DK0535231T3 - Pyrimidinnucleosid-derivater - Google Patents

Pyrimidinnucleosid-derivater

Info

Publication number: DK0535231T3
Authority: DK; Denmark
Prior art keywords: pyrimidine nucleoside; nucleoside derivatives; hydroxy; hydrogen; represent
Prior art date: 1990-06-15

Application number

DK91911192.2T

Other languages

English (en)

Inventor

Tohru Ueda

Akira Matsuda

Takuma Sasaki

Original Assignee

Sankyo Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-15

Filing date

1991-06-13

Publication date

1995-08-21

1991-06-13 Application filed by Sankyo Co filed Critical Sankyo Co

1995-08-21 Application granted granted Critical

1995-08-21 Publication of DK0535231T3 publication Critical patent/DK0535231T3/da

Links

150000003833 nucleoside derivatives Chemical class 0.000 title abstract 2
239000002718 pyrimidine nucleoside Substances 0.000 title abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002252 acyl group Chemical group 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK91911192.2T 1990-06-15 1991-06-13 Pyrimidinnucleosid-derivater DK0535231T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP15668890		1990-06-15

Publications (1)

Publication Number	Publication Date
DK0535231T3 true DK0535231T3 (da)	1995-08-21

Family

ID=15633157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK91911192.2T DK0535231T3 (da)	1990-06-15	1991-06-13	Pyrimidinnucleosid-derivater

Country Status (13)

Country	Link
US (2)	US5616567A (da)
EP (1)	EP0535231B1 (da)
JP (1)	JP2559917B2 (da)
KR (1)	KR970011306B1 (da)
AT (1)	ATE122041T1 (da)
CA (1)	CA2085345C (da)
DE (1)	DE69109482T2 (da)
DK (1)	DK0535231T3 (da)
ES (1)	ES2074719T3 (da)
HK (1)	HK1005871A1 (da)
HU (1)	HU218924B (da)
RU (1)	RU2116306C1 (da)
WO (1)	WO1991019713A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2085557C1 (ru) *	1991-09-30	1997-07-27	Санкио Компани Лимитед	Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения
EP0640092B1 (en)	1992-05-12	1996-12-11	Merrell Pharmaceuticals Inc.	A process for the preparation of ribonucleotide reductase inhibitors
AP2006003708A0 (en) *	2000-05-26	2006-08-31	Idenix Cayman Ltd	Methods and compositions for treating flavivirusesand pestiviruses
JP3748536B2 (ja) *	2001-02-09	2006-02-22	三共株式会社	ピリミジンヌクレオシド誘導体の結晶
MY142304A (en)	2005-01-31	2010-11-15	Taiho Pharmaceutical Co Ltd	Novel pyrimidine nucleoside compound or salt thereof
BRPI0609095A2 (pt) *	2005-05-11	2010-02-17	Nippon Kayaku Kk	derivado polimérico de antagonista metabólico de citidina, agente antitumor e antiviral e método para produzir o referido derivado
GB0523041D0 (en) *	2005-11-11	2005-12-21	Cyclacel Ltd	Combination
GB0526419D0 (en) *	2005-12-23	2006-02-08	Cyclacel Ltd	Formulation
EP2045256A4 (en) *	2006-07-21	2009-09-02	Taiho Pharmaceutical Co Ltd	2'-CYANOPYRIMIDINNUKLEOSIDVERBINDUNG
PL2084174T3 (pl) *	2006-10-10	2013-12-31	Gilead Pharmasset Llc	Sposób otrzymywania nukleozydów rybofuranozylopirymidynowych
GB0625283D0 (en)	2006-12-19	2007-01-24	Cyclacel Ltd	Combination
BRPI0817234A2 (pt) *	2007-09-26	2014-09-30	Sinai School Medicine	Análogos de azacitidina e seus usos
US8124593B2 (en)	2007-11-05	2012-02-28	Cyclacel Limited	Methods of treatment using sapacitabine
US7863255B2 (en) *	2008-04-29	2011-01-04	Taiho Pharmaceutical Co., Ltd.	Methods of administering antitumor agent comprising deoxycytidine derivative
GB0808359D0 (en) *	2008-05-08	2008-06-18	Cyclacel Ltd	Process
GB0808357D0 (en) *	2008-05-08	2008-06-18	Cyclacel Ltd	Process
KR101667641B1 (ko)	2008-06-09	2016-10-20	싸이클라셀 리미티드	데시타빈 및 프로카인과 같은 ｄｎａ 메틸전이효소 저해제와 사팍시타빈 또는 ｃｎｄａｃ의 조합
FI2431376T4 (fi)	2009-05-15	2024-03-13	Delta Fly Pharma Inc	1-(2'-syano-2'-deoksi-beeta-D-arabinofuranosyyli)sytosiinimonohydrokloridin uusi vakaa kide
HUE046177T2 (hu)	2011-04-14	2020-02-28	Cyclacel Ltd	Szapacitabin és decitabin kombinációjának adagolási rendje akut mieloid leukémia kezelésére
SG10201610936RA (en)	2011-12-22	2017-02-27	Alios Biopharma Inc	Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en)	2012-03-21	2016-09-13	Alios Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en)	2012-03-21	2020-08-25	Janssen Biopharma, Inc.	Substituted nucleosides, nucleotides and analogs thereof
WO2013171473A1 (en)	2012-05-15	2013-11-21	Cyclacel Limited	Dosage regimen for sapacitabine and seliciclib
WO2019081951A1 (en)	2017-10-27	2019-05-02	Cyclacel Limited	DOSAGE REGIME
US11957701B2 (en)	2020-07-17	2024-04-16	Delta-Fly Pharma, Inc.	Therapy and new therapeutic agent for blood cancer

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2007094A6 (es) *	1987-07-29	1989-06-01	Consejo Superior Investigacion	Procedimiento para la preparacion de 3 -c- ciano-2,3 -didesoxinucleosido.

1991
- 1991-06-11 JP JP3138859A patent/JP2559917B2/ja not_active Expired - Lifetime
- 1991-06-13 ES ES91911192T patent/ES2074719T3/es not_active Expired - Lifetime
- 1991-06-13 CA CA002085345A patent/CA2085345C/en not_active Expired - Lifetime
- 1991-06-13 HU HU9203967A patent/HU218924B/hu unknown
- 1991-06-13 WO PCT/JP1991/000797 patent/WO1991019713A1/ja not_active Ceased
- 1991-06-13 DE DE69109482T patent/DE69109482T2/de not_active Expired - Lifetime
- 1991-06-13 AT AT91911192T patent/ATE122041T1/de not_active IP Right Cessation
- 1991-06-13 RU RU92016591/04A patent/RU2116306C1/ru active
- 1991-06-13 KR KR1019920703246A patent/KR970011306B1/ko not_active Expired - Lifetime
- 1991-06-13 DK DK91911192.2T patent/DK0535231T3/da active
- 1991-06-13 EP EP91911192A patent/EP0535231B1/en not_active Expired - Lifetime
1994
- 1994-09-07 US US08/301,720 patent/US5616567A/en not_active Expired - Lifetime
1995
- 1995-06-01 US US08/457,510 patent/US5654420A/en not_active Expired - Lifetime
1998
- 1998-06-05 HK HK98104955A patent/HK1005871A1/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE122041T1 (de)	1995-05-15
WO1991019713A1 (fr)	1991-12-26
ES2074719T3 (es)	1995-09-16
KR930700485A (ko)	1993-03-15
US5654420A (en)	1997-08-05
KR970011306B1 (ko)	1997-07-09
HUT62582A (en)	1993-05-28
DE69109482D1 (en)	1995-06-08
DE69109482T2 (de)	1996-02-15
CA2085345A1 (en)	1991-12-16
HU9203967D0 (en)	1993-03-29
CA2085345C (en)	2001-08-07
JPH04235182A (ja)	1992-08-24
EP0535231A4 (en)	1993-06-30
JP2559917B2 (ja)	1996-12-04
EP0535231A1 (en)	1993-04-07
HU218924B (hu)	2000-12-28
HK1005871A1 (en)	1999-01-29
US5616567A (en)	1997-04-01
EP0535231B1 (en)	1995-05-03
RU2116306C1 (ru)	1998-07-27

Publication	Publication Date	Title
KR930700485A (ko)	1993-03-15	피리미딘 뉴클레오시드 유도체
PT784974E (pt)	2003-09-30	Preparacao de derivados de xantina numa dispersao solida
ATE416186T1 (de)	2008-12-15	Phenylethylenamin-derivate
DK0536936T3 (da)	1997-01-13	Pyrimidinnukleosidderivater med anti-tumor-aktivitet, deres fremstilling og anvendelse
DE3851179D1 (de)	1994-09-29	Oxetanocin.
FI952101A0 (fi)	1995-05-03	Merkaptanfoerening
MX9101232A (es)	1992-05-04	Derivados de benceno,piridina y pirimidina
ATE232528T1 (de)	2003-02-15	Pyrimidinylpyrazolderivate
ES2169220T3 (es)	2002-07-01	Derivados de vitamina d3 con sustituyentes en la posicion 2.
ATE134376T1 (de)	1996-03-15	Mono- und bis-alkylaminoanthracycline
ES2096572T3 (es)	1997-03-16	Nuevos derivados de glucosidos de antraciclina y procedimiento para su preparacion.
FI904728A0 (fi)	1990-09-26	Benzanilider.
ATE90685T1 (de)	1993-07-15	Disaccharidderivate.
ES2149180T3 (es)	2000-11-01	Derivado de pirazolotiazolopirimidina.
ATE140919T1 (de)	1996-08-15	Indolderivate
GB0217638D0 (en)	2002-09-11	Total synthesis of myriaporones