Halvsyntetiske glykosaminglykosaner med heparin- eller heparanstruktur og fremgangsmåte til fremstilling derav
DK0629203T3 (da)	2001-11-12	Desosaminoderivater af makrolider som immunosuppressive midler og antifungale midler
CA2086643A1 (en)	1993-07-17	Oxepane isomers of rapamycin useful as immunosuppressive agents
ATE194352T1 (de)	2000-07-15	Reduktionsprodukte von rapamycin als immunosuppressive, entzündungshemmende und antifungale mittel
ATE154615T1 (de)	1997-07-15	Halbsynthetische glykosaminoglykane, die in 3- position mit nukleophilen radikalen substituierte alpha-l-galakturonsäure enthalten
ES2169272T3 (es)	2002-07-01	Diaminopirimidinas, composiciones farmaceuticas que las contienen y su utilizacion como agente antibacteriano.
ATE150468T1 (de)	1997-04-15	Dermatansulfatoligosaccharide, verfahren zu ihrer herstellung und diese enthaltende phamazeutische zusammensetzungen
IT8421432A0 (it)	1984-06-15	Composti costituiti da 5-ammino-3-osso-4-(sostituito-fenil)-2,3-diidrofurano e suoi derivati, con proprieta' erbicide e di regolazione della crescita delle piante.
NO20003397L (no)	2000-08-31	3 '-epimerie K-252A-derivater
NO20016326L (no)	2001-12-21	Anvendelse av proteinet UK 114 for å hindre avstötning av organtransplantatet
IT1265430B1 (it)	1996-11-22	Derivati del pirrolo e loro impieghi
IT1122321B (it)	1986-04-23	Derivati del benzotiopirano parentesi quadra aperta 3,4-d parentesi quadra chiusa pirazolo ad attivita'antiaritmica,cardiocircolatoria e antiinfiammatoria