ATE194352T1 - Reduktionsprodukte von rapamycin als immunosuppressive, entzündungshemmende und antifungale mittel - Google Patents

Reduktionsprodukte von rapamycin als immunosuppressive, entzündungshemmende und antifungale mittel

Info

Publication number: ATE194352T1
Authority: AT; Austria
Prior art keywords: rapamycin; immunosuppressive; inflammatory; antifungal agents; reduction products
Prior art date: 1991-05-07

Application number

AT92303916T

Other languages

English (en)

Inventor

Craig Eugene Caufield

Philip Floyd Hughes

John Henry Musser

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-07

Filing date

1992-04-30

Publication date

2000-07-15

1991-05-07 Priority claimed from US07/696,692 external-priority patent/US5102876A/en

1991-08-07 Priority claimed from US07/741,714 external-priority patent/US5138051A/en

1992-04-30 Application filed by American Home Prod filed Critical American Home Prod

2000-07-15 Application granted granted Critical

2000-07-15 Publication of ATE194352T1 publication Critical patent/ATE194352T1/de

Links

ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 title abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title abstract 2
229960002930 sirolimus Drugs 0.000 title abstract 2
229940121363 anti-inflammatory agent Drugs 0.000 title 1
239000002260 anti-inflammatory agent Substances 0.000 title 1
230000003110 anti-inflammatory effect Effects 0.000 title 1
229940121375 antifungal agent Drugs 0.000 title 1
239000003429 antifungal agent Substances 0.000 title 1
230000001506 immunosuppresive effect Effects 0.000 title 1
229940125721 immunosuppressive agent Drugs 0.000 title 1
239000003018 immunosuppressive agent Substances 0.000 title 1
208000023275 Autoimmune disease Diseases 0.000 abstract 1
206010007134 Candida infections Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
SIPUZPBQZHNSDW-UHFFFAOYSA-N bis(2-methylpropyl)aluminum Chemical compound CC(C)C[Al]CC(C)C SIPUZPBQZHNSDW-UHFFFAOYSA-N 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
125000000468 ketone group Chemical group 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
-1 sodium triacetoxyborohydride Chemical compound 0.000 abstract 1
239000012321 sodium triacetoxyborohydride Substances 0.000 abstract 1
238000002054 transplantation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT92303916T 1991-05-07 1992-04-30 Reduktionsprodukte von rapamycin als immunosuppressive, entzündungshemmende und antifungale mittel ATE194352T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US07/696,692 US5102876A (en)	1991-05-07	1991-05-07	Reduction products of rapamycin
US07/741,714 US5138051A (en)	1991-08-07	1991-08-07	Rapamycin analogs as immunosuppressants and antifungals

Publications (1)

Publication Number	Publication Date
ATE194352T1 true ATE194352T1 (de)	2000-07-15

Family

ID=27105845

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92303916T ATE194352T1 (de)	1991-05-07	1992-04-30	Reduktionsprodukte von rapamycin als immunosuppressive, entzündungshemmende und antifungale mittel

Country Status (15)

Country	Link
EP (1)	EP0512754B1 (de)
JP (1)	JP3108192B2 (de)
KR (1)	KR100230877B1 (de)
AT (1)	ATE194352T1 (de)
AU (1)	AU647616B2 (de)
DE (1)	DE69231215T2 (de)
DK (1)	DK0512754T3 (de)
ES (1)	ES2147724T3 (de)
FI (1)	FI97472C (de)
GR (1)	GR3034033T3 (de)
HU (1)	HU217868B (de)
MX (1)	MX9202031A (de)
NZ (1)	NZ242616A (de)
PH (1)	PH30228A (de)
PT (1)	PT512754E (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5776943A (en) *	1991-05-14	1998-07-07	American Home Products Corporation	Rapamycin metabolites
US5118677A (en) *	1991-05-20	1992-06-02	American Home Products Corporation	Amide esters of rapamycin
GB9302567D0 (en) *	1993-02-10	1993-03-24	Smithkline Beecham Plc	Novel compound
CH686761A5 (de)	1993-05-27	1996-06-28	Sandoz Ag	Galenische Formulierungen.
JP3480624B2 (ja)	1995-06-09	2003-12-22	シャープ株式会社	強誘電体薄膜被覆基板、その製造方法、及びキャパシタ構造素子
JP3133922B2 (ja)	1995-06-09	2001-02-13	シャープ株式会社	強誘電体薄膜被覆基板、その製造方法、及びキャパシタ構造素子
US6258823B1 (en) *	1996-07-12	2001-07-10	Ariad Pharmaceuticals, Inc.	Materials and method for treating or preventing pathogenic fungal infection
GB9826882D0 (en)	1998-12-07	1999-01-27	Novartis Ag	Organic compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5023262A (en)	1990-08-14	1991-06-11	American Home Products Corporation	Hydrogenated rapamycin derivatives

1992
- 1992-04-28 FI FI921893A patent/FI97472C/fi not_active IP Right Cessation
- 1992-04-28 JP JP04109579A patent/JP3108192B2/ja not_active Expired - Fee Related
- 1992-04-30 DK DK92303916T patent/DK0512754T3/da active
- 1992-04-30 PH PH44299A patent/PH30228A/en unknown
- 1992-04-30 MX MX9202031A patent/MX9202031A/es unknown
- 1992-04-30 PT PT92303916T patent/PT512754E/pt unknown
- 1992-04-30 ES ES92303916T patent/ES2147724T3/es not_active Expired - Lifetime
- 1992-04-30 EP EP92303916A patent/EP0512754B1/de not_active Expired - Lifetime
- 1992-04-30 DE DE69231215T patent/DE69231215T2/de not_active Expired - Fee Related
- 1992-04-30 AT AT92303916T patent/ATE194352T1/de not_active IP Right Cessation
- 1992-04-30 HU HU9201468A patent/HU217868B/hu not_active IP Right Cessation
- 1992-05-01 KR KR1019920007431A patent/KR100230877B1/ko not_active Expired - Fee Related
- 1992-05-05 NZ NZ24261692A patent/NZ242616A/en unknown
- 1992-05-05 AU AU16008/92A patent/AU647616B2/en not_active Ceased
2000
- 2000-07-27 GR GR20000401723T patent/GR3034033T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
PT512754E (pt)	2000-11-30
FI97472B (fi)	1996-09-13
HUT62589A (en)	1993-05-28
KR100230877B1 (ko)	1999-11-15
NZ242616A (en)	1994-07-26
AU1600892A (en)	1992-11-12
DE69231215D1 (de)	2000-08-10
AU647616B2 (en)	1994-03-24
JPH05117279A (ja)	1993-05-14
FI921893A0 (fi)	1992-04-28
FI921893L (fi)	1992-11-08
EP0512754B1 (de)	2000-07-05
EP0512754A1 (de)	1992-11-11
KR920021553A (ko)	1992-12-18
ES2147724T3 (es)	2000-10-01
JP3108192B2 (ja)	2000-11-13
HU9201468D0 (en)	1992-07-28
HU217868B (hu)	2000-04-28
DK0512754T3 (da)	2000-09-18
GR3034033T3 (en)	2000-11-30
MX9202031A (es)	1992-11-01
PH30228A (en)	1997-02-05
FI97472C (fi)	1996-12-27
DE69231215T2 (de)	2000-11-09

Legal Events

Date	Code	Title	Description
2000-11-15	UEP	Publication of translation of european patent specification
2005-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE161266T1 (de)	1998-01-15	Imidazolidyl-makrolide mit immunosuppressiver wirkung
BG100474A (bg)	1996-12-31	О-арил, о-алкил, о-алкенил и о-алкинил-макролидис имуносупресивно действие
MX9205137A (es)	1993-04-01	O-heteroaril, o-alquilheteroaril, o-alquenilheteroaril y o-alquinilheteroarilmacrolidas que tienen actividad inmunosupresora.
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DE69231215D1 (de)	2000-08-10	Reduktionsprodukte von Rapamycin als immunosuppressive, entzündungshemmende und antifungale Mittel
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